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Leonard B. Bacharier, MD

Robert C. Strunk Endowed Chair for Lung and Respiratory Research Professor of Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-2694

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy.
Lee-Sarwar K, Kelly RS, Lasky-Su J, Moody DB, Mola AR, Cheng TY, Comstock LE, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Bunyavanich S, Savage JH, Weiss ST, Brennan PJ, Litonjua AA
J Allergy Clin Immunol. 2018 May 2; pii: S0091-6749(18)30628-6. doi: 10.1016/j.jaci.2018.04.016.

PMID:
    29729303
    [PubMed - as supplied by publisher]
Related citations


The pediatric asthma yardstick: practical recommendations for a sustained step-up in asthma therapy for children with inadequately controlled asthma.
Chipps BE, Bacharier LB, Farrar JR, Jackson DJ, Murphy KR, Phipatanakul W, Szefler SJ, Teague WG, Zeiger RS
Ann Allergy Asthma Immunol. 2018 Apr 10; pii: S1081-1206(18)30253-9. doi: 10.1016/j.anai.2018.04.002.

PMID:
    29653238
    [PubMed - as supplied by publisher]
Related citations


Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.
DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W
BMC Pulm Med. 2018 Apr 10; 18(1)58. doi: 10.1186/s12890-018-0612-x.

PMID:
    29631584
    [PubMed - in process]
Related citations


Caregiver and pediatric provider perspectives on symptom-based inhaled corticosteroid therapy in asthma.
Dy T, Lewis EM, Murugan V, Gehlert S, Taylor J, Garbutt J, Bacharier LB, Castro M, Sumino K
Respir Med. 2018 Apr; 137201-205. doi: 10.1016/j.rmed.2018.03.001.

PMID:
    29605205
    [PubMed - in process]
Related citations


Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.
Altman MC, Whalen E, Togias A, O'Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, LeBeau P, Jaffee K, Visness CM, Busse WW, Gern JE
J Allergy Clin Immunol. 2018 Mar 5; pii: S0091-6749(18)30307-5. doi: 10.1016/j.jaci.2018.02.019.

PMID:
    29518416
    [PubMed - as supplied by publisher]
Related citations


Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations.
Jackson DJ, Bacharier LB, Mauger DT, Boehmer S, Beigelman A, Chmiel JF, Fitzpatrick AM, Gaffin JM, Morgan WJ, Peters SP, Phipatanakul W, Sheehan WJ, Cabana MD, Holguin F, Martinez FD, Pongracic JA, Baxi SN, Benson M, Blake K, Covar R, Gentile DA, Israel E, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Long D, Ly N, Marbin J, Moy JN, Myers RE, Olin JT, Raissy HH, Robison RG, Ross K, Sorkness CA, Lemanske RF Jr., National Heart, Lung, and Blood Institute AsthmaNet.
N Engl J Med. 2018 Mar 8; 378(10)891-901. doi: 10.1056/NEJMoa1710988.

PMID:
    29504498
    [PubMed - indexed for MEDLINE]
Related citations


Recurrent wheezing in children following human metapneumovirus infection.
Coverstone AM, Wilson B, Burgdorf D, Schechtman KB, Storch GA, Holtzman MJ, Castro M, Bacharier LB, Sumino K
J Allergy Clin Immunol. 2018 Mar 2; pii: S0091-6749(18)30293-8. doi: 10.1016/j.jaci.2018.02.008.

PMID:
    29481834
    [PubMed - as supplied by publisher]
Related citations


Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy.
Kattan M, Bacharier LB, O'Connor GT, Cohen R, Sorkness RL, Morgan W, Gergen PJ, Jaffee KF, Visness CM, Wood RA, Bloomberg GR, Doyle S, Burton R, Gern JE
J Allergy Clin Immunol Pract. 2018 Feb 13; pii: S2213-2198(18)30015-1. doi: 10.1016/j.jaip.2017.12.028.

PMID:
    29449165
    [PubMed - as supplied by publisher]
Related citations


Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia.
Willen SM, Rodeghier M, Strunk RC, Bacharier LB, Rosen CL, Kirkham FJ, DeBaun MR, Cohen RT
Br J Haematol. 2018 Feb; 180(4)571-577. doi: 10.1111/bjh.15076.

