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John Carl Morris, MD

Harvey A. and Dorismae Hacker Friedman Professor of Neurology
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project
Director, Alzheimer's Disease Research Center

Specialty Areas

Neurology - Adult
Memory Disorders and Diagnosis
Alzheimer's Disease
Dementia

Board Certifications

Internal Medicine
Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Referred by Self or Referring Physician

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985
Email: morrisj@neuro.wustl.edu

Education

Education

Fellowship: Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri 1985
Residency: Neuropathology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1982
Chief Residency: Neurology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1981
Residency: Internal Medicine, Akron General Medical Center, Akron, Ohio 1979
Medical Degree: University Of Rochester School of Medicine and Dentistry, Rochester, New York 1974
B.A.: Ohio Wesleyan University, Delaware, Ohio 1970

Publication & Research

Publication & Research

Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network.
Bussy A, Snider BJ, Coble D, Xiong C, Fagan AM, Cruchaga C, Benzinger TLS, Gordon BA, Hassenstab J, Bateman RJ, Morris JC, Dominantly Inherited Alzheimer Network.
Neurobiol Aging. 2018 Oct 13; 7542-50. doi: 10.1016/j.neurobiolaging.2018.10.011.

PMID:
    30530186
    [PubMed - as supplied by publisher]
Related citations


Small or Non-Small Cell Lung Cancer Based Therapy for Treatment of Large Cell Neuroendocrine Cancer of The Lung? University of Cincinnati Experience.
Eldessouki I, Gaber O, Namad T, Wang J, Morris JC, Abdel Karim N
J Oncol. 2018; 20189761826. doi: 10.1155/2018/9761826.

PMID:
    30515212
    [PubMed]
Related citations


Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ, KEYNOTE-040 investigators.
Lancet. 2018 Nov 30; pii: S0140-6736(18)31999-8. doi: 10.1016/S0140-6736(18)31999-8.

PMID:
    30509740
    [PubMed - as supplied by publisher]
Related citations


Examining the Complicated Relationship Between Depressive Symptoms and Cognitive Impairment in Preclinical Alzheimer Disease.
Javaherian K, Newman BM, Weng H, Hassenstab J, Xiong C, Coble D, Fagan AM, Benzinger T, Morris JC
Alzheimer Dis Assoc Disord. 2018 Nov 26; doi: 10.1097/WAD.0000000000000284.

PMID:
    30489279
    [PubMed - as supplied by publisher]
Related citations


CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline.
Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Jucker M, Masters CL, Rossor MN, Ringman JM, Shaw LM, Trojanowski JQ, Weiner M, Ewers M, Haass C, Dominantly Inherited Alzheimer Network., Alzheimer's Disease Neuroimaging Initiative.
EMBO Mol Med. 2018 Dec; 10(12)pii: e9712. doi: 10.15252/emmm.201809712.

PMID:
    30482868
    [PubMed - in process]
Related citations


The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, Nordberg A, White LR, Nielsen HM, Dominantly Inherited Alzheimer Network (DIAN).
Acta Neuropathol Commun. 2018 Nov 26; 6(1)130. doi: 10.1186/s40478-018-0624-z.

PMID:
    30477568
    [PubMed - in process]
Related citations


A comprehensive screening of copy number variability in dementia with Lewy bodies.
Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, Ansorge O, Clarimon J, Lleo A, Morenas-Rodriguez E, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Serrano GE, Beach TG, Lesage S, Galasko D, Masliah E, Santana I, Pastor P, Diez-Fairen M, Aguilar M, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Pickering-Brown S, Mann D, Halliday GM, Hardy J, Trojanowski JQ, Dickson DW, Singleton A, Stone DJ, Guerreiro R, Bras J
Neurobiol Aging. 2018 Oct 24; pii: S0197-4580(18)30383-X. doi: 10.1016/j.neurobiolaging.2018.10.019.

PMID:
    30448004
    [PubMed - as supplied by publisher]
Related citations


Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.
Peloso GM, van der Lee SJ, International Genomics of Alzheimer's Project (IGAP)., Destefano AL, Seshardi S
Alzheimers Dement (Amst). 2018; 10595-598. doi: 10.1016/j.dadm.2018.08.008.

PMID:
    30422133
    [PubMed]
Related citations


Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.
Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, Goate A, Jack CR Jr, Karch C, Klunk W, Koeppe RA, Marcus DS, Mayeux R, McDade E, Noble JM, Ringman J, Saykin AJ, Thompson PM, Xiong C, Morris JC, Bateman RJ, Benzinger TLS, Dominantly Inherited Alzheimer Network.
Alzheimers Dement (Amst). 2018; 10669-677. doi: 10.1016/j.dadm.2018.08.012.

