Patient Portal

Leonard B. Bacharier, MD

Robert C. Strunk Endowed Chair for Lung and Respiratory Research Professor of Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-2694

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Severe asthma during childhood and adolescence: A longitudinal study.
Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B
J Allergy Clin Immunol. 2019 Oct 14; pii: S0091-6749(19)31318-1. doi: 10.1016/j.jaci.2019.09.030.

PMID:
    31622688
    [PubMed - as supplied by publisher]
Related citations


Development and initial validation of the Asthma Severity Scoring System (ASSESS).
Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN
J Allergy Clin Immunol. 2019 Oct 8; pii: S0091-6749(19)31254-0. doi: 10.1016/j.jaci.2019.09.018.

PMID:
    31604088
    [PubMed - as supplied by publisher]
Related citations


Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.
Wechsler ME, Szefler SJ, Ortega VE, Pongracic JA, Chinchilli V, Lima JJ, Krishnan JA, Kunselman SJ, Mauger D, Bleecker ER, Bacharier LB, Beigelman A, Benson M, Blake KV, Cabana MD, Cardet JC, Castro M, Chmiel JF, Covar R, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Grossman N, Holguin F, Jackson DJ, Kumar H, Kraft M, LaForce CF, Lang J, Lazarus SC, Lemanske RF Jr, Long D, Lugogo N, Martinez F, Meyers DA, Moore WC, Moy J, Naureckas E, Olin JT, Peters SP, Phipatanakul W, Que L, Raissy H, Robison RG, Ross K, Sheehan W, Smith LJ, Solway J, Sorkness CA, Sullivan-Vedder L, Wenzel S, White S, Israel E, NHLBI AsthmaNet.
N Engl J Med. 2019 Sep 26; 381(13)1227-1239. doi: 10.1056/NEJMoa1905560.

PMID:
    31553835
    [PubMed - indexed for MEDLINE]
Related citations


Ecallantide: An alternative treatment of refractory angioedema in adolescents with systemic lupus erythematosus.
Kanchongkittiphon W, Kabil N, Bacharier LB, Kitcharoensakkul M
J Allergy Clin Immunol Pract. 2019 Sep 18; pii: S2213-2198(19)30777-9. doi: 10.1016/j.jaip.2019.08.052.

PMID:
    31541765
    [PubMed - as supplied by publisher]
Related citations


Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.
Grossman NL, Ortega VE, King TS, Bleecker ER, Ampleford EA, Bacharier LB, Cabana MD, Cardet JC, Carr TF, Castro M, Denlinger LC, Denson JL, Fandino N, Fitzpatrick AM, Hawkins GA, Holguin F, Krishnan JA, Lazarus SC, Nyenhuis SM, Phipatanakul W, Ramratnam SK, Wenzel S, Peters SP, Meyers DA, Wechsler ME, Israel E
J Allergy Clin Immunol. 2019 Sep 11; pii: S0091-6749(19)31180-7. doi: 10.1016/j.jaci.2019.08.033.

PMID:
    31520679
    [PubMed - as supplied by publisher]
Related citations


Fecal short-chain fatty acids in pregnancy and offspring asthma and allergic outcomes.
Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Rifas-Shiman SL, Carey VJ, Harshfield BJ, Laranjo N, Gold DR, Weiss ST, Litonjua AA
J Allergy Clin Immunol Pract. 2019 Sep 5; pii: S2213-2198(19)30759-7. doi: 10.1016/j.jaip.2019.08.036.

PMID:
    31494295
    [PubMed - as supplied by publisher]
Related citations


Advances in asthma, asthma-COPD overlap, and related biologics in 2018.
Bacharier LB, Mori A, Kita H
J Allergy Clin Immunol. 2019 Oct; 144(4)906-919. doi: 10.1016/j.jaci.2019.08.021.

PMID:
    31476323
    [PubMed - in process]
Related citations


Clinical significance of the bronchodilator response in children with severe asthma.
Coverstone AM, Bacharier LB, Wilson BS, Fitzpatrick AM, Teague WG, Phipatanakul W, Wenzel SE, Gaston BM, Bleecker ER, Moore WC, Ramratnam S, Jarjour NN, Ly NP, Fahy JV, Mauger DT, Schechtman KB, Yin-DeClue H, Boomer JS, Castro M
Pediatr Pulmonol. 2019 Nov; 54(11)1694-1703. doi: 10.1002/ppul.24473.

