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Laura J. Bierut, MD

Professor, Psychiatry
Co-Director, Outpatient Psychiatry Clinic

Specialty Areas

Adult Psychiatry

Board Certifications

Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Molecular biology, bipolar illness, genetics, genetic analysis, nicotine, marijuana, cocaine, alcohol dependence, smoking, substance dependence, substance abuse, major depressive disorder, alcoholism, depression, family studies

  • Education
  • Publication & Research

Education

Education

Residency: Psychiatry, Washington University/Barnes Hospital, St. Louis, Missouri 1991
Medical Degree: Washington University, St. Louis, Missouri 1987
B.A.: Harvard University, Cambridge, Massachusetts 1982

Publication & Research

Publication & Research

Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.
Zhang TX, Saccone NL, Bierut LJ, Rice JP
Brain Behav. 2017 Apr; 7(4)e00651. doi: 10.1002/brb3.651.

PMID:
    28413702
    [PubMed - in process]
Related citations


Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.
Culverhouse RC, Saccone NL, Horton AC, Ma Y, Anstey KJ, Banaschewski T, Burmeister M, Cohen-Woods S, Etain B, Fisher HL, Goldman N, Guillaume S, Horwood J, Juhasz G, Lester KJ, Mandelli L, Middeldorp CM, Olié E, Villafuerte S, Air TM, Araya R, Bowes L, Burns R, Byrne EM, Coffey C, Coventry WL, Gawronski KA, Glei D, Hatzimanolis A, Hottenga JJ, Jaussent I, Jawahar C, Jennen-Steinmetz C, Kramer JR, Lajnef M, Little K, Zu Schwabedissen HM, Nauck M, Nederhof E, Petschner P, Peyrot WJ, Schwahn C, Sinnamon G, Stacey D, Tian Y, Toben C, Van der Auwera S, Wainwright N, Wang JC, Willemsen G, Anderson IM, Arolt V, Åslund C, Bagdy G, Baune BT, Bellivier F, Boomsma DI, Courtet P, Dannlowski U, de Geus EJ, Deakin JF, Easteal S, Eley T, Fergusson DM, Goate AM, Gonda X, Grabe HJ, Holzman C, Johnson EO, Kennedy M, Laucht M, Martin NG, Munafò MR, Nilsson KW, Oldehinkel AJ, Olsson CA, Ormel J, Otte C, Patton GC, Penninx BW, Ritchie K, Sarchiapone M, Scheid JM, Serretti A, Smit JH, Stefanis NC, Surtees PG, Völzke H, Weinstein M, Whooley M, Nurnberger JI Jr, Breslau N, Bierut LJ
Mol Psychiatry. 2017 Apr 4; doi: 10.1038/mp.2017.44.

PMID:
    28373689
    [PubMed - as supplied by publisher]
Related citations


Marijuana advertising exposure among current marijuana users in the U.S.
Krauss MJ, Sowles SJ, Sehi A, Spitznagel EL, Berg CJ, Bierut LJ, Cavazos-Rehg PA
Drug Alcohol Depend. 2017 May 1; 174192-200. doi: 10.1016/j.drugalcdep.2017.01.017.

PMID:
    28365173
    [PubMed - in process]
Related citations


A Commentary on Maes et al. "A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents".
Bierut LJ, Johnson EO
Nicotine Tob Res. 2017 Jan 28; doi: 10.1093/ntr/ntx022.

PMID:
    28339609
    [PubMed - as supplied by publisher]
Related citations


Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.
Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ
Pharmacogenomics J. 2017 Mar 14; doi: 10.1038/tpj.2016.92.

PMID:
    28290528
    [PubMed - as supplied by publisher]
Related citations


Genetic correlation between smoking behaviors and schizophrenia.
Hartz SM, Horton AC, Hancock DB, Baker TB, Caporaso NE, Chen LS, Hokanson JE, Lutz SM, Marazita ML, McNeil DW, Pato CN, Pato MT, Johnson EO, Bierut LJ
Schizophr Res. 2017 Mar 8; pii: S0920-9964(17)30111-1. doi: 10.1016/j.schres.2017.02.022.

PMID:
    28285025
    [PubMed - as supplied by publisher]
Related citations


Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study.
Bucholz KK, McCutcheon VV, Agrawal A, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Nurnberger JI Jr, Salvatore JE, Schuckit MA, Bierut LJ, Foroud TM, Chan G, Hesselbrock M, Meyers JL, Edenberg HJ, Porjesz B
Alcohol Clin Exp Res. 2017 Feb; 41(2)359-368. doi: 10.1111/acer.13293.

