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Katherine Nelson Weilbaecher, MD

Professor, Medicine
Division of Oncology
Section, Medical Oncology

Specialty Areas

Breast Oncology
Medical Oncology
Breast Health
Oncology

Board Certifications

Internal Medicine
Medical Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Breast cancer, bone metastases, melanoma

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-747-7222

Suite: B
Floor: 7
Office Phone: 314-747-9281
Fax: 314-454-8979

Center for Advanced Medicine
Breast Health Center

4921 Parkview Place
St. Louis, MO 63110

Suite: F
Floor: 5
Office Phone: 314-454-8117

Education

Education

Fellowship: Medicine, Harvard Medical School, Boston, Massachusetts 1998
Fellowship: Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 1998
Residency: Stanford University Hospital, Standford California 1994
Medical Degree: Stanford University School of Medicine, Palo Alto, California 1992
A.B.: Harvard University, Cambridge, Massachusetts 1987

Publication & Research

Publication & Research

Bone-induced expression of integrin β3 enables targeted nanotherapy of breast cancer metastases.
Ross MH, Esser AK, Fox GC, Schmieder AH, Yang X, Hu G, Pan D, Su X, Xu Y, Novack DV, Walsh T, Colditz GA, Lukaszewicz GH, Cordell E, Novack JS, Fitzpatrick JAJ, Waning DL, Mohammad KS, Guise TA, Lanza GM, Weilbaecher KN
Cancer Res. 2017 Aug 30; pii: canres.1225.2017. doi: 10.1158/0008-5472.CAN-17-1225.

PMID:
    28855208
    [PubMed - as supplied by publisher]
Related citations


Evaluating Acetate Metabolism for Imaging and Targeting in Multiple Myeloma.
Fontana F, Ge X, Su X, Hathi D, Xiang J, Cenci S, Civitelli R, Shoghi KI, Akers WJ, D'avignon A, Weilbaecher KN, Shokeen M
Clin Cancer Res. 2017 Jan 15; 23(2)416-429. doi: 10.1158/1078-0432.CCR-15-2134.

PMID:
    27486177
    [PubMed - in process]
Related citations


Antagonizing Integrin β3 Increases Immunosuppression in Cancer.
Su X, Esser AK, Amend SR, Xiang J, Xu Y, Ross MH, Fox GC, Kobayashi T, Steri V, Roomp K, Fontana F, Hurchla MA, Knolhoff BL, Meyer MA, Morgan EA, Tomasson JC, Novack JS, Zou W, Faccio R, Novack DV, Robinson SD, Teitelbaum SL, DeNardo DG, Schneider JG, Weilbaecher KN
Cancer Res. 2016 Jun 15; 76(12)3484-95. doi: 10.1158/0008-5472.CAN-15-2663.

PMID:
    27216180
    [PubMed - indexed for MEDLINE]
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Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.
Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA
Cell Rep. 2016 Jan 5; 14(1)82-92. doi: 10.1016/j.celrep.2015.12.016.

PMID:
    26725121
    [PubMed - indexed for MEDLINE]
Related citations


Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model.
Esser AK, Schmieder AH, Ross MH, Xiang J, Su X, Cui G, Zhang H, Yang X, Allen JS, Williams T, Wickline SA, Pan D, Lanza GM, Weilbaecher KN
Nanomedicine. 2016 Jan; 12(1)201-11. doi: 10.1016/j.nano.2015.10.003.

PMID:
    26515754
    [PubMed - indexed for MEDLINE]
Related citations


Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery.
Pan D, Pham CT, Weilbaecher KN, Tomasson MH, Wickline SA, Lanza GM
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan-Feb; 8(1)85-106. doi: 10.1002/wnan.1355.

PMID:
    26296541
    [PubMed - indexed for MEDLINE]
Related citations


CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer.
Xiang J, Hurchla MA, Fontana F, Su X, Amend SR, Esser AK, Douglas GJ, Mudalagiriyappa C, Luker KE, Pluard T, Ademuyiwa FO, Romagnoli B, Tuffin G, Chevalier E, Luker GD, Bauer M, Zimmermann J, Aft RL, Dembowsky K, Weilbaecher KN
Mol Cancer Ther. 2015 Nov; 14(11)2473-85. doi: 10.1158/1535-7163.MCT-15-0252.

PMID:
    26269605
    [PubMed - indexed for MEDLINE]
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Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.
Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH
PLoS One. 2015; 10(5)e0127828. doi: 10.1371/journal.pone.0127828.

