FollowMyHealth Patient Portal

Joseph C. Corbo, MD, PhD

Associate Professor - Pathology & Immunology
Division of Neuropathology

Specialty Areas

Pathology
Neuropathology

Board Certifications

Anatomic Pathology
Neuropathology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

pathology and immunology, neuropathology

  • Education
  • Publication & Research

Education

Education

Bachelor of Arts, Linguistics: Stanford University, Stanford, CA 1990
Bachelor of Science, Biological Sciences: Stanford University, Stanford, CA 1990
Medical Degree: University of California San Diego, La Jolla, CA 1999
PhD, Biology: University of California San Diego, La Jolla, CA 1997
Residency, Anatomic Pathology: Brigham and Women’s Hospital, Boston, MA 2001
Fellowship, Neuropathology: Harvard Medical School, Boston, MA 2003
Fellowship, Research - Genetics: Harvard Medical School, Boston, MA 2005

Publication & Research

Publication & Research

The role of retinol dehydrogenase 10 in the cone visual cycle.
Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ
Sci Rep. 2017 May 24; 7(1)2390. doi: 10.1038/s41598-017-02549-8.

PMID:
    28539612
    [PubMed - in process]
Related citations


High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.
Toomey MB, Lopes RJ, Araújo PM, Johnson JD, Gazda MA, Afonso S, Mota PG, Koch RE, Hill GE, Corbo JC, Carneiro M
Proc Natl Acad Sci U S A. 2017 May 16; 114(20)5219-5224. doi: 10.1073/pnas.1700751114.

PMID:
    28465440
    [PubMed - in process]
Related citations


Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors.
Hughes AE, Enright JM, Myers CA, Shen SQ, Corbo JC
Sci Rep. 2017 Mar 3; 743184. doi: 10.1038/srep43184.

PMID:
    28256534
    [PubMed - in process]
Related citations


Specialized photoreceptor composition in the raptor fovea.
Mitkus M, Olsson P, Toomey MB, Corbo JC, Kelber A
J Comp Neurol. 2017 Jun 15; 525(9)2152-2163. doi: 10.1002/cne.24190.

PMID:
    28199005
    [PubMed - in process]
Related citations


A Simple Grammar Defines Activating and Repressing cis-Regulatory Elements in Photoreceptors.
White MA, Kwasnieski JC, Myers CA, Shen SQ, Corbo JC, Cohen BA
Cell Rep. 2016 Oct 25; 17(5)1247-1254. doi: 10.1016/j.celrep.2016.09.066.

PMID:
    27783940
    [PubMed - in process]
Related citations


Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds.
Toomey MB, Lind O, Frederiksen R, Curley RW Jr, Riedl KM, Wilby D, Schwartz SJ, Witt CC, Harrison EH, Roberts NW, Vorobyev M, McGraw KJ, Cornwall MC, Kelber A, Corbo JC
Elife. 2016 Jul 12; 5pii: e15675. doi: 10.7554/eLife.15675.

PMID:
    27402384
    [PubMed - in process]
Related citations


Genetic Basis for Red Coloration in Birds.
Lopes RJ, Johnson JD, Toomey MB, Ferreira MS, Araujo PM, Melo-Ferreira J, Andersson L, Hill GE, Corbo JC, Carneiro M
Curr Biol. 2016 Jun 6; 26(11)1427-34. doi: 10.1016/j.cub.2016.03.076.

PMID:
    27212400
    [PubMed - in process]
Related citations


Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.
Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP
FEBS Lett. 2016 May; 590(9)1304-12. doi: 10.1002/1873-3468.12167.

PMID:
    27059013
    [PubMed - indexed for MEDLINE]
Related citations


Circadian and light-driven regulation of rod dark adaptation.
Xue Y, Shen SQ, Corbo JC, Kefalov VJ
Sci Rep. 2015 Dec 2; 517616. doi: 10.1038/srep17616.

