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Faculty Physicians

Li-Shiun Chen, MD, MPH, ScD

Instructor, Psychiatry

Specialty Areas

Schizophrenia
Mood Disorders
Adult Psychiatry

Board Certifications

Certified

Areas of Clinical Interest

Schizophrenia, early psychosis, mood disorders, substance dependence, community psychiatry, genetics, family and sibling studies.















Dr. Chen is the adolescent & adult psychiatry assessment supervisor for the First Contact Assessment Service, which evaluates individuals who are showing early signs of a possible psychotic disorder such as schizophrenia. In addition to assessment by a psychiatrist, First Contact assessments include diagnostic interviews and cognitive testing by a psychologist. The First Contact Assessment Service generally does not follow patients over time, but provides evaluation reports to the treating psychiatrist.

  • Education
  • Publication & Research

Education

Education

Medical Degree: National Taiwan University, School of Medicine, Taipei, Taiwan 1993
Sc.D.: Psychiatric Epidemiology, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 1998
M.P.H.: Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 1995

Publication & Research

Publication & Research

CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
Chen LS, Hung RJ, Baker T, Horton A, Culverhouse R, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Lutz S, Rosenberger A, Aben KK, Andrew AS, Breslau N, Chang SC, Dieffenbach AK, Dienemann H, Frederiksen B, Han J, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden HF, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Heinrich J, Hokanson JE, Hunter DJ, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare D, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz MR, Kraft P, Amos CI, Bierut LJ
J Natl Cancer Inst. 2015 May; 107(5)pii: djv100. doi: 10.1093/jnci/djv100.

PMID:
    25873736
    [PubMed - indexed for MEDLINE]
Related citations


A very rare case of trisomy 4q32.3-4q35.2 and trisomy 21q11.2-21q22.11 in a patient with recombinant chromosomes 4 and 21.
Chen LS, Xue D, Xi ZM, Liu DN, Zou PS, Ma M, Xia Y, Chen XH, Qiu GB, Cao DH
Gene. 2015 May 25; 563(1)72-5. doi: 10.1016/j.gene.2015.03.006.

PMID:
    25752286
    [PubMed - indexed for MEDLINE]
Related citations


Irritable bowel syndrome and the incidence of colorectal neoplasia: a prospective cohort study with community-based screened population in Taiwan.
Chang HC, Yen AM, Fann JC, Chiu SY, Liao CS, Chen HH, Yang KC, Chen LS, Lin YM
Br J Cancer. 2015 Jan 6; 112(1)171-6. doi: 10.1038/bjc.2014.575.

PMID:
    25474251
    [PubMed - indexed for MEDLINE]
Related citations


Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.
Masjkur J, Arps-Forker C, Poser SW, Nikolakopoulou P, Toutouna L, Chenna R, Chavakis T, Chatzigeorgiou A, Chen LS, Dubrovska A, Choudhary P, Uphues I, Mark M, Bornstein SR, Androutsellis-Theotokis A
J Biol Chem. 2014 Dec 19; 289(51)35503-16. doi: 10.1074/jbc.M114.590687.

PMID:
    25371201
    [PubMed - indexed for MEDLINE]
Related citations


Mechanism-based combinations with Pim kinase inhibitors in cancer treatments.
Yang Q, Chen LS, Gandhi V
Curr Pharm Des. 2014; 20(42)6670-81.

PMID:
    25341939
    [PubMed - indexed for MEDLINE]
Related citations


Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents.
Lin HC, Huang YK, Shiue HS, Chen LS, Choy CS, Huang SR, Han BC, Hsueh YM
Food Chem Toxicol. 2014 Dec; 7460-7. doi: 10.1016/j.fct.2014.08.018.

PMID:
    25241017
    [PubMed - indexed for MEDLINE]
Related citations


Fuzzy set regression method to evaluate the heterogeneity of misclassifications in disease screening with interval-scaled variables: application to osteoporosis (KCIS No. 26).
Chen LS, Yen MF, Chiu YH, Chen HH
Int J Biostat. 2014; 10(2)261-76. doi: 10.1515/ijb-2014-0032.

PMID:
    25153243
    [PubMed - indexed for MEDLINE]
Related citations


Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
Wu C, Wang Z, Song X, Feng XS, Abnet CC, He J, Hu N, Zuo XB, Tan W, Zhan Q, Hu Z, He Z, Jia W, Zhou Y, Yu K, Shu XO, Yuan JM, Zheng W, Zhao XK, Gao SG, Yuan ZQ, Zhou FY, Fan ZM, Cui JL, Lin HL, Han XN, Li B, Chen X, Dawsey SM, Liao L, Lee MP, Ding T, Qiao YL, Liu Z, Liu Y, Yu D, Chang J, Wei L, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Han JJ, Zhou SL, Zhang P, Zhang DY, Yuan Y, Huang Y, Liu C, Zhai K, Qiao Y, Jin G, Guo C, Fu J, Miao X, Lu C, Yang H, Wang C, Wheeler WA, Gail M, Yeager M, Yuenger J, Guo ET, Li AL, Zhang W, Li XM, Sun LD, Ma BG, Li Y, Tang S, Peng XQ, Liu J, Hutchinson A, Jacobs K, Giffen C, Burdette L, Fraumeni JF Jr, Shen H, Ke Y, Zeng Y, Wu T, Kraft P, Chung CC, Tucker MA, Hou ZC, Liu YL, Hu YL, Liu Y, Wang L, Yuan G, Chen LS, Liu X, Ma T, Meng H, Sun L, Li XM, Li XM, Ku JW, Zhou YF, Yang LQ, Wang Z, Li Y, Qige Q, Yang WJ, Lei GY, Chen LQ, Li EM, Yuan L, Yue WB, Wang R, Wang LW, Fan XP, Zhu FH, Zhao WX, Mao YM, Zhang M, Xing GL, Li JL, Han M, Ren JL, Liu B, Ren SW, Kong QP, Li F, Sheyhidin I, Wei W, Zhang YR, Feng CW, Wang J, Yang YH, Hao HZ, Bao QD, Liu BC, Wu AQ, Xie D, Yang WC, Wang L, Zhao XH, Chen SQ, Hong JY, Zhang XJ, Freedman ND, Goldstein AM, Lin D, Taylor PR, Wang LD, Chanock SJ
Nat Genet. 2014 Sep; 46(9)1001-6. doi: 10.1038/ng.3064.

