Patient Portal

John Carl Morris, MD

Harvey A. and Dorismae Hacker Friedman Professor of Neurology
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project
Director, Alzheimer's Disease Research Center

Specialty Areas

Neurology - Adult
Memory Disorders and Diagnosis
Alzheimer's Disease
Dementia

Board Certifications

Internal Medicine
Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Referred by Self or Referring Physician

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985
Email: morrisj@neuro.wustl.edu

Education

Education

Fellowship: Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri 1985
Residency: Neuropathology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1982
Chief Residency: Neurology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1981
Residency: Internal Medicine, Akron General Medical Center, Akron, Ohio 1979
Medical Degree: University Of Rochester School of Medicine and Dentistry, Rochester, New York 1974
B.A.: Ohio Wesleyan University, Delaware, Ohio 1970

Publication & Research

Publication & Research

Complex interactions underlie racial disparity in the risk of developing Alzheimer's disease dementia.
Xiong C, Luo J, Coble D, Agboola F, Kukull W, Morris JC
Alzheimers Dement. 2020 Feb 17; doi: 10.1002/alz.12060.

PMID:
    32067357
    [PubMed - as supplied by publisher]
Related citations


Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning.
Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J, Gordon BA, Lim YY, Masters CL, Rossor M, Fox NC, O'Connor A, Chhatwal J, Salloway S, Danek A, Hassenstab J, Schofield PR, Morris JC, Bateman RJ, Alzheimer's disease neuroimaging initiative (ADNI)., Dominantly Inherited Alzheimer Network (DIAN)., Ewers M
Alzheimers Dement. 2020 Feb 11; doi: 10.1002/alz.12032.

PMID:
    32043733
    [PubMed - as supplied by publisher]
Related citations


Spatial navigation ability predicts progression of dementia symptomatology.
Levine TF, Allison SL, Stojanovic M, Fagan AM, Morris JC, Head D
Alzheimers Dement. 2020 Feb 11; doi: 10.1002/alz.12031.

PMID:
    32043719
    [PubMed - as supplied by publisher]
Related citations


Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang LS, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR, Alzheimer’s Disease Genetics Consortium.
Nat Commun. 2020 Feb 3; 11(1)667. doi: 10.1038/s41467-019-14279-8.

PMID:
    32015339
    [PubMed - in process]
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Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies.
Orme T, Hernandez D, Ross OA, Kun-Rodrigues C, Darwent L, Shepherd CE, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Morgan K, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Trojanowski JQ, Serrano GE, Beach TG, Lesage S, Galasko D, Masliah E, Santana I, Pastor P, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Pickering-Brown S, Mann D, Halliday G, Stone DJ, Dickson DW, Hardy J, Singleton A, Guerreiro R, Bras J
Acta Neuropathol Commun. 2020 Jan 29; 8(1)5. doi: 10.1186/s40478-020-0879-z.

PMID:
    31996268
    [PubMed - in process]
Related citations


FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.
Yan T, Liang J, Gao J, Wang L, Fujioka H, Alzheimer Disease Neuroimaging Initiative., Zhu X, Wang X
Nat Commun. 2020 Jan 21; 11(1)411. doi: 10.1038/s41467-019-13962-0.

PMID:
    31964863
    [PubMed - in process]
Related citations


Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
Franzmeier N, Neitzel J, Rubinski A, Smith R, Strandberg O, Ossenkoppele R, Hansson O, Ewers M, Alzheimer’s Disease Neuroimaging Initiative (ADNI).
Nat Commun. 2020 Jan 17; 11(1)347. doi: 10.1038/s41467-019-14159-1.

PMID:
    31953405
    [PubMed - in process]
Related citations


Enhancing tristetraprolin activity reduces the severity of cigarette smoke-induced experimental chronic obstructive pulmonary disease.
Nair PM, Starkey MR, Haw TJ, Liu G, Collison AM, Mattes J, Wark PA, Morris JC, Verrills NM, Clark AR, Ammit AJ, Hansbro PM
Clin Transl Immunology. 2019; 8(10)e01084. doi: 10.1002/cti2.1084.

PMID:
    31921419
    [PubMed]
Related citations


Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN).
Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, Farlow M, O'Connor A, Ghetti B, Graff-Radford N, Goldman J, Gräber S, Karch CM, Lee JH, Levin J, Martins RN, Masters C, Mori H, Noble J, Salloway S, Schofield P, Morris JC, Bateman RJ, Hassenstab J, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2020 Jan; 16(1)219-228. doi: 10.1002/alz.12010.

PMID:
    31914221
    [PubMed - in process]
Related citations


Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers.
Contreras JA, Aslanyan V, Sweeney MD, Sanders LMJ, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P, Benzinger TL, Pa J
Neurobiol Aging. 2020 Feb; 86112-122. doi: 10.1016/j.neurobiolaging.2019.10.013.

PMID:
    31870643
    [PubMed - in process]
Related citations


Extended treatment with MY-NEOVAX, personalized neoantigen-enhanced oncolytic viruses, for two end-stage cancer patients.
Bouvet M, Reid TR, Larson C, Oronsky B, Carter C, Morris JC
Oxf Med Case Reports. 2019 Nov; 2019(11)461-463. doi: 10.1093/omcr/omz105.

