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Faculty Physicians

Joshua B. Rubin, MD, PhD

Professor, Pediatrics
Division of Hematology and Oncology
Co-Director, Pediatric Neuro-Oncology Center
St Louis Children's Hospital

Specialty Areas

Pediatric Hematology
Pediatric Oncology

Board Certifications

Pediatric Hematology Oncology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric hematology, pediatric oncology, brain tumor. optic glioma, neurofibromatosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite 9
Floor: Floor 9 South
Office Phone: 314-454-6018
Fax: 314-454-2780

Education

Education

BS, Biology: Yale University, New Haven, CT 1982
Masters of Science: Albert Einstein College of Medicine, New York, NY 1992
Medical Degree: Albert Einstein College of Medicine, New York, NY 1994
Ph D: Neuroscience, Albert Einstein College of Medicine, New York, NY 1994

Publication & Research

Publication & Research

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.
Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim SK, Lee JY, Rao AA, Giannini C, Li KK, Ng HK, Yao Y, Kumabe T, Tominaga T, Grajkowska WA, Perek-Polnik M, Low DC, Seow WT, Chang KT, Mora J, Pollack IF, Hamilton RL, Leary S, Moore AS, Ingram WJ, Hallahan AR, Jouvet A, Fèvre-Montange M, Vasiljevic A, Faure-Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil AG, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Schüller U, Jung S, Jang WY, French PJ, Kros JM, van Veelen MC, Massimi L, Leonard JR, Rubin JB, Vibhakar R, Chambless LB, Cooper MK, Thompson RC, Faria CC, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko KM, López-Aguilar E, Lyden D, Garzia L, Shih DJ, Kijima N, Schneider C, Adamski J, Northcott PA, Kool M, Jones DT, Chan JA, Nikolic A, Garre ML, Van Meir EG, Osuka S, Olson JJ, Jahangiri A, Castro BA, Gupta N, Weiss WA, Moxon-Emre I, Mabbott DJ, Lassaletta A, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD
Lancet Oncol. 2016 Mar 11; pii: S1470-2045(15)00581-1. doi: 10.1016/S1470-2045(15)00581-1.

PMID:
    26976201
    [PubMed - as supplied by publisher]
Related citations


Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions.
Sengupta R, Barone A, Marasa J, Taylor S, Jackson E, Warrington NM, Rao S, Kim AH, Leonard JR, Piwnica-Worms D, Rubin JB
Oncotarget. 2015 Jul 30; 6(21)18282-92.

PMID:
    26286961
    [PubMed - in process]
Related citations


Targeting brain tumor cAMP: the case for sex-specific therapeutics.
Warrington NM, Sun T, Rubin JB
Front Pharmacol. 2015; 6153. doi: 10.3389/fphar.2015.00153.

PMID:
    26283963
    [PubMed]
Related citations


Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis.
Ward SA, Rubin JB
Cancers (Basel). 2015 Aug 6; 7(3)1484-98. doi: 10.3390/cancers7030848.

PMID:
    26258793
    [PubMed]
Related citations


Sexual selection and cancer biology.
Rubin JB
Oncotarget. 2015 Jun 30; 6(18)15714-5.

PMID:
    26158217
    [PubMed - in process]
Related citations


An integrative view on sex differences in brain tumors.
Sun T, Plutynski A, Ward S, Rubin JB
Cell Mol Life Sci. 2015 Sep; 72(17)3323-42. doi: 10.1007/s00018-015-1930-2.

PMID:
    25985759
    [PubMed - indexed for MEDLINE]
Related citations


The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, Fisher MJ, Tabori U, Allen JC, Schiffman JD, Gutmann DH, Rubin JB
Cancer Res. 2015 Jan 1; 75(1)16-21. doi: 10.1158/0008-5472.CAN-14-1891.

PMID:
    25381154
    [PubMed - indexed for MEDLINE]
Related citations


Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma.
Barone A, Sengupta R, Warrington NM, Smith E, Wen PY, Brekken RA, Romagnoli B, Douglas G, Chevalier E, Bauer MP, Dembowsky K, Piwnica-Worms D, Rubin JB
Oncotarget. 2014 Oct 30; 5(20)9811-22.

