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John Patterson Atkinson, MD

Samuel B. Grant Professor, Medicine
Division of Rheumatology
Professor, Molecular Microbiology

Specialty Areas

Rheumatology
Autoimmune Disease

Board Certifications

Allergy & Immunology
Internal Medicine
Rheumatology

Hospital Affiliations

Barnes-Jewish Hospital
VA Medical Center - St. Louis

Referral Information

Physician Referral Required

Areas of Clinical Interest

SLE, vasculitis, autoimmunity, complement, hereditary angioedema, idiopathic inflammatory syndromes

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-286-2635
Fax: 314-286-2338

Education

Education

Fellowship: Rheumatology, Massachusetts General Hospital, Nat Institutes of Health, Boston, Massachusetts 1974
Fellowship: Allergy & Clinical Immunology, National Institutes of Health, Boston, Massachusetts 1974
Residency: Internal Medicine, Massachusetts General Hospital, Nat Institutes of Health, Boston, Massachusetts 1972
Medical Degree: Kansas University, Lawrence, Kansas 1969
B.A.: Kansas University, Lawrence, Kansas 1965

Publication & Research

Publication & Research

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.
Lokki AI, Daly E, Triebwasser M, Kurki MI, Roberson EDO, Häppölä P, Auro K, Perola M, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Salmon JE, Meri S, Daly M, Atkinson JP, Laivuori H
Hypertension. 2017 Aug; 70(2)365-371. doi: 10.1161/HYPERTENSIONAHA.117.09406.

PMID:
    28652462
    [PubMed - indexed for MEDLINE]
Related citations


DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd
J Autoimmun. 2017 Jul; 8113-23. doi: 10.1016/j.jaut.2017.03.001.

PMID:
    28325644
    [PubMed - in process]
Related citations


Complement's hidden arsenal: New insights and novel functions inside the cell.
Liszewski MK, Elvington M, Kulkarni HS, Atkinson JP
Mol Immunol. 2017 Apr; 842-9. doi: 10.1016/j.molimm.2017.01.004.

PMID:
    28196665
    [PubMed - indexed for MEDLINE]
Related citations


A C3(H20) recycling pathway is a component of the intracellular complement system.
Elvington M, Liszewski MK, Bertram P, Kulkarni HS, Atkinson JP
J Clin Invest. 2017 Mar 1; 127(3)970-981. doi: 10.1172/JCI89412.

PMID:
    28192370
    [PubMed - indexed for MEDLINE]
Related citations


Complement Dysregulation and Disease: Insights from Contemporary Genetics.
Liszewski MK, Java A, Schramm EC, Atkinson JP
Annu Rev Pathol. 2017 Jan 24; 1225-52. doi: 10.1146/annurev-pathol-012615-044145.

PMID:
    27959629
    [PubMed - indexed for MEDLINE]
Related citations


Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.
Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B
J Clin Invest. 2016 Dec 1; 126(12)4640-4653. doi: 10.1172/JCI85856.

PMID:
    27841764
    [PubMed - indexed for MEDLINE]
Related citations


Secreted NS1 Protects Dengue Virus from Mannose-Binding Lectin-Mediated Neutralization.
Thiemmeca S, Tamdet C, Punyadee N, Prommool T, Songjaeng A, Noisakran S, Puttikhunt C, Atkinson JP, Diamond MS, Ponlawat A, Avirutnan P
J Immunol. 2016 Nov 15; 197(10)4053-4065.

PMID:
    27798151
    [PubMed - indexed for MEDLINE]
Related citations


Evolution of the complement system: from defense of the single cell to guardian of the intravascular space.
Elvington M, Liszewski MK, Atkinson JP
Immunol Rev. 2016 Nov; 274(1)9-15. doi: 10.1111/imr.12474.

PMID:
    27782327
    [PubMed - indexed for MEDLINE]
Related citations


Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.
Stam AH, Kothari PH, Shaikh A, Gschwendter A, Jen JC, Hodgkinson S, Hardy TA, Hayes M, Kempster PA, Kotschet KE, Bajema IM, van Duinen SG, Maat-Schieman ML, de Jong PT, de Smet MD, de Wolff-Rouendaal D, Dijkman G, Pelzer N, Kolar GR, Schmidt RE, Lacey J, Joseph D, Fintak DR, Grand MG, Brunt EM, Liapis H, Hajj-Ali RA, Kruit MC, van Buchem MA, Dichgans M, Frants RR, van den Maagdenberg AM, Haan J, Baloh RW, Atkinson JP, Terwindt GM, Ferrari MD
Brain. 2016 Sep 6; pii: aww217.