PMID:
    31844525
    [PubMed]
Related citations


Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome.
Lessov-Schlaggar CN, Del Rosario OL, Morris JC, Ances BM, Schlaggar BL, Constantino JN
J Neurodev Disord. 2019 Dec 16; 11(1)39. doi: 10.1186/s11689-019-9300-2.

PMID:
    31842726
    [PubMed - in process]
Related citations


Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease.
Llibre-Guerra JJ, Li Y, Schindler SE, Gordon BA, Fagan AM, Morris JC, Benzinger TLS, Hassenstab J, Wang G, Allegri R, Berman SB, Chhatwal J, Farlow MR, Holtzman DM, Jucker M, Levin J, Noble JM, Salloway S, Schofield P, Karch C, Fox NC, Xiong C, Bateman RJ, McDade E
JAMA Netw Open. 2019 Dec 2; 2(12)e1917126. doi: 10.1001/jamanetworkopen.2019.17126.

PMID:
    31825500
    [PubMed - in process]
Related citations


The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.
Duchek JM, Aschenbrenner AJ, Fagan AM, Benzinger TLS, Morris JC, Balota DA
J Int Neuropsychol Soc. 2019 Dec 11; 1-11. doi: 10.1017/S1355617719001358.

PMID:
    31822309
    [PubMed - as supplied by publisher]
Related citations


Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
Moore KM, Nicholas J, Grossman M, McMillan CT, Irwin DJ, Massimo L, Van Deerlin VM, Warren JD, Fox NC, Rossor MN, Mead S, Bocchetta M, Boeve BF, Knopman DS, Graff-Radford NR, Forsberg LK, Rademakers R, Wszolek ZK, van Swieten JC, Jiskoot LC, Meeter LH, Dopper EG, Papma JM, Snowden JS, Saxon J, Jones M, Pickering-Brown S, Le Ber I, Camuzat A, Brice A, Caroppo P, Ghidoni R, Pievani M, Benussi L, Binetti G, Dickerson BC, Lucente D, Krivensky S, Graff C, Öijerstedt L, Fallström M, Thonberg H, Ghoshal N, Morris JC, Borroni B, Benussi A, Padovani A, Galimberti D, Scarpini E, Fumagalli GG, Mackenzie IR, Hsiung GR, Sengdy P, Boxer AL, Rosen H, Taylor JB, Synofzik M, Wilke C, Sulzer P, Hodges JR, Halliday G, Kwok J, Sanchez-Valle R, Lladó A, Borrego-Ecija S, Santana I, Almeida MR, Tábuas-Pereira M, Moreno F, Barandiaran M, Indakoetxea B, Levin J, Danek A, Rowe JB, Cope TE, Otto M, Anderl-Straub S, de Mendonça A, Maruta C, Masellis M, Black SE, Couratier P, Lautrette G, Huey ED, Sorbi S, Nacmias B, Laforce R Jr, Tremblay ML, Vandenberghe R, Damme PV, Rogalski EJ, Weintraub S, Gerhard A, Onyike CU, Ducharme S, Papageorgiou SG, Ng ASL, Brodtmann A, Finger E, Guerreiro R, Bras J, Rohrer JD, FTD Prevention Initiative.
Lancet Neurol. 2020 Feb; 19(2)145-156. doi: 10.1016/S1474-4422(19)30394-1.

PMID:
    31810826
    [PubMed - in process]
Related citations


Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?
Yang P, Perlmutter JS, Benzinger TLS, Morris JC, Xu J
Ageing Res Rev. 2020 Jan; 57100994. doi: 10.1016/j.arr.2019.100994.

PMID:
    31765822
    [PubMed - in process]
Related citations


Driving in the elderly in health and disease.
Carr DB, Stowe JD, Morris JC
Handb Clin Neurol. 2019; 167563-573. doi: 10.1016/B978-0-12-804766-8.00031-5.

PMID:
    31753155
    [PubMed - in process]
Related citations


Comparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument.
Morris GM, Holden TR, Weng H, Xiong C, Coble DW, Cairns NJ, Morris JC
Alzheimer Dis Assoc Disord. 2019 Nov 13; doi: 10.1097/WAD.0000000000000362.

PMID:
    31725472
    [PubMed - as supplied by publisher]
Related citations


Differences in Driving Outcomes Among Cognitively Normal African American and Caucasian Older Adults.
Babulal GM, Stout SH, Williams MM, Rajasekar G, Harmon A, Vivoda J, Zuelsdorff M, Benzinger TLS, Morris JC, Ances B, Roe CM
J Racial Ethn Health Disparities. 2019 Nov 4; doi: 10.1007/s40615-019-00655-z.

PMID:
    31686371
    [PubMed - as supplied by publisher]
Related citations


Prediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers.
Gupta Y, Lama RK, Kwon GR, Alzheimer's Disease Neuroimaging Initiative.
Front Comput Neurosci. 2019; 1372. doi: 10.3389/fncom.2019.00072.

PMID:
    31680923
    [PubMed]
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