PMID:
    25129146
    [PubMed - indexed for MEDLINE]
Related citations


Blood collection methods affect cellular protein integrity: implications for clinical trial biomarkers and ZAP-70 in CLL.
Chen LS, Keating MJ, Gandhi V
Blood. 2014 Aug 14; 124(7)1192-5. doi: 10.1182/blood-2014-04-565754.

PMID:
    25124785
    [PubMed - indexed for MEDLINE]
Related citations


The performance of a diabetic retinopathy risk score for screening for diabetic retinopathy in Chinese overweight/obese patients with type 2 diabetes mellitus.
Wang J, Chen H, Zhang H, Yang F, Chen RP, Li YB, Yang C, Lin SD, Chen LS, Liang GX, Cai DH
Ann Med. 2014 Sep; 46(6)417-23. doi: 10.3109/07853890.2013.878977.

PMID:
    25088608
    [PubMed - indexed for MEDLINE]
Related citations


Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.
Bloom AJ, Hartz SM, Baker TB, Chen LS, Piper ME, Fox L, Martinez M, Hatsukami D, Johnson EO, Laurie CC, Saccone NL, Goate A, Bierut LJ
Ann Am Thorac Soc. 2014 Sep; 11(7)1003-10. doi: 10.1513/AnnalsATS.201401-010OC.

PMID:
    25072098
    [PubMed - indexed for MEDLINE]
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Tumor characteristics of breast cancer in predicting axillary lymph node metastasis.
Tseng HS, Chen LS, Kuo SJ, Chen ST, Wang YF, Chen DR
Med Sci Monit. 2014 Jul 7; 201155-61. doi: 10.12659/MSM.890491.

PMID:
    24998473
    [PubMed - indexed for MEDLINE]
Related citations


Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy.
Chen PS, Chen LS, Fishbein MC, Lin SF, Nattel S
Circ Res. 2014 Apr 25; 114(9)1500-15. doi: 10.1161/CIRCRESAHA.114.303772.

PMID:
    24763467
    [PubMed - indexed for MEDLINE]
Related citations


CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction.
Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S
Nicotine Tob Res. 2014 Sep; 16(9)1224-31. doi: 10.1093/ntr/ntu059.

PMID:
    24727484
    [PubMed - indexed for MEDLINE]
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Quantification of dapaconazole in human plasma using high-performance liquid chromatography coupled to tandem mass spectrometry: application to a phase I study.
de Moraes FC, Bittencourt SF, Perissutti E, Frencentese F, Arruda AM, Chen LS, Babadópulos T, De Nucci G
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1; 958102-7. doi: 10.1016/j.jchromb.2014.01.053.

PMID:
    24705538
    [PubMed - indexed for MEDLINE]
Related citations


Faecal haemoglobin concentrations vary with sex and age, but data are not transferable across geography for colorectal cancer screening.
Fraser CG, Rubeca T, Rapi S, Chen LS, Chen HH
Clin Chem Lab Med. 2014 Aug; 52(8)1211-6. doi: 10.1515/cclm-2014-0115.

PMID:
    24637000
    [PubMed - indexed for MEDLINE]
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Surveillance of influenza from household to community in Taiwan.
Hsu CY, Yen AM, Chen LS, Chen HH
Trans R Soc Trop Med Hyg. 2014 Apr; 108(4)213-20. doi: 10.1093/trstmh/tru023.

PMID:
    24627426
    [PubMed - indexed for MEDLINE]
Related citations


Variations in the MHC region confer risk to esophageal squamous cell carcinoma on the subjects from high-incidence area in northern China.
Shen FF, Yue WB, Zhou FY, Pan Y, Zhao XK, Jin Y, Song X, Li B, Han XN, Tang S, Li Y, Yuan G, Chen LS, Liu YL, Hu YL, Li XM, Ren JL, Wang LD
PLoS One. 2014; 9(3)e90438. doi: 10.1371/journal.pone.0090438.

PMID:
    24595008
    [PubMed - indexed for MEDLINE]
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Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: statistical evaluation of epistasis.
Chen LS, Fann JC, Chiu SY, Yen AM, Wahlfors T, Tammela TL, Chen HH, Auvinen A, Schleutker J
PLoS One. 2014; 9(2)e89508. doi: 10.1371/journal.pone.0089508.

PMID:
    24586834
    [PubMed - indexed for MEDLINE]
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A penalized EM algorithm incorporating missing data mechanism for Gaussian parameter estimation.
Chen LS, Prentice RL, Wang P
Biometrics. 2014 Jun; 70(2)312-22. doi: 10.1111/biom.12149.

PMID:
    24471933
    [PubMed - indexed for MEDLINE]
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