PMID:
    27604306
    [PubMed - as supplied by publisher]
Related citations


Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD.
Wagner EK, Raychaudhuri S, Villalonga MB, Java A, Triebwasser MP, Daly MJ, Atkinson JP, Seddon JM
Sci Rep. 2016 Aug 30; 631531. doi: 10.1038/srep31531.

PMID:
    27572114
    [PubMed - in process]
Related citations


The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype.
Lyzogubov VV, Bora PS, Wu X, Horn LE, de Roque R, Rudolf XV, Atkinson JP, Bora NS
Am J Pathol. 2016 Aug; 186(8)2088-2104. doi: 10.1016/j.ajpath.2016.03.021.

PMID:
    27295359
    [PubMed - indexed for MEDLINE]
Related citations


Von Willebrand factor regulates complement on endothelial cells.
Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr WH, Licht C
Kidney Int. 2016 Jul; 90(1)123-34. doi: 10.1016/j.kint.2016.03.023.

PMID:
    27236750
    [PubMed - in process]
Related citations


Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.
Forneris F, Wu J, Xue X, Ricklin D, Lin Z, Sfyroera G, Tzekou A, Volokhina E, Granneman JC, Hauhart R, Bertram P, Liszewski MK, Atkinson JP, Lambris JD, Gros P
EMBO J. 2016 May 17; 35(10)1133-49. doi: 10.15252/embj.201593673.

PMID:
    27013439
    [PubMed - indexed for MEDLINE]
Related citations


Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function.
Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, Mastroeni D, Clarke EV, Rogers J, Atkinson JP, Tenner AJ
PLoS One. 2016; 11(2)e0149792. doi: 10.1371/journal.pone.0149792.

PMID:
    26914463
    [PubMed - indexed for MEDLINE]
Related citations


Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases.
Lintner KE, Wu YL, Yang Y, Spencer CH, Hauptmann G, Hebert LA, Atkinson JP, Yu CY
Front Immunol. 2016; 736. doi: 10.3389/fimmu.2016.00036.

PMID:
    26913032
    [PubMed]
Related citations


Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration.
Triebwasser MP, Roberson ED, Yu Y, Schramm EC, Wagner EK, Raychaudhuri S, Seddon JM, Atkinson JP
Invest Ophthalmol Vis Sci. 2015 Oct; 56(11)6873-8. doi: 10.1167/iovs.15-17432.

PMID:
    26501415
    [PubMed - indexed for MEDLINE]
Related citations


A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H.
Chauvet S, Roumenina LT, Bruneau S, Marinozzi MC, Rybkine T, Schramm EC, Java A, Atkinson JP, Aldigier JC, Bridoux F, Touchard G, Fremeaux-Bacchi V
J Am Soc Nephrol. 2016 Jun; 27(6)1665-77. doi: 10.1681/ASN.2015040348.

PMID:
    26471127
    [PubMed - indexed for MEDLINE]
Related citations


Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N
Immunity. 2015 Sep 15; 43(3)463-74. doi: 10.1016/j.immuni.2015.07.022.

PMID:
    26320659
    [PubMed - indexed for MEDLINE]
Related citations


Role of complement receptor 1 (CR1; CD35) on epithelial cells: A model for understanding complement-mediated damage in the kidney.
Java A, Liszewski MK, Hourcade DE, Zhang F, Atkinson JP
Mol Immunol. 2015 Oct; 67(2 Pt B)584-95. doi: 10.1016/j.molimm.2015.07.016.

PMID:
    26260209
    [PubMed - indexed for MEDLINE]
Related citations


Complement regulator CD46: genetic variants and disease associations.
Liszewski MK, Atkinson JP
Hum Genomics. 2015 Jun 10; 97. doi: 10.1186/s40246-015-0029-z.

PMID:
    26054645
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Compliment

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2017