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Lee Ratner, MD, PhD

Professor, Medicine
Division of Oncology
Section, Medical Oncology
Professor, Pathology
Professor, Microbiology

Specialty Areas

Oncology
Medical Oncology
Hematology
Sarcoma

Board Certifications

Internal Medicine
Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

HIV, AIDS, human immunodeficiency virus, hematology, oncology, AIDS-related malignancies

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-747-7222

Suite: B
Floor: 7
Office Phone: 314-362-7578
Fax: 314-747-2120

Education

Education

Fellowship: Oncology, National Cancer Institute, NIH, Bethesda, Maryland 1985
Residency: Internal Medicine, Washington Univ School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri 1982
Medical Degree, PhD: Yale University School of Medicine, New Haven, Connecticut 1979
B.A., M.A.: Chemistry, Harvard University, Cambridge, Massachusetts 1973

Publication & Research

Publication & Research

The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30<sup>II</sup> and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma.
Hutchison T, Malu A, Yapindi L, Bergeson R, Peck K, Romeo M, Harrod C, Pope J, Smitherman L, Gwinn W, Ratner L, Yates C, Harrod R
Virology. 2018 Jul; 52039-58. doi: 10.1016/j.virol.2018.05.007.

PMID:
    29777913
    [PubMed - in process]
Related citations


Rapid Progression of Adult T-Cell Leukemia-Lymphoma after PD-1 Inhibitor Therapy.
Ratner L, Waldmann TA, Janakiram M, Brammer JE
N Engl J Med. 2018 May 17; 378(20)1947-1948. doi: 10.1056/NEJMc1803181.

PMID:
    29768155
    [PubMed - indexed for MEDLINE]
Related citations


Factors leading to the discard of deceased donor kidneys in the United States.
Mohan S, Chiles MC, Patzer RE, Pastan SO, Husain SA, Carpenter DJ, Dube GK, Crew RJ, Ratner LE, Cohen DJ
Kidney Int. 2018 May 5; pii: S0085-2538(18)30206-0. doi: 10.1016/j.kint.2018.02.016.

PMID:
    29735310
    [PubMed - as supplied by publisher]
Related citations


PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.
Pérès E, Blin J, Ricci EP, Artesi M, Hahaut V, Van den Broeke A, Corbin A, Gazzolo L, Ratner L, Jalinot P, Duc Dodon M
PLoS Pathog. 2018 Mar; 14(3)e1006933. doi: 10.1371/journal.ppat.1006933.

PMID:
    29566098
    [PubMed - in process]
Related citations


Analysis of dendritic cells and ischemia-reperfusion changes in postimplantation renal allograft biopsies may serve as predictors of subsequent rejection episodes.
Batal I, Mohan S, De Serres SA, Vasilescu ER, Tsapepas D, Crew RJ, Patel SS, Serban G, McCune K, Husain SA, Chang JH, Herter JM, Bhagat G, Markowitz GS, D'Agati VD, Hardy MA, Ratner L, Chandraker A
Kidney Int. 2018 May; 93(5)1227-1239. doi: 10.1016/j.kint.2017.12.015.

PMID:
    29544662
    [PubMed - in process]
Related citations


An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.
Cherian MA, Olson S, Sundaramoorthi H, Cates K, Cheng X, Harding J, Martens A, Challen GA, Tyagi M, Ratner L, Rauch D
J Biol Chem. 2018 May 4; 293(18)6844-6858. doi: 10.1074/jbc.RA117.000164.

PMID:
    29540473
    [PubMed - in process]
Related citations


The human T-cell leukemia virus type-1 p30<sup>II</sup> protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis.
Romeo M, Hutchison T, Malu A, White A, Kim J, Gardner R, Smith K, Nelson K, Bergeson R, McKee R, Harrod C, Ratner L, Lüscher B, Martinez E, Harrod R
Virology. 2018 May; 518103-115. doi: 10.1016/j.virol.2018.02.010.

PMID:
    29462755
    [PubMed - indexed for MEDLINE]
Related citations


Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice.
Huey DD, Bolon B, La Perle KMD, Kannian P, Jacobson S, Ratner L, Green PL, Niewiesk S
Comp Med. 2018 Feb 1; 68(1)4-14.

PMID:
    29460716
    [PubMed - in process]
Related citations


A liver for a kidney: Ethics of trans-organ paired exchange.
Samstein B, de Melo-Martin I, Kapur S, Ratner L, Emond J
Am J Transplant. 2018 May; 18(5)1077-1082. doi: 10.1111/ajt.14690.

PMID:
    29442420
    [PubMed - in process]
Related citations


Safety and Preliminary Efficacy of Vorinostat With R-EPOCH in High-risk HIV-associated Non-Hodgkin's Lymphoma (AMC-075).
Ramos JC, Sparano JA, Rudek MA, Moore PC, Cesarman E, Reid EG, Henry D, Ratner L, Aboulafia D, Lee JY, Ambinder RF, Mitsuyasu R, Noy A
Clin Lymphoma Myeloma Leuk. 2018 Mar; 18(3)180-190.e2. doi: 10.1016/j.clml.2018.01.004.

