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Faculty Physicians

John S. Daniels, MD

Associate Professor, Clinical Medicine
Washington University Clinical Associates
University Internal Medicine and Diabetes Associates

Specialty Areas

Endocrinology
Diabetes
Internal Medicine
Primary Care

Board Certifications

Internal Medicine
Endocrinology and Metabolism

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Endocrinology, diabetes, metabolism

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
University Internal Medicine and Diabetes Associates

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 13
Office Phone: 314-333-4100
Fax: 314-333-4115

Education

Education

Fellowship: Endocrinology and Metabolism, Washington University School of Medicine, St. Louis, Missouri 1979
Residency: Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 1977
Medical Degree: University of Arkansas School of Medicine, Little Rock, Arkansas 1974
B.A.: Washington University, St. Louis, Missouri 1970

Publication & Research

Publication & Research

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.
Conde-Ceide S, Alcázar J, Alonso de Diego SA, López S, Martín-Martín ML, Martínez-Viturro CM, Pena MA, Tong HM, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Lindsley CW, Bartolomé-Nebreda JM
Bioorg Med Chem Lett. 2016 Jan 15; 26(2)429-34. doi: 10.1016/j.bmcl.2015.11.098.

PMID:
    26684851
    [PubMed - in process]
Related citations


State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects.
Gould RW, Nedelcovych MT, Gong X, Tsai E, Bubser M, Bridges TM, Wood MR, Duggan ME, Brandon NJ, Dunlop J, Wood MW, Ivarsson M, Noetzel MJ, Daniels JS, Niswender CM, Lindsley CW, Conn PJ, Jones CK
Neuropharmacology. 2016 Mar; 102244-53. doi: 10.1016/j.neuropharm.2015.11.016.

PMID:
    26617071
    [PubMed - in process]
Related citations


Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.
Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA
J Med Chem. 2015 Nov 25; 58(22)9027-40. doi: 10.1021/acs.jmedchem.5b01371.

PMID:
    26524606
    [PubMed - in process]
Related citations


Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.
Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ
Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45)14078-83. doi: 10.1073/pnas.1512812112.

PMID:
    26508634
    [PubMed - in process]
Related citations


VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.
Nickols HH, Yuh JP, Gregory KJ, Morrison RD, Bates BS, Stauffer SR, Emmitte KA, Bubser M, Peng W, Nedelcovych MT, Thompson A, Lv X, Xiang Z, Daniels JS, Niswender CM, Lindsley CW, Jones CK, Conn PJ
J Pharmacol Exp Ther. 2016 Jan; 356(1)123-36. doi: 10.1124/jpet.115.226597.

PMID:
    26503377
    [PubMed - in process]
Related citations


Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Malosh C, Turlington M, Bridges TM, Rook JM, Noetzel MJ, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martínez-Viturro CM, Piedrafita M, Sánchez-Casado MR, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 Nov 15; 25(22)5115-20. doi: 10.1016/j.bmcl.2015.10.009.

PMID:
    26475522
    [PubMed - in process]
Related citations


Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.
Engers JL, Rodriguez AL, Konkol LC, Morrison RD, Thompson AD, Byers FW, Blobaum AL, Chang S, Venable DF, Loch MT, Niswender CM, Daniels JS, Jones CK, Conn PJ, Lindsley CW, Emmitte KA
J Med Chem. 2015 Sep 24; 58(18)7485-500. doi: 10.1021/acs.jmedchem.5b01005.

PMID:
    26335039
    [PubMed - indexed for MEDLINE]
Related citations


Partial mGlu<sub>5</sub> Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.
Gould RW, Amato RJ, Bubser M, Joffe ME, Nedelcovych MT, Thompson AD, Nickols HH, Yuh JP, Zhan X, Felts AS, Rodriguez AL, Morrison RD, Byers FW, Rook JM, Daniels JS, Niswender CM, Conn PJ, Emmitte KA, Lindsley CW, Jones CK
Neuropsychopharmacology. 2015 Aug 28; doi: 10.1038/npp.2015.265.

