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Leonard B. Bacharier, MD

Professor, Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma
Cystic Fibrosis

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

Missouri Baptist Medical Center
Barnes-Jewish West County Hospital
St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

Barnes-Jewish West County Hospital
Medical Building Three

1020 N. Mason Road
St. Louis, MO 63141

Suite: Suite 110
Office Phone: 314-454-2694
Fax: 314-454-2219

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Preventing Exacerbations in Preschoolers With Recurrent Wheeze: A Meta-analysis.
Kaiser SV, Huynh T, Bacharier LB, Rosenthal JL, Bakel LA, Parkin PC, Cabana MD
Pediatrics. 2016 May 26; pii: e20154496.

PMID:
    27230765
    [PubMed - as supplied by publisher]
Related citations


Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children--Reply.
Bacharier LB, Guilbert TW, Martinez FD
JAMA. 2016 May 17; 315(19)2122-3. doi: 10.1001/jama.2016.0921.

PMID:
    27187309
    [PubMed - indexed for MEDLINE]
Related citations


The influence of atopy and asthma on immune responses in inner-city adults.
Kakumanu S, Jaffee K, Visness CM, Dresen A, Burger M, Witter FR, O'Connor GT, Cruikshank WW, Shreffler WG, Bacharier LB, Gern JE
Immun Inflamm Dis. 2016 Mar; 4(1)80-90. doi: 10.1002/iid3.96.

PMID:
    27042305
    [PubMed]
Related citations


Vitamin D<sub>3</sub> therapy in patients with asthma complicated by sinonasal disease: Secondary analysis of the Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma trial.
Jiao J, King TS, McKenzie M, Bacharier LB, Dixon AE, Codispoti CD, Dunn RM, Grossman NL, Lugogo NL, Ramratnam SK, Traister RS, Wechsler ME, Castro M, National Heart, Lung, and Blood Institute's AsthmaNet
J Allergy Clin Immunol. 2016 Mar 10; pii: S0091-6749(16)00197-4. doi: 10.1016/j.jaci.2015.12.1329.

PMID:
    26971692
    [PubMed - as supplied by publisher]
Related citations


Vitamin D3 treatment of vitamin D-insufficient asthmatic patients does not alter immune cell function.
Reid B, Girodet PO, Boomer JS, Abdel-Gadir A, Zheng K, Wechsler ME, Bacharier LB, Kunselman SJ, King TS, Israel E, Castro M, Cernadas M, Green JM
J Allergy Clin Immunol. 2016 Feb 10; pii: S0091-6749(16)00033-6. doi: 10.1016/j.jaci.2015.11.030.

PMID:
    26874367
    [PubMed - as supplied by publisher]
Related citations


Temporal biological variability in dendritic cells and regulatory T cells in peripheral blood of healthy adults.
Kitcharoensakkul M, Bacharier LB, Yin-Declue H, Boomer JS, Burgdorf D, Wilson B, Schechtman K, Castro M
J Immunol Methods. 2016 Apr; 43163-5. doi: 10.1016/j.jim.2016.02.006.

PMID:
    26859243
    [PubMed - in process]
Related citations


Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention.
Beigelman A, Bacharier LB
Curr Opin Allergy Clin Immunol. 2016 Apr; 16(2)172-8. doi: 10.1097/ACI.0000000000000244.

PMID:
    26854761
    [PubMed - in process]
Related citations


Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.
Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O'Connor GT, Sandel M, Iverson RE Jr, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST
JAMA. 2016 Jan 26; 315(4)362-70. doi: 10.1001/jama.2015.18589.

PMID:
    26813209
    [PubMed - indexed for MEDLINE]
Related citations


Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks.
Beigelman A, Bacharier LB
J Allergy Clin Immunol Pract. 2016 Jan-Feb; 4(1)1-8; quiz 9-10. doi: 10.1016/j.jaip.2015.10.003.

PMID:
    26772922
    [PubMed - in process]
Related citations


The recurrently wheezing preschool child-benign or asthma in the making?
Bacharier LB
Ann Allergy Asthma Immunol. 2015 Dec; 115(6)463-70. doi: 10.1016/j.anai.2015.09.019.

