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Li-Shiun Chen, MD, MPH, ScD

Instructor, Psychiatry

Specialty Areas

Schizophrenia
Mood Disorders
Adult Psychiatry

Board Certifications

Certified

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Schizophrenia, early psychosis, mood disorders, substance dependence, community psychiatry, genetics, family and sibling studies.















Dr. Chen is the adolescent & adult psychiatry assessment supervisor for the First Contact Assessment Service, which evaluates individuals who are showing early signs of a possible psychotic disorder such as schizophrenia. In addition to assessment by a psychiatrist, First Contact assessments include diagnostic interviews and cognitive testing by a psychologist. The First Contact Assessment Service generally does not follow patients over time, but provides evaluation reports to the treating psychiatrist.

  • Education
  • Publication & Research

Education

Education

Medical Degree: National Taiwan University, School of Medicine, Taipei, Taiwan 1993
Sc.D.: Psychiatric Epidemiology, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 1998
M.P.H.: Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 1995

Publication & Research

Publication & Research

How are lung cancer risk perceptions and cigarette smoking related?-testing an accuracy hypothesis.
Chen LS, Kaphingst KA, Tseng TS, Zhao S
Transl Cancer Res. 2016 Oct; 5(Suppl 5)S964-S971. doi: 10.21037/tcr.2016.10.75.

PMID:
    29147644
    [PubMed]
Related citations


Trends of long noncoding RNA research from 2007 to 2016: a bibliometric analysis.
Miao Y, Xu SY, Chen LS, Liang GY, Pu YP, Yin LH
Oncotarget. 2017 Oct 10; 8(47)83114-83127. doi: 10.18632/oncotarget.20851.

PMID:
    29137328
    [PubMed]
Related citations


Long term intermittent high amplitude subcutaneous nerve stimulation reduces sympathetic tone in ambulatory dogs.
Yuan Y, Jiang Z, Zhao Y, Tsai WC, Patel J, Chen LS, Shen C, Lin SF, Chen HV, Everett TH 4th, Fishbein MC, Chen Z, Chen PS
Heart Rhythm. 2017 Oct 25; pii: S1547-5271(17)31242-0. doi: 10.1016/j.hrthm.2017.10.028.

PMID:
    29081397
    [PubMed - as supplied by publisher]
Related citations


The presence of F cells with a fetal phenotype in adults with hemoglobinopathies limits the utility of flow cytometry for quantitation of fetomaternal hemorrhage.
Othman J, Orellana D, Chen LS, Russell M, Khoo TL
Cytometry B Clin Cytom. 2017 Oct 26; doi: 10.1002/cyto.b.21598.

PMID:
    29072803
    [PubMed - as supplied by publisher]
Related citations


[Relationship between Work Ⅱ type of congenital first branchial cleft anomaly and facial nerve and surgical strategies].
Zhang B, Chen LS, Huang SL, Liang L, Gong XX, Wu PN, Zhang SY, Luo XN, Zhan JD, Sheng XL, Lu ZM
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Oct 7; 52(10)760-765. doi: 10.3760/cma.j.issn.1673-0860.2017.10.009.

PMID:
    29050094
    [PubMed - in process]
Related citations


[Value of modified Killian's method in diagnosis of congenital pyriform sinus fistula].
Huang SL, Chen LS, Zhang B, Liang L, Gong XX, Zhou ZG, Zhang SX, Luo XN, Lu ZM, Zhang SY
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Oct 7; 52(10)744-748. doi: 10.3760/cma.j.issn.1673-0860.2017.10.006.

PMID:
    29050091
    [PubMed - in process]
Related citations


Landscape of X chromosome inactivation across human tissues.
Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A, GTEx Consortium., Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group., Statistical Methods groups—Analysis Working Group., Enhancing GTEx (eGTEx) groups., NIH Common Fund., NIH/NCI., NIH/NHGRI., NIH/NIMH., NIH/NIDA., Biospecimen Collection Source Site—NDRI., Biospecimen Collection Source Site—RPCI., Biospecimen Core Resource—VARI., Brain Bank Repository—University of Miami Brain Endowment Bank., Leidos Biomedical—Project Management., ELSI Study., Genome Browser Data Integration &Visualization—EBI., Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz., Lappalainen T, Regev A, Ardlie KG, Hacohen N, MacArthur DG
Nature. 2017 Oct 11; 550(7675)244-248. doi: 10.1038/nature24265.

PMID:
    29022598
    [PubMed - in process]
Related citations


Genetic effects on gene expression across human tissues.
GTEx Consortium., Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group., Statistical Methods groups—Analysis Working Group., Enhancing GTEx (eGTEx) groups., NIH Common Fund., NIH/NCI., NIH/NHGRI., NIH/NIMH., NIH/NIDA., Biospecimen Collection Source Site—NDRI., Biospecimen Collection Source Site—RPCI., Biospecimen Core Resource—VARI., Brain Bank Repository—University of Miami Brain Endowment Bank., Leidos Biomedical—Project Management., ELSI Study., Genome Browser Data Integration &Visualization—EBI., Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz., Lead analysts:., Laboratory, Data Analysis &Coordinating Center (LDACC):., NIH program management:., Biospecimen collection:., Pathology:., eQTL manuscript working group:., Battle A, Brown CD, Engelhardt BE, Montgomery SB
Nature. 2017 Oct 11; 550(7675)204-213. doi: 10.1038/nature24277.