PMID:
    29426719
    [PubMed - in process]
Related citations


Expanding clarity or confusion? Volatility of the 5-tier ratings assessing quality of transplant centers in the United States.
Schold JD, Andreoni KA, Chandraker AK, Gaston RS, Locke JE, Mathur AK, Pruett TL, Rana A, Ratner LE, Buccini LD
Am J Transplant. 2018 Jun; 18(6)1494-1501. doi: 10.1111/ajt.14659.

PMID:
    29316241
    [PubMed - in process]
Related citations


Brentuximab vedotin with AVD shows safety, in the absence of strong CYP3A4 inhibitors, in newly diagnosed HIV-associated Hodgkin lymphoma.
Rubinstein PG, Moore PC, Rudek MA, Henry DH, Ramos JC, Ratner L, Reid E, Sharon E, Noy A, AIDS Malignancy Consortium (AMC).
AIDS. 2018 Mar 13; 32(5)605-611. doi: 10.1097/QAD.0000000000001729.

PMID:
    29280762
    [PubMed - in process]
Related citations


Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors.
Husain SA, Chiles MC, Lee S, Pastan SO, Patzer RE, Tanriover B, Ratner LE, Mohan S
Clin J Am Soc Nephrol. 2018 Jan 6; 13(1)118-127. doi: 10.2215/CJN.06550617.

PMID:
    29217537
    [PubMed - in process]
Related citations


Sex differences in the pituitary TGFβ1 system: The role of TGFβ1 in prolactinoma development.
Recouvreux MV, Faraoni EY, Camilletti MA, Ratner L, Abeledo-Machado A, Rulli SB, Díaz-Torga G
Front Neuroendocrinol. 2017 Oct 24; pii: S0091-3022(17)30063-8. doi: 10.1016/j.yfrne.2017.10.003.

PMID:
    29074127
    [PubMed - as supplied by publisher]
Related citations


HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice.
Esser AK, Rauch DA, Xiang J, Harding JC, Kohart NA, Ross MH, Su X, Wu K, Huey D, Xu Y, Vij K, Green PL, Rosol TJ, Niewiesk S, Ratner L, Weilbaecher KN
Oncotarget. 2017 Sep 19; 8(41)69250-69263. doi: 10.18632/oncotarget.20565.

PMID:
    29050201
    [PubMed]
Related citations


Complement-Activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment.
Lefaucheur C, Viglietti D, Hidalgo LG, Ratner LE, Bagnasco SM, Batal I, Aubert O, Orandi BJ, Oppenheimer F, Bestard O, Rigotti P, Reisaeter AV, Kamar N, Lebranchu Y, Duong Van Huyen JP, Bruneval P, Glotz D, Legendre C, Empana JP, Jouven X, Segev DL, Montgomery RA, Zeevi A, Halloran PF, Loupy A
J Am Soc Nephrol. 2018 Feb; 29(2)620-635. doi: 10.1681/ASN.2017050589.

PMID:
    29042454
    [PubMed - in process]
Related citations


Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study.
Orandi BJ, Luo X, King EA, Garonzik-Wang JM, Bae S, Montgomery RA, Stegall MD, Jordan SC, Oberholzer J, Dunn TB, Ratner LE, Kapur S, Pelletier RP, Roberts JP, Melcher ML, Singh P, Sudan DL, Posner MP, El-Amm JM, Shapiro R, Cooper M, Lipkowitz GS, Rees MA, Marsh CL, Sankari BR, Gerber DA, Nelson PW, Wellen J, Bozorgzadeh A, Osama Gaber A, Segev DL
Am J Transplant. 2018 Mar; 18(3)650-658. doi: 10.1111/ajt.14472.

PMID:
    28834181
    [PubMed - in process]
Related citations


Adult T-Cell Leukemia/Lymphoma.
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract. 2017 Aug; 13(8)487-492. doi: 10.1200/JOP.2017.021907.

PMID:
    28796966
    [PubMed - indexed for MEDLINE]
Related citations


Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.
Albert BJ, Niu A, Ramani R, Marshall GR, Wender PA, Williams RM, Ratner L, Barnes AB, Kyei GB
Sci Rep. 2017 Aug 7; 7(1)7456. doi: 10.1038/s41598-017-07814-4.

PMID:
    28785069
    [PubMed - in process]
Related citations


First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials.
Wasan HS, Gibbs P, Sharma NK, Taieb J, Heinemann V, Ricke J, Peeters M, Findlay M, Weaver A, Mills J, Wilson C, Adams R, Francis A, Moschandreas J, Virdee PS, Dutton P, Love S, Gebski V, Gray A, FOXFIRE trial investigators., SIRFLOX trial investigators., FOXFIRE-Global trial investigators., van Hazel G, Sharma RA
Lancet Oncol. 2017 Sep; 18(9)1159-1171. doi: 10.1016/S1470-2045(17)30457-6.

PMID:
    28781171
    [PubMed - indexed for MEDLINE]
Related citations