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John Carl Morris, MD

Harvey A. and Dorismae Hacker Friedman Professor of Neurology
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project
Director, Alzheimer's Disease Research Center

Specialty Areas

Neurology - Adult
Memory Disorders and Diagnosis
Alzheimer's Disease
Dementia

Board Certifications

Internal Medicine
Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Referred by Self or Referring Physician

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985
Email: morrisj@neuro.wustl.edu

Education

Education

Fellowship: Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri 1985
Residency: Neuropathology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1982
Chief Residency: Neurology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1981
Residency: Internal Medicine, Akron General Medical Center, Akron, Ohio 1979
Medical Degree: University Of Rochester School of Medicine and Dentistry, Rochester, New York 1974
B.A.: Ohio Wesleyan University, Delaware, Ohio 1970

Publication & Research

Publication & Research

Comparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument.
Morris GM, Holden TR, Weng H, Xiong C, Coble DW, Cairns NJ, Morris JC
Alzheimer Dis Assoc Disord. 2019 Nov 13; doi: 10.1097/WAD.0000000000000362.

PMID:
    31725472
    [PubMed - as supplied by publisher]
Related citations


Differences in Driving Outcomes Among Cognitively Normal African American and Caucasian Older Adults.
Babulal GM, Stout SH, Williams MM, Rajasekar G, Harmon A, Vivoda J, Zuelsdorff M, Benzinger TLS, Morris JC, Ances B, Roe CM
J Racial Ethn Health Disparities. 2019 Nov 4; doi: 10.1007/s40615-019-00655-z.

PMID:
    31686371
    [PubMed - as supplied by publisher]
Related citations


Prediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers.
Gupta Y, Lama RK, Kwon GR, Alzheimer's Disease Neuroimaging Initiative.
Front Comput Neurosci. 2019; 1372. doi: 10.3389/fncom.2019.00072.

PMID:
    31680923
    [PubMed]
Related citations


The Levothyroxine Absorption Test: A Four-Year Experience (2015-2018) at The Mayo Clinic.
Gonzales KM, Stan MN, Morris JC 3rd, Bernet V, Castro MR
Thyroid. 2019 Nov 2; doi: 10.1089/thy.2019.0256.

PMID:
    31680654
    [PubMed - as supplied by publisher]
Related citations


Avelumab monotherapy as first-line or second-line treatment in patients with metastatic renal cell carcinoma: phase Ib results from the JAVELIN Solid Tumor trial.
Vaishampayan U, Schöffski P, Ravaud A, Borel C, Peguero J, Chaves J, Morris JC, Kotecki N, Smakal M, Zhou D, Guenther S, Bajars M, Gulley JL
J Immunother Cancer. 2019 Oct 24; 7(1)275. doi: 10.1186/s40425-019-0746-2.

PMID:
    31651359
    [PubMed - in process]
Related citations


Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer.
Gulati S, Desai J, Palackdharry SM, Morris JC, Zhu Z, Jandarov R, Riaz MK, Takiar V, Mierzwa M, Gutkind JS, Molinolo A, Desai PB, Sadraei NH, Wise-Draper TM
Cancer. 2019 Oct 18; doi: 10.1002/cncr.32539.

PMID:
    31626727
    [PubMed - as supplied by publisher]
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Association of Acquired and Heritable Factors With Intergenerational Differences in Age at Symptomatic Onset of Alzheimer Disease Between Offspring and Parents With Dementia.
Day GS, Cruchaga C, Wingo T, Schindler SE, Coble D, Morris JC
JAMA Netw Open. 2019 Oct 2; 2(10)e1913491. doi: 10.1001/jamanetworkopen.2019.13491.

PMID:
    31617930
    [PubMed - in process]
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The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases.
Li H, Yang P, Knight W, Guo Y, Perlmutter JS, Benzinger TLS, Morris JC, Xu J
J Neurochem. 2019 Oct 15; doi: 10.1111/jnc.14898.

PMID:
    31613384
    [PubMed - as supplied by publisher]
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Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.
Horgusluoglu-Moloch E, Risacher SL, Crane PK, Hibar D, Thompson PM, Saykin AJ, Nho K, Alzheimer’s Disease Neuroimaging Initiative (ADNI).
Sci Rep. 2019 Oct 10; 9(1)14498. doi: 10.1038/s41598-019-50507-3.

PMID:
    31601890
    [PubMed - in process]
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A Phase 2 Study of Pembrolizumab Combined with Chemoradiotherapy as Initial Treatment for Anaplastic Thyroid Cancer.
Chintakuntlawar A, Yin J, Foote RL, Kasperbauer JL, Rivera M, Asmus E, Garces Y, Janus JR, Liu MC, Ma DJ, Moore EJ, Morris JC 3rd, Neben-Wittich M, Price DL, Price KA, Ryder M, Van Abel KM, Hilger CR, Samb E, Bible KC
Thyroid. 2019 Oct 9; doi: 10.1089/thy.2019.0086.

