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Keith A. Hruska, MD

Professor, Pediatrics
Division of Pediatric Nephrology
Professor, Medicine and Cell Biology

Specialty Areas

Pediatric Nephrology

Board Certifications

Internal Medicine
Nephrology

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric and adult kidney disease, chronic kidney diseases, kidney stones, the CKD-MBD, vascular calcification, kidney tubulointerstitial disease, tubulointerstitial fibrosis, transplantation of neocartilage, hyperparathyroidism, calcium and phosphorus metabolism, diabetic nephropathy

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 5
Office Phone: 314-362-9096
Fax: 314-747-5213

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C
Floor: 2nd Floor
Office Phone: 314-454-6043
Fax: 314-454-4283

Education

Education

Fellowship: Nephrology, Washington University School of Medicine, St. Louis, Missouri 1974
Residency : Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 1972
Medical Degree: Creighton University, Omaha, Nebraska 1969
B.S.: Creighton University, Omaha, Nebraska 1965

Publication & Research

Publication & Research

Crosstalk between kidney and bone - Bench to bedside.
Hruska KA, Lanske B, Moe OW
Bone. 2017 Jul; 1001-3. doi: 10.1016/j.bone.2017.03.046.

PMID:
    28412470
    [PubMed - in process]
Related citations


The chronic kidney disease - Mineral bone disorder (CKD-MBD): Advances in pathophysiology.
Hruska KA, Sugatani T, Agapova O, Fang Y
Bone. 2017 Jul; 10080-86. doi: 10.1016/j.bone.2017.01.023.

PMID:
    28119179
    [PubMed - in process]
Related citations


Bone Mineral Density and Progression of Subclinical Atherosclerosis in African-Americans With Type 2 Diabetes.
Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J, Langefeld CD, Lenchik L, Hruska KA, Carr JJ, Freedman BI
J Clin Endocrinol Metab. 2016 Nov; 101(11)4135-4141.

PMID:
    27552541
    [PubMed - indexed for MEDLINE]
Related citations


Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease.
Sugatani T, Agapova OA, Fang Y, Berman AG, Wallace JM, Malluche HH, Faugere MC, Smith W, Sung V, Hruska KA
Kidney Int. 2017 Jan; 91(1)86-95. doi: 10.1016/j.kint.2016.07.039.

PMID:
    27666759
    [PubMed - in process]
Related citations


Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease.
Agapova OA, Fang Y, Sugatani T, Seifert ME, Hruska KA
Kidney Int. 2016 Jun; 89(6)1231-43. doi: 10.1016/j.kint.2016.02.002.

PMID:
    27165838
    [PubMed - in process]
Related citations


Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study.
Seifert ME, Ashoor IF, Chiang ML, Chishti AS, Dietzen DJ, Gipson DS, Janjua HS, Selewski DT, Hruska KA
Pediatr Transplant. 2016 May; 20(3)378-87. doi: 10.1111/petr.12682.

PMID:
    26880121
    [PubMed - indexed for MEDLINE]
Related citations


Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus.
Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC
Am J Nephrol. 2015; 42(6)391-401. doi: 10.1159/000443241.

PMID:
    26693712
    [PubMed - indexed for MEDLINE]
Related citations


Androgens Enhance Male Urinary Tract Infection Severity in a New Model.
Olson PD, Hruska KA, Hunstad DA
J Am Soc Nephrol. 2016 Jun; 27(6)1625-34. doi: 10.1681/ASN.2015030327.

PMID:
    26449605
    [PubMed - indexed for MEDLINE]
Related citations


The Kidney-Vascular-Bone Axis in the Chronic Kidney Disease-Mineral Bone Disorder.
Seifert ME, Hruska KA
Transplantation. 2016 Mar; 100(3)497-505. doi: 10.1097/TP.0000000000000903.

PMID:
    26356179
    [PubMed - indexed for MEDLINE]
Related citations


SIRT6 deficiency culminates in low-turnover osteopenia.
Sugatani T, Agapova O, Malluche HH, Hruska KA
Bone. 2015 Dec; 81168-77. doi: 10.1016/j.bone.2015.07.018.

PMID:
    26189760
    [PubMed - indexed for MEDLINE]
Related citations


Pathophysiology of the chronic kidney disease-mineral bone disorder.
Hruska KA, Seifert M, Sugatani T
Curr Opin Nephrol Hypertens. 2015 Jul; 24(4)303-9. doi: 10.1097/MNH.0000000000000132.

PMID:
    26050115
    [PubMed - indexed for MEDLINE]
Related citations


Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease.
Anyaegbu EI, Shaw AS, Hruska KA, Jain S
Pediatr Nephrol. 2015 Jun; 30(6)983-9. doi: 10.1007/s00467-014-3031-0.

PMID:
    25530085
    [PubMed - indexed for MEDLINE]
Related citations


Left ventricular mass progression despite stable blood pressure and kidney function in stage 3 chronic kidney disease.
Seifert ME, de Las Fuentes L, Ginsberg C, Rothstein M, Dietzen DJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA
Am J Nephrol. 2014; 39(5)392-9. doi: 10.1159/000362251.

PMID:
    24818573
    [PubMed - indexed for MEDLINE]
Related citations


CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder.
Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register TC, Freedman BI, Monier-Faugere MC, Malluche H, Hruska KA
J Am Soc Nephrol. 2014 Aug; 25(8)1760-73. doi: 10.1681/ASN.2013080818.

PMID:
    24578135
    [PubMed - indexed for MEDLINE]
Related citations


Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity.
Sugatani T, Hildreth BE 3rd, Toribio RE, Malluche HH, Hruska KA
J Cell Biochem. 2014 Jun; 115(6)1043-7. doi: 10.1002/jcb.24759.

PMID:
    24420069
    [PubMed - indexed for MEDLINE]
Related citations


Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study.
Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI
J Clin Endocrinol Metab. 2014 Jan; 99(1)315-21. doi: 10.1210/jc.2013-3168.

PMID:
    24178795
    [PubMed - indexed for MEDLINE]
Related citations


Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease.
Seifert ME, de las Fuentes L, Rothstein M, Dietzen DJ, Bierhals AJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA
Am J Nephrol. 2013; 38(2)158-67. doi: 10.1159/000353569.

PMID:
    23941761
    [PubMed - indexed for MEDLINE]
Related citations


Early chronic kidney disease-mineral bone disorder stimulates vascular calcification.
Fang Y, Ginsberg C, Sugatani T, Monier-Faugere MC, Malluche H, Hruska KA
Kidney Int. 2014 Jan; 85(1)142-50. doi: 10.1038/ki.2013.271.

PMID:
    23884339
    [PubMed - indexed for MEDLINE]
Related citations


HDAC dependent transcriptional repression of Bmp-7 potentiates TGF-β mediated renal fibrosis in obstructive uropathy.
Manson SR, Song JB, Hruska KA, Austin PF
J Urol. 2014 Jan; 191(1)242-52. doi: 10.1016/j.juro.2013.06.110.

PMID:
    23820056
    [PubMed - indexed for MEDLINE]
Related citations


Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study.
Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI
J Clin Endocrinol Metab. 2013 May; 98(5)1916-22. doi: 10.1210/jc.2012-4126.

PMID:
    23543659
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Isto Technologies

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2017