Patient Portal

Leonard B. Bacharier, MD

Robert C. Strunk Endowed Chair for Lung and Respiratory Research Professor of Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-2694

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort.
Pomés A, Glesner J, Calatroni A, Visness CM, Wood RA, O'Connor GT, Kattan M, Bacharier LB, Wheatley LM, Gern JE, Busse WW, NIAID-funded Inner-City Asthma Consortium.
J Allergy Clin Immunol. 2019 Jun 12; pii: S0091-6749(19)30759-6. doi: 10.1016/j.jaci.2019.05.036.

PMID:
    31201891
    [PubMed - as supplied by publisher]
Related citations


The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population.
Gern JE, Jackson DJ, Lemanske RF Jr, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O'Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, Bacharier LB
Respir Res. 2019 Jun 10; 20(1)115. doi: 10.1186/s12931-019-1088-9.

PMID:
    31182091
    [PubMed - in process]
Related citations


Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.
Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF Jr, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA, National Heart, Lung, and Blood Institute AsthmaNet.
N Engl J Med. 2019 May 23; 380(21)2009-2019. doi: 10.1056/NEJMoa1814917.

PMID:
    31112384
    [PubMed - indexed for MEDLINE]
Related citations


Biologics for Severe Asthma: Treatment-Specific Effects Are Important in Choosing a Specific Agent.
Krings JG, McGregor MC, Bacharier LB, Castro M
J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5)1379-1392. doi: 10.1016/j.jaip.2019.03.008.

PMID:
    31076056
    [PubMed - in process]
Related citations


The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age.
Schulten V, Frazier A, Calatroni A, Kattan M, Bacharier LB, O'Connor GT, Sandel MT, Wood RA, Wheatley LM, Togias A, Visness CM, Dresen A, Gern JE, Sette A
Clin Exp Allergy. 2019 May 2; doi: 10.1111/cea.13406.

PMID:
    31046157
    [PubMed - as supplied by publisher]
Related citations


Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.
Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ
Nat Immunol. 2019 May; 20(5)637-651. doi: 10.1038/s41590-019-0347-8.

PMID:
    30962590
    [PubMed - indexed for MEDLINE]
Related citations


Key Issues in Pediatric Asthma.
Bacharier LB, Guilbert TW
Immunol Allergy Clin North Am. 2019 May; 39(2)xv-xvi. doi: 10.1016/j.iac.2019.02.001.

PMID:
    30954179
    [PubMed - in process]
Related citations


New Directions in Pediatric Asthma.
Bacharier LB, Guilbert TW
Immunol Allergy Clin North Am. 2019 May; 39(2)283-295. doi: 10.1016/j.iac.2018.12.012.

PMID:
    30954177
    [PubMed - in process]
Related citations


Management of Asthma in the Preschool Child.
Kwong CG, Bacharier LB
Immunol Allergy Clin North Am. 2019 May; 39(2)177-190. doi: 10.1016/j.iac.2018.12.003.

PMID:
    30954169
    [PubMed - in process]
Related citations


Potential Strategies and Targets for the Prevention of Pediatric Asthma.
Polk BI, Bacharier LB
Immunol Allergy Clin North Am. 2019 May; 39(2)151-162. doi: 10.1016/j.iac.2018.12.010.

PMID:
    30954167
    [PubMed - in process]
Related citations


Integrative analysis of the intestinal metabolome of childhood asthma.
Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Weiss ST, Litonjua AA
J Allergy Clin Immunol. 2019 Mar 23; pii: S0091-6749(19)30406-3. doi: 10.1016/j.jaci.2019.02.032.