PMID:
    31595822
    [PubMed - as supplied by publisher]
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An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.
Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, Gentsch J, Wang F, Dominantly Inherited Alzheimer Network (DIAN)., Salloway S, Masters CL, Lee JH, Graff-Radford NR, Chhatwal JP, Bateman RJ, Morris JC, Karch CM, Harari O, Cruchaga C
Nat Neurosci. 2019 Nov; 22(11)1903-1912. doi: 10.1038/s41593-019-0501-5.

PMID:
    31591557
    [PubMed - in process]
Related citations


New Perspective for Non-invasive Brain Stimulation Site Selection in Mild Cognitive Impairment: Based on Meta- and Functional Connectivity Analyses.
Liu J, Zhang B, Wilson G, Kong J, Alzheimer’s Disease Neuroimaging Initiative.
Front Aging Neurosci. 2019; 11228. doi: 10.3389/fnagi.2019.00228.

PMID:
    31551754
    [PubMed]
Related citations


Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease.
Wang G, Aschenbrenner AJ, Li Y, McDade E, Liu L, Benzinger TLS, Bateman RJ, Morris JC, Hassenstab JJ, Xiong C
Alzheimers Dement (N Y). 2019; 5450-457. doi: 10.1016/j.trci.2019.07.007.

PMID:
    31517032
    [PubMed]
Related citations


A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.
Xiong C, Luo J, Agboola F, Li Y, Albert M, Johnson SC, Koscik RL, Masters CL, Soldan A, Villemagne VL, Li QX, McDade EM, Fagan AM, Massoumzadeh P, Benzinger T, Hassenstab J, Bateman RJ, Morris JC, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2019 Sep 7; pii: S1552-5260(19)35122-2. doi: 10.1016/j.jalz.2019.06.4955.

PMID:
    31506247
    [PubMed - as supplied by publisher]
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Association between personality and tau-PET binding in cognitively normal older adults.
Schultz SA, Gordon BA, Mishra S, Su Y, Morris JC, Ances BM, Duchek JM, Balota DA, Benzinger TLS
Brain Imaging Behav. 2019 Sep 5; doi: 10.1007/s11682-019-00163-y.

PMID:
    31486975
    [PubMed - as supplied by publisher]
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The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.
Li Z, Farias FHG, Dube U, Del-Aguila JL, Mihindukulasuriya KA, Fernandez MV, Ibanez L, Budde JP, Wang F, Lake AM, Deming Y, Perez J, Yang C, Bahena JA, Qin W, Bradley JL, Davenport R, Bergmann K, Morris JC, Perrin RJ, Benitez BA, Dougherty JD, Harari O, Cruchaga C
Acta Neuropathol. 2019 Aug 27; doi: 10.1007/s00401-019-02066-0.

PMID:
    31456032
    [PubMed - as supplied by publisher]
Related citations


Retrospective Study of the Effect of Statins on the Outcome of Lung Cancer Patients, University of Cincinnati Experience.
Gaber O, Eldessouki I, Hassan R, Magdy M, Morris JC, Abdel Karim N
Asian Pac J Cancer Prev. 2019 Aug 1; 20(8)2391-2396. doi: 10.31557/APJCP.2019.20.8.2391.

PMID:
    31450911
    [PubMed - in process]
Related citations


The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory.
Li Y, Yao Z, Yu Y, Fu Y, Zou Y, Hu B, Alzheimer’s Disease Neuroimaging Initiative.
Front Aging Neurosci. 2019; 11208. doi: 10.3389/fnagi.2019.00208.

PMID:
    31440157
    [PubMed]
Related citations


Impact of Cognitive Impairment Across Specialties: Summary of a Report From the U13 Conference Series.
Carpenter CR, McFarland F, Avidan M, Berger M, Inouye SK, Karlawish J, Lin FR, Marcantonio E, Morris JC, Reuben DB, Shah RC, Whitson HE, Asthana S, Verghese J
J Am Geriatr Soc. 2019 Oct; 67(10)2011-2017. doi: 10.1111/jgs.16093.

PMID:
    31436318
    [PubMed - in process]
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Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AGA, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Bossù P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y, Alzheimer Disease Genetics Consortium (ADGC)., European Alzheimer’s Disease Initiative (EADI)., Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE)., Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES)., Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett D, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, O'Donovan MC, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA
Nat Genet. 2019 Sep; 51(9)1423-1424. doi: 10.1038/s41588-019-0495-7.

PMID:
    31417202
    [PubMed]
Related citations