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John Carl Morris, MD

Harvey A. and Dorismae Hacker Friedman Professor of Neurology
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project
Director, Alzheimer's Disease Research Center

Specialty Areas

Neurology - Adult
Memory Disorders and Diagnosis
Alzheimer's Disease
Dementia

Board Certifications

Internal Medicine
Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Referred by Self or Referring Physician

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985
Email: morrisj@neuro.wustl.edu

Education

Education

Fellowship: Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri 1985
Residency: Neuropathology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1982
Chief Residency: Neurology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1981
Residency: Internal Medicine, Akron General Medical Center, Akron, Ohio 1979
Medical Degree: University Of Rochester School of Medicine and Dentistry, Rochester, New York 1974
B.A.: Ohio Wesleyan University, Delaware, Ohio 1970

Publication & Research

Publication & Research

Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers.
Stout SH, Babulal GM, Ma C, Carr DB, Head DM, Grant EA, Williams MM, Holtzman DM, Fagan AM, Morris JC, Roe CM
Alzheimers Dement. 2018 Jan 9; pii: S1552-5260(17)33854-2. doi: 10.1016/j.jalz.2017.11.011.

PMID:
    29328928
    [PubMed - as supplied by publisher]
Related citations


Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case-Control Study of Patients with Head and Neck Squamous Cell Carcinoma.
Wise-Draper T, Sendilnathan A, Palackdharry S, Pease N, Qualtieri J, Butler R, Sadraei NH, Morris JC, Patil Y, Wilson K, Mark J, Casper K, Takiar V, Lane A, Privette Vinnedge L
Transl Oncol. 2017 Dec 28; 11(1)168-174. doi: 10.1016/j.tranon.2017.12.001.

PMID:
    29289845
    [PubMed - as supplied by publisher]
Related citations


Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.
Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, Lleo A, Morenas-Rodriguez E, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Serrano GE, Beach TG, Lesage S, Galasko D, Masliah E, Santana I, Pastor P, Diez-Fairen M, Aguilar M, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Pickering-Brown S, Mann D, Halliday GM, Hardy J, Trojanowski JQ, Dickson DW, Singleton A, Stone DJ, Bras J
Lancet Neurol. 2018 Jan; 17(1)64-74. doi: 10.1016/S1474-4422(17)30400-3.

PMID:
    29263008
    [PubMed - indexed for MEDLINE]
Related citations


Validity and power of minimization algorithm in longitudinal analysis of clinical trials.
Weng H, Bateman R, Morris JC, Xiong C
Biostat Epidemiol. 2017; 1(1)59-77. doi: 10.1080/24709360.2017.1331822.

PMID:
    29250611
    [PubMed]
Related citations


Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS).
Weintraub S, Besser L, Dodge HH, Teylan M, Ferris S, Goldstein FC, Giordani B, Kramer J, Loewenstein D, Marson D, Mungas D, Salmon D, Welsh-Bohmer K, Zhou XH, Shirk SD, Atri A, Kukull WA, Phelps C, Morris JC
Alzheimer Dis Assoc Disord. 2017 Dec 29; doi: 10.1097/WAD.0000000000000223.

PMID:
    29240561
    [PubMed - as supplied by publisher]
Related citations


Effect of sleep on overnight CSF amyloid-β kinetics.
Lucey BP, Hicks TJ, McLeland JS, Toedebusch CD, Boyd J, Elbert DL, Patterson BW, Baty J, Morris JC, Ovod V, Mawuenyega KG, Bateman RJ
Ann Neurol. 2017 Dec 8; doi: 10.1002/ana.25117.

PMID:
    29220873
    [PubMed - as supplied by publisher]
Related citations


Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ, Aalten P, Lee DY, Vandenberghe R, Resende de Oliveira C, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonça A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJ, Amyloid Biomarker Study Group., Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BNM, Blennow K, van Buchem MA, Cavedo E, Chen K, Chipi E, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gkatzima O, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Johannsen P, Klimkowicz-Mrowiec A, Köhler S, Koglin N, van Laere K, de Leon M, Lisetti V, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Nordlund A, Novak GP, Paraskevas GP, Perera G, Peters O, Ramakers IHGB, Rami L, Rodríguez-Rodríguez E, Roe CM, Rot U, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Zetterberg H
JAMA Psychiatry. 2018 Jan 1; 75(1)84-95. doi: 10.1001/jamapsychiatry.2017.3391.

PMID:
    29188296
    [PubMed - in process]
Related citations


Estimating diagnostic accuracy for clustered ordinal diagnostic groups in the three-class case-Application to the early diagnosis of Alzheimer disease.
Xiong C, Luo J, Chen L, Gao F, Liu J, Wang G, Bateman R, Morris JC
Stat Methods Med Res. 2017 Jan 1; 962280217742539. doi: 10.1177/0962280217742539.

