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Leonard B. Bacharier, MD

Professor, Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-2694

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Editorial: moving ahead faster than ever.
Bacharier LB, Szefler SJ
Curr Opin Allergy Clin Immunol. 2017 Jan 30; doi: 10.1097/ACI.0000000000000353.

PMID:
    28141627
    [PubMed - as supplied by publisher]
Related citations


Management of preschool recurrent wheezing and asthma: a phenotype-based approach.
Beigelman A, Bacharier LB
Curr Opin Allergy Clin Immunol. 2017 Jan 21; doi: 10.1097/ACI.0000000000000344.

PMID:
    28118241
    [PubMed - as supplied by publisher]
Related citations


Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy.
Gern JE, Calatroni A, Jaffee KF, Lynn H, Dresen A, Cruikshank WW, Lederman HM, Sampson HA, Shreffler W, Bacharier LB, Gergen PJ, Gold DR, Kattan M, O'Connor GT, Sandel MT, Wood RA, Bloomberg GR
J Allergy Clin Immunol. 2017 Jan 13; pii: S0091-6749(17)30030-1. doi: 10.1016/j.jaci.2016.10.052.

PMID:
    28089873
    [PubMed - as supplied by publisher]
Related citations


Strategies to alter the natural history of childhood asthma.
Lee-Sarwar KA, Bacharier LB, Litonjua AA
Curr Opin Allergy Clin Immunol. 2017 Jan 11; doi: 10.1097/ACI.0000000000000340.

PMID:
    28079559
    [PubMed - as supplied by publisher]
Related citations


Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.
Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy J, Fitzpatrick A, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E, and the Severe Asthma Research Program.
Am J Respir Crit Care Med. 2016 Dec 14;

PMID:
    27967215
    [PubMed - as supplied by publisher]
Related citations


Individualized therapy for persistent asthma in young children.
Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan W, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Szefler SJ, National Institutes of Health/National Heart, Lung, and Blood Institute AsthmaNet.
J Allergy Clin Immunol. 2016 Dec; 138(6)1608-1618.e12. doi: 10.1016/j.jaci.2016.09.028.

PMID:
    27777180
    [PubMed - in process]
Related citations


Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents.
Pongracic JA, Krouse RZ, Babineau DC, Zoratti EM, Cohen RT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Johnson CC, Bacharier LB, Gern JE, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW, Liu AH
J Allergy Clin Immunol. 2016 Oct; 138(4)1030-1041. doi: 10.1016/j.jaci.2016.06.059.

PMID:
    27720017
    [PubMed - in process]
Related citations


Treatment for severe eosinophilic asthma-consistent effect of anti-interleukin-5 antibodies?
Castro M, Bacharier LB
Lancet. 2016 Oct 29; 388(10056)2059-2060. doi: 10.1016/S0140-6736(16)31537-9.

PMID:
    27609409
    [PubMed - indexed for MEDLINE]
Related citations


Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.
Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.
Am J Respir Crit Care Med. 2017 Feb 1; 195(3)302-313. doi: 10.1164/rccm.201602-0419OC.

PMID:
    27556234
    [PubMed - in process]
Related citations


Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W, NIH/NHLBI AsthmaNet.
N Engl J Med. 2016 Aug 18; 375(7)619-30. doi: 10.1056/NEJMoa1515990.

PMID:
    27532828
    [PubMed - indexed for MEDLINE]
Related citations


Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze.
Zhou Y, Bacharier LB, Isaacson-Schmid M, Baty J, Schechtman KB, Sajol G, Wylie K, Storch GA, Castro M, Beigelman A
J Allergy Clin Immunol. 2016 Oct; 138(4)1215-1219.e5. doi: 10.1016/j.jaci.2016.03.054.

PMID:
    27339392
    [PubMed - in process]
Related citations


Daily global stress is associated with nocturnal asthma awakenings in school-age children.
Horner CC, Dula C, Bacharier LB, Garbutt JM, Gonzalez C, Deych E, Shannon WD, Strunk RC
J Allergy Clin Immunol. 2016 Oct; 138(4)1196-1199.e3. doi: 10.1016/j.jaci.2016.01.054.

PMID:
    27246525
    [PubMed - in process]
Related citations


Preventing Exacerbations in Preschoolers With Recurrent Wheeze: A Meta-analysis.
Kaiser SV, Huynh T, Bacharier LB, Rosenthal JL, Bakel LA, Parkin PC, Cabana MD
Pediatrics. 2016 Jun; 137(6)pii: e20154496. doi: 10.1542/peds.2015-4496.

PMID:
    27230765
    [PubMed - in process]
Related citations


Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children--Reply.
Bacharier LB, Guilbert TW, Martinez FD
JAMA. 2016 May 17; 315(19)2122-3. doi: 10.1001/jama.2016.0921.

PMID:
    27187309
    [PubMed - indexed for MEDLINE]
Related citations


The influence of atopy and asthma on immune responses in inner-city adults.
Kakumanu S, Jaffee K, Visness CM, Dresen A, Burger M, Witter FR, O'Connor GT, Cruikshank WW, Shreffler WG, Bacharier LB, Gern JE
Immun Inflamm Dis. 2016 Feb 26; 4(1)80-90. doi: 10.1002/iid3.96.

PMID:
    27042305
    [PubMed]
Related citations


Vitamin D3 therapy in patients with asthma complicated by sinonasal disease: Secondary analysis of the Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma trial.
Jiao J, King TS, McKenzie M, Bacharier LB, Dixon AE, Codispoti CD, Dunn RM, Grossman NL, Lugogo NL, Ramratnam SK, Traister RS, Wechsler ME, Castro M, National Heart, Lung, and Blood Institute's AsthmaNet.
J Allergy Clin Immunol. 2016 Aug; 138(2)589-592.e2. doi: 10.1016/j.jaci.2015.12.1329.

PMID:
    26971692
    [PubMed - in process]
Related citations


Vitamin D3 treatment of vitamin D-insufficient asthmatic patients does not alter immune cell function.
Reid B, Girodet PO, Boomer JS, Abdel-Gadir A, Zheng K, Wechsler ME, Bacharier LB, Kunselman SJ, King TS, Israel E, Castro M, Cernadas M, Green JM
J Allergy Clin Immunol. 2016 Jul; 138(1)286-289.e9. doi: 10.1016/j.jaci.2015.11.030.

PMID:
    26874367
    [PubMed - in process]
Related citations


Temporal biological variability in dendritic cells and regulatory T cells in peripheral blood of healthy adults.
Kitcharoensakkul M, Bacharier LB, Yin-Declue H, Boomer JS, Burgdorf D, Wilson B, Schechtman K, Castro M
J Immunol Methods. 2016 Apr; 43163-5. doi: 10.1016/j.jim.2016.02.006.

PMID:
    26859243
    [PubMed - indexed for MEDLINE]
Related citations


Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention.
Beigelman A, Bacharier LB
Curr Opin Allergy Clin Immunol. 2016 Apr; 16(2)172-8. doi: 10.1097/ACI.0000000000000244.

PMID:
    26854761
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.
Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O'Connor GT, Sandel M, Iverson RE Jr, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST
JAMA. 2016 Jan 26; 315(4)362-70. doi: 10.1001/jama.2015.18589.

PMID:
    26813209
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.