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Laura J. Bierut, MD

Professor, Psychiatry
Co-Director, Outpatient Psychiatry Clinic

Specialty Areas

Adult Psychiatry

Board Certifications

Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Molecular biology, bipolar illness, genetics, genetic analysis, nicotine, marijuana, cocaine, alcohol dependence, smoking, substance dependence, substance abuse, major depressive disorder, alcoholism, depression, family studies

  • Education
  • Publication & Research

Education

Education

Residency: Psychiatry, Washington University/Barnes Hospital, St. Louis, Missouri 1991
Medical Degree: Washington University, St. Louis, Missouri 1987
B.A.: Harvard University, Cambridge, Massachusetts 1982

Publication & Research

Publication & Research

Marijuana Promotion Online: an Investigation of Dispensary Practices.
Cavazos-Rehg PA, Krauss MJ, Cahn E, Lee KE, Ferguson E, Rajbhandari B, Sowles SJ, Floyd GM, Berg C, Bierut LJ
Prev Sci. 2018 Apr 9; doi: 10.1007/s11121-018-0889-2.

PMID:
    29629505
    [PubMed - as supplied by publisher]
Related citations


Human Genetics of Addiction: New Insights and Future Directions.
Hancock DB, Markunas CA, Bierut LJ, Johnson EO
Curr Psychiatry Rep. 2018 Mar 5; 20(2)8. doi: 10.1007/s11920-018-0873-3.

PMID:
    29504045
    [PubMed - in process]
Related citations


Tobacco use prevalence and smoking cessation pharmacotherapy prescription patterns among hospitalized patients by medical specialty.
Srivastava AB, Ramsey AT, McIntosh LD, Bailey TC, Fisher SL, Fox L, Castro M, Ma Y, Baker TB, Chen LS, Bierut LJ
Nicotine Tob Res. 2018 Feb 22; doi: 10.1093/ntr/nty031.

PMID:
    29481616
    [PubMed - as supplied by publisher]
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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto ARVR, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Kühnel B, Leander K, Lee WJ, Lin KH, 'an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stančáková A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B, Caizheng Y, Campbell A, Canouil M, Chakravarti A, CHARGE Neurology Working Group., Chauhan G, Christensen K, Cocca M, COGENT-Kidney Consortium., Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Fisher VA, Forouhi NG, Franco OH, Friedlander Y, Gao H, GIANT Consortium., Gigante B, Graff M, Gu CC, Gu D, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Hofman A, Howard BV, Hunt S, Irvin MR, Jia Y, Joehanes R, Justice AE, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Komulainen P, Kooperberg C, Krieger JE, Kubo M, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Lifelines Cohort Study., Lim SH, Lin S, Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Long J, Louie T, Mägi R, Mahajan A, Meitinger T, Metspalu A, Milani L, Momozawa Y, Morris AP, Mosley TH Jr., Munson P, Murray AD, Nalls MA, Nasri U, Norris JM, North K, Ogunniyi A, Padmanabhan S, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Seshadri S, Sever P, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Newman AB, Oldehinkel AJ, Pereira AC, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Kardia SLR, Kritchevsky SB, Levy D, O'Connell JR, Psaty BM, van Dam RM, Sims M, Arnett DK, Mook-Kanamori DO, Kelly TN, Fox ER, Hayward C, Fornage M, Rotimi CN, Province MA, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Caulfield MJ, Elliott P, Rice K, Munroe PB, Morrison AC, Cupples LA, Rao DC, Chasman DI
Am J Hum Genet. 2018 Mar 1; 102(3)375-400. doi: 10.1016/j.ajhg.2018.01.015.

PMID:
    29455858
    [PubMed - in process]
Related citations


Is the Fagerström test for nicotine dependence invariant across secular trends in smoking? A question for cross-birth cohort analysis of nicotine dependence.
Glasheen C, Johnson EO, Saccone NL, Lutz SM, Baker TB, McNeil DW, Marazita ML, Hokanson JE, Bierut LJ, Hancock DB
Drug Alcohol Depend. 2018 Apr 1; 185127-132. doi: 10.1016/j.drugalcdep.2017.12.013.

PMID:
    29438887
    [PubMed - in process]
Related citations


Toward the implementation of genomic applications for smoking cessation and smoking-related diseases.
Ramsey AT, Chen LS, Hartz SM, Saccone NL, Fisher SL, Proctor EK, Bierut LJ
Transl Behav Med. 2018 Jan 29; 8(1)7-17. doi: 10.1093/tbm/ibx060.

PMID:
    29385591
    [PubMed - in process]
Related citations


A reciprocal effects analysis of cannabis use and perceptions of risk.
Salloum NC, Krauss MJ, Agrawal A, Bierut LJ, Grucza RA
Addiction. 2018 Jan 27; doi: 10.1111/add.14174.

PMID:
    29377544
    [PubMed - as supplied by publisher]
Related citations


Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.
Bierut LJ, Tyndale RF
Trends Mol Med. 2018 Feb; 24(2)187-196. doi: 10.1016/j.molmed.2017.12.001.

PMID:
    29307500
    [PubMed - in process]
Related citations


The state of knowledge about the relationship between 5-HTTLPR, stress, and depression.
Culverhouse RC, Saccone NL, Bierut LJ
J Affect Disord. 2018 Mar 1; 228205-206. doi: 10.1016/j.jad.2017.12.002.

