Patient Portal

Kory Lavine, MD, PhD

Assistant Professor, Medicine
Cardiovascular Diseases

Specialty Areas

Cardiology
Cardiovascular Disease
Heart Failure / Transplant

Board Certifications

Internal Medicine
Cardiovascular Disease

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Advanced heart failure, cardiac transplantation, circulatory assist devices.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Heart & Vascular Center

4921 Parkview Place
St. Louis, MO 63110

Barnes-Jewish West County Hospital
Medical Building Two

10 Barnes West Drive
Creve Coeur, MO 63141

Suite: 200
Office Phone: 314-362-1291

Education

Education

Fellowship, Advanced Heart Failure and Transplant: Washington University School of Medicine, St. Louis, MO 2016
Fellowship, Cardiology: Washington University School of Medicine, St. Louis, MO 2013
Residency, Internal Medicine: Barnes-Jewish Hospital, St. Louis, MO 2010
Medical Degree: Washington University School of Medicine, St. Louis, MO 2008
PhD, Medical Scientist Training Program: Washington University School of Medicine, St. Louis, MO 2008
BS, Biological Sciences: The University of Rochester, Rochester, NY 2001

Publication & Research

Publication & Research

Publisher Correction: Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.
Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S
Nat Immunol. 2019 May; 20(5)664. doi: 10.1038/s41590-019-0363-8.

PMID:
    30862954
    [PubMed]
Related citations


Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation.
Li W, Feng G, Gauthier JM, Lokshina I, Higashikubo R, Evans S, Liu X, Hassan A, Tanaka S, Cicka M, Hsiao HM, Ruiz-Perez D, Bredemeyer A, Gross RW, Mann DL, Tyurina YY, Gelman AE, Kagan VE, Linkermann A, Lavine KJ, Kreisel D
J Clin Invest. 2019 Feb 26; 130pii: 126428. doi: 10.1172/JCI126428.

PMID:
    30830879
    [PubMed - in process]
Related citations


Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart.
Heo GS, Kopecky B, Sultan D, Ou M, Feng G, Bajpai G, Zhang X, Luehmann H, Detering L, Su Y, Leuschner F, Combadière C, Kreisel D, Gropler RJ, Brody SL, Liu Y, Lavine KJ
Circ Res. 2019 Mar 15; 124(6)881-890. doi: 10.1161/CIRCRESAHA.118.314030.

PMID:
    30661445
    [PubMed - in process]
Related citations


Tissue Resident CCR2- and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury.
Bajpai G, Bredemeyer A, Li W, Zaitsev K, Koenig AL, Lokshina I, Mohan J, Ivey B, Hsiao HM, Weinheimer C, Kovacs A, Epelman S, Artyomov M, Kreisel D, Lavine KJ
Circ Res. 2019 Jan 18; 124(2)263-278. doi: 10.1161/CIRCRESAHA.118.314028.

PMID:
    30582448
    [PubMed - in process]
Related citations


Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.
Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S
Nat Immunol. 2019 Jan; 20(1)29-39. doi: 10.1038/s41590-018-0272-2.

PMID:
    30538339
    [PubMed - in process]
Related citations


The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).
Lavine KJ, Pinto AR, Epelman S, Kopecky BJ, Clemente-Casares X, Godwin J, Rosenthal N, Kovacic JC
J Am Coll Cardiol. 2018 Oct 30; 72(18)2213-2230. doi: 10.1016/j.jacc.2018.08.2149.

PMID:
    30360829
    [PubMed - in process]
Related citations


The human heart contains distinct macrophage subsets with divergent origins and functions.
Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ
Nat Med. 2018 Aug; 24(8)1234-1245. doi: 10.1038/s41591-018-0059-x.

PMID:
    29892064
    [PubMed - in process]
Related citations


Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β.
Hsiao HM, Fernandez R, Tanaka S, Li W, Spahn JH, Chiu S, Akbarpour M, Ruiz-Perez D, Wu Q, Turam C, Scozzi D, Takahashi T, Luehmann HP, Puri V, Budinger GRS, Krupnick AS, Misharin AV, Lavine KJ, Liu Y, Gelman AE, Bharat A, Kreisel D
J Clin Invest. 2018 Jul 2; 128(7)2833-2847. doi: 10.1172/JCI98436.

PMID:
    29781811
    [PubMed - in process]
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Visualization of Monocytic Cells in Regressing Atherosclerotic Plaques by Intravital 2-Photon and Positron Emission Tomography-Based Imaging-Brief Report.
Li W, Luehmann HP, Hsiao HM, Tanaka S, Higashikubo R, Gauthier JM, Sultan D, Lavine KJ, Brody SL, Gelman AE, Gropler RJ, Liu Y, Kreisel D
Arterioscler Thromb Vasc Biol. 2018 May; 38(5)1030-1036. doi: 10.1161/ATVBAHA.117.310517.

