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Faculty Physicians

John Zempel, MD, PhD

Associate Professor, Neurology and Pediatrics
Division of Pediatric Neurology
Director, EEG Laboratories, St. Louis Children's Hospital

Specialty Areas

Pediatric Neurology
EEG
Sleep Medicine
Pediatric Epilepsy

Board Certifications

Child Neurology
Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Epilepsy in children, autism, pediatric sleep disorders, Landau-Kleffner syndrome.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite D
Floor: Floor 2
Office Phone: 314-454-4089
Fax: 314-454-4225

Education

Education

Fellowship: Pediatric Epilepsy, St. Louis Children's Hospital, St. Louis, Missouri 2003
Residency: Child Neurology, St. Louis Children's Hospital, St. Louis, Missouri 2000
Residency: Adult Neurology, Barnes-Jewish Hospital at Washington University School of Medicine, St. Louis, Missouri 1998
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1997
Ph.D.: Neurobiology, Washington University, St. Louis, Missouri 1995
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1995
B.S. : Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin 1985

Publication & Research

Publication & Research

Myoclonic atonic epilepsy: another generalized epilepsy syndrome that is "not so" generalized.
Zempel JM, Mano T
Neurology. 2014 Apr 29; 82(17)1486-7. doi: 10.1212/WNL.0000000000000368.

PMID:
    24696505
    [PubMed - indexed for MEDLINE]
Related citations


Average is optimal: an inverted-U relationship between trial-to-trial brain activity and behavioral performance.
He BJ, Zempel JM
PLoS Comput Biol. 2013; 9(11)e1003348. doi: 10.1371/journal.pcbi.1003348.

PMID:
    24244146
    [PubMed - indexed for MEDLINE]
Related citations


Hypothermia for pediatric refractory status epilepticus.
Guilliams K, Rosen M, Buttram S, Zempel J, Pineda J, Miller B, Shoykhet M
Epilepsia. 2013 Sep; 54(9)1586-94. doi: 10.1111/epi.12331.

PMID:
    23906244
    [PubMed - indexed for MEDLINE]
Related citations


Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury.
Srinivasakumar P, Zempel J, Wallendorf M, Lawrence R, Inder T, Mathur A
J Pediatr. 2013 Aug; 163(2)465-70. doi: 10.1016/j.jpeds.2013.01.041.

PMID:
    23452588
    [PubMed - indexed for MEDLINE]
Related citations


Determination of neural state classification metrics from the power spectrum of human ECoG.
Kelsey M, Politte D, Verner R, Zempel JM, Nolan T, Babajani-Feremi A, Prior F, Larson-Prior LJ
Conf Proc IEEE Eng Med Biol Soc. 2012; 20124336-40. doi: 10.1109/EMBC.2012.6346926.

PMID:
    23366887
    [PubMed - indexed for MEDLINE]
Related citations


Automating the analysis of EEG recordings from prematurely-born infants: a Bayesian approach.
Mitchell TJ, Neil JJ, Zempel JM, Thio LL, Inder TE, Bretthorst GL
Clin Neurophysiol. 2013 Mar; 124(3)452-61. doi: 10.1016/j.clinph.2012.09.003.

PMID:
    23014143
    [PubMed - indexed for MEDLINE]
Related citations


Modulation of the brain's functional network architecture in the transition from wake to sleep.
Larson-Prior LJ, Power JD, Vincent JL, Nolan TS, Coalson RS, Zempel J, Snyder AZ, Schlaggar BL, Raichle ME, Petersen SE
Prog Brain Res. 2011; 193277-94. doi: 10.1016/B978-0-444-53839-0.00018-1.

PMID:
    21854969
    [PubMed - indexed for MEDLINE]
Related citations


Decoding motor signals from the pediatric cortex: implications for brain-computer interfaces in children.
Breshears JD, Gaona CM, Roland JL, Sharma M, Anderson NR, Bundy DT, Freudenburg ZV, Smyth MD, Zempel J, Limbrick DD, Smart WD, Leuthardt EC
Pediatrics. 2011 Jul; 128(1)e160-8. doi: 10.1542/peds.2010-1519.

