Patient Portal

Leonard B. Bacharier, MD

Robert C. Strunk Endowed Chair for Lung and Respiratory Research Professor of Pediatrics
Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Allergy
Pediatric Immunology
Pediatric Asthma

Board Certifications

Allergy & Clinical Immunology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Asthma in children, allergy and lung disease in children, immunology

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-2694

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-2694

Education

Education

Fellowship: Pediatric Allergy and Immunology, Children's Hospital, Boston, Massachusetts
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1992
B.S.: Biophysics, The Johns Hopkins University, Baltimore, Maryland

Publication & Research

Publication & Research

Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C 3rd, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE, Environmental Influences on Child Health Outcomes-Children's Respiratory Research Workgroup.
Lancet Respir Med. 2020 May; 8(5)482-492. doi: 10.1016/S2213-2600(20)30011-4.

PMID:
    32380068
    [PubMed - in process]
Related citations


Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.
Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC
J Allergy Clin Immunol. 2020 Jul; 146(1)203-206.e3. doi: 10.1016/j.jaci.2020.04.009.

PMID:
    32333915
    [PubMed - indexed for MEDLINE]
Related citations


Correction to: Efficacy of Macrolides on Acute Asthma or Wheezing Exacerbations in Children with Recurrent Wheezing: A Systematic Review and Meta‑analysis.
Pincheira MA, Bacharier LB, Castro-Rodriguez JA
Paediatr Drugs. 2020 Apr; 22(2)241. doi: 10.1007/s40272-020-00390-7.

PMID:
    32166730
    [PubMed]
Related citations


Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes.
Fitzpatrick AM, Bacharier LB, Jackson DJ, Szefler SJ, Beigelman A, Cabana M, Covar R, Guilbert T, Holguin F, Lemanske RF, Martinez FD, Morgan W, Phipatanakul W, Pongracic JA, Raissy HH, Zeiger RS, Mauger DT
J Allergy Clin Immunol Pract. 2020 Mar 7; pii: S2213-2198(20)30231-2. doi: 10.1016/j.jaip.2020.02.032.

PMID:
    32156610
    [PubMed - as supplied by publisher]
Related citations


Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction.
Litonjua AA, Carey VJ, Laranjo N, Stubbs BJ, Mirzakhani H, O'Connor GT, Sandel M, Beigelman A, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST
N Engl J Med. 2020 Feb 6; 382(6)525-533. doi: 10.1056/NEJMoa1906137.

PMID:
    32023372
    [PubMed - indexed for MEDLINE]
Related citations


Serum IL-6: A biomarker in childhood asthma?
Jackson DJ, Bacharier LB, Calatroni A, Gill MA, Hu J, Liu AH, Wheatley LM, Gern JE, Gruchalla RS, Khurana Hershey GK, Kattan M, Kercsmar CM, Kim H, O'Connor GT, Patel S, Pongracic JA, Wood RA, Busse WW
J Allergy Clin Immunol. 2020 Jun; 145(6)1701-1704.e3. doi: 10.1016/j.jaci.2020.01.021.

PMID:
    32004524
    [PubMed - in process]
Related citations


Efficacy of Macrolides on Acute Asthma or Wheezing Exacerbations in Children with Recurrent Wheezing: A Systematic Review and Meta-analysis.
Pincheira MA, Bacharier LB, Castro-Rodriguez JA
Paediatr Drugs. 2020 Apr; 22(2)217-228. doi: 10.1007/s40272-019-00371-5.

PMID:
    31939108
    [PubMed - indexed for MEDLINE]
Related citations


Impaired tumor necrosis factor-α secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze.
Kitcharoensakkul M, Bacharier LB, Yin-Declue H, Boomer JS, Sajol G, Leung MK, Wilson B, Schechtman KB, Atkinson JP, Green JM, Castro M
Immun Inflamm Dis. 2020 Mar; 8(1)30-39. doi: 10.1002/iid3.281.

PMID:
    31901157
    [PubMed - in process]
Related citations


The upper-airway microbiota and loss of asthma control among asthmatic children.
Zhou Y, Jackson D, Bacharier LB, Mauger D, Boushey H, Castro M, Durack J, Huang Y, Lemanske RF Jr, Storch GA, Weinstock GM, Wylie K, Covar R, Fitzpatrick AM, Phipatanakul W, Robison RG, Beigelman A
Nat Commun. 2019 Dec 16; 10(1)5714. doi: 10.1038/s41467-019-13698-x.

PMID:
    31844063
    [PubMed - indexed for MEDLINE]
Related citations


Severe asthma during childhood and adolescence: A longitudinal study.
Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B
J Allergy Clin Immunol. 2020 Jan; 145(1)140-146.e9. doi: 10.1016/j.jaci.2019.09.030.

PMID:
    31622688
    [PubMed - indexed for MEDLINE]
Related citations


Development and initial validation of the Asthma Severity Scoring System (ASSESS).
Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN
J Allergy Clin Immunol. 2020 Jan; 145(1)127-139. doi: 10.1016/j.jaci.2019.09.018.

PMID:
    31604088
    [PubMed - indexed for MEDLINE]
Related citations


Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.
Wechsler ME, Szefler SJ, Ortega VE, Pongracic JA, Chinchilli V, Lima JJ, Krishnan JA, Kunselman SJ, Mauger D, Bleecker ER, Bacharier LB, Beigelman A, Benson M, Blake KV, Cabana MD, Cardet JC, Castro M, Chmiel JF, Covar R, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Grossman N, Holguin F, Jackson DJ, Kumar H, Kraft M, LaForce CF, Lang J, Lazarus SC, Lemanske RF Jr, Long D, Lugogo N, Martinez F, Meyers DA, Moore WC, Moy J, Naureckas E, Olin JT, Peters SP, Phipatanakul W, Que L, Raissy H, Robison RG, Ross K, Sheehan W, Smith LJ, Solway J, Sorkness CA, Sullivan-Vedder L, Wenzel S, White S, Israel E, NHLBI AsthmaNet.
N Engl J Med. 2019 Sep 26; 381(13)1227-1239. doi: 10.1056/NEJMoa1905560.

