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John F. DiPersio, MD, PhD

Virginia E. and Samuel J Golman Endowed Professorship of Medicine, Pathology & Immunology
Professor, Pediatrics
Professor, Pathology
Chief, Division of Oncology
Deputy Director, Siteman Cancer Center

Specialty Areas

Bone Marrow Transplant
Hematology
Leukemia
Hematologic Malignancies
Gene Therapy

Board Certifications

Hematology
Internal Medicine
Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hematology, oncology, bone marrow transplantation, hematopoietic stem cell transplantation, molecular biology, cellular biology, leukemia, MDS, aplastic anemia

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-747-7222

Suite: B
Floor: 7
Office Phone: 314-454-8304
Fax: 314-454-7551

Education

Education

Fellowship: Hematology & Oncology, UCLA School of Medicine, Los Angeles, CA 1987
Chief Resident: Internal Medicine, Parkland Memorial Hospital, Dallas, TX 1984
Residency: Internal Medicine, Parkland Memorial Hospital, Dallas, TX 1983
Ph.D.: Microbiology, University of Rochester School of Medicine, Rochester, NY 1980
Medical Degree: University Of Rochester School of Medicine, Rochester, NY 1980
B.A.: Biology, Williams College 1973

Publication & Research

Publication & Research

Immune responses and long-term disease recurrence status after telomerase-based dendritic cell immunotherapy in patients with acute myeloid leukemia.
Khoury HJ, Collins RH Jr, Blum W, Stiff PS, Elias L, Lebkowski JS, Reddy A, Nishimoto KP, Sen D, Wirth ED 3rd, Case CC, DiPersio JF
Cancer. 2017 Apr 14; doi: 10.1002/cncr.30696.

PMID:
    28411378
    [PubMed - as supplied by publisher]
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Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells.
Karpova D, Ritchey J, Holt M, Abou-Ezzi G, Monlish D, Batoon L, Millard S, Spohn G, Wiercinska E, Chendamarai E, Yang W, Christ S, Gehrs L, Schuettpelz LG, Dembowsky K, Pettit AR, Rettig M, Boenig H, DiPersio JF
Blood. 2017 Apr 11; pii: blood-2016-10-746909. doi: 10.1182/blood-2016-10-746909.

PMID:
    28400375
    [PubMed - as supplied by publisher]
Related citations


Azacitidine Mitigates Graft-versus-Host Disease via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells In Vivo.
Cooper ML, Choi J, Karpova D, Vij K, Ritchey J, Schroeder MA, DiPersio JF
J Immunol. 2017 May 1; 198(9)3746-3754. doi: 10.4049/jimmunol.1502399.

PMID:
    28330901
    [PubMed - in process]
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Fresh or Cryopreserved CD34<sup>+</sup>-Selected Mobilized Peripheral Blood Stem and Progenitor Cells for the Treatment of Poor Graft Function after Allogeneic Hematopoietic Cell Transplantation.
Ghobadi A, Fiala MA, Ramsingh G, Gao F, Abboud CN, Stockerl-Goldstein K, Uy GL, Grossman BJ, Westervelt P, DiPersio JF
Biol Blood Marrow Transplant. 2017 Mar 18; pii: S1083-8791(17)30338-5. doi: 10.1016/j.bbmt.2017.03.019.

PMID:
    28323004
    [PubMed - as supplied by publisher]
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Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft.
Schroeder MA, Rettig MP, Lopez S, Christ S, Fiala M, Eades W, Mir FA, Shao J, McFarland K, Trinkaus K, Shannon W, Deych E, Yu J, Vij R, Stockerl-Goldstein K, Cashen AF, Uy GL, Abboud CN, Westervelt P, DiPersio JF
Blood. 2017 Mar 14; pii: blood-2016-09-739722. doi: 10.1182/blood-2016-09-739722.

PMID:
    28292947
    [PubMed - as supplied by publisher]
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A phase 1/2 study of chemosensitization with plerixafor plus G-CSF in relapsed or refractory acute myeloid leukemia.
Uy GL, Rettig MP, Stone RM, Konopleva MY, Andreeff M, McFarland K, Shannon W, Fletcher TR, Reineck T, Eades W, Stockerl-Goldstein K, Abboud CN, Jacoby MA, Westervelt P, DiPersio JF
Blood Cancer J. 2017 Mar 10; 7(3)e542. doi: 10.1038/bcj.2017.21.

PMID:
    28282031
    [PubMed - in process]
Related citations


Cardiomyopathy in patients after posttransplant cyclophosphamide-based hematopoietic cell transplantation.
Lin CJ, Vader JM, Slade M, DiPersio JF, Westervelt P, Romee R
Cancer. 2017 Mar 6; doi: 10.1002/cncr.30534.