PMID:
    21690116
    [PubMed - indexed for MEDLINE]
Related citations


Fluctuating concepts of childhood absence epilepsy.
Zempel JM, Ciliberto M
Neurology. 2011 Jun 7; 76(23)1952-3. doi: 10.1212/WNL.0b013e31821e55e2.

PMID:
    21646621
    [PubMed - indexed for MEDLINE]
Related citations


The temporal structures and functional significance of scale-free brain activity.
He BJ, Zempel JM, Snyder AZ, Raichle ME
Neuron. 2010 May 13; 66(3)353-69. doi: 10.1016/j.neuron.2010.04.020.

PMID:
    20471349
    [PubMed - indexed for MEDLINE]
Related citations


Electrographic seizures in preterm infants during the first week of life are associated with cerebral injury.
Shah DK, Zempel J, Barton T, Lukas K, Inder TE
Pediatr Res. 2010 Jan; 67(1)102-6. doi: 10.1203/PDR.0b013e3181bf5914.

PMID:
    19745782
    [PubMed - indexed for MEDLINE]
Related citations


Cortical network functional connectivity in the descent to sleep.
Larson-Prior LJ, Zempel JM, Nolan TS, Prior FW, Snyder AZ, Raichle ME
Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11)4489-94. doi: 10.1073/pnas.0900924106.

PMID:
    19255447
    [PubMed - indexed for MEDLINE]
Related citations


A pilot study of continuous limited-channel aEEG in term infants with encephalopathy.
Lawrence R, Mathur A, Nguyen The Tich S, Zempel J, Inder T
J Pediatr. 2009 Jun; 154(6)835-41.e1. doi: 10.1016/j.jpeds.2009.01.002.

PMID:
    19230897
    [PubMed - indexed for MEDLINE]
Related citations


Electrophysiological correlates of the brain's intrinsic large-scale functional architecture.
He BJ, Snyder AZ, Zempel JM, Smyth MD, Raichle ME
Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41)16039-44. doi: 10.1073/pnas.0807010105.

PMID:
    18843113
    [PubMed - indexed for MEDLINE]
Related citations


Utility of prolonged bedside amplitude-integrated encephalogram in encephalopathic infants.
Mathur AM, Morris LD, Teteh F, Inder TE, Zempel J
Am J Perinatol. 2008 Nov; 25(10)611-5. doi: 10.1055/s-0028-1090598.

PMID:
    18841534
    [PubMed - indexed for MEDLINE]
Related citations


Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum.
Johnston JM, Vaishnavi SN, Smyth MD, Zhang D, He BJ, Zempel JM, Shimony JS, Snyder AZ, Raichle ME
J Neurosci. 2008 Jun 18; 28(25)6453-8. doi: 10.1523/JNEUROSCI.0573-08.2008.

PMID:
    18562616
    [PubMed - indexed for MEDLINE]
Related citations


Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants.
Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, Mathur A, Inder TE
Pediatrics. 2008 Jun; 121(6)1146-54. doi: 10.1542/peds.2007-1839.

PMID:
    18519484
    [PubMed - indexed for MEDLINE]
Related citations


Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
Gurnett CA, Veile R, Zempel J, Blackburn L, Lovett M, Bowcock A
Arch Neurol. 2008 Apr; 65(4)550-3. doi: 10.1001/archneur.65.4.550.

PMID:
    18413482
    [PubMed - indexed for MEDLINE]
Related citations


Intrinsic functional architecture in the anaesthetized monkey brain.
Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Van Essen DC, Zempel JM, Snyder LH, Corbetta M, Raichle ME
Nature. 2007 May 3; 447(7140)83-6.

PMID:
    17476267
    [PubMed - indexed for MEDLINE]
Related citations


Outcome following surgery for temporal lobe epilepsy with hippocampal involvement in preadolescent children: emphasis on mesial temporal sclerosis.
Smyth MD, Limbrick DD Jr, Ojemann JG, Zempel J, Robinson S, O'Brien DF, Saneto RP, Goyal M, Appleton RE, Mangano FT, Park TS
J Neurosurg. 2007 Mar; 106(3 Suppl)205-10.

PMID:
    17465386
    [PubMed - indexed for MEDLINE]
Related citations