FollowMyHealth Patient Portal

Faculty Physicians

Joshua B. Rubin, MD, PhD

Professor, Pediatrics
Division of Hematology and Oncology
Co-Director, Pediatric Neuro-Oncology Center
St Louis Children's Hospital

Specialty Areas

Pediatric Hematology
Pediatric Oncology

Board Certifications

Pediatric Hematology Oncology
Pediatrics

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric hematology, pediatric oncology, brain tumor. optic glioma, neurofibromatosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite 9
Floor: Floor 9 South
Office Phone: 314-454-6018
Fax: 314-454-2780

Education

Education

BS, Biology: Yale University, New Haven, CT 1982
Masters of Science: Albert Einstein College of Medicine, New York, NY 1992
Medical Degree: Albert Einstein College of Medicine, New York, NY 1994
Ph D: Neuroscience, Albert Einstein College of Medicine, New York, NY 1994

Publication & Research

Publication & Research

Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions.
Sengupta R, Barone A, Marasa J, Taylor S, Jackson E, Warrington NM, Rao S, Kim AH, Leonard JR, Piwnica-Worms D, Rubin JB
Oncotarget. 2015 Jul 30; 6(21)18282-92.

PMID:
    26286961
    [PubMed - in process]
Related citations


Targeting brain tumor cAMP: the case for sex-specific therapeutics.
Warrington NM, Sun T, Rubin JB
Front Pharmacol. 2015; 6153. doi: 10.3389/fphar.2015.00153.

PMID:
    26283963
    [PubMed]
Related citations


Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis.
Ward SA, Rubin JB
Cancers (Basel). 2015 Aug 6; 7(3)1484-98. doi: 10.3390/cancers7030848.

PMID:
    26258793
    [PubMed]
Related citations


Sexual selection and cancer biology.
Rubin JB
Oncotarget. 2015 Jun 30; 6(18)15714-5.

PMID:
    26158217
    [PubMed - in process]
Related citations


An integrative view on sex differences in brain tumors.
Sun T, Plutynski A, Ward S, Rubin JB
Cell Mol Life Sci. 2015 Sep; 72(17)3323-42. doi: 10.1007/s00018-015-1930-2.

PMID:
    25985759
    [PubMed - indexed for MEDLINE]
Related citations


WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.
Zhukova N, Ramaswamy V, Remke M, Martin DC, Castelo-Branco P, Zhang CH, Fraser M, Tse K, Poon R, Shih DJ, Baskin B, Ray PN, Bouffet E, Dirks P, von Bueren AO, Pfaff E, Korshunov A, Jones DT, Northcott PA, Kool M, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T, Gessi M, Rutkowski S, Bognár L, Cho BK, Eberhart CG, Conter CF, Fouladi M, French PJ, Grajkowska WA, Gupta N, Hauser P, Jabado N, Vasiljevic A, Jung S, Kim SK, Klekner A, Kumabe T, Lach B, Leonard JR, Liau LM, Massimi L, Pollack IF, Ra YS, Rubin JB, Van Meir EG, Wang KC, Weiss WA, Zitterbart K, Bristow RG, Alman B, Hawkins CE, Malkin D, Clifford SC, Pfister SM, Taylor MD, Tabori U
Acta Neuropathol Commun. 2014 Dec 24; 2174. doi: 10.1186/s40478-014-0174-y.

PMID:
    25539912
    [PubMed - indexed for MEDLINE]
Related citations


The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, Fisher MJ, Tabori U, Allen JC, Schiffman JD, Gutmann DH, Rubin JB
Cancer Res. 2015 Jan 1; 75(1)16-21. doi: 10.1158/0008-5472.CAN-14-1891.

PMID:
    25381154
    [PubMed - indexed for MEDLINE]
Related citations


Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma.
Barone A, Sengupta R, Warrington NM, Smith E, Wen PY, Brekken RA, Romagnoli B, Douglas G, Chevalier E, Bauer MP, Dembowsky K, Piwnica-Worms D, Rubin JB
Oncotarget. 2014 Oct 30; 5(20)9811-22.

PMID:
    25238146
    [PubMed - indexed for MEDLINE]
Related citations


PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.
Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB
PLoS One. 2014; 9(9)e107397. doi: 10.1371/journal.pone.0107397.

PMID:
    25203500
    [PubMed - indexed for MEDLINE]
Related citations


The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.
He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, Burns DK, Kim SH, Kool M, Pfister SM, Weinstein LS, Pomeroy SL, Gilbertson RJ, Rubin JB, Hou Y, Wechsler-Reya R, Taylor MD, Lu QR
Nat Med. 2014 Sep; 20(9)1035-42. doi: 10.1038/nm.3666.

PMID:
    25150496
    [PubMed - indexed for MEDLINE]
Related citations


Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males.
Sun T, Warrington NM, Luo J, Brooks MD, Dahiya S, Snyder SC, Sengupta R, Rubin JB
J Clin Invest. 2014 Sep; 124(9)4123-33. doi: 10.1172/JCI71048.