PMID:
    26653278
    [PubMed - indexed for MEDLINE]
Related citations


Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy.
Torgerson DG, Giri T, Druley TE, Zheng J, Huntsman S, Seibold MA, Young AL, Schweiger T, Yin-Declue H, Sajol GD, Schechtman KB, Hernandez RD, Randolph AG, Bacharier LB, Castro M
PLoS One. 2015; 10(11)e0142649. doi: 10.1371/journal.pone.0142649.

PMID:
    26587832
    [PubMed - in process]
Related citations


Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial.
Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CA, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF Jr, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD, National Heart, Lung, and Blood Institute’s AsthmaNet
JAMA. 2015 Nov 17; 314(19)2034-44. doi: 10.1001/jama.2015.13896.

PMID:
    26575060
    [PubMed - indexed for MEDLINE]
Related citations


Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants.
Beigelman A, Castro M, Schweiger TL, Wilson BS, Zheng J, Yin-DeClue H, Sajol G, Giri T, Sierra OL, Isaacson-Schmid M, Sumino K, Schechtman KB, Bacharier LB
J Pediatric Infect Dis Soc. 2015 Sep; 4(3)182-8. doi: 10.1093/jpids/piu042.

PMID:
    26336601
    [PubMed - in process]
Related citations


Update on the utility of corticosteroids in acute pediatric respiratory disorders.
Beigelman A, Chipps BE, Bacharier LB
Allergy Asthma Proc. 2015 Sep-Oct; 36(5)332-8. doi: 10.2500/aap.2015.36.3865.

PMID:
    26314814
    [PubMed - in process]
Related citations


Reply: To PMID 25458910.
Beigelman A, Bacharier LB
J Allergy Clin Immunol. 2015 Oct; 136(4)1135-6. doi: 10.1016/j.jaci.2015.07.013.

PMID:
    26309182
    [PubMed - indexed for MEDLINE]
Related citations


Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis?
Beigelman A, Bacharier LB, Baty J, Buller R, Mason S, Schechtman KB, Sajol G, Isaacson-Schmid M, Castro M, Storch GA
J Allergy Clin Immunol. 2015 Oct; 136(4)1129-31. doi: 10.1016/j.jaci.2015.06.011.

PMID:
    26215052
    [PubMed - indexed for MEDLINE]
Related citations


Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.
Strunk RC, Colvin R, Bacharier LB, Fuhlbrigge A, Forno E, Arbelaez AM, Tantisira KG, Childhood Asthma Management Program Research Group
J Allergy Clin Immunol Pract. 2015 Sep-Oct; 3(5)765-71.e2. doi: 10.1016/j.jaip.2015.05.009.

PMID:
    26164807
    [PubMed - in process]
Related citations


Severe asthma in school-age children: evaluation and phenotypic advances.
Coverstone A, Bacharier LB, Fitzpatrick AM
Curr Allergy Asthma Rep. 2015 May; 15(5)20. doi: 10.1007/s11882-015-0521-5.

PMID:
    26134431
    [PubMed - indexed for MEDLINE]
Related citations


Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma.
Gerald JK, Gerald LB, Vasquez MM, Morgan WJ, Boehmer SJ, Lemanske RF Jr, Mauger DT, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Bade E, Covar RA, Guilbert TW, Heidarian-Raissy H, Kelly HW, Malka-Rais J, Sorkness CA, Taussig LM, Chinchilli VM, Martinez FD
J Allergy Clin Immunol Pract. 2015 Jul-Aug; 3(4)540-6.e3. doi: 10.1016/j.jaip.2015.01.023.

PMID:
    25783161
    [PubMed - indexed for MEDLINE]
Related citations


Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis.
Beigelman A, Isaacson-Schmid M, Sajol G, Baty J, Rodriguez OM, Leege E, Lyons K, Schweiger TL, Zheng J, Schechtman KB, Castro M, Bacharier LB
J Allergy Clin Immunol. 2015 May; 135(5)1171-8.e1. doi: 10.1016/j.jaci.2014.10.001.

PMID:
    25458910
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.