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Faculty Physicians

John F. DiPersio, MD, PhD

Virginia E. and Samuel J Golman Endowed Professorship of Medicine, Pathology & Immunology
Professor, Pediatrics
Professor, Pathology
Chief, Division of Oncology
Deputy Director, Siteman Cancer Center

Specialty Areas

Bone Marrow Transplant
Hematology
Leukemia
Hematologic Malignancies
Gene Therapy

Board Certifications

Hematology
Internal Medicine
Oncology

Areas of Clinical Interest

Hematology, oncology, bone marrow transplantation, hematopoietic stem cell transplantation, molecular biology, cellular biology, leukemia, MDS, aplastic anemia

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-454-8304
Fax: 314-454-7551

Education

Education

Fellowship: Hematology & Oncology, UCLA School of Medicine, Los Angeles, CA 1987
Chief Resident: Internal Medicine, Parkland Memorial Hospital, Dallas, TX 1984
Residency: Internal Medicine, Parkland Memorial Hospital, Dallas, TX 1983
Ph.D.: Microbiology, University of Rochester School of Medicine, Rochester, NY 1980
Medical Degree: University Of Rochester School of Medicine, Rochester, NY 1980
B.A.: Biology, Williams College 1973

Publication & Research

Publication & Research

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
Nature. 2015 Feb 26; 518(7540)552-5. doi: 10.1038/nature13968.

PMID:
    25487151
    [PubMed - indexed for MEDLINE]
Related citations


Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, Dipersio JF, Chen F, Wilson RK, Ley TJ, Ding L
Nat Med. 2014 Dec; 20(12)1472-8. doi: 10.1038/nm.3733.

PMID:
    25326804
    [PubMed - indexed for MEDLINE]
Related citations


SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.
Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
PLoS Comput Biol. 2014 Aug; 10(8)e1003665. doi: 10.1371/journal.pcbi.1003665.

PMID:
    25102416
    [PubMed - indexed for MEDLINE]
Related citations


CMV prophylaxis in hematopoietic-cell transplantation.
Romee R, DiPersio JF
N Engl J Med. 2014 Aug 7; 371(6)576. doi: 10.1056/NEJMc1406756#SA1.

PMID:
    25099586
    [PubMed - indexed for MEDLINE]
Related citations


A phase II study of V-BEAM as conditioning regimen before second auto-SCT for multiple myeloma.
Wang TF, Fiala MA, Cashen AF, Uy GL, Abboud CN, Fletcher T, Wu N, Westervelt P, DiPersio JF, Stockerl-Goldstein KE, Vij R
Bone Marrow Transplant. 2014 Nov; 49(11)1366-70. doi: 10.1038/bmt.2014.163.

PMID:
    25068418
    [PubMed - indexed for MEDLINE]
Related citations


Reconsideration of age as a contraindication for curative therapy of sickle cell disease.
King AA, DiPersio JF
JAMA. 2014 Jul 2; 312(1)33-4. doi: 10.1001/jama.2014.7193.

PMID:
    25058214
    [PubMed - indexed for MEDLINE]
Related citations


Conservative management of pneumatosis intestinalis after allogeneic hematopoietic SCT.
Bhamidipati PK, Ghobadi A, Bauer S, DiPersio JF, Pusic I
Bone Marrow Transplant. 2014 Nov; 49(11)1436-8. doi: 10.1038/bmt.2014.148.

PMID:
    25046216
    [PubMed - indexed for MEDLINE]
Related citations


Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic.
Al-Hussaini M, DiPersio JF
Expert Rev Hematol. 2014 Aug; 7(4)439-64. doi: 10.1586/17474086.2014.932687.

PMID:
    25025370
    [PubMed - indexed for MEDLINE]
Related citations


Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.
Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, Mardis ER, Wilson RK, Ley TJ, Walter MJ, Graubert TA
PLoS Genet. 2014 Jul; 10(7)e1004462. doi: 10.1371/journal.pgen.1004462.

PMID:
    25010716
    [PubMed - indexed for MEDLINE]
Related citations


Haploidentical transplantation using G-CSF-mobilized T-cell replete PBSCs and post-transplantation CY after non-myeloablative conditioning is safe and is associated with favorable outcomes.
Bhamidipati PK, DiPersio JF, Stokerl-Goldstein K, Rashidi A, Gao F, Uy GL, Westervelt P, Vij R, Schroeder MA, Abboud CN, Keller JW, Fehniger TA, Romee R
Bone Marrow Transplant. 2014 Aug; 49(8)1124-6. doi: 10.1038/bmt.2014.108.