PMID:
    28262921
    [PubMed - as supplied by publisher]
Related citations


Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial.
Verstovsek S, Mesa RA, Gotlib J, Gupta V, DiPersio JF, Catalano JV, Deininger MW, Miller CB, Silver RT, Talpaz M, Winton EF, Harvey JH Jr, Arcasoy MO, Hexner EO, Lyons RM, Paquette R, Raza A, Jones M, Kornacki D, Sun K, Kantarjian H, COMFORT-I investigators.
J Hematol Oncol. 2017 Feb 22; 10(1)55. doi: 10.1186/s13045-017-0417-z.

PMID:
    28228106
    [PubMed - in process]
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CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - in process]
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Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia.
Han L, Jorgensen JL, Brooks C, Shi C, Zhang Q, Nogueras González GM, Cavazos A, Pan R, Mu H, Wang SA, Zhou J, Ai-Atrash G, Ciurea SO, Rettig M, DiPersio JF, Cortes J, Huang X, Kantarjian HM, Andreeff M, Ravandi F, Konopleva M
Clin Cancer Res. 2017 Jan 17; doi: 10.1158/1078-0432.CCR-16-1904.

PMID:
    28096272
    [PubMed - as supplied by publisher]
Related citations


T Cell-Replete Peripheral Blood Haploidentical Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide Results in Outcomes Similar to Transplantation from Traditionally Matched Donors in Active Disease Acute Myeloid Leukemia.
How J, Slade M, Vu K, DiPersio JF, Westervelt P, Uy GL, Abboud CN, Vij R, Schroeder MA, Fehniger TA, Romee R
Biol Blood Marrow Transplant. 2017 Apr; 23(4)648-653. doi: 10.1016/j.bbmt.2017.01.068.

PMID:
    28087457
    [PubMed - in process]
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Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - in process]
Related citations


Single institution experience with G-CSF mobilized T-cell replete haploidentical hematopoietic cell transplantation.
Huselton E, Slade M, DiPersio JF, Westervelt P, Vij R, Uy GL, Fehniger TA, Abboud CN, Gao F, Schroeder MA, Romee R
Bone Marrow Transplant. 2017 Jan 9; doi: 10.1038/bmt.2016.354.

PMID:
    28067881
    [PubMed - as supplied by publisher]
Related citations


Epidemiology of infections following haploidentical peripheral blood hematopoietic cell transplantation.
Slade M, Goldsmith S, Romee R, DiPersio JF, Dubberke ER, Westervelt P, Uy GL, Lawrence SJ
Transpl Infect Dis. 2017 Feb; 19(1)doi: 10.1111/tid.12629.

PMID:
    28030755
    [PubMed - in process]
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TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
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A proposed biology- and biomarker-based algorithm for management of acute GvHD.
Ali AM, DiPersio JF, Schroeder MA
Bone Marrow Transplant. 2017 Feb; 52(2)337-340. doi: 10.1038/bmt.2016.289.

PMID:
    27869807
    [PubMed - in process]
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Tissue polymerase chain reaction for the diagnosis of cytomegalovirus disease after allogeneic hematopoietic cell transplantation.
Rashidi A, Vij KR, Buller RS, Wylie KM, Storch GA, DiPersio JF
Am J Hematol. 2017 Feb; 92(2)E19-E20. doi: 10.1002/ajh.24609.

PMID:
    27859620
    [PubMed - in process]
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Cytomegalovirus viremia, disease, and impact on relapse in T-cell replete peripheral blood haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide.
Goldsmith SR, Slade M, DiPersio JF, Westervelt P, Lawrence SJ, Uy GL, Abboud CN, Vij R, Schroeder MA, Fehniger TA, Dubberke ER, Trinkaus K, Romee R
Haematologica. 2016 Nov; 101(11)e465-e468.

PMID:
    27443287
    [PubMed - in process]
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Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia. 2017 Apr; 31(4)872-881. doi: 10.1038/leu.2016.282.

PMID:
    27740633
    [PubMed - in process]
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Enhanced in utero allogeneic engraftment in mice after mobilizing fetal HSCs by α4β1/7 inhibition.
Kim AG, Vrecenak JD, Boelig MM, Eissenberg L, Rettig MP, Riley JS, Holt MS, Conner MA, Loukogeorgakis SP, Li H, DiPersio JF, Flake AW, Peranteau WH
Blood. 2016 Nov 17; 128(20)2457-2461.

PMID:
    27650329
    [PubMed - in process]
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