PMID:
    31424170
    [PubMed - in process]
Related citations


A Pragmatic Trial of Symptom-Based Inhaled Corticosteroid Use in African-American Children with Mild Asthma.
Sumino K, Bacharier LB, Taylor J, Chadwick-Mansker K, Curtis V, Nash A, Jackson-Triggs S, Moen J, Schechtman KB, Garbutt J, Castro M
J Allergy Clin Immunol Pract. 2019 Jul 29; pii: S2213-2198(19)30602-6. doi: 10.1016/j.jaip.2019.06.030.

PMID:
    31371165
    [PubMed - as supplied by publisher]
Related citations


Airway Inflammatory Patterns in Severe Childhood Asthma-How Might This Change General Practice?
Coverstone AM, Bacharier LB
J Allergy Clin Immunol Pract. 2019 Jul - Aug; 7(6)1813-1814. doi: 10.1016/j.jaip.2019.04.017.

PMID:
    31279464
    [PubMed - in process]
Related citations


Preschool Wheezing Phenotypes Exhibit Heterogeneity in Disease Expression and Prognosis.
Bacharier LB, Guilbert TW
Ann Am Thorac Soc. 2019 Jul; 16(7)820-822. doi: 10.1513/AnnalsATS.201903-234ED.

PMID:
    31259636
    [PubMed - indexed for MEDLINE]
Related citations


GINA 2019: a fundamental change in asthma management: Treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents.
Reddel HK, FitzGerald JM, Bateman ED, Bacharier LB, Becker A, Brusselle G, Buhl R, Cruz AA, Fleming L, Inoue H, Ko FW, Krishnan JA, Levy ML, Lin J, Pedersen SE, Sheikh A, Yorgancioglu A, Boulet LP
Eur Respir J. 2019 Jun; 53(6)pii: 1901046. doi: 10.1183/13993003.01046-2019.

PMID:
    31249014
    [PubMed - in process]
Related citations


Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort.
Pomés A, Glesner J, Calatroni A, Visness CM, Wood RA, O'Connor GT, Kattan M, Bacharier LB, Wheatley LM, Gern JE, Busse WW, National Institute of Allergy and Infectious Diseases–funded Inner-City Asthma Consortium.
J Allergy Clin Immunol. 2019 Oct; 144(4)935-944. doi: 10.1016/j.jaci.2019.05.036.

PMID:
    31201891
    [PubMed - in process]
Related citations


The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population.
Gern JE, Jackson DJ, Lemanske RF Jr, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O'Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, Bacharier LB
Respir Res. 2019 Jun 10; 20(1)115. doi: 10.1186/s12931-019-1088-9.

PMID:
    31182091
    [PubMed - in process]
Related citations


Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.
Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF Jr, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA, National Heart, Lung, and Blood Institute AsthmaNet.
N Engl J Med. 2019 May 23; 380(21)2009-2019. doi: 10.1056/NEJMoa1814917.

PMID:
    31112384
    [PubMed - indexed for MEDLINE]
Related citations


Biologics for Severe Asthma: Treatment-Specific Effects Are Important in Choosing a Specific Agent.
Krings JG, McGregor MC, Bacharier LB, Castro M
J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5)1379-1392. doi: 10.1016/j.jaip.2019.03.008.

PMID:
    31076056
    [PubMed - in process]
Related citations


The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age.
Schulten V, Frazier A, Calatroni A, Kattan M, Bacharier LB, O'Connor GT, Sandel MT, Wood RA, Wheatley LM, Togias A, Visness CM, Dresen A, Gern JE, Sette A
Clin Exp Allergy. 2019 Aug; 49(8)1087-1094. doi: 10.1111/cea.13406.

PMID:
    31046157
    [PubMed - in process]
Related citations


Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.
Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ
Nat Immunol. 2019 May; 20(5)637-651. doi: 10.1038/s41590-019-0347-8.

PMID:
    30962590
    [PubMed - indexed for MEDLINE]
Related citations


Key Issues in Pediatric Asthma.
Bacharier LB, Guilbert TW
Immunol Allergy Clin North Am. 2019 May; 39(2)xv-xvi. doi: 10.1016/j.iac.2019.02.001.

PMID:
    30954179
    [PubMed - in process]
Related citations


New Directions in Pediatric Asthma.
Bacharier LB, Guilbert TW
Immunol Allergy Clin North Am. 2019 May; 39(2)283-295. doi: 10.1016/j.iac.2018.12.012.

PMID:
    30954177
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: Astrazenica

Royalties:

Equity: No

Consulting/Advisory Board: $1 - $9,999

Speaker Fees: $1 - $9,999

Reporting Date: May 01, 2019


Company Name: DBV-Paraxel

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2019


Company Name: Novartis

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $20,000 - $39,999

Reporting Date: May 01, 2019


Company Name: Regeneron

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $20,000 - $39,999

Reporting Date: May 01, 2019

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.