Patient Portal

Li-Shiun Chen, MD, MPH, ScD

Associate Professor, Psychiatry

Specialty Areas

Mood Disorders
Adult Psychiatry

Board Certifications


Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Schizophrenia, early psychosis, mood disorders, substance dependence, community psychiatry, genetics, family and sibling studies.

Dr. Chen is the adolescent & adult psychiatry assessment supervisor for the First Contact Assessment Service, which evaluates individuals who are showing early signs of a possible psychotic disorder such as schizophrenia. In addition to assessment by a psychiatrist, First Contact assessments include diagnostic interviews and cognitive testing by a psychologist. The First Contact Assessment Service generally does not follow patients over time, but provides evaluation reports to the treating psychiatrist.

  • Education
  • Publication & Research



Medical Degree: National Taiwan University, School of Medicine, Taipei, Taiwan 1993
Sc.D.: Psychiatric Epidemiology, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 1998
M.P.H.: Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 1995

Publication & Research

Publication & Research

Chen LS, Baker T, Brownson RC, Carney RM, Jorenby D, Hartz S, Smock N, Johnson M, Ziedonis D, Bierut LJ, (2016 Nov). Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives. Community Ment Health J. .  

Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Rosenberger A, Aben KK, Andrew AS, Chang SC, Saum KU, Dienemann H, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden EH, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Brüske I, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare MD, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz MR, Amos CI, Bierut LJ, (2016 Sep). Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis. EBioMedicine. 11: 219-226.  

Chen LS, Hung RJ., Baker TB, Horton A, Culverhouse R, Saccone NL, Cheng I, Deng B, et al, Spitz, MR, Kraft P, Amos CI, Bierut LJ, 2015. CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis-A Meta-Analysis. J Natl Cancer Inst. 2015 Apr 14;107(5)  

Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L (2014 Jan). Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction. 109(1): 128-37.  

Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson EO, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ (2012 Jul 1). Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. Am J Psychiatry. 169(7): 735-42.  

Chen LS, Baker, TB, Korpecki, JM, Johnson KE, Hook JP, Brownson RC, Bierut LJ. Low-burden strategies to promote smoking cessation treatment in patients with serious mental illness. Psychiatric Services. 2018 in press.