PMID:
    30417072
    [PubMed]
Related citations


Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.
Schilling LP, Pascoal TA, Zimmer ER, Mathotaarachchi S, Shin M, de Mello Rieder CR, Gauthier S, Palmini A, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative.
Mol Neurobiol. 2018 Nov 9; doi: 10.1007/s12035-018-1405-1.

PMID:
    30414086
    [PubMed - as supplied by publisher]
Related citations


Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.
Babulal GM, Chen S, Williams MM, Trani JF, Bakhshi P, Chao GL, Stout SH, Fagan AM, Benzinger TLS, Holtzman DM, Morris JC, Roe CM
J Alzheimers Dis. 2018; 66(3)1213-1221. doi: 10.3233/JAD-180564.

PMID:
    30400098
    [PubMed - in process]
Related citations


Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes.
Qiu Y, Milanes JE, Jones JA, Noorai RE, Shankar V, Morris JC
mSphere. 2018 Oct 31; 3(5)pii: e00366-18. doi: 10.1128/mSphere.00366-18.

PMID:
    30381351
    [PubMed - in process]
Related citations


Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set.
Besser L, Kukull W, Knopman DS, Chui H, Galasko D, Weintraub S, Jicha G, Carlsson C, Burns J, Quinn J, Sweet RA, Rascovsky K, Teylan M, Beekly D, Thomas G, Bollenbeck M, Monsell S, Mock C, Zhou XH, Thomas N, Robichaud E, Dean M, Hubbard J, Jacka M, Schwabe-Fry K, Wu J, Phelps C, Morris JC, Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers.
Alzheimer Dis Assoc Disord. 2018 Oct-Dec; 32(4)351-358. doi: 10.1097/WAD.0000000000000279.

PMID:
    30376508
    [PubMed - in process]
Related citations


Distinct cytokine profiles in human brains resilient to Alzheimer's pathology.
Barroeta-Espar I, Weinstock LD, Perez-Nievas BG, Meltzer AC, Siao Tick Chong M, Amaral AC, Murray ME, Moulder KL, Morris JC, Cairns NJ, Parisi JE, Lowe VJ, Petersen RC, Kofler J, Ikonomovic MD, López O, Klunk WE, Mayeux RP, Frosch MP, Wood LB, Gomez-Isla T
Neurobiol Dis. 2019 Jan; 121327-337. doi: 10.1016/j.nbd.2018.10.009.

PMID:
    30336198
    [PubMed - in process]
Related citations


Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.
Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement. 2018 Oct 13; pii: S1552-5260(18)33514-3. doi: 10.1016/j.jalz.2018.08.005.

PMID:
    30321505
    [PubMed - as supplied by publisher]
Related citations


Patients with BRCA mutations have superior outcomes after intraperitoneal chemotherapy in optimally resected high grade ovarian cancer.
Naumann RW, Morris JC, Tait DL, Higgins RV, Crane EK, Drury LK, Amacker-North L, Templin M, Brown J
Gynecol Oncol. 2018 Dec; 151(3)477-480. doi: 10.1016/j.ygyno.2018.10.003.

PMID:
    30309722
    [PubMed - in process]
Related citations


Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers.
Roe CM, Ances BM, Head D, Babulal GM, Stout SH, Grant EA, Hassenstab J, Xiong C, Holtzman DM, Benzinger TLS, Schindler SE, Fagan AM, Morris JC
Brain. 2018 Nov 1; 141(11)3233-3248. doi: 10.1093/brain/awy244.

PMID:
    30304397
    [PubMed - in process]
Related citations


Widespread distribution of tauopathy in preclinical Alzheimer's disease.
Schultz SA, Gordon BA, Mishra S, Su Y, Perrin RJ, Cairns NJ, Morris JC, Ances BM, Benzinger TLS
Neurobiol Aging. 2018 Dec; 72177-185. doi: 10.1016/j.neurobiolaging.2018.08.022.

PMID:
    30292840
    [PubMed - in process]
Related citations


Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease.
Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Fox NN, Graff-Radford NR, Levin J, Danek A, Vöglein J, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement. 2018 Nov; 14(11)1427-1437. doi: 10.1016/j.jalz.2018.06.3059.

PMID:
    30266303
    [PubMed - in process]
Related citations


Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease.
Gangishetti U, Christina Howell J, Perrin RJ, Louneva N, Watts KD, Kollhoff A, Grossman M, Wolk DA, Shaw LM, Morris JC, Trojanowski JQ, Fagan AM, Arnold SE, Hu WT
Alzheimers Res Ther. 2018 Sep 25; 10(1)98. doi: 10.1186/s13195-018-0426-3.

PMID:
    30253800
    [PubMed - in process]
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