PMID:
    28073157
    [PubMed - in process]
Related citations


CYP2A6 metabolism in the development of smoking behaviors in young adults.
Olfson E, Bloom J, Bertelsen S, Budde JP, Breslau N, Brooks A, Culverhouse R, Chan G, Chen LS, Chorlian D, Dick DM, Edenberg HJ, Hartz S, Hatsukami D, Hesselbrock VM, Johnson EO, Kramer JR, Kuperman S, Meyers JL, Nurnberger J, Porjesz B, Saccone NL, Schuckit MA, Stitzel J, Tischfield JA, Rice JP, Goate A, Bierut LJ
Addict Biol. 2016 Dec 29; doi: 10.1111/adb.12477.

PMID:
    28032407
    [PubMed - as supplied by publisher]
Related citations


Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives.
Chen LS, Baker T, Brownson RC, Carney RM, Jorenby D, Hartz S, Smock N, Johnson M, Ziedonis D, Bierut LJ
Community Ment Health J. 2016 Nov 30;

PMID:
    27900650
    [PubMed - as supplied by publisher]
Related citations


KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.
Johnson EO, Hancock DB, Levy JL, Gaddis NC, Page GP, Glasheen C, Saccone NL, Bierut LJ, Kral AH
Addict Biol. 2016 Nov; 21(6)1217-1232. doi: 10.1111/adb.12286.

PMID:
    26202629
    [PubMed - indexed for MEDLINE]
Related citations


Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.
Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP, Hart RP
Sci Rep. 2016 Oct 4; 634341. doi: 10.1038/srep34341.

PMID:
    27698409
    [PubMed - in process]
Related citations


Implications of Personal Genomic Testing for Health Behaviors: The Case of Smoking.
Olfson E, Hartz S, Carere DA, Green RC, Roberts JS, Bierut LJ, PGen Study Group.
Nicotine Tob Res. 2016 Dec; 18(12)2273-2277.

PMID:
    27613923
    [PubMed - in process]
Related citations


Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement.
Carey CE, Agrawal A, Bucholz KK, Hartz SM, Lynskey MT, Nelson EC, Bierut LJ, Bogdan R
Front Genet. 2016; 7149. doi: 10.3389/fgene.2016.00149.

PMID:
    27574527
    [PubMed]
Related citations


Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis.
Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Rosenberger A, Aben KK, Andrew AS, Chang SC, Saum KU, Dienemann H, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden EH, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Brüske I, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare MD, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz MR, Amos CI, Bierut LJ
EBioMedicine. 2016 Sep; 11219-226. doi: 10.1016/j.ebiom.2016.08.012.

PMID:
    27543155
    [PubMed - indexed for MEDLINE]
Related citations


The significant impact of education, poverty, and race on Internet-based research participant engagement.
Hartz SM, Quan T, Ibiebele A, Fisher SL, Olfson E, Salyer P, Bierut LJ
Genet Med. 2017 Feb; 19(2)240-243. doi: 10.1038/gim.2016.91.

PMID:
    27467456
    [PubMed - in process]
Related citations


An Analysis of Depression, Self-Harm, and Suicidal Ideation Content on Tumblr.
Cavazos-Rehg PA, Krauss MJ, Sowles SJ, Connolly S, Rosas C, Bharadwaj M, Grucza R, Bierut LJ
Crisis. 2017 Jan; 38(1)44-52. doi: 10.1027/0227-5910/a000409.

PMID:
    27445014
    [PubMed - in process]
Related citations


The Impact of the Minimum Legal Drinking Age on Alcohol-Related Chronic Disease Mortality.
Plunk AD, Krauss MJ, Syed-Mohammed H, Hur M, Cavzos-Rehg PA, Bierut LJ, Grucza RA
Alcohol Clin Exp Res. 2016 Aug; 40(8)1761-8. doi: 10.1111/acer.13123.

PMID:
    27340945
    [PubMed - in process]
Related citations


Marijuana-Related Posts on Instagram.
Cavazos-Rehg PA, Krauss MJ, Sowles SJ, Bierut LJ
Prev Sci. 2016 Aug; 17(6)710-20. doi: 10.1007/s11121-016-0669-9.

PMID:
    27262456
    [PubMed - in process]
Related citations


Declining Prevalence of Marijuana Use Disorders Among Adolescents in the United States, 2002 to 2013.
Grucza RA, Agrawal A, Krauss MJ, Bongu J, Plunk AD, Cavazos-Rehg PA, Bierut LJ
J Am Acad Child Adolesc Psychiatry. 2016 Jun; 55(6)487-494.e6. doi: 10.1016/j.jaac.2016.04.002.

PMID:
    27238067
    [PubMed - in process]
Related citations


Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J, GCAN., WTCCC3., Heid IM, Winkler TW, GIANT., Grant SF, EGG., Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H, Price Foundation Collaborative Group., Children’s Hospital of Philadelphia/Price Foundation., Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J
Mol Psychiatry. 2017 Feb; 22(2)192-201. doi: 10.1038/mp.2016.71.

PMID:
    27184124
    [PubMed - in process]
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