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Jonathan William Heusel, MD, PhD

Associate Professor, Pathology and Immunology
Associate Professor, Genetics
Chief Medical Officer, Genomics and Pathology Services

Specialty Areas

Pathology
Molecular Pathology

Board Certifications

Molecular Genetic Pathology
Clinical Pathology

Hospital Affiliations

Barnes-Jewish Hospital

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

Fellowship, NIH Postdoctoral Research, Rheumatology: Washington University School of Medicine, St. Louis, MO 2001
Fellowship, Research: Howard Hughes Medical Institute 2000
PhD, Immunology/MSTP: Washington University School of Medicine, St. Louis, MO 1995
Medical Degree: Washington University School of Medicine, St. Louis, MO 1995
BS, Biology: University of Nebraska, Lincoln, NB 1987

Publication & Research

Publication & Research

Acute graft-versus-host disease following lung transplantation in a patient with a novel <i>TERT</i> mutation.
Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
Thorax. 2018 May; 73(5)489-492. doi: 10.1136/thoraxjnl-2017-211121.

PMID:
    29382801
    [PubMed - in process]
Related citations


Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma With Deficient DNA Mismatch Repair.
Lee PJ, McNulty S, Duncavage EJ, Heusel JW, Hagemann IS
Int J Gynecol Pathol. 2017 Oct 27; doi: 10.1097/PGP.0000000000000459.

PMID:
    29084048
    [PubMed - as supplied by publisher]
Related citations


<i>FGFR2</i> amplification in colorectal adenocarcinoma.
Carter JH, Cottrell CE, McNulty SN, Vigh-Conrad KA, Lamp S, Heusel JW, Duncavage EJ
Cold Spring Harb Mol Case Stud. 2017 Nov; 3(6)pii: a001495. doi: 10.1101/mcs.a001495.

PMID:
    28835367
    [PubMed - indexed for MEDLINE]
Related citations


Routine use of clinical exome-based next-generation sequencing for evaluation of patients with thrombotic microangiopathies.
Gaut JP, Jain S, Pfeifer JD, Vigh-Conrad KA, Corliss M, Sharma MK, Heusel JW, Cottrell CE
Mod Pathol. 2017 Dec; 30(12)1739-1747. doi: 10.1038/modpathol.2017.90.

PMID:
    28752844
    [PubMed - in process]
Related citations


Targeted Next-Generation Sequencing in Molecular Subtyping of Lower-Grade Diffuse Gliomas: Application of the World Health Organization's 2016 Revised Criteria for Central Nervous System Tumors.
Carter JH, McNulty SN, Cimino PJ, Cottrell CE, Heusel JW, Vigh-Conrad KA, Duncavage EJ
J Mol Diagn. 2017 Mar; 19(2)328-337. doi: 10.1016/j.jmoldx.2016.10.010.

PMID:
    28042970
    [PubMed - indexed for MEDLINE]
Related citations


Concurrent MPL W515L and Y591D mutations in a patient with myelofibrosis.
Rashidi A, Heusel JW, Oh ST
Blood Cells Mol Dis. 2016 Sep; 601-2. doi: 10.1016/j.bcmd.2016.05.010.

PMID:
    27519934
    [PubMed - indexed for MEDLINE]
Related citations


Extrinsic allospecific signals of hematopoietic origin dictate iNKT cell lineage-fate decisions during development.
Strong BS, Newkold TJ, Lee AE, Turner LE, Alhajjat AM, Heusel JW, Shaaban AF
Sci Rep. 2016 Jun 29; 628837. doi: 10.1038/srep28837.

PMID:
    27354027
    [PubMed - in process]
Related citations


Prenatal Allogeneic Tolerance in Mice Remains Stable Despite Potent Viral Immune Activation.
Strong BS, Ryken KO, Lee AE, Turner LE, Wadhwani RK, Newkold TJ, Alhajjat AM, Heusel JW, Shaaban AF
J Immunol. 2015 Oct 15; 195(8)4001-9. doi: 10.4049/jimmunol.1500844.

PMID:
    26363051
    [PubMed - indexed for MEDLINE]
Related citations


Identification of Medically Actionable Secondary Findings in the 1000 Genomes.
Olfson E, Cottrell CE, Davidson NO, Gurnett CA, Heusel JW, Stitziel NO, Chen LS, Hartz S, Nagarajan R, Saccone NL, Bierut LJ
PLoS One. 2015; 10(9)e0135193. doi: 10.1371/journal.pone.0135193.

