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Laura J. Bierut, MD

Professor, Psychiatry
Co-Director, Outpatient Psychiatry Clinic

Specialty Areas

Adult Psychiatry

Board Certifications

Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Molecular biology, bipolar illness, genetics, genetic analysis, nicotine, marijuana, cocaine, alcohol dependence, smoking, substance dependence, substance abuse, major depressive disorder, alcoholism, depression, family studies

  • Education
  • Publication & Research

Education

Education

Residency: Psychiatry, Washington University/Barnes Hospital, St. Louis, Missouri 1991
Medical Degree: Washington University, St. Louis, Missouri 1987
B.A.: Harvard University, Cambridge, Massachusetts 1982

Publication & Research

Publication & Research

Physicians-in-training are not prepared to prescribe medical marijuana.
Evanoff AB, Quan T, Dufault C, Awad M, Bierut LJ
Drug Alcohol Depend. 2017 Sep 4; 180151-155. doi: 10.1016/j.drugalcdep.2017.08.010.

PMID:
    28892720
    [PubMed - as supplied by publisher]
Related citations


Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia.
Hartz SM, Horton AC, Oehlert M, Carey CE, Agrawal A, Bogdan R, Chen LS, Hancock DB, Johnson EO, Pato CN, Pato MT, Rice JP, Bierut LJ
Biol Psychiatry. 2017 Jun 6; pii: S0006-3223(17)31624-4. doi: 10.1016/j.biopsych.2017.04.020.

PMID:
    28739213
    [PubMed - as supplied by publisher]
Related citations


Exposure to and Content of Marijuana Product Reviews.
Cavazos-Rehg PA, Krauss MJ, Sowles SJ, Murphy GM, Bierut LJ
Prev Sci. 2017 Jul 5; doi: 10.1007/s11121-017-0818-9.

PMID:
    28681195
    [PubMed - as supplied by publisher]
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV, SpiroMeta Consortium., Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI
Nat Genet. 2017 Jul; 49(7)1126-1132. doi: 10.1038/ng.3892.

PMID:
    28604730
    [PubMed - in process]
Related citations


Genome-wide association study of heavy smoking and daily/nondaily smoking in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL).
Saccone NL, Emery LS, Sofer T, Gogarten SM, Becker DM, Bottinger EP, Chen LS, Culverhouse RC, Duan W, Hancock DB, Hosgood HD, Johnson EO, Loos RJF, Louie T, Papanicolaou G, Perreira KM, Rodriquez EJ, Schurmann C, Stilp AM, Szpiro AA, Talavera GA, Taylor KD, Thrasher JF, Yanek LR, Laurie CC, Pérez-Stable EJ, Bierut LJ, Kaplan RC
Nicotine Tob Res. 2017 May 17; doi: 10.1093/ntr/ntx107.

PMID:
    28520984
    [PubMed - as supplied by publisher]
Related citations


Leveraging genomic data in smoking cessation trials in the era of Precision Medicine: Why and how.
Chen LS, Zawertailo L, Piasecki TM, Kaprio J, Foreman M, Elliott HR, David SP, Bergen AW, Baurley JW, Tyndale RF, Baker TB, Bierut LJ, Saccone NL, Genetics and Treatment Workgroup of the Society for Research on Nicotine and Tobacco (SRNT).
Nicotine Tob Res. 2017 May 12; doi: 10.1093/ntr/ntx097.

PMID:
    28498934
    [PubMed - as supplied by publisher]
Related citations


The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings.
Saccone NL, Baurley JW, Bergen AW, David SP, Elliott HR, Foreman MG, Kaprio J, Piasecki TM, Relton CL, Zawertailo L, Bierut LJ, Tyndale RF, Chen LS, Genetics and Treatment Networks of the Society for Research on Nicotine and Tobacco (SRNT).
Nicotine Tob Res. 2017 May 3; doi: 10.1093/ntr/ntx096.

PMID:
    28472521
    [PubMed - as supplied by publisher]
Related citations


Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC
Mol Psychiatry. 2017 Apr 25; doi: 10.1038/mp.2017.77.

PMID:
    28439101
    [PubMed - as supplied by publisher]
Related citations


Multiple Levels of Influence That Impact Youth Tobacco Use.
Cavazos-Rehg PA, Krauss MJ, Sowles SJ, Spitznagel EL, Grucza R, Chaloupka FJ, Bierut LJ
Tob Regul Sci. 2016 Apr; 2(2)106-122. doi: 10.18001/TRS.2.2.2.

PMID:
    28435848
    [PubMed]
Related citations


Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.
Zhang TX, Saccone NL, Bierut LJ, Rice JP
Brain Behav. 2017 Apr; 7(4)e00651. doi: 10.1002/brb3.651.

