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Lee Ratner, MD, PhD

Professor, Medicine
Division of Oncology
Section, Medical Oncology
Professor, Pathology
Professor, Microbiology

Specialty Areas

Oncology
Medical Oncology
Hematology
Sarcoma

Board Certifications

Internal Medicine
Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

HIV, AIDS, human immunodeficiency virus, hematology, oncology, AIDS-related malignancies

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-362-7578
Fax: 314-747-2120

Education

Education

Fellowship: Oncology, National Cancer Institute, NIH, Bethesda, Maryland 1985
Residency: Internal Medicine, Washington Univ School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri 1982
Medical Degree, PhD: Yale University School of Medicine, New Haven, Connecticut 1979
B.A., M.A.: Chemistry, Harvard University, Cambridge, Massachusetts 1973

Publication & Research

Publication & Research

Association between the "Timed Up and Go Test" at Transplant Evaluation and Outcomes after Kidney Transplantation.
Michelson AT, Tsapepas DS, Husain SA, Brennan C, Chiles MC, Runge B, Lione J, Kil BH, Cohen DJ, Ratner LE, Mohan S
Clin Transplant. 2018 Sep 19; e13410. doi: 10.1111/ctr.13410.

PMID:
    30230036
    [PubMed - as supplied by publisher]
Related citations


PD-1 Inhibitor Therapy in Adult T-Cell Leukemia-Lymphoma.
Ratner L, the Authors.
N Engl J Med. 2018 Aug 16; 379(7)696-697. doi: 10.1056/NEJMc1807852.

PMID:
    30110590
    [PubMed - indexed for MEDLINE]
Related citations


North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Shah UA, Chung EY, Giricz O, Pradhan K, Kataoka K, Gordon-Mitchell S, Bhagat TD, Mai Y, Wei Y, Ishida E, Choudhary GS, Joseph A, Rice R, Gitego N, Parrish C, Bartenstein M, Goel S, Mantzaris I, Shastri A, Derman O, Binder A, Gritsman K, Kornblum N, Braunschweig I, Bhagat C, Hall J, Graber A, Ratner L, Wang Y, Ogawa S, Verma A, Ye BH, Janakiram M
Blood. 2018 Aug 13; pii: blood-2018-01-824607. doi: 10.1182/blood-2018-01-824607.

PMID:
    30104217
    [PubMed - as supplied by publisher]
Related citations


Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.
Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA
J Natl Compr Canc Netw. 2018 Aug; 16(8)986-1017. doi: 10.6004/jnccn.2018.0066.

PMID:
    30099375
    [PubMed - in process]
Related citations


Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies.
Gibbs P, Heinemann V, Sharma NK, Taieb J, Ricke J, Peeters M, Findlay M, Robinson B, Jackson C, Strickland A, Gebski V, Van Buskirk M, Zhao H, van Hazel G, SIRFLOX and FOXFIRE Global Trial Investigators.
Clin Colorectal Cancer. 2018 Jun 12; pii: S1533-0028(18)30198-1. doi: 10.1016/j.clcc.2018.06.001.

PMID:
    30033117
    [PubMed - as supplied by publisher]
Related citations


Programming of the reproductive axis by hormonal and genetic manipulation in mice.
Rulli SB, Cambiasso MJ, Ratner LD
Reproduction. 2018 Jun 25; pii: REP-18-0054. doi: 10.1530/REP-18-0054.

PMID:
    29941464
    [PubMed - as supplied by publisher]
Related citations


The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30<sup>II</sup> and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma.
Hutchison T, Malu A, Yapindi L, Bergeson R, Peck K, Romeo M, Harrod C, Pope J, Smitherman L, Gwinn W, Ratner L, Yates C, Harrod R
Virology. 2018 Jul; 52039-58. doi: 10.1016/j.virol.2018.05.007.

PMID:
    29777913
    [PubMed - indexed for MEDLINE]
Related citations


Rapid Progression of Adult T-Cell Leukemia-Lymphoma after PD-1 Inhibitor Therapy.
Ratner L, Waldmann TA, Janakiram M, Brammer JE
N Engl J Med. 2018 May 17; 378(20)1947-1948. doi: 10.1056/NEJMc1803181.

PMID:
    29768155
    [PubMed - indexed for MEDLINE]
Related citations


Factors leading to the discard of deceased donor kidneys in the United States.
Mohan S, Chiles MC, Patzer RE, Pastan SO, Husain SA, Carpenter DJ, Dube GK, Crew RJ, Ratner LE, Cohen DJ
Kidney Int. 2018 Jul; 94(1)187-198. doi: 10.1016/j.kint.2018.02.016.

