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John F. DiPersio, MD, PhD

Virginia E. and Samuel J Golman Endowed Professorship of Medicine, Pathology & Immunology
Professor, Pediatrics
Professor, Pathology
Chief, Division of Oncology
Deputy Director, Siteman Cancer Center

Specialty Areas

Bone Marrow Transplant
Hematology
Leukemia
Hematologic Malignancies
Gene Therapy

Board Certifications

Hematology
Internal Medicine
Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hematology, oncology, bone marrow transplantation, hematopoietic stem cell transplantation, molecular biology, cellular biology, leukemia, MDS, aplastic anemia

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-747-7222

Suite: B
Floor: 7
Office Phone: 314-454-8304
Fax: 314-454-7551

Education

Education

Fellowship: Hematology & Oncology, UCLA School of Medicine, Los Angeles, CA 1987
Chief Resident: Internal Medicine, Parkland Memorial Hospital, Dallas, TX 1984
Residency: Internal Medicine, Parkland Memorial Hospital, Dallas, TX 1983
Ph.D.: Microbiology, University of Rochester School of Medicine, Rochester, NY 1980
Medical Degree: University Of Rochester School of Medicine, Rochester, NY 1980
B.A.: Biology, Williams College 1973

Publication & Research

Publication & Research

Pathogenic Germline Variants in 10,389 Adult Cancers.
Huang KL, Mashl RJ, Wu Y, Ritter DI, Wang J, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, Scott AD, Krassowski M, Cherniack AD, Houlahan KE, Jayasinghe R, Wang LB, Zhou DC, Liu D, Cao S, Kim YW, Koire A, McMichael JF, Hucthagowder V, Kim TB, Hahn A, Wang C, McLellan MD, Al-Mulla F, Johnson KJ, Cancer Genome Atlas Research Network., Lichtarge O, Boutros PC, Raphael B, Lazar AJ, Zhang W, Wendl MC, Govindan R, Jain S, Wheeler D, Kulkarni S, Dipersio JF, Reimand J, Meric-Bernstam F, Chen K, Shmulevich I, Plon SE, Chen F, Ding L
Cell. 2018 Apr 5; 173(2)355-370.e14. doi: 10.1016/j.cell.2018.03.039.

PMID:
    29625052
    [PubMed - in process]
Related citations


A Phase 1 Trial of CNDO-109-Activated Natural Killer Cells in Patients with High-Risk Acute Myeloid Leukemia.
Fehniger TA, Miller JS, Stuart RK, Cooley S, Salhotra A, Curtsinger J, Westervelt P, DiPersio JF, Hillman TM, Silver N, Szarek M, Gorelik L, Lowdell MW, Rowinsky E
Biol Blood Marrow Transplant. 2018 Mar 27; pii: S1083-8791(18)30132-0. doi: 10.1016/j.bbmt.2018.03.019.

PMID:
    29597002
    [PubMed - as supplied by publisher]
Related citations


Lenalidomide results in a durable complete remission in acute myeloid leukemia accompanied by persistence of somatic mutations and a T cell infiltrate in the bone marrow.
Bansal D, Vij K, Chang GS, Miller CA, DiPersio JF, Vij R, Heath SE, Westervelt P, Welch JS, Fehniger TA
Haematologica. 2018 Mar 22; pii: haematol.2017.184168. doi: 10.3324/haematol.2017.184168.

PMID:
    29567774
    [PubMed - as supplied by publisher]
Related citations


A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5.
White BS, Lanc I, O'Neal J, Gupta H, Fulton RS, Schmidt H, Fronick C, Belter EA Jr., Fiala M, King J, Ahmann GJ, DeRome M, Mardis ER, Vij R, DiPersio JF, Levy J, Auclair D, Tomasson MH
Blood Cancer J. 2018 Mar 21; 8(3)35. doi: 10.1038/s41408-018-0062-y.

PMID:
    29563506
    [PubMed - in process]
Related citations


Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
JCI Insight. 2018 Mar 8; 3(5)pii: 98962. doi: 10.1172/jci.insight.98962.

PMID:
    29515031
    [PubMed - as supplied by publisher]
Related citations


An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.
Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
Leukemia. 2018 Feb 20; doi: 10.1038/s41375-018-0065-5.

PMID:
    29483708
    [PubMed - as supplied by publisher]
Related citations


First-in-human Phase 1 Clinical Study of the IL-15 Superagonist Complex ALT-803 to Treat Relapse after Transplantation.
Romee R, Cooley S, Berrien-Elliott MM, Westervelt P, Verneris MR, Wagner JE, Weisdorf DJ, Blazar BR, Ustun C, DeFor TE, Vivek S, Peck L, DiPersio JF, Cashen AF, Kyllo R, Musiek A, Schaffer A, Anadkat MJ, Rosman I, Miller D, Egan JO, Jeng EK, Rock A, Wong HC, Fehniger TA, Miller JS
Blood. 2018 Feb 20; pii: blood-2017-12-823757. doi: 10.1182/blood-2017-12-823757.

PMID:
    29463563
    [PubMed - as supplied by publisher]
Related citations


Plerixafor Plus Granulocyte Colony-Stimulating Factor for Patients with Non-Hodgkin Lymphoma and Multiple Myeloma: Long-Term Follow-Up Report.
Micallef IN, Stiff PJ, Nademanee AP, Maziarz RT, Horwitz ME, Stadtmauer EA, Kaufman JL, McCarty JM, Vargo R, Cheverton PD, Struijs M, Bolwell B, DiPersio JF
Biol Blood Marrow Transplant. 2018 Feb 2; pii: S1083-8791(18)30056-9. doi: 10.1016/j.bbmt.2018.01.039.

