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John S. Daniels, MD

Associate Professor, Clinical Medicine
Washington University Clinical Associates
University Internal Medicine and Diabetes Associates

Specialty Areas

Endocrinology
Diabetes
Internal Medicine
Primary Care

Board Certifications

Internal Medicine
Endocrinology and Metabolism

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Endocrinology, diabetes, metabolism

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
University Internal Medicine and Diabetes Associates

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 13
Office Phone: 314-333-4100
Fax: 314-333-4115

Education

Education

Fellowship: Endocrinology and Metabolism, Washington University School of Medicine, St. Louis, Missouri 1979
Residency: Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 1977
Medical Degree: University of Arkansas School of Medicine, Little Rock, Arkansas 1974
B.A.: Washington University, St. Louis, Missouri 1970

Publication & Research

Publication & Research

Development and antiparkinsonian activity of VU0418506, a selective positive allosteric modulator of metabotropic glutamate receptor 4 homomers without activity at mGlu2/4 heteromers.
Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ
ACS Chem Neurosci. 2016 Jul 21;

PMID:
    27441572
    [PubMed - as supplied by publisher]
Related citations


Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).
Gogliotti RD, Blobaum AL, Morrison RM, Daniels JS, Salovich JM, Cheung YY, Rodriguez AL, Loch MT, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
Bioorg Med Chem Lett. 2016 Jul 1; 26(13)2984-7. doi: 10.1016/j.bmcl.2016.05.029.

PMID:
    27234146
    [PubMed - in process]
Related citations


Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.
Gogliotti RD, Engers DW, Garcia-Barrantes PM, Panarese JD, Gentry PR, Blobaum AL, Morrison RD, Daniels JS, Thompson AD, Jones CK, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR
Bioorg Med Chem Lett. 2016 Jun 15; 26(12)2915-9. doi: 10.1016/j.bmcl.2016.04.041.

PMID:
    27131990
    [PubMed - in process]
Related citations


Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu<sub>4</sub>).
Engers DW, Blobaum AL, Gogliotti RD, Cheung YY, Salovich JM, Garcia-Barrantes PM, Daniels JS, Morrison R, Jones CK, Soars MG, Zhuo X, Hurley J, Macor JE, Bronson JJ, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
ACS Chem Neurosci. 2016 May 3;

PMID:
    27075300
    [PubMed - as supplied by publisher]
Related citations


N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.
Felts AS, Rodriguez AL, Morrison RD, Venable DF, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA
Bioorg Med Chem Lett. 2016 Apr 15; 26(8)1894-900. doi: 10.1016/j.bmcl.2016.03.026.

PMID:
    26988308
    [PubMed - in process]
Related citations


Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
Crouch RD, Morrison RD, Byers FW, Lindsley CW, Emmitte KA, Daniels JS
Drug Metab Dispos. 2016 Aug; 44(8)1296-303. doi: 10.1124/dmd.115.068338.

PMID:
    26936972
    [PubMed - in process]
Related citations


mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.
Gogliotti RG, Senter RK, Rook JM, Ghoshal A, Zamorano R, Malosh C, Stauffer SR, Bridges TM, Bartolome JM, Daniels JS, Jones CK, Lindsley CW, Conn PJ, Niswender CM
Hum Mol Genet. 2016 Mar 2; pii: ddw074.

PMID:
    26936821
    [PubMed - as supplied by publisher]
Related citations


Discovery and characterization of a small molecule that restores E-cadherin expression in cancer cell lines via a new mechanism
Stoops SL, Waterson AG, An H, Deane N, Daniels JS, Morrison R, Engers JL, Beauchamp D, Lindsley CW
. 2010;

PMID:
    26913352
    [PubMed]
Related citations


Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.
Conde-Ceide S, Alcázar J, Alonso de Diego SA, López S, Martín-Martín ML, Martínez-Viturro CM, Pena MA, Tong HM, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Lindsley CW, Bartolomé-Nebreda JM
Bioorg Med Chem Lett. 2016 Jan 15; 26(2)429-34. doi: 10.1016/j.bmcl.2015.11.098.

