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Faculty Physicians

Joseph P. Gaut, MD, PhD

Assistant Professor, Pathology & Immunology

Specialty Areas

Pathology - Anatomic
Surgical Pathology
Nephropathology

Board Certifications

Pathology

Areas of Clinical Interest

Medical kidney disease

  • Education
  • Publication & Research

Education

Education

Medical Degree: Washington University School of Medicine, St. Louis, MO 2004
AB, Chemistry: Washington University, St. Louis, MO 1996
Residency, Anatomic Pathology: Massachusetts General Hospital, Boston, MA 2009
Residency, Anatomic & Clinical Pathology: Barnes Jewish Hospital, St. Louis, MO 2011
Fellowship, Surgical Pathology: Washington University School of Medicine, St. Louis, MO 2012

Publication & Research

Publication & Research

Claudin 1 and nephrin label cellular crescents in diabetic glomerulosclerosis.
Gaut JP, Hoshi M, Jain S, Liapis H
Hum Pathol. 2014 Mar; 45(3)628-35. doi: 10.1016/j.humpath.2013.10.030.

PMID:
    24529330
    [PubMed - indexed for MEDLINE]
Related citations


Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury.
Gaut JP, Crimmins DL, Ohlendorf MF, Lockwood CM, Griest TA, Brada NA, Hoshi M, Sato B, Hotchkiss RS, Jain S, Ladenson JH
Clin Chem. 2014 May; 60(5)747-57. doi: 10.1373/clinchem.2013.212993.

PMID:
    24486646
    [PubMed - indexed for MEDLINE]
Related citations


Reply: The role of arrhythmias in defining cardiac dysfunction during sepsis.
Takasu O, Gaut JP, Swanson PE, Hotchkiss RS
Am J Respir Crit Care Med. 2013 Sep 15; 188(6)751. doi: 10.1164/rccm.201303-0548LE.

PMID:
    24032388
    [PubMed - indexed for MEDLINE]
Related citations


Differentiation of human bone marrow mesenchymal stem cells on decellularized extracellular matrix materials.
Hoganson DM, Meppelink AM, Hinkel CJ, Goldman SM, Liu XH, Nunley RM, Gaut JP, Vacanti JP
J Biomed Mater Res A. 2014 Aug; 102(8)2875-83. doi: 10.1002/jbm.a.34941.

PMID:
    24027176
    [PubMed - indexed for MEDLINE]
Related citations


Acute antibody-mediated rejection after lung transplantation.
Witt CA, Gaut JP, Yusen RD, Byers DE, Iuppa JA, Bennett Bain K, Alexander Patterson G, Mohanakumar T, Trulock EP, Hachem RR
J Heart Lung Transplant. 2013 Oct; 32(10)1034-40. doi: 10.1016/j.healun.2013.07.004.

PMID:
    23953920
    [PubMed - indexed for MEDLINE]
Related citations


Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.
Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, Hotchkiss RS
Am J Respir Crit Care Med. 2013 Mar 1; 187(5)509-17. doi: 10.1164/rccm.201211-1983OC.

PMID:
    23348975
    [PubMed - indexed for MEDLINE]
Related citations


Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors.
Gaut JP, Crimmins DL, Lockwood CM, McQuillan JJ, Ladenson JH
Mod Pathol. 2013 May; 26(5)716-24. doi: 10.1038/modpathol.2012.202.

PMID:
    23196795
    [PubMed - indexed for MEDLINE]
Related citations


The renal biopsy in the genomic era.
Liapis H, Gaut JP
Pediatr Nephrol. 2013 Aug; 28(8)1207-19. doi: 10.1007/s00467-012-2356-9.

PMID:
    23179194
    [PubMed - indexed for MEDLINE]
Related citations


De novo membranoproliferative glomerulonephritis III in a renal transplant patient: case report and review of the literature.
Java A, Gaut JP, Brennan DC
Transpl Int. 2012 May; 25(5)e58-61. doi: 10.1111/j.1432-2277.2012.01452.x.

PMID:
    22380572
    [PubMed - indexed for MEDLINE]
Related citations


Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense.
Hirche TO, Gaut JP, Heinecke JW, Belaaouaj A
J Immunol. 2005 Feb 1; 174(3)1557-65.

PMID:
    15661916
    [PubMed - indexed for MEDLINE]
Related citations


Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tandem mass spectrometry.
Gaut JP, Byun J, Tran HD, Heinecke JW
Anal Biochem. 2002 Jan 15; 300(2)252-9.

PMID:
    11779118
    [PubMed - indexed for MEDLINE]
Related citations


Mechanisms for oxidizing low-density lipoprotein. Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis.
Gaut JP, Heinecke JW
Trends Cardiovasc Med. 2001 Apr-May; 11(3-4)103-12.

PMID:
    11685998
    [PubMed - indexed for MEDLINE]
Related citations


Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.
Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Brennan ML, Lusis AJ, Belaaouaj A, Hotchkiss RS, Heinecke JW
Proc Natl Acad Sci U S A. 2001 Oct 9; 98(21)11961-6.

PMID:
    11593004
    [PubMed - indexed for MEDLINE]
Related citations


Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions.
Hazen SL, Gaut JP, Crowley JR, Hsu FF, Heinecke JW
Biochem J. 2000 Dec 15; 352 Pt 3693-9.

PMID:
    11104675
    [PubMed - indexed for MEDLINE]
Related citations


Modification of proteins and lipids by myeloperoxidase.
Hazen SL, Hsu FF, Gaut JP, Crowley JR, Heinecke JW
Methods Enzymol. 1999; 30088-105.

PMID:
    9919513
    [PubMed - indexed for MEDLINE]
Related citations


Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase.
McCormick ML, Gaut JP, Lin TS, Britigan BE, Buettner GR, Heinecke JW
J Biol Chem. 1998 Nov 27; 273(48)32030-7.

PMID:
    9822676
    [PubMed - indexed for MEDLINE]
Related citations


p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies epsilon-amino groups of protein lysine residues.
Hazen SL, Gaut JP, Hsu FF, Crowley JR, d'Avignon A, Heinecke JW
J Biol Chem. 1997 Jul 4; 272(27)16990-8.

PMID:
    9202012
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Research focuses on acute kidney injury and the development of novel biomarkers to specifically and sensitively detect kidney injury in critically ill human patients. Other research interests include the pathophysiology of acute kidney injury and various types of glomerular disease.