Patient Portal

Jonathan J. Miner, MD, PhD

Assistant Professor, Medicine
Division of Rheumatology

Specialty Areas

Internal Medicine
Rheumatology
Autoimmune Disease

Board Certifications

Internal Medicine
Rheumatology

Hospital Affiliations

Barnes-Jewish Hospital

Languages

Russian

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Vasculitis, vasculopathy, rare autoimmune and autoinflammatory diseases.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-286-2635
Fax: 314-286-2338

Education

Education

Fellowship, Rheumatology: Washington University School of Medicine, St. Louis, MO 2015
Residency, Internal Medicine: Barnes-Jewish Hospital, St. Louis, MO 2012
Medical Degree: University of Oklahoma College of Medicine, Oklahoma City, OK 2010
PhD, Biochemistry and Molecular Biology: University of Oklahoma College of Medicine, Oklahoma, OK 2010
BA/BS, Russian and Zoology: Brigham Young University, Provo, UT 2002

Publication & Research

Publication & Research

A Human STAT1 Gain-of-Function Mutation Impairs CD8<sup>+</sup> T Cell Responses against Gammaherpesvirus 68.
Qian W, Miner CA, Ingle H, Platt DJ, Baldridge MT, Miner JJ
J Virol. 2019 Oct 1; 93(19)pii: e00307-19. doi: 10.1128/JVI.00307-19.

PMID:
    31315996
    [PubMed - in process]
Related citations


Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ.
Ingle H, Lee S, Ai T, Orvedahl A, Rodgers R, Zhao G, Sullender M, Peterson ST, Locke M, Liu TC, Yokoyama CC, Sharp B, Schultz-Cherry S, Miner JJ, Baldridge MT
Nat Microbiol. 2019 Jul; 4(7)1120-1128. doi: 10.1038/s41564-019-0416-7.

PMID:
    30936486
    [PubMed - indexed for MEDLINE]
Related citations


STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N
J Exp Med. 2019 Apr 1; 216(4)867-883. doi: 10.1084/jem.20182192.

PMID:
    30886058
    [PubMed - in process]
Related citations


STING-associated lung disease in mice relies on T cells but not type I interferon.
Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ
J Allergy Clin Immunol. 2019 Jul; 144(1)254-266.e8. doi: 10.1016/j.jaci.2019.01.044.

PMID:
    30772497
    [PubMed - in process]
Related citations


Tofacitinib for refractory uveitis and scleritis.
Paley MA, Karacal H, Rao PK, Margolis TP, Miner JJ
Am J Ophthalmol Case Rep. 2019 Mar; 1353-55. doi: 10.1016/j.ajoc.2018.12.001.

PMID:
    30582071
    [PubMed]
Related citations


A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice.
Bennion BG, Ingle H, Ai TL, Miner CA, Platt DJ, Smith AM, Baldridge MT, Miner JJ
J Virol. 2019 Feb 15; 93(4)pii: e01806-18. doi: 10.1128/JVI.01806-18.

PMID:
    30463976
    [PubMed - in process]
Related citations


HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.
MacDuff DA, Baldridge MT, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW
J Virol. 2018 Dec 1; 92(23)pii: e01368-18. doi: 10.1128/JVI.01368-18.

PMID:
    30209176
    [PubMed - in process]
Related citations


Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK
Proc Natl Acad Sci U S A. 2018 Aug 14; 115(33)E7768-E7775. doi: 10.1073/pnas.1806239115.

PMID:
    30061387
    [PubMed - indexed for MEDLINE]
Related citations


Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.
Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ
Sci Transl Med. 2018 Jan 31; 10(426)pii: eaao7090. doi: 10.1126/scitranslmed.aao7090.

PMID:
    29386359
    [PubMed - in process]
Related citations


Editorial: Lessons Learned From Chikungunya in the Americas.
Miner JJ, Lenschow DJ
Arthritis Rheumatol. 2018 Apr; 70(4)477-479. doi: 10.1002/art.40421.

PMID:
    29361204
    [PubMed - indexed for MEDLINE]
Related citations


Consequences of congenital Zika virus infection.
Platt DJ, Miner JJ
Curr Opin Virol. 2017 Dec; 271-7. doi: 10.1016/j.coviro.2017.09.005.

PMID:
    29080429
    [PubMed - indexed for MEDLINE]
Related citations


STING-associated vasculopathy develops independently of IRF3 in mice.
Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Wu J, Platt DJ, Yan N, Miner JJ
J Exp Med. 2017 Nov 6; 214(11)3279-3292. doi: 10.1084/jem.20171351.

PMID:
    28951494
    [PubMed - indexed for MEDLINE]
Related citations


Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero.
Jagger BW, Miner JJ, Cao B, Arora N, Smith AM, Kovacs A, Mysorekar IU, Coyne CB, Diamond MS
Cell Host Microbe. 2017 Sep 13; 22(3)366-376.e3. doi: 10.1016/j.chom.2017.08.012.

PMID:
    28910635
    [PubMed - indexed for MEDLINE]
Related citations


Congenital Zika virus infection: More than just microcephaly.
Miner JJ
Sci Transl Med. 2017 Jun 7; 9(393)pii: eaan8195. doi: 10.1126/scitranslmed.aan8195.

PMID:
    28592568
    [PubMed - indexed for MEDLINE]
Related citations


Dengue Antibodies, then Zika: A Fatal Sequence in Mice.
Miner JJ, Diamond MS
Immunity. 2017 May 16; 46(5)771-773. doi: 10.1016/j.immuni.2017.04.023.

PMID:
    28514683
    [PubMed - indexed for MEDLINE]
Related citations


Defeating Zika.
Miner JJ
Sci Transl Med. 2017 Apr 26; 9(387)pii: eaan2785. doi: 10.1126/scitranslmed.aan2785.

PMID:
    28446685
    [PubMed - indexed for MEDLINE]
Related citations


Gamete fusion gone viral.
Miner JJ
Sci Transl Med. 2017 Mar 15; 9(381)pii: eaam9866. doi: 10.1126/scitranslmed.aam9866.

PMID:
    28298425
    [PubMed - indexed for MEDLINE]
Related citations


Zika Virus Pathogenesis and Tissue Tropism.
Miner JJ, Diamond MS
Cell Host Microbe. 2017 Feb 8; 21(2)134-142. doi: 10.1016/j.chom.2017.01.004.

PMID:
    28182948
    [PubMed - indexed for MEDLINE]
Related citations


Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.
Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S
Lancet Infect Dis. 2017 Apr; 17(4)e107-e117. doi: 10.1016/S1473-3099(16)30385-1.

PMID:
    28159534
    [PubMed - indexed for MEDLINE]
Related citations


Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis.
Miner JJ, Cook LE, Hong JP, Smith AM, Richner JM, Shimak RM, Young AR, Monte K, Poddar S, Crowe JE Jr, Lenschow DJ, Diamond MS
Sci Transl Med. 2017 Feb 1; 9(375)pii: eaah3438. doi: 10.1126/scitranslmed.aah3438.

PMID:
    28148840
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Innate immunity, vasculitis and viral pathogenesis