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Leonard B. Bacharier, MD

Professor, Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-2694

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Inflammatory and Co-Morbid Features of Patients with Severe Asthma and Frequent Exacerbations.
Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN, National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators
Am J Respir Crit Care Med. 2016 Aug 24;

PMID:
    27556234
    [PubMed - as supplied by publisher]
Related citations


Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W, NIH/NHLBI AsthmaNet
N Engl J Med. 2016 Aug 18; 375(7)619-30. doi: 10.1056/NEJMoa1515990.

PMID:
    27532828
    [PubMed - indexed for MEDLINE]
Related citations


Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze.
Zhou Y, Bacharier LB, Isaacson-Schmid M, Baty J, Schechtman KB, Sajol G, Wylie K, Storch GA, Castro M, Beigelman A
J Allergy Clin Immunol. 2016 May 18; pii: S0091-6749(16)30288-3. doi: 10.1016/j.jaci.2016.03.054.

PMID:
    27339392
    [PubMed - as supplied by publisher]
Related citations


Daily global stress is associated with nocturnal asthma awakenings in school-age children.
Horner CC, Dula C, Bacharier LB, Garbutt JM, Gonzalez C, Deych E, Shannon WD, Strunk RC
J Allergy Clin Immunol. 2016 Apr 21; pii: S0091-6749(16)30093-8. doi: 10.1016/j.jaci.2016.01.054.

PMID:
    27246525
    [PubMed - as supplied by publisher]
Related citations


Preventing Exacerbations in Preschoolers With Recurrent Wheeze: A Meta-analysis.
Kaiser SV, Huynh T, Bacharier LB, Rosenthal JL, Bakel LA, Parkin PC, Cabana MD
Pediatrics. 2016 Jun; 137(6)pii: e20154496. doi: 10.1542/peds.2015-4496.

PMID:
    27230765
    [PubMed - in process]
Related citations


Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children--Reply.
Bacharier LB, Guilbert TW, Martinez FD
JAMA. 2016 May 17; 315(19)2122-3. doi: 10.1001/jama.2016.0921.

PMID:
    27187309
    [PubMed - indexed for MEDLINE]
Related citations


The influence of atopy and asthma on immune responses in inner-city adults.
Kakumanu S, Jaffee K, Visness CM, Dresen A, Burger M, Witter FR, O'Connor GT, Cruikshank WW, Shreffler WG, Bacharier LB, Gern JE
Immun Inflamm Dis. 2016 Mar; 4(1)80-90. doi: 10.1002/iid3.96.

PMID:
    27042305
    [PubMed]
Related citations


Vitamin D3 therapy in patients with asthma complicated by sinonasal disease: Secondary analysis of the Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma trial.
Jiao J, King TS, McKenzie M, Bacharier LB, Dixon AE, Codispoti CD, Dunn RM, Grossman NL, Lugogo NL, Ramratnam SK, Traister RS, Wechsler ME, Castro M, National Heart, Lung, and Blood Institute's AsthmaNet
J Allergy Clin Immunol. 2016 Aug; 138(2)589-592.e2. doi: 10.1016/j.jaci.2015.12.1329.

PMID:
    26971692
    [PubMed - in process]
Related citations


Vitamin D3 treatment of vitamin D-insufficient asthmatic patients does not alter immune cell function.
Reid B, Girodet PO, Boomer JS, Abdel-Gadir A, Zheng K, Wechsler ME, Bacharier LB, Kunselman SJ, King TS, Israel E, Castro M, Cernadas M, Green JM
J Allergy Clin Immunol. 2016 Jul; 138(1)286-289.e9. doi: 10.1016/j.jaci.2015.11.030.

PMID:
    26874367
    [PubMed - in process]
Related citations


Temporal biological variability in dendritic cells and regulatory T cells in peripheral blood of healthy adults.
Kitcharoensakkul M, Bacharier LB, Yin-Declue H, Boomer JS, Burgdorf D, Wilson B, Schechtman K, Castro M
J Immunol Methods. 2016 Apr; 43163-5. doi: 10.1016/j.jim.2016.02.006.

PMID:
    26859243
    [PubMed - indexed for MEDLINE]
Related citations


Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention.
Beigelman A, Bacharier LB
Curr Opin Allergy Clin Immunol. 2016 Apr; 16(2)172-8. doi: 10.1097/ACI.0000000000000244.

PMID:
    26854761
    [PubMed - in process]
Related citations


Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.
Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O'Connor GT, Sandel M, Iverson RE Jr, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST
JAMA. 2016 Jan 26; 315(4)362-70. doi: 10.1001/jama.2015.18589.

PMID:
    26813209
    [PubMed - indexed for MEDLINE]
Related citations


Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks.
Beigelman A, Bacharier LB
J Allergy Clin Immunol Pract. 2016 Jan-Feb; 4(1)1-8; quiz 9-10. doi: 10.1016/j.jaip.2015.10.003.

PMID:
    26772922
    [PubMed - in process]
Related citations


The recurrently wheezing preschool child-benign or asthma in the making?
Bacharier LB
Ann Allergy Asthma Immunol. 2015 Dec; 115(6)463-70. doi: 10.1016/j.anai.2015.09.019.

PMID:
    26653278
    [PubMed - indexed for MEDLINE]
Related citations


Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy.
Torgerson DG, Giri T, Druley TE, Zheng J, Huntsman S, Seibold MA, Young AL, Schweiger T, Yin-Declue H, Sajol GD, Schechtman KB, Hernandez RD, Randolph AG, Bacharier LB, Castro M
PLoS One. 2015; 10(11)e0142649. doi: 10.1371/journal.pone.0142649.

PMID:
    26587832
    [PubMed - indexed for MEDLINE]
Related citations


Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial.
Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CA, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF Jr, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD, National Heart, Lung, and Blood Institute’s AsthmaNet
JAMA. 2015 Nov 17; 314(19)2034-44. doi: 10.1001/jama.2015.13896.

PMID:
    26575060
    [PubMed - indexed for MEDLINE]
Related citations


Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants.
Beigelman A, Castro M, Schweiger TL, Wilson BS, Zheng J, Yin-DeClue H, Sajol G, Giri T, Sierra OL, Isaacson-Schmid M, Sumino K, Schechtman KB, Bacharier LB
J Pediatric Infect Dis Soc. 2015 Sep; 4(3)182-8. doi: 10.1093/jpids/piu042.

PMID:
    26336601
    [PubMed - in process]
Related citations


Update on the utility of corticosteroids in acute pediatric respiratory disorders.
Beigelman A, Chipps BE, Bacharier LB
Allergy Asthma Proc. 2015 Sep-Oct; 36(5)332-8. doi: 10.2500/aap.2015.36.3865.

PMID:
    26314814
    [PubMed - indexed for MEDLINE]
Related citations


Reply: To PMID 25458910.
Beigelman A, Bacharier LB
J Allergy Clin Immunol. 2015 Oct; 136(4)1135-6. doi: 10.1016/j.jaci.2015.07.013.

PMID:
    26309182
    [PubMed - indexed for MEDLINE]
Related citations


Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis?
Beigelman A, Bacharier LB, Baty J, Buller R, Mason S, Schechtman KB, Sajol G, Isaacson-Schmid M, Castro M, Storch GA
J Allergy Clin Immunol. 2015 Oct; 136(4)1129-31. doi: 10.1016/j.jaci.2015.06.011.

PMID:
    26215052
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.