PMID:
    29268203
    [PubMed - in process]
Related citations


A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.
Polimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J, Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup.
Genome Med. 2017 Nov 27; 9(1)99. doi: 10.1186/s13073-017-0491-4.

PMID:
    29178946
    [PubMed - in process]
Related citations


Genome-wide association study identifies a novel locus for cannabis dependence.
Agrawal A, Chou YL, Carey CE, Baranger DAA, Zhang B, Sherva R, Wetherill L, Kapoor M, Wang JC, Bertelsen S, Anokhin AP, Hesselbrock V, Kramer J, Lynskey MT, Meyers JL, Nurnberger JI, Rice JP, Tischfield J, Bierut LJ, Degenhardt L, Farrer LA, Gelernter J, Hariri AR, Heath AC, Kranzler HR, Madden PAF, Martin NG, Montgomery GW, Porjesz B, Wang T, Whitfield JB, Edenberg HJ, Foroud T, Goate AM, Bogdan R, Nelson EC
Mol Psychiatry. 2017 Nov 7; doi: 10.1038/mp.2017.200.

PMID:
    29112194
    [PubMed - as supplied by publisher]
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Declines in prevalence of adolescent substance use disorders and delinquent behaviors in the USA: a unitary trend?
Grucza RA, Krueger RF, Agrawal A, Plunk AD, Krauss MJ, Bongu J, Cavazos-Rehg PA, Bierut LJ
Psychol Med. 2017 Oct 25; 1-12. doi: 10.1017/S0033291717002999.

PMID:
    29065935
    [PubMed - as supplied by publisher]
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Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
Hancock DB, Guo Y, Reginsson GW, Gaddis NC, Lutz SM, Sherva R, Loukola A, Minica CC, Markunas CA, Han Y, Young KA, Gudbjartsson DF, Gu F, McNeil DW, Qaiser B, Glasheen C, Olson S, Landi MT, Madden PAF, Farrer LA, Vink J, Saccone NL, Neale MC, Kranzler HR, McKay J, Hung RJ, Amos CI, Marazita ML, Boomsma DI, Baker TB, Gelernter J, Kaprio J, Caporaso NE, Thorgeirsson TE, Hokanson JE, Bierut LJ, Stefansson K, Johnson EO
Mol Psychiatry. 2017 Oct 3; doi: 10.1038/mp.2017.193.

PMID:
    28972577
    [PubMed - as supplied by publisher]
Related citations


Physicians-in-training are not prepared to prescribe medical marijuana.
Evanoff AB, Quan T, Dufault C, Awad M, Bierut LJ
Drug Alcohol Depend. 2017 Nov 1; 180151-155. doi: 10.1016/j.drugalcdep.2017.08.010.

PMID:
    28892720
    [PubMed - in process]
Related citations


Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia.
Hartz SM, Horton AC, Oehlert M, Carey CE, Agrawal A, Bogdan R, Chen LS, Hancock DB, Johnson EO, Pato CN, Pato MT, Rice JP, Bierut LJ
Biol Psychiatry. 2017 Nov 15; 82(10)709-715. doi: 10.1016/j.biopsych.2017.04.020.

PMID:
    28739213
    [PubMed - in process]
Related citations


Exposure to and Content of Marijuana Product Reviews.
Cavazos-Rehg PA, Krauss MJ, Sowles SJ, Murphy GM, Bierut LJ
Prev Sci. 2018 Feb; 19(2)127-137. doi: 10.1007/s11121-017-0818-9.

PMID:
    28681195
    [PubMed - in process]
Related citations


Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV, SpiroMeta Consortium., Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI
Nat Genet. 2017 Jul; 49(7)1126-1132. doi: 10.1038/ng.3892.

PMID:
    28604730
    [PubMed - indexed for MEDLINE]
Related citations


Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Saccone NL, Emery LS, Sofer T, Gogarten SM, Becker DM, Bottinger EP, Chen LS, Culverhouse RC, Duan W, Hancock DB, Hosgood HD, Johnson EO, Loos RJF, Louie T, Papanicolaou G, Perreira KM, Rodriquez EJ, Schurmann C, Stilp AM, Szpiro AA, Talavera GA, Taylor KD, Thrasher JF, Yanek LR, Laurie CC, Pérez-Stable EJ, Bierut LJ, Kaplan RC
Nicotine Tob Res. 2018 Mar 6; 20(4)448-457. doi: 10.1093/ntr/ntx107.

PMID:
    28520984
    [PubMed - in process]
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Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.
Chen LS, Zawertailo L, Piasecki TM, Kaprio J, Foreman M, Elliott HR, David SP, Bergen AW, Baurley JW, Tyndale RF, Baker TB, Bierut LJ, Saccone NL, Genetics and Treatment Workgroup of the Society for Research on Nicotine and Tobacco (SRNT).
Nicotine Tob Res. 2018 Mar 6; 20(4)414-424. doi: 10.1093/ntr/ntx097.

PMID:
    28498934
    [PubMed - in process]
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The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings.
Saccone NL, Baurley JW, Bergen AW, David SP, Elliott HR, Foreman MG, Kaprio J, Piasecki TM, Relton CL, Zawertailo L, Bierut LJ, Tyndale RF, Chen LS, Genetics and Treatment Networks of the Society for Research on Nicotine and Tobacco (SRNT).
Nicotine Tob Res. 2018 Mar 6; 20(4)403-413. doi: 10.1093/ntr/ntx096.

PMID:
    28472521
    [PubMed - in process]
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