PMID:
    29567678
    [PubMed - in process]
Related citations


Recognition of self-DNA drives cardiac inflammation: why broken hearts fail.
Lavine KJ, Mann DL
Nat Med. 2017 Dec 7; 23(12)1400-1401. doi: 10.1038/nm.4455.

PMID:
    29216037
    [PubMed - in process]
Related citations


A CD103<sup>+</sup> Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis.
Clemente-Casares X, Hosseinzadeh S, Barbu I, Dick SA, Macklin JA, Wang Y, Momen A, Kantores C, Aronoff L, Farno M, Lucas TM, Avery J, Zarrin-Khat D, Elsaesser HJ, Razani B, Lavine KJ, Husain M, Brooks DG, Robbins CS, Cybulsky M, Epelman S
Immunity. 2017 Nov 21; 47(5)974-989.e8. doi: 10.1016/j.immuni.2017.10.011.

PMID:
    29166591
    [PubMed - indexed for MEDLINE]
Related citations


Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart.
Huang LH, Lavine KJ, Randolph GJ
JACC Basic Transl Sci. 2017 Aug; 2(4)477-483. doi: 10.1016/j.jacbts.2017.02.005.

PMID:
    28989985
    [PubMed]
Related citations


Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Zhu Y, Herndon JM, Sojka DK, Kim KW, Knolhoff BL, Zuo C, Cullinan DR, Luo J, Bearden AR, Lavine KJ, Yokoyama WM, Hawkins WG, Fields RC, Randolph GJ, DeNardo DG
Immunity. 2017 Sep 19; 47(3)597. doi: 10.1016/j.immuni.2017.08.018.

PMID:
    28930665
    [PubMed]
Related citations


Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Zhu Y, Herndon JM, Sojka DK, Kim KW, Knolhoff BL, Zuo C, Cullinan DR, Luo J, Bearden AR, Lavine KJ, Yokoyama WM, Hawkins WG, Fields RC, Randolph GJ, DeNardo DG
Immunity. 2017 Aug 15; 47(2)323-338.e6. doi: 10.1016/j.immuni.2017.07.014.

PMID:
    28813661
    [PubMed - indexed for MEDLINE]
Related citations


Pediatric and adult dilated cardiomyopathy represent distinct pathological entities.
Patel MD, Mohan J, Schneider C, Bajpai G, Purevjav E, Canter CE, Towbin J, Bredemeyer A, Lavine KJ
JCI Insight. 2017 Jul 20; 2(14)pii: 94382. doi: 10.1172/jci.insight.94382.

PMID:
    28724792
    [PubMed]
Related citations


Macrophages Facilitate Electrical Conduction in the Heart.
Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M
Cell. 2017 Apr 20; 169(3)510-522.e20. doi: 10.1016/j.cell.2017.03.050.

PMID:
    28431249
    [PubMed - indexed for MEDLINE]
Related citations


Skeletal muscle inflammation and atrophy in heart failure.
Lavine KJ, Sierra OL
Heart Fail Rev. 2017 Mar; 22(2)179-189. doi: 10.1007/s10741-016-9593-0.

PMID:
    28091823
    [PubMed - indexed for MEDLINE]
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Heart-resident CCR2<sup>+</sup> macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling.
Li W, Hsiao HM, Higashikubo R, Saunders BT, Bharat A, Goldstein DR, Krupnick AS, Gelman AE, Lavine KJ, Kreisel D
JCI Insight. 2016 Aug 4; 1(12)pii: 87315. doi: 10.1172/jci.insight.87315.

PMID:
    27536731
    [PubMed]
Related citations


Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M
Circ Res. 2016 Sep 16; 119(7)853-64. doi: 10.1161/CIRCRESAHA.116.309001.

PMID:
    27444755
    [PubMed - indexed for MEDLINE]
Related citations


Slicing Into Human Translational Cardiovascular Biology.
Lavine KJ, Schilling JD
JACC Basic Transl Sci. 2016 Apr; 1(3)168-169. doi: 10.1016/j.jacbts.2016.03.007.

PMID:
    30167509
    [PubMed]
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Areas of Research Interest

Understanding the immunological mechanisms that govern cardiac recovery and the pathogenesis of heart failure, with a focus on the mechanisms that distinguish pediatric from adult cardiomyopathy. Pathogenesis of primary graft dysfunction in cardiac transplantation. Understanding the role of macrophages in coronary development and collateral growth of the coronary vasculature.