PMID:
    29182052
    [PubMed - as supplied by publisher]
Related citations


Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance Among Older Adults with and without Preclinical Alzheimer's Disease.
Roe CM, Babulal GM, Mishra S, Gordon BA, Stout SH, Ott BR, Carr DB, Ances BM, Morris JC, Benzinger TLS
J Alzheimers Dis. 2018; 61(2)509-513. doi: 10.3233/JAD-170521.

PMID:
    29171997
    [PubMed - in process]
Related citations


Cancer vaccine strategies: translation from mice to human clinical trials.
Berzofsky JA, Terabe M, Trepel JB, Pastan I, Stroncek DF, Morris JC, Wood LV
Cancer Immunol Immunother. 2017 Nov 15; doi: 10.1007/s00262-017-2084-x.

PMID:
    29143114
    [PubMed - as supplied by publisher]
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Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.
Flaherty DP, Harris MT, Schroeder CE, Khan H, Kahney EW, Hackler AL, Patrick SL, Weiner WS, Aubé J, Sharlow ER, Morris JC, Golden JE
ChemMedChem. 2017 Dec 7; 12(23)1994-2005. doi: 10.1002/cmdc.201700592.

PMID:
    29105342
    [PubMed - indexed for MEDLINE]
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Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.
Fernández MV, Kim JH, Budde JP, Black K, Medvedeva A, Saef B, Deming Y, Del-Aguila J, Ibañez L, Dube U, Harari O, Norton J, Chasse R, Morris JC, Goate A, NIA-LOAD family study group., NCRAD., Cruchaga C
PLoS Genet. 2017 Nov; 13(11)e1007045. doi: 10.1371/journal.pgen.1007045.

PMID:
    29091718
    [PubMed - indexed for MEDLINE]
Related citations


Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline.
Risacher SL, Anderson WH, Charil A, Castelluccio PF, Shcherbinin S, Saykin AJ, Schwarz AJ, Alzheimer's Disease Neuroimaging Initiative.
Neurology. 2017 Nov 21; 89(21)2176-2186. doi: 10.1212/WNL.0000000000004670.

PMID:
    29070667
    [PubMed - indexed for MEDLINE]
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In vivo staging of regional amyloid deposition.
Grothe MJ, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel SJ, Alzheimer's Disease Neuroimaging Initiative.
Neurology. 2017 Nov 14; 89(20)2031-2038. doi: 10.1212/WNL.0000000000004643.

PMID:
    29046362
    [PubMed - indexed for MEDLINE]
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Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany.
Bailey DL, Pichler BJ, Gückel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AM, Law I, Morris JC, Nikolaou K, Nuyts J, Ordonez AA, Pantel K, Quick HH, Riklund K, Sabri O, Sattler B, Troost EGC, Zaiss M, Zender L, Beyer T
Mol Imaging Biol. 2017 Oct 2; doi: 10.1007/s11307-017-1123-5.

PMID:
    28971346
    [PubMed - as supplied by publisher]
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C, Alzheimer’s Disease Neuroimaging Initiative., Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM
Nature. 2017 Sep 28; 549(7673)523-527. doi: 10.1038/nature24016.

PMID:
    28959956
    [PubMed - in process]
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Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.
Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Deming Y, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, Dominantly Inherited Alzheimer Network (DIAN)., Disease Neuroimaging Initiative (ADNI)., NIA-LOAD family study., Harari O
Alzheimers Dement. 2017 Sep 21; pii: S1552-5260(17)33708-1. doi: 10.1016/j.jalz.2017.08.013.

PMID:
    28943286
    [PubMed - as supplied by publisher]
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Corrigendum: Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images.
Guo S, Lai C, Wu C, Cen G, Alzheimer's Disease Neuroimaging Initiative.
Front Aging Neurosci. 2017; 9293. doi: 10.3389/fnagi.2017.00293.

PMID:
    28900396
    [PubMed]
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Factors Influencing Successful Lumbar Puncture in Alzheimer Research.
Moulder KL, Besser LM, Beekly D, Blennow K, Kukull W, Morris JC
Alzheimer Dis Assoc Disord. 2017 Oct-Dec; 31(4)287-294. doi: 10.1097/WAD.0000000000000209.

PMID:
    28891819
    [PubMed - in process]
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OPTIMIZING LENVATINIB THERAPY IN PATIENTS WITH METASTATIC RADIOACTIVE IODINE-RESISTANT DIFFERENTIATED THYROID CANCERS.
Jasim S, Iniguez-Ariza NM, Hilger CR, Chintakuntlawar AV, Ryder MM, Morris JC 3rd, Bible KC
Endocr Pract. 2017 Oct; 23(10)1254-1261. doi: 10.4158/EP171822.OR.

PMID:
    28816536
    [PubMed - indexed for MEDLINE]
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