PMID:
    25238146
    [PubMed - indexed for MEDLINE]
Related citations


PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.
Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB
PLoS One. 2014; 9(9)e107397. doi: 10.1371/journal.pone.0107397.

PMID:
    25203500
    [PubMed - indexed for MEDLINE]
Related citations


The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.
He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, Burns DK, Kim SH, Kool M, Pfister SM, Weinstein LS, Pomeroy SL, Gilbertson RJ, Rubin JB, Hou Y, Wechsler-Reya R, Taylor MD, Lu QR
Nat Med. 2014 Sep; 20(9)1035-42. doi: 10.1038/nm.3666.

PMID:
    25150496
    [PubMed - indexed for MEDLINE]
Related citations


Reply: To PMID 24375753.
Diggs-Andrews KA, Brown JA, Gianino SM, D'Agostino McGowan L, Rubin JB, Wozniak DF, Gutmann DH
Ann Neurol. 2014 May; 75(5)800-1. doi: 10.1002/ana.24156.

PMID:
    24752946
    [PubMed - indexed for MEDLINE]
Related citations


Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.
Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset PO, Bechet D, Faury D, De Jay N, Ramkissoon LA, Corcoran A, Jones DT, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers DC, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Leary S, Jallo G, Cohen K, Gupta N, Prados MD, Carret AS, Ellezam B, Crevier L, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Dong Z, Siegel PM, Malkin H, Ligon AH, Albrecht S, Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW
Nat Genet. 2014 May; 46(5)462-6. doi: 10.1038/ng.2950.

PMID:
    24705250
    [PubMed - indexed for MEDLINE]
Related citations


Antiangiogenic agents for nonmalignant brain tumors.
Hawasli AH, Rubin JB, Tran DD, Adkins DR, Waheed S, Hullar TE, Gutmann DH, Evans J, Leonard JR, Zipfel GJ, Chicoine MR
J Neurol Surg B Skull Base. 2013 Jun; 74(3)136-41. doi: 10.1055/s-0033-1338262.

PMID:
    24436903
    [PubMed]
Related citations


Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1.
Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH
Ann Neurol. 2014 Feb; 75(2)309-16. doi: 10.1002/ana.24093.

PMID:
    24375753
    [PubMed - indexed for MEDLINE]
Related citations


F11R is a novel monocyte prognostic biomarker for malignant glioma.
Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH
PLoS One. 2013; 8(10)e77571. doi: 10.1371/journal.pone.0077571.

PMID:
    24147027
    [PubMed - indexed for MEDLINE]
Related citations


Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche.
Brooks MD, Sengupta R, Snyder SC, Rubin JB
Curr Pathobiol Rep. 2013 Jun 1; 1(2)101-110.

PMID:
    23766946
    [PubMed]
Related citations


Opportunities and challenges for successful use of bevacizumab in pediatrics.
Barone A, Rubin JB
Front Oncol. 2013; 392. doi: 10.3389/fonc.2013.00092.

PMID:
    23641361
    [PubMed]
Related citations


Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS.
Patel JR, Williams JL, Muccigrosso MM, Liu L, Sun T, Rubin JB, Klein RS
Acta Neuropathol. 2012 Dec; 124(6)847-60. doi: 10.1007/s00401-012-1034-0.

PMID:
    22933014
    [PubMed - indexed for MEDLINE]
Related citations


Parent-of-origin in individuals with familial neurofibromatosis type 1 and optic pathway gliomas.
Johnson KJ, Fisher MJ, Listernick RL, North KN, Schorry EK, Viskochil D, Weinstein M, Rubin JB, Gutmann DH
Fam Cancer. 2012 Dec; 11(4)653-6. doi: 10.1007/s10689-012-9549-z.

PMID:
    22829012
    [PubMed - indexed for MEDLINE]
Related citations


CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma.
Rao S, Sengupta R, Choe EJ, Woerner BM, Jackson E, Sun T, Leonard J, Piwnica-Worms D, Rubin JB
PLoS One. 2012; 7(3)e33005. doi: 10.1371/journal.pone.0033005.

PMID:
    22427929
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Neurobiology, specifically the role of CXCR4 in tumor-genesis in the CNS and the nature of the intracellular signals that support these functions.