PMID:
    24842528
    [PubMed - indexed for MEDLINE]
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A phase I dose escalation study of oral bexarotene in combination with intravenous decitabine in patients with AML.
Welch JS, Niu H, Uy GL, Westervelt P, Abboud CN, Vij R, Stockerl-Goldstein KE, Jacoby M, Pusic I, Schroeder MA, Dipersio JF, Cashen AF
Am J Hematol. 2014 Aug; 89(8)E103-8. doi: 10.1002/ajh.23735.

PMID:
    24723466
    [PubMed - indexed for MEDLINE]
Related citations


Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, Dipersio JF, Wilson RK, Ley TJ
Cancer Cell. 2014 Mar 17; 25(3)379-92. doi: 10.1016/j.ccr.2014.01.031.

PMID:
    24613412
    [PubMed - indexed for MEDLINE]
Related citations


Phase I study of cladribine, cytarabine, granulocyte colony stimulating factor (CLAG regimen) and midostaurin and all-trans retinoic acid in relapsed/refractory AML.
Ramsingh G, Westervelt P, McBride A, Stockerl-Goldstein K, Vij R, Fiala M, Uy G, Cashen A, Dipersio JF, Abboud CN
Int J Hematol. 2014 Mar; 99(3)272-8. doi: 10.1007/s12185-014-1503-4.

PMID:
    24488798
    [PubMed - indexed for MEDLINE]
Related citations


Advances in stem cell mobilization.
Hopman RK, DiPersio JF
Blood Rev. 2014 Jan; 28(1)31-40. doi: 10.1016/j.blre.2014.01.001.

PMID:
    24476957
    [PubMed - indexed for MEDLINE]
Related citations


Genomic tools in acute myeloid leukemia: From the bench to the bedside.
White BS, DiPersio JF
Cancer. 2014 Apr 15; 120(8)1134-44. doi: 10.1002/cncr.28552.

PMID:
    24474533
    [PubMed - indexed for MEDLINE]
Related citations


Phase I study of oral clofarabine consolidation in adults aged 60 and older with acute myeloid leukemia.
Jacoby MA, Martin MG, Uy GL, Westervelt P, Dipersio JF, Cashen A, Stockerl-Goldstein K, Vij R, Luo J, Reineck T, Bernabe N, Abboud CN
Am J Hematol. 2014 May; 89(5)487-92. doi: 10.1002/ajh.23663.

PMID:
    24415560
    [PubMed - indexed for MEDLINE]
Related citations


Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial.
Choi SW, Braun T, Chang L, Ferrara JL, Pawarode A, Magenau JM, Hou G, Beumer JH, Levine JE, Goldstein S, Couriel DR, Stockerl-Goldstein K, Krijanovski OI, Kitko C, Yanik GA, Lehmann MH, Tawara I, Sun Y, Paczesny S, Mapara MY, Dinarello CA, DiPersio JF, Reddy P
Lancet Oncol. 2014 Jan; 15(1)87-95. doi: 10.1016/S1470-2045(13)70512-6.

PMID:
    24295572
    [PubMed - indexed for MEDLINE]
Related citations


F11R is a novel monocyte prognostic biomarker for malignant glioma.
Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH
PLoS One. 2013; 8(10)e77571. doi: 10.1371/journal.pone.0077571.

PMID:
    24147027
    [PubMed - indexed for MEDLINE]
Related citations


Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen.
Manjappa S, Bhamidipati PK, Stokerl-Goldstein KE, DiPersio JF, Uy GL, Westervelt P, Liu J, Schroeder MA, Vij R, Abboud CN, Fehniger TA, Cashen AF, Pusic I, Jacoby M, Meera SJ, Romee R
Biol Blood Marrow Transplant. 2014 Jan; 20(1)46-52. doi: 10.1016/j.bbmt.2013.10.003.

PMID:
    24120526
    [PubMed - indexed for MEDLINE]
Related citations


Prospective cohort study comparing intravenous busulfan to total body irradiation in hematopoietic cell transplantation.
Bredeson C, LeRademacher J, Kato K, Dipersio JF, Agura E, Devine SM, Appelbaum FR, Tomblyn MR, Laport GG, Zhu X, McCarthy PL, Ho VT, Cooke KR, Armstrong E, Smith A, Rizzo JD, Burkart JM, Pasquini MC
Blood. 2013 Dec 5; 122(24)3871-8. doi: 10.1182/blood-2013-08-519009.

PMID:
    24081656
    [PubMed - indexed for MEDLINE]
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