PMID:
    30914378
    [PubMed - as supplied by publisher]
Related citations


Association of the Infant Gut Microbiome With Early Childhood Neurodevelopmental Outcomes: An Ancillary Study to the VDAART Randomized Clinical Trial.
Sordillo JE, Korrick S, Laranjo N, Carey V, Weinstock GM, Gold DR, O'Connor G, Sandel M, Bacharier LB, Beigelman A, Zeiger R, Litonjua AA, Weiss ST
JAMA Netw Open. 2019 Mar 1; 2(3)e190905. doi: 10.1001/jamanetworkopen.2019.0905.

PMID:
    30901046
    [PubMed - in process]
Related citations


Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors.
Birrueta G, Frazier A, Pomés A, Glesner J, Filep S, Schal C, Jeong KY, McMurtrey C, Vander Schans T, Hildebrand WH, Busse P, Beigelman A, Bacharier LB, Peters B, Sette A, Schulten V
Front Immunol. 2019; 10313. doi: 10.3389/fimmu.2019.00313.

PMID:
    30891032
    [PubMed - in process]
Related citations


Using only a subset of pneumococcal serotypes is reliable for the diagnosis of specific antibody deficiency in children: A proof-of-concept study.
Kitcharoensakkul M, Kau AL, Bacharier LB, Goss CW, Beigelman A
Pediatr Allergy Immunol. 2019 May; 30(3)392-395. doi: 10.1111/pai.13026.

PMID:
    30681739
    [PubMed - indexed for MEDLINE]
Related citations


Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children.
Guilbert TW, Bacharier LB, Mauger DT, Phipatanakul W, Szefler SJ, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana MD, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF Jr, Ly N, Meade K, Morgan W, Moy J, Olin JT, Peters SP, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Teague WG, Thyne S, Martinez FD, National Heart, Lung, and Blood Institute's AsthmaNet.
J Allergy Clin Immunol. 2019 May; 143(5)1934-1937.e4. doi: 10.1016/j.jaci.2018.10.071.

PMID:
    30660645
    [PubMed - in process]
Related citations


Phenotypes of wheezing and asthma in preschool children.
Kwong CG, Bacharier LB
Curr Opin Allergy Clin Immunol. 2019 Apr; 19(2)148-153. doi: 10.1097/ACI.0000000000000516.

PMID:
    30640211
    [PubMed - in process]
Related citations


Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program.
Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG
J Allergy Clin Immunol. 2019 Jun; 143(6)2052-2061. doi: 10.1016/j.jaci.2018.11.022.

PMID:
    30635198
    [PubMed - in process]
Related citations


Gut microbiota and overweight in 3-year old children.
Karvonen AM, Sordillo JE, Gold DR, Bacharier LB, O'Connor GT, Zeiger RS, Beigelman A, Weiss ST, Litonjua AA
Int J Obes (Lond). 2019 Apr; 43(4)713-723. doi: 10.1038/s41366-018-0290-z.

PMID:
    30568265
    [PubMed - in process]
Related citations


The Asthma Controller Step-down Yardstick.
Chipps BE, Bacharier LB, Murphy KR, Lang D, Farrar JR, Rank M, Oppenheimer J, Zeiger RS
Ann Allergy Asthma Immunol. 2019 Mar; 122(3)241-262.e4. doi: 10.1016/j.anai.2018.12.004.

PMID:
    30550809
    [PubMed - in process]
Related citations


Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children.
Mirzakhani H, Carey VJ, Zeiger R, Bacharier LB, O'Connor GT, Schatz MX, Laranjo N, Weiss ST, Litonjua AA
Clin Exp Allergy. 2019 Apr; 49(4)419-429. doi: 10.1111/cea.13320.

PMID:
    30461089
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: Astrazenica

Royalties:

Equity: No

Consulting/Advisory Board: $1 - $9,999

Speaker Fees: $1 - $9,999

Reporting Date: May 01, 2019


Company Name: DBV-Paraxel

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2019


Company Name: Novartis

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $20,000 - $39,999

Reporting Date: May 01, 2019


Company Name: Regeneron

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $20,000 - $39,999

Reporting Date: May 01, 2019

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.