PMID:
    31553835
    [PubMed - indexed for MEDLINE]
Related citations


Ecallantide: An alternative treatment of refractory angioedema in adolescents with systemic lupus erythematosus.
Kanchongkittiphon W, Kabil N, Bacharier LB, Kitcharoensakkul M
J Allergy Clin Immunol Pract. 2020 Mar; 8(3)1115-1116. doi: 10.1016/j.jaip.2019.08.052.

PMID:
    31541765
    [PubMed - in process]
Related citations


Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.
Grossman NL, Ortega VE, King TS, Bleecker ER, Ampleford EA, Bacharier LB, Cabana MD, Cardet JC, Carr TF, Castro M, Denlinger LC, Denson JL, Fandino N, Fitzpatrick AM, Hawkins GA, Holguin F, Krishnan JA, Lazarus SC, Nyenhuis SM, Phipatanakul W, Ramratnam SK, Wenzel S, Peters SP, Meyers DA, Wechsler ME, Israel E
J Allergy Clin Immunol. 2019 Dec; 144(6)1524-1533. doi: 10.1016/j.jaci.2019.08.033.

PMID:
    31520679
    [PubMed - indexed for MEDLINE]
Related citations


Fecal short-chain fatty acids in pregnancy and offspring asthma and allergic outcomes.
Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Rifas-Shiman SL, Carey VJ, Harshfield BJ, Laranjo N, Gold DR, Weiss ST, Litonjua AA
J Allergy Clin Immunol Pract. 2020 Mar; 8(3)1100-1102.e13. doi: 10.1016/j.jaip.2019.08.036.

PMID:
    31494295
    [PubMed - in process]
Related citations


Advances in asthma, asthma-COPD overlap, and related biologics in 2018.
Bacharier LB, Mori A, Kita H
J Allergy Clin Immunol. 2019 Oct; 144(4)906-919. doi: 10.1016/j.jaci.2019.08.021.

PMID:
    31476323
    [PubMed - indexed for MEDLINE]
Related citations


Clinical significance of the bronchodilator response in children with severe asthma.
Coverstone AM, Bacharier LB, Wilson BS, Fitzpatrick AM, Teague WG, Phipatanakul W, Wenzel SE, Gaston BM, Bleecker ER, Moore WC, Ramratnam S, Jarjour NN, Ly NP, Fahy JV, Mauger DT, Schechtman KB, Yin-DeClue H, Boomer JS, Castro M
Pediatr Pulmonol. 2019 Nov; 54(11)1694-1703. doi: 10.1002/ppul.24473.

PMID:
    31424170
    [PubMed - indexed for MEDLINE]
Related citations


A Pragmatic Trial of Symptom-Based Inhaled Corticosteroid Use in African-American Children with Mild Asthma.
Sumino K, Bacharier LB, Taylor J, Chadwick-Mansker K, Curtis V, Nash A, Jackson-Triggs S, Moen J, Schechtman KB, Garbutt J, Castro M
J Allergy Clin Immunol Pract. 2020 Jan; 8(1)176-185.e2. doi: 10.1016/j.jaip.2019.06.030.

PMID:
    31371165
    [PubMed - in process]
Related citations


Airway Inflammatory Patterns in Severe Childhood Asthma-How Might This Change General Practice?
Coverstone AM, Bacharier LB
J Allergy Clin Immunol Pract. 2019 Jul - Aug; 7(6)1813-1814. doi: 10.1016/j.jaip.2019.04.017.

PMID:
    31279464
    [PubMed - indexed for MEDLINE]
Related citations


Preschool Wheezing Phenotypes Exhibit Heterogeneity in Disease Expression and Prognosis.
Bacharier LB, Guilbert TW
Ann Am Thorac Soc. 2019 Jul; 16(7)820-822. doi: 10.1513/AnnalsATS.201903-234ED.

PMID:
    31259636
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2019:

Company Name: Astrazenica

Royalties:

Equity: No

Consulting/Advisory Board: $1 - $9,999

Speaker Fees: $60,000 - $79,999

Reporting Date: May 01, 2020


Company Name: DBV Technologies

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2020


Company Name: Novartis

Royalties:

Equity: No

Consulting/Advisory Board: $1 - $9,999

Speaker Fees: $1 - $9,999

Reporting Date: May 01, 2020


Company Name: Regeneron

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $40,000 - $59,999

Reporting Date: May 01, 2020


Company Name: Sanofi

Royalties:

Equity: No

Consulting/Advisory Board: $1 - $9,999

Speaker Fees: $20,000 - $39,999

Reporting Date: May 01, 2020

Areas of Research Interest

Dr. Bacharier's research focuses on childhood asthma. Specifically, he is co-principal investigator for the NHBLI’s AsthmaNet, a multi-centered network examining novel therapeutic approaches to asthma in children and adults. He is an investigator in the Childhood Asthma Research and Education (CARE) Network, an NHLBI-funded multi-centered network examining novel therapeutic strategies in children with asthma. He is a co-investigator in the Childhood Asthma Management Program, a multi-centered prospective trial examining the effects of early treatment of asthma on lung growth. He also serves as Co-Principal Investigator of a study examining the role of early infection with Respiratory Syncytial Virus upon the subsequent development of asthma.