PMID:
    29022597
    [PubMed - in process]
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Dynamic landscape and regulation of RNA editing in mammals.
Tan MH, Li Q, Shanmugam R, Piskol R, Kohler J, Young AN, Liu KI, Zhang R, Ramaswami G, Ariyoshi K, Gupte A, Keegan LP, George CX, Ramu A, Huang N, Pollina EA, Leeman DS, Rustighi A, Goh YPS, GTEx Consortium., Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group., Statistical Methods groups—Analysis Working Group., Enhancing GTEx (eGTEx) groups., NIH Common Fund., NIH/NCI., NIH/NHGRI., NIH/NIMH., NIH/NIDA., Biospecimen Collection Source Site—NDRI., Biospecimen Collection Source Site—RPCI., Biospecimen Core Resource—VARI., Brain Bank Repository—University of Miami Brain Endowment Bank., Leidos Biomedical—Project Management., ELSI Study., Genome Browser Data Integration &Visualization—EBI., Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz., Chawla A, Del Sal G, Peltz G, Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K, Li JB
Nature. 2017 Oct 11; 550(7675)249-254. doi: 10.1038/nature24041.

PMID:
    29022589
    [PubMed - in process]
Related citations


The impact of rare variation on gene expression across tissues.
Li X, Kim Y, Tsang EK, Davis JR, Damani FN, Chiang C, Hess GT, Zappala Z, Strober BJ, Scott AJ, Li A, Ganna A, Bassik MC, Merker JD, GTEx Consortium., Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group., Statistical Methods groups—Analysis Working Group., Enhancing GTEx (eGTEx) groups., NIH Common Fund., NIH/NCI., NIH/NHGRI., NIH/NIMH., NIH/NIDA., Biospecimen Collection Source Site—NDRI., Biospecimen Collection Source Site—RPCI., Biospecimen Core Resource—VARI., Brain Bank Repository—University of Miami Brain Endowment Bank., Leidos Biomedical—Project Management., ELSI Study., Genome Browser Data Integration &Visualization—EBI., Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz., Hall IM, Battle A, Montgomery SB
Nature. 2017 Oct 11; 550(7675)239-243. doi: 10.1038/nature24267.

PMID:
    29022581
    [PubMed - in process]
Related citations


Identifying <i>cis</i>-mediators for <i>trans</i>-eQTLs across many human tissues using genomic mediation analysis.
Yang F, Wang J, GTEx Consortium., Pierce BL, Chen LS
Genome Res. 2017 Nov; 27(11)1859-1871. doi: 10.1101/gr.216754.116.

PMID:
    29021290
    [PubMed - in process]
Related citations


Co-expression networks reveal the tissue-specific regulation of transcription and splicing.
Saha A, Kim Y, Gewirtz ADH, Jo B, Gao C, McDowell IC, GTEx Consortium., Engelhardt BE, Battle A
Genome Res. 2017 Nov; 27(11)1843-1858. doi: 10.1101/gr.216721.116.

PMID:
    29021288
    [PubMed - in process]
Related citations


Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease.
eGTEx Project.
Nat Genet. 2017 Oct 11; doi: 10.1038/ng.3969.

PMID:
    29019975
    [PubMed - as supplied by publisher]
Related citations


Triterpenoids from <i>Ganoderma lucidum</i> inhibit the activation of EBV antigens as telomerase inhibitors.
Zheng DS, Chen LS
Exp Ther Med. 2017 Oct; 14(4)3273-3278. doi: 10.3892/etm.2017.4883.

PMID:
    28912878
    [PubMed]
Related citations


Long-term manganese-toxicity-induced alterations of physiology and leaf protein profiles in two Citrus species differing in manganese-tolerance.
You X, Yang LT, Qi YP, Guo P, Lai NW, Ye X, Li Q, Chen LS
J Plant Physiol. 2017 Nov; 218249-257. doi: 10.1016/j.jplph.2017.08.011.

PMID:
    28910703
    [PubMed - in process]
Related citations


Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.
Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhäuser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T
J Clin Invest. 2017 Oct 2; 127(10)3624-3639. doi: 10.1172/JCI92571.

PMID:
    28846069
    [PubMed - indexed for MEDLINE]
Related citations


MicroRNA-mediated responses to long-term magnesium-deficiency in Citrus sinensis roots revealed by Illumina sequencing.
Liang WW, Huang JH, Li CP, Yang LT, Ye X, Lin D, Chen LS
BMC Genomics. 2017 Aug 24; 18(1)657. doi: 10.1186/s12864-017-3999-5.

PMID:
    28836935
    [PubMed - in process]
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Left cervical vagal nerve stimulation reduces skin sympathetic nerve activity in patients with drug resistant epilepsy.
Yuan Y, Hassel JL, Doytchinova A, Adams D, Wright KC, Meshberger C, Chen LS, Guerra MP, Shen C, Lin SF, Everett TH 4th, Salanova V, Chen PS
Heart Rhythm. 2017 Aug 1; pii: S1547-5271(17)30960-8. doi: 10.1016/j.hrthm.2017.07.035.

PMID:
    28778733
    [PubMed - as supplied by publisher]
Related citations


Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia.
Hartz SM, Horton AC, Oehlert M, Carey CE, Agrawal A, Bogdan R, Chen LS, Hancock DB, Johnson EO, Pato CN, Pato MT, Rice JP, Bierut LJ
Biol Psychiatry. 2017 Nov 15; 82(10)709-715. doi: 10.1016/j.biopsych.2017.04.020.

PMID:
    28739213
    [PubMed - in process]
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Chlorinated adenosine analogue induces AMPK and autophagy in chronic lymphocytic leukaemia cells during therapy.
Stellrecht CM, Chen LS, Ayres ML, Dennison JB, Shentu S, Chen Y, Keating MJ, Wierda WG, Gandhi V
Br J Haematol. 2017 Oct; 179(2)266-271. doi: 10.1111/bjh.14859.

PMID:
    28737232
    [PubMed - indexed for MEDLINE]
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