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Faculty Physicians

John S. Daniels, MD

Associate Professor, Clinical Medicine
Washington University Clinical Associates
University Internal Medicine and Diabetes Associates

Specialty Areas

Endocrinology
Diabetes
Internal Medicine
Primary Care

Board Certifications

Internal Medicine
Endocrinology and Metabolism

Areas of Clinical Interest

Endocrinology, diabetes, metabolism

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 13
Office Phone: 314-333-4100
Additional Phone: 1-800-437-5315
Fax: 314-333-4115

Education

Education

Fellowship: Endocrinology and Metabolism, Washington University School of Medicine, St. Louis, Missouri 1979
Residency: Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 1977
Medical Degree: University of Arkansas School of Medicine, Little Rock, Arkansas 1974
B.A.: Washington University, St. Louis, Missouri 1970

Publication & Research

Publication & Research

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ
Neuron. 2015 May 20; 86(4)1029-40. doi: 10.1016/j.neuron.2015.03.063.

PMID:
    25937172
    [PubMed - indexed for MEDLINE]
Related citations


Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains.
O'Reilly MC, Oguin TH 3rd, Scott SA, Thomas PG, Locuson CW, Morrison RD, Daniels JS, Brown HA, Lindsley CW
ChemMedChem. 2014 Dec; 9(12)2633-7. doi: 10.1002/cmdc.201402333.

PMID:
    25210004
    [PubMed - indexed for MEDLINE]
Related citations


Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.
Wen W, Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Locuson CW 2nd, Wood MR, Daniels JS, Wu W, Lindsley CW, Hamm HE, Stauffer SR
Bioorg Med Chem Lett. 2014 Oct 1; 24(19)4708-13. doi: 10.1016/j.bmcl.2014.08.021.

PMID:
    25176330
    [PubMed - indexed for MEDLINE]
Related citations


Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).
Gentry PR, Kokubo M, Bridges TM, Noetzel MJ, Cho HP, Lamsal A, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR
J Med Chem. 2014 Sep 25; 57(18)7804-10. doi: 10.1021/jm500995y.

PMID:
    25147929
    [PubMed - indexed for MEDLINE]
Related citations


Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.
Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW
ACS Chem Biol. 2014 Oct 17; 9(10)2334-46. doi: 10.1021/cb500560h.

PMID:
    25137254
    [PubMed - indexed for MEDLINE]
Related citations


Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.
Oguin TH 3rd, Sharma S, Stuart AD, Duan S, Scott SA, Jones CK, Daniels JS, Lindsley CW, Thomas PG, Brown HA
J Biol Chem. 2014 Sep 12; 289(37)25405-17. doi: 10.1074/jbc.M114.558817.

PMID:
    25065577
    [PubMed - indexed for MEDLINE]
Related citations


Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
Bates BS, Rodriguez AL, Felts AS, Morrison RD, Venable DF, Blobaum AL, Byers FW, Lawson KP, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA
Bioorg Med Chem Lett. 2014 Aug 1; 24(15)3307-14. doi: 10.1016/j.bmcl.2014.06.003.

PMID:
    24969015
    [PubMed - indexed for MEDLINE]
Related citations


Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
Turlington M, Noetzel MJ, Bridges TM, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Tong HM, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2014 Aug 1; 24(15)3641-6. doi: 10.1016/j.bmcl.2014.04.087.

PMID:
    24961642
    [PubMed - indexed for MEDLINE]
Related citations


Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).
Turlington M, Malosh C, Jacobs J, Manka JT, Noetzel MJ, Vinson PN, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martín-Martín ML, Tong HM, López S, MacDonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR
J Med Chem. 2014 Jul 10; 57(13)5620-37. doi: 10.1021/jm500259z.

PMID:
    24914612
    [PubMed - indexed for MEDLINE]
Related citations


Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe.
Gentry PR, Kokubo M, Bridges TM, Cho HP, Smith E, Chase P, Hodder PS, Utley TJ, Rajapakse A, Byers F, Niswender CM, Morrison RD, Daniels JS, Wood MR, Conn PJ, Lindsley CW
ChemMedChem. 2014 Aug; 9(8)1677-82. doi: 10.1002/cmdc.201402051.

