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Joseph E. Ippolito, MD, PhD

Joseph E. Ippolito, MD, PhD
Instructor, Radiology
Division of Diagnostic Radiology
Medical Director, Center for Clinical Imaging Research

Specialty Areas

Radiology
Magnetic Resonance Imaging
Abdominal Imaging

Hospital Affiliations

Barnes-Jewish West County Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Body MRI, PET/MR hybrid imaging, prostate imaging, neuroendocrine cancer imaging

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: F
Floor: 3
Office Phone: (314) 286-2673

Barnes-Jewish West County Hospital

12634 Olive Blvd.
Creve Coeur, MO 63141

Office Phone: (314) 996-8082

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Education

Education

PhD, Molecular Biophysics: Washington University School of Medicine, St. Louis, MO 2007
Medical Degree: Washington University School of Medicine, St. Louis, MO 2007
Residency, Diagnostic Radiology: Barnes Jewish Hospital, St. Louis, MO 2012
Fellowship, Body Magnetic Resonance Imaging: Washington University School of Medicine, St. Louis, MO 2013
BS, Biological Sciences; Biochemistry: Cornell University, College of Agriculture and Life Sciences, Ithaca, NY 1998

Publication & Research

Publication & Research

Synergy of Sex Differences in Visceral Fat Measured with CT and Tumor Metabolism Helps Predict Overall Survival in Patients with Renal Cell Carcinoma.
Nguyen GK, Mellnick VM, Yim AK, Salter A, Ippolito JE
Radiology. 2018 Jun; 287(3)884-892. doi: 10.1148/radiol.2018171504.

PMID:
    29558292
    [PubMed - in process]
Related citations


Multiparametric MRI and [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography Imaging Is a Potential Prognostic Imaging Biomarker in Recurrent Glioblastoma.
Hassanzadeh C, Rao YJ, Chundury A, Rowe J, Ponisio MR, Sharma A, Miller-Thomas M, Tsien CI, Ippolito JE
Front Oncol. 2017; 7178. doi: 10.3389/fonc.2017.00178.

PMID:
    28868256
    [PubMed]
Related citations


Sexual dimorphism in glioma glycolysis underlies sex differences in survival.
Ippolito JE, Yim AK, Luo J, Chinnaiyan P, Rubin JB
JCI Insight. 2017 Aug 3; 2(15)pii: 92142. doi: 10.1172/jci.insight.92142.

PMID:
    28768910
    [PubMed - as supplied by publisher]
Related citations


Radiogenomics of High-Grade Serous Ovarian Cancer: Multireader Multi-Institutional Study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group.
Vargas HA, Huang EP, Lakhman Y, Ippolito JE, Bhosale P, Mellnick V, Shinagare AB, Anello M, Kirby J, Fevrier-Sullivan B, Freymann J, Jaffe CC, Sala E
Radiology. 2017 Nov; 285(2)482-492. doi: 10.1148/radiol.2017161870.

PMID:
    28641043
    [PubMed - indexed for MEDLINE]
Related citations


Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey-Holden Prostate Cancer Academy Meeting.
Miyahira AK, Roychowdhury S, Goswami S, Ippolito JE, Priceman SJ, Pritchard CC, Sfanos KS, Subudhi SK, Simons JW, Pienta KJ, Soule HR
Prostate. 2017 Feb; 77(2)123-144. doi: 10.1002/pros.23260.

PMID:
    27679977
    [PubMed - indexed for MEDLINE]
Related citations


Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide.
Ippolito JE, Brandenburg MW, Ge X, Crowley JR, Kirmess KM, Som A, D'Avignon DA, Arbeit JM, Achilefu S, Yarasheski KE, Milbrandt J
PLoS One. 2016; 11(7)e0159675. doi: 10.1371/journal.pone.0159675.

PMID:
    27438712
    [PubMed - indexed for MEDLINE]
Related citations


Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo.
Som A, Bloch S, Ippolito JE, Achilefu S
Sci Rep. 2016 Jun 15; 627803. doi: 10.1038/srep27803.

PMID:
    27302093
    [PubMed - in process]
Related citations


Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo.
Som A, Raliya R, Tian L, Akers W, Ippolito JE, Singamaneni S, Biswas P, Achilefu S
Nanoscale. 2016 Jul 7; 8(25)12639-47. doi: 10.1039/c5nr06162h.

PMID:
    26745389
    [PubMed - in process]
Related citations


A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.
Elhammali A, Ippolito JE, Collins L, Crowley J, Marasa J, Piwnica-Worms D
Cancer Discov. 2014 Jul; 4(7)828-39. doi: 10.1158/2159-8290.CD-13-0572.

PMID:
    24740997
    [PubMed - indexed for MEDLINE]
Related citations


A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.
Ippolito JE, Piwnica-Worms D
PLoS One. 2014; 9(2)e88667. doi: 10.1371/journal.pone.0088667.

PMID:
    24551133
    [PubMed - indexed for MEDLINE]
Related citations


Current concepts in neuroendocrine cancer metabolism.
Ippolito JE
Pituitary. 2006; 9(3)193-202.

PMID:
    17001465
    [PubMed - indexed for MEDLINE]
Related citations


Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.
Ippolito JE, Merritt ME, Bäckhed F, Moulder KL, Mennerick S, Manchester JK, Gammon ST, Piwnica-Worms D, Gordon JI
Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33)12505-10.

PMID:
    16895983
    [PubMed - indexed for MEDLINE]
Related citations


Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches.
Giannakis M, Stappenbeck TS, Mills JC, Leip DG, Lovett M, Clifton SW, Ippolito JE, Glasscock JI, Arumugam M, Brent MR, Gordon JI
J Biol Chem. 2006 Apr 21; 281(16)11292-300.

PMID:
    16464855
    [PubMed - indexed for MEDLINE]
Related citations


An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers.
Ippolito JE, Xu J, Jain S, Moulder K, Mennerick S, Crowley JR, Townsend RR, Gordon JI
Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28)9901-6.

PMID:
    15998737
    [PubMed - indexed for MEDLINE]
Related citations


A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype.
Syder AJ, Karam SM, Mills JC, Ippolito JE, Ansari HR, Farook V, Gordon JI
Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13)4471-6.

PMID:
    15070742
    [PubMed - indexed for MEDLINE]
Related citations


Molecular characterization of a metastatic neuroendocrine cell cancer arising in the prostates of transgenic mice.
Hu Y, Ippolito JE, Garabedian EM, Humphrey PA, Gordon JI
J Biol Chem. 2002 Nov 15; 277(46)44462-74.

PMID:
    12228243
    [PubMed - indexed for MEDLINE]
Related citations


Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801.
Hess GP, Ulrich H, Breitinger HG, Niu L, Gameiro AM, Grewer C, Srivastava S, Ippolito JE, Lee SM, Jayaraman V, Coombs SE
Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25)13895-900.

PMID:
    11095713
    [PubMed - indexed for MEDLINE]
Related citations


In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor.
Ulrich H, Ippolito JE, Pagán OR, Eterović VA, Hann RM, Shi H, Lis JT, Eldefrawi ME, Hess GP
Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24)14051-6.

PMID:
    9826651
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Cancer metabolism with an emphasis on castrate resistant prostate cancer and neuroendocrine cancers, metabolic imaging with PET, MRI, and optical imaging, metabolism-directed cancer therapeutics.