PMID:
    26315507
    [PubMed - as supplied by publisher]
Related citations


Optimization of a small molecule probe that restores e-cadherin expression.
Brogan JT, Stoops SL, Brady S, An H, Weaver C, Daniels JS, Beauchamp RD, Lindsley CW, Waterson AG
Bioorg Med Chem Lett. 2015 Oct 1; 25(19)4260-4. doi: 10.1016/j.bmcl.2015.07.104.

PMID:
    26299347
    [PubMed - in process]
Related citations


A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.
Blobaum AL, Byers FW, Bridges TM, Locuson CW, Conn PJ, Lindsley CW, Daniels JS
Drug Metab Dispos. 2015 Nov; 43(11)1718-26. doi: 10.1124/dmd.115.064006.

PMID:
    26265743
    [PubMed - in process]
Related citations


Evaluation of tizanidine as a marker of canine CYP1A2 activity.
Locuson CW, Williams P, Adcock JM, Daniels JS
J Vet Pharmacol Ther. 2015 Jul 30; doi: 10.1111/jvp.12256.

PMID:
    26228837
    [PubMed - as supplied by publisher]
Related citations


Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound.
Zhou Y, Malosh C, Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW
Bioorg Med Chem Lett. 2015 Sep 1; 25(17)3515-9. doi: 10.1016/j.bmcl.2015.06.096.

PMID:
    26183084
    [PubMed - in process]
Related citations


Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.
Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Garcia-Barrantes PM, Lavreysen H, Mackie C, Vinson PN, Rook JM, Bridges TM, Daniels JS, Megens A, Langlois X, Drinkenburg WH, Ahnaou A, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW
ACS Med Chem Lett. 2015 Jun 11; 6(6)716-20. doi: 10.1021/acsmedchemlett.5b00181.

PMID:
    26157544
    [PubMed]
Related citations


Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.
Ghoshal A, Rook JM, Dickerson JW, Roop GN, Morrison RD, Jalan-Sakrikar N, Lamsal A, Noetzel MJ, Poslusney MS, Wood MR, Melancon BJ, Stauffer SR, Xiang Z, Daniels JS, Niswender CM, Jones CK, Lindsley CW, Conn PJ
Neuropsychopharmacology. 2016 Jan; 41(2)598-610. doi: 10.1038/npp.2015.189.

PMID:
    26108886
    [PubMed - in process]
Related citations


Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility.
Senter T, Gogliotti RD, Han C, Locuson CW, Morrison R, Daniels JS, Cierpicki T, Grembecka J, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 Jul 1; 25(13)2720-5. doi: 10.1016/j.bmcl.2015.04.026.

PMID:
    25987377
    [PubMed - in process]
Related citations


Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ
Neuron. 2015 May 20; 86(4)1029-40. doi: 10.1016/j.neuron.2015.03.063.

PMID:
    25937172
    [PubMed - indexed for MEDLINE]
Related citations


VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.
Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F
J Infect Dis. 2015 Nov 1; 212(9)1439-48. doi: 10.1093/infdis/jiv228.

PMID:
    25883390
    [PubMed - indexed for MEDLINE]
Related citations


Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity
Gentry PR, Kokubo M, Bridges TM, Daniels JS, Niswender CM, Smith E, Chase P, Hodder PS, Rosen H, Conn PJ, Engers J, Brewer KA, Wood MR, Lindsley CW
. 2010;

PMID:
    25834910
    [PubMed]
Related citations


Progress towards small molecule inhibitors of the Menin-Mixed Lineage Leukemia (MLL) interaction with in vivo utility
Senter T, Gogliotti R, Han C, Locuson CW II, Morrison R, Daniels JS, Cierpicki T, Grembecka J, Lindsley CW, Stauffer SR
. 2010;

PMID:
    25834909
    [PubMed]
Related citations


Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core
Gentry PR, Kokubo M, Bridges TM, Daniels JS, Niswender CM, Smith E, Chase P, Hodder PS, Rosen H, Conn PJ, Engers J, Brewer KA, Lindsley CW, Wood MR
. 2010;

PMID:
    25834908
    [PubMed]
Related citations