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Lawrence Tychsen, MD

Professor, Ophthalmology and Visual Sciences
Professor, Neurobiology
Professor, Ophthalmology in Pediatrics, Dept of Pediatrics
John F. Hardesty, MD, Distinguished Professor of Ophthalmology and Visual Sciences

Specialty Areas

Pediatric Ophthalmology
Ocular Motility Disorders - Adult
Cataract

Board Certifications

Ophthalmology
Pediatric Ophthalmology

Hospital Affiliations

Barnes-Jewish Hospital
Shriners Hospital for Children - St. Louis
St. Louis Children's Hospital

Areas of Clinical Interest

Strabismus (crossed-eyes), nystagmus and eye movement disorders, cerebral palsy, amblyopia, pediatric cataract, IOL, refractive surgery, pediatric glaucoma, pediatric nasolacrimal disorders and ptosis, adult diplopia.   More Information on Pediatric Eye Care

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6026
Fax: 314-454-2368

Barnes-Jewish West County Hospital
Medical Building One

1040 N. Mason Road
Creve Coeur, MO 63141

Suite: Suite 219
Office Phone: 314-996-7400
Fax: 314-996-7401

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: C
Floor: 2
Office Phone: 314-454-6026

Education

Education

Fellowship: Pediatric Ophthalmology, Smith-Kettlewell Institute of Visual Sciences, San Francisco 1985
Fellowship: Pediatric Ophthalmology, Neuro-Ophthalmology, Neurobiology, University of California, San Francisco 1985
Residency: University of Iowa Hospital and Clinics 1983
Fellowship: Neuro-ophthalmology,National Eye Institute, Bethesda, Maryland 1980
Medical School: Georgetown University, Washington, DC 1979
B.S. Biology: Georgetown University, Washington, D.C. 1975

Publication & Research

Publication & Research

Neuroimaging evidence of deficient axon myelination in Wolfram syndrome.
Lugar HM, Koller JM, Rutlin J, Marshall BA, Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T, Washington University Wolfram Syndrome Research Study Group
Sci Rep. 2016 Feb 18; 621167. doi: 10.1038/srep21167.

PMID:
    26888576
    [PubMed - in process]
Related citations


Selective cognitive and psychiatric manifestations in Wolfram Syndrome.
Bischoff AN, Reiersen AM, Buttlaire A, Al-Lozi A, Doty T, Marshall BA, Hershey T, Washington University Wolfram Syndrome Research Group
Orphanet J Rare Dis. 2015 May 30; 1066. doi: 10.1186/s13023-015-0282-1.

PMID:
    26025012
    [PubMed - indexed for MEDLINE]
Related citations


A randomized trial of adding a plano lens to atropine for amblyopia.
Pediatric Eye Disease Investigator Group, Wallace DK, Lazar EL, Repka MX, Holmes JM, Kraker RT, Hoover DL, Weise KK, Waters AL, Rice ML, Peters RJ
J AAPOS. 2015 Feb; 19(1)42-8. doi: 10.1016/j.jaapos.2014.10.022.

PMID:
    25727586
    [PubMed - indexed for MEDLINE]
Related citations


Time course and predictors of amblyopia improvement with 2 hours of daily patching.
Wallace DK, Lazar EL, Crouch ER 3rd, Hoover DL, Kraker RT, Tamkins SM, Pediatric Eye Disease Investigator Group
JAMA Ophthalmol. 2015 May; 133(5)606-9. doi: 10.1001/jamaophthalmol.2015.6.

PMID:
    25695355
    [PubMed - indexed for MEDLINE]
Related citations


Ophthalmologic correlates of disease severity in children and adolescents with Wolfram syndrome.
Hoekel J, Chisholm SA, Al-Lozi A, Hershey T, Tychsen L, Washington University Wolfram Study Group
J AAPOS. 2014 Oct; 18(5)461-465.e1. doi: 10.1016/j.jaapos.2014.07.162.

PMID:
    25439303
    [PubMed - indexed for MEDLINE]
Related citations


Atropine vs patching for treatment of moderate amblyopia: follow-up at 15 years of age of a randomized clinical trial.
Repka MX, Kraker RT, Holmes JM, Summers AI, Glaser SR, Barnhardt CN, Tien DR, Pediatric Eye Disease Investigator Group
JAMA Ophthalmol. 2014 Jul; 132(7)799-805. doi: 10.1001/jamaophthalmol.2014.392.

PMID:
    24789375
    [PubMed - indexed for MEDLINE]
Related citations


Pseudopapilledema and association with idiopathic intracranial hypertension.
Liu B, Murphy RK, Mercer D, Tychsen L, Smyth MD
Childs Nerv Syst. 2014 Jul; 30(7)1197-200. doi: 10.1007/s00381-014-2390-y.

PMID:
    24573961
    [PubMed - indexed for MEDLINE]
Related citations


Office probing for treatment of nasolacrimal duct obstruction in infants.
Miller AM, Chandler DL, Repka MX, Hoover DL, Lee KA, Melia M, Rychwalski PJ, Silbert DI, Pediatric Eye Disease Investigator Group, Beck RW, Crouch ER 3rd, Donahue S, Holmes JM, Quinn GE, Sala NA, Schloff S, Wallace DK, Foster NC, Frick KD, Golden RP, Lambert SR, Tien DR, Weakley DR Jr
J AAPOS. 2014 Feb; 18(1)26-30. doi: 10.1016/j.jaapos.2013.10.016.