PMID:
    25083989
    [PubMed - indexed for MEDLINE]
Related citations


Each individual is a surprise: a conversation with Marianne Horney Eckardt.
Rubin JB
Am J Psychoanal. 2014 Jun; 74(2)115-22. doi: 10.1057/ajp.2014.3.

PMID:
    24882069
    [PubMed - indexed for MEDLINE]
Related citations


Reply: To PMID 24375753.
Diggs-Andrews KA, Brown JA, Gianino SM, D'Agostino McGowan L, Rubin JB, Wozniak DF, Gutmann DH
Ann Neurol. 2014 May; 75(5)800-1. doi: 10.1002/ana.24156.

PMID:
    24752946
    [PubMed - indexed for MEDLINE]
Related citations


Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.
Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset PO, Bechet D, Faury D, De Jay N, Ramkissoon LA, Corcoran A, Jones DT, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers DC, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Leary S, Jallo G, Cohen K, Gupta N, Prados MD, Carret AS, Ellezam B, Crevier L, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Dong Z, Siegel PM, Malkin H, Ligon AH, Albrecht S, Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW
Nat Genet. 2014 May; 46(5)462-6. doi: 10.1038/ng.2950.

PMID:
    24705250
    [PubMed - indexed for MEDLINE]
Related citations


Cytogenetic prognostication within medulloblastoma subgroups.
Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria CC, Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan JA, Robinson S, Bognár L, Klekner A, Saad AG, Liau LM, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Phillips JJ, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M, Jouvet A, Jabado N, Pollack IF, Weiss WA, Lee JY, Cho BK, Kim SK, Wang KC, Leonard JR, Rubin JB, de Torres C, Lavarino C, Mora J, Cho YJ, Tabori U, Olson JM, Gajjar A, Packer RJ, Rutkowski S, Pomeroy SL, French PJ, Kloosterhof NK, Kros JM, Van Meir EG, Clifford SC, Bourdeaut F, Delattre O, Doz FF, Hawkins CE, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka JT, Pfister SM, Taylor MD
J Clin Oncol. 2014 Mar 20; 32(9)886-96. doi: 10.1200/JCO.2013.50.9539.

PMID:
    24493713
    [PubMed - indexed for MEDLINE]
Related citations


Antiangiogenic agents for nonmalignant brain tumors.
Hawasli AH, Rubin JB, Tran DD, Adkins DR, Waheed S, Hullar TE, Gutmann DH, Evans J, Leonard JR, Zipfel GJ, Chicoine MR
J Neurol Surg B Skull Base. 2013 Jun; 74(3)136-41. doi: 10.1055/s-0033-1338262.

PMID:
    24436903
    [PubMed]
Related citations


Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1.
Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH
Ann Neurol. 2014 Feb; 75(2)309-16. doi: 10.1002/ana.24093.

PMID:
    24375753
    [PubMed - indexed for MEDLINE]
Related citations


TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, Zhukova N, Vanner R, Kros JM, French PJ, Van Meir EG, Vibhakar R, Zitterbart K, Chan JA, Bognár L, Klekner A, Lach B, Jung S, Saad AG, Liau LM, Albrecht S, Zollo M, Cooper MK, Thompson RC, Delattre OO, Bourdeaut F, Doz FF, Garami M, Hauser P, Carlotti CG, Van Meter TE, Massimi L, Fults D, Pomeroy SL, Kumabe T, Ra YS, Leonard JR, Elbabaa SK, Mora J, Rubin JB, Cho YJ, McLendon RE, Bigner DD, Eberhart CG, Fouladi M, Wechsler-Reya RJ, Faria CC, Croul SE, Huang A, Bouffet E, Hawkins CE, Dirks PB, Weiss WA, Schüller U, Pollack IF, Rutkowski S, Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grajkowska WA, Kim SK, Rutka JT, Malkin D, Tabori U, Pfister SM, Korshunov A, von Deimling A, Taylor MD
Acta Neuropathol. 2013 Dec; 126(6)917-29. doi: 10.1007/s00401-013-1198-2.

PMID:
    24174164
    [PubMed - indexed for MEDLINE]
Related citations


F11R is a novel monocyte prognostic biomarker for malignant glioma.
Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH
PLoS One. 2013; 8(10)e77571. doi: 10.1371/journal.pone.0077571.

PMID:
    24147027
    [PubMed - indexed for MEDLINE]
Related citations


A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer.
Robison NJ, Campigotto F, Chi SN, Manley PE, Turner CD, Zimmerman MA, Chordas CA, Werger AM, Allen JC, Goldman S, Rubin JB, Isakoff MS, Pan WJ, Khatib ZA, Comito MA, Bendel AE, Pietrantonio JB, Kondrat L, Hubbs SM, Neuberg DS, Kieran MW
Pediatr Blood Cancer. 2014 Apr; 61(4)636-42. doi: 10.1002/pbc.24794.

PMID:
    24123865
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Neurobiology, specifically the role of CXCR4 in tumor-genesis in the CNS and the nature of the intracellular signals that support these functions.