PMID:
    28413702
    [PubMed - indexed for MEDLINE]
Related citations


Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.
Culverhouse RC, Saccone NL, Horton AC, Ma Y, Anstey KJ, Banaschewski T, Burmeister M, Cohen-Woods S, Etain B, Fisher HL, Goldman N, Guillaume S, Horwood J, Juhasz G, Lester KJ, Mandelli L, Middeldorp CM, Olié E, Villafuerte S, Air TM, Araya R, Bowes L, Burns R, Byrne EM, Coffey C, Coventry WL, Gawronski KA, Glei D, Hatzimanolis A, Hottenga JJ, Jaussent I, Jawahar C, Jennen-Steinmetz C, Kramer JR, Lajnef M, Little K, Zu Schwabedissen HM, Nauck M, Nederhof E, Petschner P, Peyrot WJ, Schwahn C, Sinnamon G, Stacey D, Tian Y, Toben C, Van der Auwera S, Wainwright N, Wang JC, Willemsen G, Anderson IM, Arolt V, Åslund C, Bagdy G, Baune BT, Bellivier F, Boomsma DI, Courtet P, Dannlowski U, de Geus EJ, Deakin JF, Easteal S, Eley T, Fergusson DM, Goate AM, Gonda X, Grabe HJ, Holzman C, Johnson EO, Kennedy M, Laucht M, Martin NG, Munafò MR, Nilsson KW, Oldehinkel AJ, Olsson CA, Ormel J, Otte C, Patton GC, Penninx BW, Ritchie K, Sarchiapone M, Scheid JM, Serretti A, Smit JH, Stefanis NC, Surtees PG, Völzke H, Weinstein M, Whooley M, Nurnberger JI Jr, Breslau N, Bierut LJ
Mol Psychiatry. 2017 Apr 4; doi: 10.1038/mp.2017.44.

PMID:
    28373689
    [PubMed - as supplied by publisher]
Related citations


Marijuana advertising exposure among current marijuana users in the U.S.
Krauss MJ, Sowles SJ, Sehi A, Spitznagel EL, Berg CJ, Bierut LJ, Cavazos-Rehg PA
Drug Alcohol Depend. 2017 May 1; 174192-200. doi: 10.1016/j.drugalcdep.2017.01.017.

PMID:
    28365173
    [PubMed - in process]
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A Commentary on Maes et al. "A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents".
Bierut LJ, Johnson EO
Nicotine Tob Res. 2017 Jan 28; doi: 10.1093/ntr/ntx022.

PMID:
    28339609
    [PubMed - as supplied by publisher]
Related citations


Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.
Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ
Pharmacogenomics J. 2017 Mar 14; doi: 10.1038/tpj.2016.92.

PMID:
    28290528
    [PubMed - as supplied by publisher]
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Genetic correlation between smoking behaviors and schizophrenia.
Hartz SM, Horton AC, Hancock DB, Baker TB, Caporaso NE, Chen LS, Hokanson JE, Lutz SM, Marazita ML, McNeil DW, Pato CN, Pato MT, Johnson EO, Bierut LJ
Schizophr Res. 2017 Mar 8; pii: S0920-9964(17)30111-1. doi: 10.1016/j.schres.2017.02.022.

PMID:
    28285025
    [PubMed - as supplied by publisher]
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Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study.
Bucholz KK, McCutcheon VV, Agrawal A, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Nurnberger JI Jr, Salvatore JE, Schuckit MA, Bierut LJ, Foroud TM, Chan G, Hesselbrock M, Meyers JL, Edenberg HJ, Porjesz B
Alcohol Clin Exp Res. 2017 Feb; 41(2)359-368. doi: 10.1111/acer.13293.

PMID:
    28073157
    [PubMed - in process]
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CYP2A6 metabolism in the development of smoking behaviors in young adults.
Olfson E, Bloom J, Bertelsen S, Budde JP, Breslau N, Brooks A, Culverhouse R, Chan G, Chen LS, Chorlian D, Dick DM, Edenberg HJ, Hartz S, Hatsukami D, Hesselbrock VM, Johnson EO, Kramer JR, Kuperman S, Meyers JL, Nurnberger J, Porjesz B, Saccone NL, Schuckit MA, Stitzel J, Tischfield JA, Rice JP, Goate A, Bierut LJ
Addict Biol. 2016 Dec 29; doi: 10.1111/adb.12477.

PMID:
    28032407
    [PubMed - as supplied by publisher]
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Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives.
Chen LS, Baker T, Brownson RC, Carney RM, Jorenby D, Hartz S, Smock N, Johnson M, Ziedonis D, Bierut LJ
Community Ment Health J. 2017 Aug; 53(6)695-702. doi: 10.1007/s10597-016-0065-8.

PMID:
    27900650
    [PubMed - in process]
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KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.
Johnson EO, Hancock DB, Levy JL, Gaddis NC, Page GP, Glasheen C, Saccone NL, Bierut LJ, Kral AH
Addict Biol. 2016 Nov; 21(6)1217-1232. doi: 10.1111/adb.12286.

PMID:
    26202629
    [PubMed - indexed for MEDLINE]
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Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.
Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP, Hart RP
Sci Rep. 2016 Oct 4; 634341. doi: 10.1038/srep34341.

PMID:
    27698409
    [PubMed - in process]
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