PMID:
    24692176
    [PubMed - indexed for MEDLINE]
Related citations


Where there's smoke there must be ire! Nicotine addiction treatment: a review.
Potts DA, Daniels JS
Mo Med. 2014 Jan-Feb; 111(1)80-1, 83-4.

PMID:
    24645304
    [PubMed - indexed for MEDLINE]
Related citations


Neurovascular unit on a chip: implications for translational applications.
Alcendor DJ, Block FE 3rd, Cliffel DE, Daniels JS, Ellacott KL, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, McCawley LJ, McLaughlin B, McLean JA, Niswender KD, Pensabene V, Seale KT, Sherrod SD, Sung HJ, Tabb DL, Webb DJ, Wikswo JP
Stem Cell Res Ther. 2013; 4 Suppl 1S18. doi: 10.1186/scrt379.

PMID:
    24564885
    [PubMed - indexed for MEDLINE]
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Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.
Jones CK, Sheffler DJ, Williams R, Jadhav SB, Felts AS, Morrison RD, Niswender CM, Daniels JS, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2014 Feb 15; 24(4)1067-70. doi: 10.1016/j.bmcl.2014.01.013.

PMID:
    24461352
    [PubMed - indexed for MEDLINE]
Related citations


Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).
Gentry PR, Kokubo M, Bridges TM, Kett NR, Harp JM, Cho HP, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Wood MR, Lindsley CW
J Med Chem. 2013 Nov 27; 56(22)9351-5. doi: 10.1021/jm4013246.

PMID:
    24164599
    [PubMed - indexed for MEDLINE]
Related citations


Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.
Turlington M, Chun A, Tomar S, Eggler A, Grum-Tokars V, Jacobs J, Daniels JS, Dawson E, Saldanha A, Chase P, Baez-Santos YM, Lindsley CW, Hodder P, Mesecar AD, Stauffer SR
Bioorg Med Chem Lett. 2013 Nov 15; 23(22)6172-7. doi: 10.1016/j.bmcl.2013.08.112.

PMID:
    24080461
    [PubMed - indexed for MEDLINE]
Related citations


Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
Turlington M, Noetzel MJ, Chun A, Zhou Y, Gogliotti RD, Nguyen ED, Gregory KJ, Vinson PN, Rook JM, Gogi KK, Xiang Z, Bridges TM, Daniels JS, Jones C, Niswender CM, Meiler J, Conn PJ, Lindsley CW, Stauffer SR
J Med Chem. 2013 Oct 24; 56(20)7976-96. doi: 10.1021/jm401028t.

PMID:
    24050755
    [PubMed - indexed for MEDLINE]
Related citations


Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.
Blobaum AL, Bridges TM, Byers FW, Turlington ML, Mattmann ME, Morrison RD, Mackie C, Lavreysen H, Bartolomé JM, Macdonald GJ, Steckler T, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR, Daniels JS
Drug Metab Dispos. 2013 Dec; 41(12)2066-75. doi: 10.1124/dmd.113.052662.

PMID:
    24003250
    [PubMed - indexed for MEDLINE]
Related citations


Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.
Manka JT, Rodriguez AL, Morrison RD, Venable DF, Cho HP, Blobaum AL, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA
Bioorg Med Chem Lett. 2013 Sep 15; 23(18)5091-6. doi: 10.1016/j.bmcl.2013.07.029.

PMID:
    23932792
    [PubMed - indexed for MEDLINE]
Related citations


Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.
Bridges TM, Rook JM, Noetzel MJ, Morrison RD, Zhou Y, Gogliotti RD, Vinson PN, Xiang Z, Jones CK, Niswender CM, Lindsley CW, Stauffer SR, Conn PJ, Daniels JS
Drug Metab Dispos. 2013 Sep; 41(9)1703-14. doi: 10.1124/dmd.113.052084.

PMID:
    23821185
    [PubMed - indexed for MEDLINE]
Related citations


ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD
ACS Chem Neurosci. 2013 Sep 18; 4(9)1278-86. doi: 10.1021/cn400062a.

PMID:
    23730969
    [PubMed - indexed for MEDLINE]
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