PMID:
    29735310
    [PubMed - in process]
Related citations


PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.
Pérès E, Blin J, Ricci EP, Artesi M, Hahaut V, Van den Broeke A, Corbin A, Gazzolo L, Ratner L, Jalinot P, Duc Dodon M
PLoS Pathog. 2018 Mar; 14(3)e1006933. doi: 10.1371/journal.ppat.1006933.

PMID:
    29566098
    [PubMed - indexed for MEDLINE]
Related citations


Analysis of dendritic cells and ischemia-reperfusion changes in postimplantation renal allograft biopsies may serve as predictors of subsequent rejection episodes.
Batal I, Mohan S, De Serres SA, Vasilescu ER, Tsapepas D, Crew RJ, Patel SS, Serban G, McCune K, Husain SA, Chang JH, Herter JM, Bhagat G, Markowitz GS, D'Agati VD, Hardy MA, Ratner L, Chandraker A
Kidney Int. 2018 May; 93(5)1227-1239. doi: 10.1016/j.kint.2017.12.015.

PMID:
    29544662
    [PubMed - in process]
Related citations


An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.
Cherian MA, Olson S, Sundaramoorthi H, Cates K, Cheng X, Harding J, Martens A, Challen GA, Tyagi M, Ratner L, Rauch D
J Biol Chem. 2018 May 4; 293(18)6844-6858. doi: 10.1074/jbc.RA117.000164.

PMID:
    29540473
    [PubMed - in process]
Related citations


The human T-cell leukemia virus type-1 p30<sup>II</sup> protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis.
Romeo M, Hutchison T, Malu A, White A, Kim J, Gardner R, Smith K, Nelson K, Bergeson R, McKee R, Harrod C, Ratner L, Lüscher B, Martinez E, Harrod R
Virology. 2018 May; 518103-115. doi: 10.1016/j.virol.2018.02.010.

PMID:
    29462755
    [PubMed - indexed for MEDLINE]
Related citations


Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice.
Huey DD, Bolon B, La Perle KMD, Kannian P, Jacobson S, Ratner L, Green PL, Niewiesk S
Comp Med. 2018 Feb 1; 68(1)4-14.

PMID:
    29460716
    [PubMed - in process]
Related citations


A liver for a kidney: Ethics of trans-organ paired exchange.
Samstein B, de Melo-Martin I, Kapur S, Ratner L, Emond J
Am J Transplant. 2018 May; 18(5)1077-1082. doi: 10.1111/ajt.14690.

PMID:
    29442420
    [PubMed - in process]
Related citations


Safety and Preliminary Efficacy of Vorinostat With R-EPOCH in High-risk HIV-associated Non-Hodgkin's Lymphoma (AMC-075).
Ramos JC, Sparano JA, Rudek MA, Moore PC, Cesarman E, Reid EG, Henry D, Ratner L, Aboulafia D, Lee JY, Ambinder RF, Mitsuyasu R, Noy A
Clin Lymphoma Myeloma Leuk. 2018 Mar; 18(3)180-190.e2. doi: 10.1016/j.clml.2018.01.004.

PMID:
    29426719
    [PubMed - in process]
Related citations


Expanding clarity or confusion? Volatility of the 5-tier ratings assessing quality of transplant centers in the United States.
Schold JD, Andreoni KA, Chandraker AK, Gaston RS, Locke JE, Mathur AK, Pruett TL, Rana A, Ratner LE, Buccini LD
Am J Transplant. 2018 Jun; 18(6)1494-1501. doi: 10.1111/ajt.14659.

PMID:
    29316241
    [PubMed - in process]
Related citations


Brentuximab vedotin with AVD shows safety, in the absence of strong CYP3A4 inhibitors, in newly diagnosed HIV-associated Hodgkin lymphoma.
Rubinstein PG, Moore PC, Rudek MA, Henry DH, Ramos JC, Ratner L, Reid E, Sharon E, Noy A, AIDS Malignancy Consortium (AMC).
AIDS. 2018 Mar 13; 32(5)605-611. doi: 10.1097/QAD.0000000000001729.

PMID:
    29280762
    [PubMed - in process]
Related citations


Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors.
Husain SA, Chiles MC, Lee S, Pastan SO, Patzer RE, Tanriover B, Ratner LE, Mohan S
Clin J Am Soc Nephrol. 2018 Jan 6; 13(1)118-127. doi: 10.2215/CJN.06550617.

PMID:
    29217537
    [PubMed - in process]
Related citations


Sex differences in the pituitary TGFβ1 system: The role of TGFβ1 in prolactinoma development.
Recouvreux MV, Faraoni EY, Camilletti MA, Ratner L, Abeledo-Machado A, Rulli SB, Díaz-Torga G
Front Neuroendocrinol. 2018 Jul; 50118-122. doi: 10.1016/j.yfrne.2017.10.003.

PMID:
    29074127
    [PubMed - in process]
Related citations