FollowMyHealth Patient Portal

Faculty Physicians

Keith A. Hruska, MD

Professor, Pediatrics
Division of Pediatric Nephrology
Professor, Medicine and Cell Biology

Specialty Areas

Pediatric Nephrology

Board Certifications

Internal Medicine
Nephrology

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric and adult kidney disease, chronic kidney diseases, kidney stones, the CKD-MBD, vascular calcification, kidney tubulointerstitial disease, tubulointerstitial fibrosis, transplantation of neocartilage, hyperparathyroidism, calcium and phosphorus metabolism, diabetic nephropathy

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 5
Office Phone: 314-362-9096
Fax: 314-747-5213

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-6043
Fax: 314-454-4283

Education

Education

Fellowship: Nephrology, Washington University School of Medicine, St. Louis, Missouri 1974
Residency : Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 1972
Medical Degree: Creighton University, Omaha, Nebraska 1969
B.S.: Creighton University, Omaha, Nebraska 1965

Publication & Research

Publication & Research

Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus.
Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC
Am J Nephrol. 2015; 42(6)391-401. doi: 10.1159/000443241.

PMID:
    26693712
    [PubMed - in process]
Related citations


Androgens Enhance Male Urinary Tract Infection Severity in a New Model.
Olson PD, Hruska KA, Hunstad DA
J Am Soc Nephrol. 2015 Oct 8; pii: ASN.2015030327.

PMID:
    26449605
    [PubMed - as supplied by publisher]
Related citations


The Kidney-Vascular-Bone Axis in the Chronic Kidney Disease-Mineral Bone Disorder.
Seifert ME, Hruska KA
Transplantation. 2015 Sep 9;

PMID:
    26356179
    [PubMed - as supplied by publisher]
Related citations


SIRT6 deficiency culminates in low-turnover osteopenia.
Sugatani T, Agapova O, Malluche HH, Hruska KA
Bone. 2015 Dec; 81168-77. doi: 10.1016/j.bone.2015.07.018.

PMID:
    26189760
    [PubMed - in process]
Related citations


Pathophysiology of the chronic kidney disease-mineral bone disorder.
Hruska KA, Seifert M, Sugatani T
Curr Opin Nephrol Hypertens. 2015 Jul; 24(4)303-9. doi: 10.1097/MNH.0000000000000132.

PMID:
    26050115
    [PubMed - in process]
Related citations


Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease.
Anyaegbu EI, Shaw AS, Hruska KA, Jain S
Pediatr Nephrol. 2015 Jun; 30(6)983-9. doi: 10.1007/s00467-014-3031-0.

PMID:
    25530085
    [PubMed - indexed for MEDLINE]
Related citations


Left ventricular mass progression despite stable blood pressure and kidney function in stage 3 chronic kidney disease.
Seifert ME, de Las Fuentes L, Ginsberg C, Rothstein M, Dietzen DJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA
Am J Nephrol. 2014; 39(5)392-9. doi: 10.1159/000362251.

PMID:
    24818573
    [PubMed - indexed for MEDLINE]
Related citations


CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder.
Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register TC, Freedman BI, Monier-Faugere MC, Malluche H, Hruska KA
J Am Soc Nephrol. 2014 Aug; 25(8)1760-73. doi: 10.1681/ASN.2013080818.

PMID:
    24578135
    [PubMed - indexed for MEDLINE]
Related citations


Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity.
Sugatani T, Hildreth BE 3rd, Toribio RE, Malluche HH, Hruska KA
J Cell Biochem. 2014 Jun; 115(6)1043-7. doi: 10.1002/jcb.24759.

PMID:
    24420069
    [PubMed - indexed for MEDLINE]
Related citations


Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study.
Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI
J Clin Endocrinol Metab. 2014 Jan; 99(1)315-21. doi: 10.1210/jc.2013-3168.

PMID:
    24178795
    [PubMed - indexed for MEDLINE]
Related citations


Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease.
Seifert ME, de las Fuentes L, Rothstein M, Dietzen DJ, Bierhals AJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA
Am J Nephrol. 2013; 38(2)158-67. doi: 10.1159/000353569.

PMID:
    23941761
    [PubMed - indexed for MEDLINE]
Related citations


Early chronic kidney disease-mineral bone disorder stimulates vascular calcification.
Fang Y, Ginsberg C, Sugatani T, Monier-Faugere MC, Malluche H, Hruska KA
Kidney Int. 2014 Jan; 85(1)142-50. doi: 10.1038/ki.2013.271.

PMID:
    23884339
    [PubMed - indexed for MEDLINE]
Related citations


HDAC dependent transcriptional repression of Bmp-7 potentiates TGF-β mediated renal fibrosis in obstructive uropathy.
Manson SR, Song JB, Hruska KA, Austin PF
J Urol. 2014 Jan; 191(1)242-52. doi: 10.1016/j.juro.2013.06.110.

PMID:
    23820056
    [PubMed - indexed for MEDLINE]
Related citations


Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study.
Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI
J Clin Endocrinol Metab. 2013 May; 98(5)1916-22. doi: 10.1210/jc.2012-4126.

PMID:
    23543659
    [PubMed - indexed for MEDLINE]
Related citations


Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis.
Sugatani T, Hruska KA
J Cell Biochem. 2013 Jun; 114(6)1217-22. doi: 10.1002/jcb.24471.

PMID:
    23238785
    [PubMed - indexed for MEDLINE]
Related citations


Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus.
Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG, Herrington DM, Wagenknecht LE, Langefeld CD, Freedman BI
Circ Cardiovasc Genet. 2013 Feb; 6(1)97-105. doi: 10.1161/CIRCGENETICS.112.964114.

PMID:
    23233742
    [PubMed - indexed for MEDLINE]
Related citations


Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study.
Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI
BMC Nephrol. 2012 Nov 14; 13148. doi: 10.1186/1471-2369-13-148.

PMID:
    23151275
    [PubMed - indexed for MEDLINE]
Related citations


Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes.
Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI
J Clin Endocrinol Metab. 2013 Jan; 98(1)E60-5. doi: 10.1210/jc.2012-3038.

PMID:
    23125289
    [PubMed - indexed for MEDLINE]
Related citations


Endogenous BMP-7 is a critical molecular determinant of the reversibility of obstruction-induced renal injuries.
Manson SR, Niederhoff RA, Hruska KA, Austin PF
Am J Physiol Renal Physiol. 2011 Dec; 301(6)F1293-302. doi: 10.1152/ajprenal.00071.2011.

PMID:
    21880836
    [PubMed - indexed for MEDLINE]
Related citations


The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury.
Manson SR, Niederhoff RA, Hruska KA, Austin PF
J Urol. 2011 Jun; 185(6 Suppl)2523-30. doi: 10.1016/j.juro.2011.01.034.

PMID:
    21527199
    [PubMed - indexed for MEDLINE]
Related citations