Patient Portal

Katharine N. Gurba, MD, PhD

Instructor, Anesthesiology

Specialty Areas

Anesthesiology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

General anesthesia; neuraxial blocks. 

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Education

Education

Residency, Anesthesiology: Barnes-Jewish Hospital, St. Louis, MO 2018
Medical Degree: Vanderbilt University, Nashville, TN 2013
PhD, Neuroscience: Vanderbilt University, Nashville, TN 2014

Publication & Research

Publication & Research

Comparison of γ-Aminobutyric Acid, Type A (GABAA), Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS.
Botzolakis EJ, Gurba KN, Lagrange AH, Feng HJ, Stanic AK, Hu N, Macdonald RL
J Biol Chem. 2016 Sep 23; 291(39)20440-61. doi: 10.1074/jbc.M115.698860.

PMID:
    27493204
    [PubMed - indexed for MEDLINE]
Related citations


GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G).
Todd E, Gurba KN, Botzolakis EJ, Stanic AK, Macdonald RL
Neurobiol Dis. 2014 Sep; 69215-24. doi: 10.1016/j.nbd.2014.05.013.

PMID:
    24874541
    [PubMed - indexed for MEDLINE]
Related citations


Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits.
Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL
Neurochem Res. 2014 Jun; 39(6)1088-103. doi: 10.1007/s11064-013-1187-9.

PMID:
    24213971
    [PubMed - indexed for MEDLINE]
Related citations


GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating.
Gurba KN, Hernandez CC, Hu N, Macdonald RL
J Biol Chem. 2012 Apr 6; 287(15)12083-97. doi: 10.1074/jbc.M111.332528.

PMID:
    22303015
    [PubMed - indexed for MEDLINE]
Related citations


The GABRA6 mutation, R46W, associated with childhood absence epilepsy, alters 6β22 and 6β2 GABA(A) receptor channel gating and expression.
Hernandez CC, Gurba KN, Hu N, Macdonald RL
J Physiol. 2011 Dec 1; 589(Pt 23)5857-78. doi: 10.1113/jphysiol.2011.218883.

PMID:
    21930603
    [PubMed - indexed for MEDLINE]
Related citations


The effect of HSP-causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1.
Botzolakis EJ, Zhao J, Gurba KN, Macdonald RL, Hedera P
Mol Cell Neurosci. 2011 Jan; 46(1)122-35. doi: 10.1016/j.mcn.2010.08.012.

PMID:
    20816793
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Development of novel analgesics; central sensitization.