PMID:
    24568978
    [PubMed - indexed for MEDLINE]
Related citations


Comparison of the effectiveness and safety of transscleral cyclophotocoagulation and endoscopic cyclophotocoagulation in pediatric glaucoma.
Kraus CL, Tychsen L, Lueder GT, Culican SM
J Pediatr Ophthalmol Strabismus. 2014 Mar-Apr; 51(2)120-7. doi: 10.3928/01913913-20140211-01.

PMID:
    24530177
    [PubMed - indexed for MEDLINE]
Related citations


Horizontal and vertical optokinetic eye movements in macaque monkeys with infantile strabismus: directional bias and crosstalk.
Ghasia F, Tychsen L
Invest Ophthalmol Vis Sci. 2014 Jan 13; 55(1)265-74. doi: 10.1167/iovs.13-12330.

PMID:
    24204052
    [PubMed - indexed for MEDLINE]
Related citations


Congenital lymphocytic choriomeningitis virus: when to consider the diagnosis.
Anderson JL, Levy PT, Leonard KB, Smyser CD, Tychsen L, Cole FS
J Child Neurol. 2014 Jun; 29(6)837-42. doi: 10.1177/0883073813486295.

PMID:
    23666045
    [PubMed - indexed for MEDLINE]
Related citations


A randomized trial comparing the cost-effectiveness of 2 approaches for treating unilateral nasolacrimal duct obstruction.
Pediatric Eye Disease Investigator Group
Arch Ophthalmol. 2012 Dec; 130(12)1525-33. doi: 10.1001/archophthalmol.2012.2853.

PMID:
    23229693
    [PubMed - indexed for MEDLINE]
Related citations


The cause of infantile strabismus lies upstairs in the cerebral cortex, not downstairs in the brainstem.
Tychsen L
Arch Ophthalmol. 2012 Aug; 130(8)1060-1. doi: 10.1001/archophthalmol.2012.1481.

PMID:
    22893080
    [PubMed - indexed for MEDLINE]
Related citations


Pediatric refractive surgery: corneal and intraocular techniques and beyond.
Paysse EA, Tychsen L, Stahl E
J AAPOS. 2012 Jun; 16(3)291-7. doi: 10.1016/j.jaapos.2012.01.012.

PMID:
    22681949
    [PubMed - indexed for MEDLINE]
Related citations


Long-term results of botulinum toxin-augmented medial rectus recessions for large-angle infantile esotropia.
Lueder GT, Galli M, Tychsen L, Yildirim C, Pegado V
Am J Ophthalmol. 2012 Mar; 153(3)560-3. doi: 10.1016/j.ajo.2011.08.019.

PMID:
    21996305
    [PubMed - indexed for MEDLINE]
Related citations


Repair of strabismus and binocular fusion in children with cerebral palsy: gross motor function classification scale.
Ghasia F, Brunstrom-Hernandez J, Tychsen L
Invest Ophthalmol Vis Sci. 2011 Sep 29; 52(10)7664-71. doi: 10.1167/iovs.10-6906.

PMID:
    21873677
    [PubMed - indexed for MEDLINE]
Related citations


Randomized trial to evaluate combined patching and atropine for residual amblyopia.
Pediatric Eye Disease Investigator Group (PEDIG) Writing Committee, Wallace DK, Kraker RT, Beck RW, Cotter SA, Davis PL, Holmes JM, Repka MX, Suh DW
Arch Ophthalmol. 2011 Jul; 129(7)960-2. doi: 10.1001/archophthalmol.2011.174.

PMID:
    21746992
    [PubMed - indexed for MEDLINE]
Related citations


Progressive-addition lenses versus single-vision lenses for slowing progression of myopia in children with high accommodative lag and near esophoria.
Correction of Myopia Evaluation Trial 2 Study Group for the Pediatric Eye Disease Investigator Group
Invest Ophthalmol Vis Sci. 2011 Apr 25; 52(5)2749-57. doi: 10.1167/iovs.10-6631.

PMID:
    21282579
    [PubMed - indexed for MEDLINE]
Related citations


Intramuscular innervation of primate extraocular muscles: unique compartmentalization in horizontal recti.
da Silva Costa RM, Kung J, Poukens V, Yoo L, Tychsen L, Demer JL
Invest Ophthalmol Vis Sci. 2011 Apr; 52(5)2830-6. doi: 10.1167/iovs.10-6651.

PMID:
    21220556
    [PubMed - indexed for MEDLINE]
Related citations


Pilot study of levodopa dose as treatment for residual amblyopia in children aged 8 years to younger than 18 years.
Repka MX, Kraker RT, Beck RW, Atkinson CS, Bacal DA, Bremer DL, Davis PL, Gearinger MD, Glaser SR, Hoover DL, Laby DM, Morrison DG, Rogers DL, Sala NA, Suh DW, Wheeler MB, Pediatric Eye Disease Investigator Group
Arch Ophthalmol. 2010 Sep; 128(9)1215-7. doi: 10.1001/archophthalmol.2010.178.

PMID:
    20837811
    [PubMed - indexed for MEDLINE]
Related citations