PMID:
    26684851
    [PubMed - in process]
Related citations


State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects.
Gould RW, Nedelcovych MT, Gong X, Tsai E, Bubser M, Bridges TM, Wood MR, Duggan ME, Brandon NJ, Dunlop J, Wood MW, Ivarsson M, Noetzel MJ, Daniels JS, Niswender CM, Lindsley CW, Conn PJ, Jones CK
Neuropharmacology. 2016 Mar; 102244-53. doi: 10.1016/j.neuropharm.2015.11.016.

PMID:
    26617071
    [PubMed - in process]
Related citations


Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.
Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA
J Med Chem. 2015 Nov 25; 58(22)9027-40. doi: 10.1021/acs.jmedchem.5b01371.

PMID:
    26524606
    [PubMed - indexed for MEDLINE]
Related citations


Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.
Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ
Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45)14078-83. doi: 10.1073/pnas.1512812112.

PMID:
    26508634
    [PubMed - indexed for MEDLINE]
Related citations


VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.
Nickols HH, Yuh JP, Gregory KJ, Morrison RD, Bates BS, Stauffer SR, Emmitte KA, Bubser M, Peng W, Nedelcovych MT, Thompson A, Lv X, Xiang Z, Daniels JS, Niswender CM, Lindsley CW, Jones CK, Conn PJ
J Pharmacol Exp Ther. 2016 Jan; 356(1)123-36. doi: 10.1124/jpet.115.226597.

PMID:
    26503377
    [PubMed - indexed for MEDLINE]
Related citations


Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Malosh C, Turlington M, Bridges TM, Rook JM, Noetzel MJ, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martínez-Viturro CM, Piedrafita M, Sánchez-Casado MR, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 Nov 15; 25(22)5115-20. doi: 10.1016/j.bmcl.2015.10.009.

PMID:
    26475522
    [PubMed - in process]
Related citations


Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.
Engers JL, Rodriguez AL, Konkol LC, Morrison RD, Thompson AD, Byers FW, Blobaum AL, Chang S, Venable DF, Loch MT, Niswender CM, Daniels JS, Jones CK, Conn PJ, Lindsley CW, Emmitte KA
J Med Chem. 2015 Sep 24; 58(18)7485-500. doi: 10.1021/acs.jmedchem.5b01005.

PMID:
    26335039
    [PubMed - indexed for MEDLINE]
Related citations


Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.
Gould RW, Amato RJ, Bubser M, Joffe ME, Nedelcovych MT, Thompson AD, Nickols HH, Yuh JP, Zhan X, Felts AS, Rodriguez AL, Morrison RD, Byers FW, Rook JM, Daniels JS, Niswender CM, Conn PJ, Emmitte KA, Lindsley CW, Jones CK
Neuropsychopharmacology. 2016 Mar; 41(4)1166-78. doi: 10.1038/npp.2015.265.

PMID:
    26315507
    [PubMed - in process]
Related citations


Optimization of a small molecule probe that restores e-cadherin expression.
Brogan JT, Stoops SL, Brady S, An H, Weaver C, Daniels JS, Beauchamp RD, Lindsley CW, Waterson AG
Bioorg Med Chem Lett. 2015 Oct 1; 25(19)4260-4. doi: 10.1016/j.bmcl.2015.07.104.

PMID:
    26299347
    [PubMed - indexed for MEDLINE]
Related citations


A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.
Blobaum AL, Byers FW, Bridges TM, Locuson CW, Conn PJ, Lindsley CW, Daniels JS
Drug Metab Dispos. 2015 Nov; 43(11)1718-26. doi: 10.1124/dmd.115.064006.

PMID:
    26265743
    [PubMed - indexed for MEDLINE]
Related citations


Evaluation of tizanidine as a marker of canine CYP1A2 activity.
Locuson CW, Williams P, Adcock JM, Daniels JS
J Vet Pharmacol Ther. 2016 Apr; 39(2)122-30. doi: 10.1111/jvp.12256.

PMID:
    26228837
    [PubMed - in process]
Related citations


Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound.
Zhou Y, Malosh C, Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW
Bioorg Med Chem Lett. 2015 Sep 1; 25(17)3515-9. doi: 10.1016/j.bmcl.2015.06.096.

PMID:
    26183084
    [PubMed - indexed for MEDLINE]
Related citations