PMID:
    29363738
    [PubMed - indexed for MEDLINE]
Related citations


Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids.
Lang JE, Fitzpatrick AM, Mauger DT, Guilbert TW, Jackson DJ, Lemanske RF Jr., Martinez FD, Strunk RC, Zeiger RS, Phipatanakul W, Bacharier LB, Pongracic JA, Holguin F, Cabana MD, Covar RA, Raissy HH, Tang M, Szefler SJ, National Institutes of Health/National Heart, Lung and Blood Institute AsthmaNet.
J Allergy Clin Immunol. 2018 Apr; 141(4)1459-1467.e2. doi: 10.1016/j.jaci.2017.09.043.

PMID:
    29273557
    [PubMed - in process]
Related citations


Prenatal and early-life triclosan and paraben exposure and allergic outcomes.
Lee-Sarwar K, Hauser R, Calafat AM, Ye X, O'Connor GT, Sandel M, Bacharier LB, Zeiger RS, Laranjo N, Gold DR, Weiss ST, Litonjua AA, Savage JH
J Allergy Clin Immunol. 2017 Oct 27; pii: S0091-6749(17)31652-4. doi: 10.1016/j.jaci.2017.09.029.

PMID:
    29111213
    [PubMed - as supplied by publisher]
Related citations


Early-life home environment and risk of asthma among inner-city children.
O'Connor GT, Lynch SV, Bloomberg GR, Kattan M, Wood RA, Gergen PJ, Jaffee KF, Calatroni A, Bacharier LB, Beigelman A, Sandel MT, Johnson CC, Faruqi A, Santee C, Fujimura KE, Fadrosh D, Boushey H, Visness CM, Gern JE
J Allergy Clin Immunol. 2018 Apr; 141(4)1468-1475. doi: 10.1016/j.jaci.2017.06.040.

PMID:
    28939248
    [PubMed - in process]
Related citations


The Association of Maternal Asthma and Early Pregnancy Vitamin D with Risk of Preeclampsia: An Observation From Vitamin D Antenatal Asthma Reduction Trial (VDAART).
Mirzakhani H, Carey VJ, McElrath TF, Laranjo N, O'Connor G, Iverson RE, Lee-Parritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Litonjua AA, Weiss ST
J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2)600-608.e2. doi: 10.1016/j.jaip.2017.07.018.

PMID:
    28923490
    [PubMed - in process]
Related citations


Screen Time Engagement Is Increased in Urban Children With Asthma.
Rota AP, Bacharier LB, Jaffee K, Visness CM, Kattan M, O'Connor GT, Wood RA, Gergen PJ, Gern JE, Bloomberg GR
Clin Pediatr (Phila). 2017 Oct; 56(11)1048-1053. doi: 10.1177/0009922817698801.

PMID:
    28871879
    [PubMed - indexed for MEDLINE]
Related citations


Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.
Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN
J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2)545-554.e4. doi: 10.1016/j.jaip.2017.05.032.

PMID:
    28866107
    [PubMed - in process]
Related citations


Severe Asthma in Children.
Ramratnam SK, Bacharier LB, Guilbert TW
J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4)889-898. doi: 10.1016/j.jaip.2017.04.031.

PMID:
    28689839
    [PubMed - indexed for MEDLINE]
Related citations


A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.
Savage JH, Lee-Sarwar KA, Sordillo J, Bunyavanich S, Zhou Y, O'Connor G, Sandel M, Bacharier LB, Zeiger R, Sodergren E, Weinstock GM, Gold DR, Weiss ST, Litonjua AA
Allergy. 2018 Jan; 73(1)145-152. doi: 10.1111/all.13232.

PMID:
    28632934
    [PubMed - in process]
Related citations


Asthma control status in pregnancy, body mass index, and maternal vitamin D levels.
Mirzakhani H, O'Connor G, Bacharier LB, Zeiger RS, Schatz MX, Weiss ST, Litonjua AA
J Allergy Clin Immunol. 2017 Nov; 140(5)1453-1456.e7. doi: 10.1016/j.jaci.2017.03.053.

PMID:
    28606587
    [PubMed - in process]
Related citations


Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children.
Kwong CG, Bacharier LB
Curr Allergy Asthma Rep. 2017 May; 17(5)34. doi: 10.1007/s11882-017-0701-6.

PMID:
    28456910
    [PubMed - indexed for MEDLINE]
Related citations


BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA
Mucosal Immunol. 2018 Jan; 11(1)97-111. doi: 10.1038/mi.2017.24.

PMID:
    28401936
    [PubMed - in process]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: DBV-Paraxel

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2018


Company Name: Novartis

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,000 - $19,999

Reporting Date: May 01, 2018

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.