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Kelle H. Moley, MD

James P. Crane Professor in Obstetrics and Gynecology
Division of Reproductive Endocrinology
Professor, Cell Biology and Physiology
Vice Chair and Director, Basic Science Research in Obstetrics and Gynecology

Specialty Areas

Reproductive Endocrinology and Infertility
Gynecology

Board Certifications

Obstetrics and Gynecology
Reproductive Endocrinology and Infertility

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Reproductive endocrinology, polycystic ovary syndrome, gynecology, obstetrics, hyperglycemia, hyperinsulinemia, ob/gyn, hirsutism, glucose intolerance, infertility, women's health

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Fertility and Reproductive Medicine Center

4444 Forest Park Avenue
St. Louis, MO 63108

Suite: Suite 3100
Office Phone: 314-286-2400
Fax: 314-286-2455

Education

Education

Fellowship: Reproductive Endocrinology and Fertility, Washington University School of Medicine, St. Louis, Missouri 1994
Residency: Washington University School of Medicine, St. Louis, Missouri 1992
Medical Degree: Yale University School of Medicine, New Haven, Conneticutt 1988
Post Doctoral Fellowship: Cell Biology and Physiology 1998
Post Doctoral Fellowship: Molecular Biology and Pharmacology 1994

Publication & Research

Publication & Research

Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model.
Boots CE, Boudoures A, Zhang W, Drury A, Moley KH
Hum Reprod. 2016 Jul 17; pii: dew181.

PMID:
    27432748
    [PubMed - as supplied by publisher]
Related citations


Paternal smoking and germ cell death: A mechanistic link to the effects of cigarette smoke on spermatogenesis and possible long-term sequelae in offspring.
Esakky P, Moley KH
Mol Cell Endocrinol. 2016 Jul 13; pii: S0303-7207(16)30246-5. doi: 10.1016/j.mce.2016.07.015.

PMID:
    27424142
    [PubMed - as supplied by publisher]
Related citations


Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations.
Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH
Cell Rep. 2016 Jun 28; 16(1)1-8. doi: 10.1016/j.celrep.2016.05.065.

PMID:
    27320925
    [PubMed - in process]
Related citations


Maternal fructose drives placental uric acid production leading to adverse fetal outcomes.
Asghar ZA, Thompson A, Chi M, Cusumano A, Scheaffer S, Al-Hammadi N, Saben JL, Moley KH
Sci Rep. 2016 Apr 29; 625091. doi: 10.1038/srep25091.

PMID:
    27125896
    [PubMed - in process]
Related citations


Toward a Modern Science of Obesity at Washington University: How We Do It and What is the Payoff?
Colditz GA, Gehlert S, Bowen DJ, Carson K, Hovmand PS, Lee JA, Moley KH
Cancer Prev Res (Phila). 2016 Jul; 9(7)503-8. doi: 10.1158/1940-6207.CAPR-15-0060.

PMID:
    27059763
    [PubMed - in process]
Related citations


Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy.
Rhee JS, Saben JL, Mayer AL, Schulte MB, Asghar Z, Stephens C, Chi MM, Moley KH
Hum Reprod. 2016 Jun; 31(6)1315-26. doi: 10.1093/humrep/dew048.

PMID:
    27052498
    [PubMed - in process]
Related citations


Preventing germ cell death by inactivating aryl hydrocarbon receptor (AHR).
Esakky P, Moley KH
Cell Death Dis. 2016 Feb 25; 7e2116. doi: 10.1038/cddis.2016.20.

PMID:
    26913606
    [PubMed - in process]
Related citations


Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.
DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH
Sci Signal. 2016 Feb 23; 9(416)ra21. doi: 10.1126/scisignal.aac5472.

PMID:
    26905426
    [PubMed - in process]
Related citations


Effects of obesity on hormonally driven cancer in women.
Moley KH, Colditz GA
Sci Transl Med. 2016 Jan 27; 8(323)323ps3. doi: 10.1126/scitranslmed.aad8842.

PMID:
    26819193
    [PubMed - in process]
Related citations


The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model.
Boudoures AL, Chi M, Thompson A, Zhang W, Moley KH
Reproduction. 2016 Mar; 151(3)261-70. doi: 10.1530/REP-15-0419.

PMID:
    26700938
    [PubMed - in process]
Related citations


Excess Maternal Fructose Consumption Increases Fetal Loss and Impairs Endometrial Decidualization in Mice.
Saben JL, Asghar Z, Rhee JS, Drury A, Scheaffer S, Moley KH
Endocrinology. 2016 Feb; 157(2)956-68. doi: 10.1210/en.2015-1618.

PMID:
    26677880
    [PubMed - indexed for MEDLINE]
Related citations


Metabolic Determinants of Mitochondrial Function in Oocytes.
Seidler EA, Moley KH
Semin Reprod Med. 2015 Nov; 33(6)396-400. doi: 10.1055/s-0035-1567822.

PMID:
    26562288
    [PubMed - in process]
Related citations


Maternal Obesity, Cage Density, and Age Contribute to Prostate Hyperplasia in Mice.
Benesh EC, Gill J, Lamb LE, Moley KH
Reprod Sci. 2016 Feb; 23(2)176-85. doi: 10.1177/1933719115597767.

PMID:
    26243546
    [PubMed - in process]
Related citations


Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.
Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A
Aging Cell. 2015 Oct; 14(5)887-95. doi: 10.1111/acel.12368.

PMID:
    26111777
    [PubMed - in process]
Related citations


Mcl-1 is a key regulator of the ovarian reserve.
Omari S, Waters M, Naranian T, Kim K, Perumalsamy AL, Chi M, Greenblatt E, Moley KH, Opferman JT, Jurisicova A
Cell Death Dis. 2015 May 7; 6e1755. doi: 10.1038/cddis.2015.95.

PMID:
    25950485
    [PubMed - indexed for MEDLINE]
Related citations


Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes.
Zhang L, Han L, Ma R, Hou X, Yu Y, Sun S, Xu Y, Schedl T, Moley KH, Wang Q
Cell Cycle. 2015; 14(18)2959-68. doi: 10.1080/15384101.2015.1026517.

PMID:
    25790176
    [PubMed - in process]
Related citations


Adverse effects of obesity and/or high-fat diet on oocyte quality and metabolism are not reversible with resumption of regular diet in mice.
Reynolds KA, Boudoures AL, Chi MM, Wang Q, Moley KH
Reprod Fertil Dev. 2015 May; 27(4)716-24. doi: 10.1071/RD14251.

PMID:
    25775080
    [PubMed - in process]
Related citations


Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice.
Sasson IE, Vitins AP, Mainigi MA, Moley KH, Simmons RA
Diabetologia. 2015 Mar; 58(3)615-24. doi: 10.1007/s00125-014-3466-7.

PMID:
    25608625
    [PubMed - indexed for MEDLINE]
Related citations


Cigarette smoke-induced cell cycle arrest in spermatocytes [GC-2spd(ts)] is mediated through crosstalk between Ahr-Nrf2 pathway and MAPK signaling.
Esakky P, Hansen DA, Drury AM, Moley KH
J Mol Cell Biol. 2015 Feb; 7(1)73-87. doi: 10.1093/jmcb/mju049.

PMID:
    25548370
    [PubMed - indexed for MEDLINE]
Related citations


Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation.
Schulte MM, Tsai JH, Moley KH
Reprod Sci. 2015 Jan; 22(1)6-14. doi: 10.1177/1933719114561552.

PMID:
    25488942
    [PubMed - indexed for MEDLINE]
Related citations

Notes

For more info, visit the Washington University Fertility web site.