PMID:
    26332594
    [PubMed - indexed for MEDLINE]
Related citations


Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development.
Alhajjat AM, Strong BS, Lee AE, Turner LE, Wadhwani RK, Ortaldo JR, Heusel JW, Shaaban AF
J Immunol. 2015 Aug 15; 195(4)1506-16. doi: 10.4049/jimmunol.1500463.

PMID:
    26136432
    [PubMed - indexed for MEDLINE]
Related citations


An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.
Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D Jr, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzyński P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrečić L, Palandačić A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM
Genome Biol. 2014 Mar 25; 15(3)R53. doi: 10.1186/gb-2014-15-3-r53.

PMID:
    24667040
    [PubMed - indexed for MEDLINE]
Related citations


The Glycophosphatidylinositol Anchor of the MCMV Evasin, m157, Facilitates Optimal Cell Surface Expression and Ly49 Receptor Recognition.
Carlin LE, Guseva NV, Shey MR, Ballas ZK, Heusel JW
PLoS One. 2013; 8(6)e67295. doi: 10.1371/journal.pone.0067295.

PMID:
    23840655
    [PubMed - indexed for MEDLINE]
Related citations


Role of NK cell subsets in organ-specific murine melanoma metastasis.
Ballas ZK, Buchta CM, Rosean TR, Heusel JW, Shey MR
PLoS One. 2013; 8(6)e65599. doi: 10.1371/journal.pone.0065599.

PMID:
    23776508
    [PubMed - indexed for MEDLINE]
Related citations


Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection.
Schmidt NW, Khanolkar A, Hancox L, Heusel JW, Harty JT
Eur J Immunol. 2012 Mar; 42(3)629-40. doi: 10.1002/eji.201141902.

PMID:
    22161269
    [PubMed - indexed for MEDLINE]
Related citations


Glycosylation contributes to variability in expression of murine cytomegalovirus m157 and enhances stability of interaction with the NK-cell receptor Ly49H.
Guseva NV, Fullenkamp CA, Naumann PW, Shey MR, Ballas ZK, Houtman JC, Forbes CA, Scalzo AA, Heusel JW
Eur J Immunol. 2010 Sep; 40(9)2618-31. doi: 10.1002/eji.200940134.

PMID:
    20662096
    [PubMed - indexed for MEDLINE]
Related citations


Innate immune control and regulation of influenza virus infections.
McGill J, Heusel JW, Legge KL
J Leukoc Biol. 2009 Oct; 86(4)803-12. doi: 10.1189/jlb.0509368.

PMID:
    19643736
    [PubMed - indexed for MEDLINE]
Related citations


Characterization of murine cytomegalovirus m157 from infected cells and identification of critical residues mediating recognition by the NK cell receptor Ly49H.
Davis AH, Guseva NV, Ball BL, Heusel JW
J Immunol. 2008 Jul 1; 181(1)265-75.

PMID:
    18566392
    [PubMed - indexed for MEDLINE]
Related citations


Natural killer cells: emerging concepts in immunity to infection and implications for assessment of immunodeficiency.
Heusel JW, Ballas ZK
Curr Opin Pediatr. 2003 Dec; 15(6)586-93.

PMID:
    14631204
    [PubMed - indexed for MEDLINE]
Related citations


Recognition of a virus-encoded ligand by a natural killer cell activation receptor.
Smith HR, Heusel JW, Mehta IK, Kim S, Dorner BG, Naidenko OV, Iizuka K, Furukawa H, Beckman DL, Pingel JT, Scalzo AA, Fremont DH, Yokoyama WM
Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13)8826-31.

PMID:
    12060703
    [PubMed - indexed for MEDLINE]
Related citations


Vital involvement of a natural killer cell activation receptor in resistance to viral infection.
Brown MG, Dokun AO, Heusel JW, Smith HR, Beckman DL, Blattenberger EA, Dubbelde CE, Stone LR, Scalzo AA, Yokoyama WM
Science. 2001 May 4; 292(5518)934-7.

PMID:
    11340207
    [PubMed - indexed for MEDLINE]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Pieriandx

Royalties:

Equity: No

Consulting/Advisory Board: $10,001 - $25,000

Speaker Fees:

Reporting Date: May 01, 2017

Areas of Research Interest

Natural killer cell activation and function in the context of viral infection and tumor immunity; translation of clinical genomics applications for cancer and inherited disease.