PMID:
    29410180
    [PubMed - as supplied by publisher]
Related citations


Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC
Nat Commun. 2018 Jan 31; 9(1)455. doi: 10.1038/s41467-018-02858-0.

PMID:
    29386642
    [PubMed - in process]
Related citations


Acute graft-versus-host disease following lung transplantation in a patient with a novel <i>TERT</i> mutation.
Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
Thorax. 2018 May; 73(5)489-492. doi: 10.1136/thoraxjnl-2017-211121.

PMID:
    29382801
    [PubMed - in process]
Related citations


Selected biological issues affecting relapse after stem cell transplantation: role of T-cell impairment, NK cells and intrinsic tumor resistance.
van den Brink M, Uhrberg M, Jahn L, DiPersio JF, Pulsipher MA
Bone Marrow Transplant. 2018 Jan 24; doi: 10.1038/s41409-017-0078-0.

PMID:
    29367714
    [PubMed - as supplied by publisher]
Related citations


Ruxolitinib: a steroid sparing agent in chronic graft-versus-host disease.
Khoury HJ, Langston AA, Kota VK, Wilkinson JA, Pusic I, Jillella A, Bauer S, Kim AS, Roberts D, Al-Kadhimi Z, Bodo I, Winton E, Arellano M, DiPersio JF
Bone Marrow Transplant. 2018 Jan 24; doi: 10.1038/s41409-017-0081-5.

PMID:
    29367708
    [PubMed - as supplied by publisher]
Related citations


Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer.
Kotagiri N, Cooper ML, Rettig M, Egbulefu C, Prior J, Cui G, Karmakar P, Zhou M, Yang X, Sudlow G, Marsala L, Chanswangphuwana C, Lu L, Habimana-Griffin L, Shokeen M, Xu X, Weilbaecher K, Tomasson M, Lanza G, DiPersio JF, Achilefu S
Nat Commun. 2018 Jan 18; 9(1)275. doi: 10.1038/s41467-017-02758-9.

PMID:
    29348537
    [PubMed - indexed for MEDLINE]
Related citations


The Role of Janus Kinase Signaling in Graft-Versus-Host Disease and Graft Versus Leukemia.
Schroeder MA, Choi J, Staser K, DiPersio JF
Biol Blood Marrow Transplant. 2017 Dec 28; pii: S1083-8791(17)31829-3. doi: 10.1016/j.bbmt.2017.12.797.

PMID:
    29289756
    [PubMed - as supplied by publisher]
Related citations


OMIP-042: 21-color flow cytometry to comprehensively immunophenotype major lymphocyte and myeloid subsets in human peripheral blood.
Staser KW, Eades W, Choi J, Karpova D, DiPersio JF
Cytometry A. 2018 Feb; 93(2)186-189. doi: 10.1002/cyto.a.23303.

PMID:
    29288606
    [PubMed - in process]
Related citations


Diabetes mellitus as a poor mobilizer condition.
Fadini GP, DiPersio JF
Blood Rev. 2017 Nov 8; pii: S0268-960X(17)30055-3. doi: 10.1016/j.blre.2017.11.002.

PMID:
    29132746
    [PubMed - as supplied by publisher]
Related citations


Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10-day decitabine regimen.
Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS
Cancer Med. 2017 Dec; 6(12)2814-2821. doi: 10.1002/cam4.1231.

PMID:
    29058375
    [PubMed - indexed for MEDLINE]
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Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation.
Soiffer RJ, Kim HT, McGuirk J, Horwitz ME, Johnston L, Patnaik MM, Rybka W, Artz A, Porter DL, Shea TC, Boyer MW, Maziarz RT, Shaughnessy PJ, Gergis U, Safah H, Reshef R, DiPersio JF, Stiff PJ, Vusirikala M, Szer J, Holter J, Levine JD, Martin PJ, Pidala JA, Lewis ID, Ho VT, Alyea EP, Ritz J, Glavin F, Westervelt P, Jagasia MH, Chen YB
J Clin Oncol. 2017 Dec 20; 35(36)4003-4011. doi: 10.1200/JCO.2017.75.8177.

PMID:
    29040031
    [PubMed - indexed for MEDLINE]
Related citations


Donor-lymphocyte infusion following haploidentical hematopoietic cell transplantation with peripheral blood stem cell grafts and PTCy.
Goldsmith SR, Slade M, DiPersio JF, Westervelt P, Schroeder MA, Gao F, Romee R
Bone Marrow Transplant. 2017 Dec; 52(12)1623-1628. doi: 10.1038/bmt.2017.193.

PMID:
    29035393
    [PubMed - in process]
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Lack of a Prognostic Impact of the MyD88 L265P Mutation for Diffuse Large B Cell Lymphoma Patients Undergoing Autologous Stem Cell Transplantation.
Lee YS, Liu J, Fricano KA, Webb EM, Toolsie DR, Jones S, Rhoads JA, Vij R, Cashen AF, Abboud CN, Westervelt P, Bartlett NL, Dipersio JF, Kreisel FH, Lim KH
Biol Blood Marrow Transplant. 2017 Dec; 23(12)2199-2204. doi: 10.1016/j.bbmt.2017.08.022.

PMID:
    28847710
    [PubMed - in process]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Magenta Therapeutics

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2017