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Leonard B. Bacharier, MD

Professor, Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-2694

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Severe Asthma in Children.
Ramratnam SK, Bacharier LB, Guilbert TW
J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4)889-898. doi: 10.1016/j.jaip.2017.04.031.

PMID:
    28689839
    [PubMed - in process]
Related citations


Asthma control status in pregnancy, body mass index, and maternal vitamin D levels.
Mirzakhani H, O'Connor G, Bacharier LB, Zeiger RS, Schatz MX, Weiss ST, Litonjua AA
J Allergy Clin Immunol. 2017 Jun 9; pii: S0091-6749(17)30928-4. doi: 10.1016/j.jaci.2017.03.053.

PMID:
    28606587
    [PubMed - as supplied by publisher]
Related citations


Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children.
Kwong CG, Bacharier LB
Curr Allergy Asthma Rep. 2017 May; 17(5)34. doi: 10.1007/s11882-017-0701-6.

PMID:
    28456910
    [PubMed - in process]
Related citations


BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA
Mucosal Immunol. 2017 Apr 12; doi: 10.1038/mi.2017.24.

PMID:
    28401936
    [PubMed - as supplied by publisher]
Related citations


Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial.
Wolsk HM, Harshfield BJ, Laranjo N, Carey VJ, O'Connor G, Sandel M, Strunk RC, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST, Litonjua AA
J Allergy Clin Immunol. 2017 Mar 9; pii: S0091-6749(17)30217-8. doi: 10.1016/j.jaci.2017.01.013.

PMID:
    28285844
    [PubMed - as supplied by publisher]
Related citations


Reducing Exposure to Mouse Allergen Among Children and Adolescents With Asthma Is Achievable, but Is It Enough?
Bacharier LB
JAMA. 2017 Mar 14; 317(10)1023-1025. doi: 10.1001/jama.2016.21181.

PMID:
    28264092
    [PubMed - indexed for MEDLINE]
Related citations


Pediatric asthma - moving ahead faster than ever.
Bacharier LB, Szefler SJ
Curr Opin Allergy Clin Immunol. 2017 Apr; 17(2)96-98. doi: 10.1097/ACI.0000000000000353.

PMID:
    28225363
    [PubMed - in process]
Related citations


Editorial: moving ahead faster than ever.
Bacharier LB, Szefler SJ
Curr Opin Allergy Clin Immunol. 2017 Jan 30; doi: 10.1097/ACI.0000000000000353.

PMID:
    28141627
    [PubMed - as supplied by publisher]
Related citations


Management of preschool recurrent wheezing and asthma: a phenotype-based approach.
Beigelman A, Bacharier LB
Curr Opin Allergy Clin Immunol. 2017 Apr; 17(2)131-138. doi: 10.1097/ACI.0000000000000344.

PMID:
    28118241
    [PubMed - in process]
Related citations


Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy.
Gern JE, Calatroni A, Jaffee KF, Lynn H, Dresen A, Cruikshank WW, Lederman HM, Sampson HA, Shreffler W, Bacharier LB, Gergen PJ, Gold DR, Kattan M, O'Connor GT, Sandel MT, Wood RA, Bloomberg GR
J Allergy Clin Immunol. 2017 Jan 13; pii: S0091-6749(17)30030-1. doi: 10.1016/j.jaci.2016.10.052.

PMID:
    28089873
    [PubMed - as supplied by publisher]
Related citations


Strategies to alter the natural history of childhood asthma.
Lee-Sarwar KA, Bacharier LB, Litonjua AA
Curr Opin Allergy Clin Immunol. 2017 Apr; 17(2)139-145. doi: 10.1097/ACI.0000000000000340.

PMID:
    28079559
    [PubMed - in process]
Related citations


Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.
Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E, Severe Asthma Research Program.
Am J Respir Crit Care Med. 2017 Jun 1; 195(11)1439-1448. doi: 10.1164/rccm.201607-1453OC.

PMID:
    27967215
    [PubMed - in process]
Related citations


Individualized therapy for persistent asthma in young children.
Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan W, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Szefler SJ, NIH/NHLBI AsthmaNet.
J Allergy Clin Immunol. 2016 Dec; 138(6)1608-1618.e12. doi: 10.1016/j.jaci.2016.09.028.

PMID:
    27777180
    [PubMed - indexed for MEDLINE]
Related citations


Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents.
Pongracic JA, Krouse RZ, Babineau DC, Zoratti EM, Cohen RT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Johnson CC, Bacharier LB, Gern JE, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW, Liu AH
J Allergy Clin Immunol. 2016 Oct; 138(4)1030-1041. doi: 10.1016/j.jaci.2016.06.059.

PMID:
    27720017
    [PubMed - indexed for MEDLINE]
Related citations


Treatment for severe eosinophilic asthma-consistent effect of anti-interleukin-5 antibodies?
Castro M, Bacharier LB
Lancet. 2016 Oct 29; 388(10056)2059-2060. doi: 10.1016/S0140-6736(16)31537-9.

PMID:
    27609409
    [PubMed - indexed for MEDLINE]
Related citations


Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.
Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.
Am J Respir Crit Care Med. 2017 Feb 1; 195(3)302-313. doi: 10.1164/rccm.201602-0419OC.

PMID:
    27556234
    [PubMed - in process]
Related citations


Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W, NIH/NHLBI AsthmaNet.
N Engl J Med. 2016 Aug 18; 375(7)619-30. doi: 10.1056/NEJMoa1515990.

PMID:
    27532828
    [PubMed - indexed for MEDLINE]
Related citations


Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze.
Zhou Y, Bacharier LB, Isaacson-Schmid M, Baty J, Schechtman KB, Sajol G, Wylie K, Storch GA, Castro M, Beigelman A
J Allergy Clin Immunol. 2016 Oct; 138(4)1215-1219.e5. doi: 10.1016/j.jaci.2016.03.054.

PMID:
    27339392
    [PubMed - in process]
Related citations


Daily global stress is associated with nocturnal asthma awakenings in school-age children.
Horner CC, Dula C, Bacharier LB, Garbutt JM, Gonzalez C, Deych E, Shannon WD, Strunk RC
J Allergy Clin Immunol. 2016 Oct; 138(4)1196-1199.e3. doi: 10.1016/j.jaci.2016.01.054.

PMID:
    27246525
    [PubMed - in process]
Related citations


Preventing Exacerbations in Preschoolers With Recurrent Wheeze: A Meta-analysis.
Kaiser SV, Huynh T, Bacharier LB, Rosenthal JL, Bakel LA, Parkin PC, Cabana MD
Pediatrics. 2016 Jun; 137(6)pii: e20154496. doi: 10.1542/peds.2015-4496.

PMID:
    27230765
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Boehringer Ingelheim

Royalties:

Equity: No

Consulting/Advisory Board: $1,000 - $10,000

Speaker Fees: $1,000 - $10,000

Reporting Date: May 01, 2017


Company Name: Teva

Royalties:

Equity: No

Consulting/Advisory Board: $1,000 - $10,000

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2017

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.