PMID:
    26020268
    [PubMed - indexed for MEDLINE]
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Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma.
Soodgupta D, Pan D, Cui G, Senpan A, Yang X, Lu L, Weilbaecher KN, Prochownik EV, Lanza GM, Tomasson MH
Mol Cancer Ther. 2015 Jun; 14(6)1286-1294. doi: 10.1158/1535-7163.MCT-14-0774-T.

PMID:
    25824336
    [PubMed - indexed for MEDLINE]
Related citations


Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts.
Amend SR, Uluckan O, Hurchla M, Leib D, Novack DV, Silva M, Frazier W, Weilbaecher KN
J Bone Miner Res. 2015 Jan; 30(1)106-15. doi: 10.1002/jbmr.2308.

PMID:
    25042340
    [PubMed - indexed for MEDLINE]
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A randomized phase II trial investigating the effect of platelet function inhibition on circulating tumor cells in patients with metastatic breast cancer.
Roop RP, Naughton MJ, Van Poznak C, Schneider JG, Lammers PE, Pluard TJ, Johnson F, Eby CS, Weilbaecher KN
Clin Breast Cancer. 2013 Dec; 13(6)409-15. doi: 10.1016/j.clbc.2013.08.006.

PMID:
    24267729
    [PubMed - indexed for MEDLINE]
Related citations


Very late antigen-4 (α(4)β(1) Integrin) targeted PET imaging of multiple myeloma.
Soodgupta D, Hurchla MA, Jiang M, Zheleznyak A, Weilbaecher KN, Anderson CJ, Tomasson MH, Shokeen M
PLoS One. 2013; 8(2)e55841. doi: 10.1371/journal.pone.0055841.

PMID:
    23409060
    [PubMed - indexed for MEDLINE]
Related citations


Role of WNT7B-induced noncanonical pathway in advanced prostate cancer.
Zheng D, Decker KF, Zhou T, Chen J, Qi Z, Jacobs K, Weilbaecher KN, Corey E, Long F, Jia L
Mol Cancer Res. 2013 May; 11(5)482-93. doi: 10.1158/1541-7786.MCR-12-0520.

PMID:
    23386686
    [PubMed - indexed for MEDLINE]
Related citations


Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.
Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV
Cancer Discov. 2013 Feb; 3(2)212-23. doi: 10.1158/2159-8290.CD-12-0271.

PMID:
    23269702
    [PubMed - indexed for MEDLINE]
Related citations


Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis.
Hurchla MA, Weilbaecher KN
Oncoimmunology. 2012 Nov 1; 1(8)1411-1413.

PMID:
    23243611
    [PubMed]
Related citations


Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo.
Lansdell TA, Hurchla MA, Xiang J, Hovde S, Weilbaecher KN, Henry RW, Tepe JJ
ACS Chem Biol. 2013 Mar 15; 8(3)578-87. doi: 10.1021/cb300568r.

PMID:
    23198928
    [PubMed - indexed for MEDLINE]
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The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN
J Clin Invest. 2012 Oct; 122(10)3579-92. doi: 10.1172/JCI38576.

PMID:
    22996695
    [PubMed - indexed for MEDLINE]
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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.
Hurchla MA, Garcia-Gomez A, Hornick MC, Ocio EM, Li A, Blanco JF, Collins L, Kirk CJ, Piwnica-Worms D, Vij R, Tomasson MH, Pandiella A, San Miguel JF, Garayoa M, Weilbaecher KN
Leukemia. 2013 Feb; 27(2)430-40. doi: 10.1038/leu.2012.183.

PMID:
    22763387
    [PubMed - indexed for MEDLINE]
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Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter.
Chinault SL, Prior JL, Kaltenbronn KM, Penly A, Weilbaecher KN, Piwnica-Worms D, Blumer KJ
Clin Cancer Res. 2012 Aug 1; 18(15)4136-44. doi: 10.1158/1078-0432.CCR-12-0642.

PMID:
    22693355
    [PubMed - indexed for MEDLINE]
Related citations


Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.
Heller E, Hurchla MA, Xiang J, Su X, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior JL, Piwnica-Worms D, Long F, Cagan R, Weilbaecher KN
Cancer Res. 2012 Feb 15; 72(4)897-907. doi: 10.1158/0008-5472.CAN-11-2681.

PMID:
    22186138
    [PubMed - indexed for MEDLINE]
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