PMID:
    26626567
    [PubMed - indexed for MEDLINE]
Related citations


Massively parallel cis-regulatory analysis in the mammalian central nervous system.
Shen SQ, Myers CA, Hughes AE, Byrne LC, Flannery JG, Corbo JC
Genome Res. 2016 Feb; 26(2)238-55. doi: 10.1101/gr.193789.115.

PMID:
    26576614
    [PubMed - indexed for MEDLINE]
Related citations


Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.
Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC
Curr Biol. 2015 Dec 7; 25(23)3048-57. doi: 10.1016/j.cub.2015.10.018.

PMID:
    26549260
    [PubMed - indexed for MEDLINE]
Related citations


A complex carotenoid palette tunes avian colour vision.
Toomey MB, Collins AM, Frederiksen R, Cornwall MC, Timlin JA, Corbo JC
J R Soc Interface. 2015 Oct 6; 12(111)20150563. doi: 10.1098/rsif.2015.0563.

PMID:
    26446559
    [PubMed - indexed for MEDLINE]
Related citations


Optics of cone photoreceptors in the chicken (Gallus gallus domesticus).
Wilby D, Toomey MB, Olsson P, Frederiksen R, Cornwall MC, Oulton R, Kelber A, Corbo JC, Roberts NW
J R Soc Interface. 2015 Oct 6; 12(111)20150591. doi: 10.1098/rsif.2015.0591.

PMID:
    26423439
    [PubMed - indexed for MEDLINE]
Related citations


Redesign of the monomer-monomer interface of Cre recombinase yields an obligate heterotetrameric complex.
Zhang C, Myers CA, Qi Z, Mitra RD, Corbo JC, Havranek JJ
Nucleic Acids Res. 2015 Oct 15; 43(18)9076-85. doi: 10.1093/nar/gkv901.

PMID:
    26365240
    [PubMed - indexed for MEDLINE]
Related citations


CRALBP supports the mammalian retinal visual cycle and cone vision.
Xue Y, Shen SQ, Jui J, Rupp AC, Byrne LC, Hattar S, Flannery JG, Corbo JC, Kefalov VJ
J Clin Invest. 2015 Feb; 125(2)727-38. doi: 10.1172/JCI79651.

PMID:
    25607845
    [PubMed - indexed for MEDLINE]
Related citations


Transcriptome profiling of developing photoreceptor subtypes reveals candidate genes involved in avian photoreceptor diversification.
Enright JM, Lawrence KA, Hadzic T, Corbo JC
J Comp Neurol. 2015 Mar 1; 523(4)649-68. doi: 10.1002/cne.23702.

PMID:
    25349106
    [PubMed - indexed for MEDLINE]
Related citations


Hybrid mice reveal parent-of-origin and Cis- and trans-regulatory effects in the retina.
Shen SQ, Turro E, Corbo JC
PLoS One. 2014; 9(10)e109382. doi: 10.1371/journal.pone.0109382.

PMID:
    25340786
    [PubMed - indexed for MEDLINE]
Related citations


Chromophore supply rate-limits mammalian photoreceptor dark adaptation.
Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ
J Neurosci. 2014 Aug 20; 34(34)11212-21. doi: 10.1523/JNEUROSCI.1245-14.2014.

PMID:
    25143602
    [PubMed - indexed for MEDLINE]
Related citations


Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus.
Rohatgi A, Corbo JC, Monte K, Higgs S, Vanlandingham DL, Kardon G, Lenschow DJ
J Virol. 2014 Mar; 88(5)2414-25. doi: 10.1128/JVI.02716-13.

PMID:
    24335291
    [PubMed - indexed for MEDLINE]
Related citations


Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks.
White MA, Myers CA, Corbo JC, Cohen BA
Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29)11952-7. doi: 10.1073/pnas.1307449110.

PMID:
    23818646
    [PubMed - indexed for MEDLINE]
Related citations