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John Carl Morris, MD

Harvey A. and Dorismae Hacker Friedman Professor of Neurology
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project
Director, Alzheimer's Disease Research Center

Specialty Areas

Neurology - Adult
Memory Disorders and Diagnosis
Alzheimer's Disease
Dementia

Board Certifications

Internal Medicine
Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Referred by Self or Referring Physician

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985
Email: morrisj@neuro.wustl.edu

Education

Education

Fellowship: Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri 1985
Residency: Neuropathology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1982
Chief Residency: Neurology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1981
Residency: Internal Medicine, Akron General Medical Center, Akron, Ohio 1979
Medical Degree: University Of Rochester School of Medicine and Dentistry, Rochester, New York 1974
B.A.: Ohio Wesleyan University, Delaware, Ohio 1970

Publication & Research

Publication & Research

Latent structure of cognitive performance in the adult children study.
Head D, Allison S, Lucena N, Hassenstab J, Morris JC
J Clin Exp Neuropsychol. 2016 Nov 20; 1-16.

PMID:
    27868476
    [PubMed - as supplied by publisher]
Related citations


Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology.
Monsell SE, Mock C, Fardo DW, Bertelsen S, Cairns NJ, Roe CM, Ellingson SR, Morris JC, Goate AM, Kukull WA
Alzheimer Dis Assoc Disord. 2016 Nov 15;

PMID:
    27849641
    [PubMed - as supplied by publisher]
Related citations


The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells.
Rahman MM, Prünte L, Lebender LF, Patel BS, Gelissen I, Hansbro PM, Morris JC, Clark AR, Verrills NM, Ammit AJ
Sci Rep. 2016 Nov 16; 637297. doi: 10.1038/srep37297.

PMID:
    27849062
    [Unknown status]
Related citations


Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40.
Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, Holtzman DM, Morris JC, Goate AM, Dougherty JD, Cruchaga C
BMC Neurol. 2016 Nov 10; 16(1)217.

PMID:
    27832767
    [PubMed - in process]
Related citations


Asymptomatic Alzheimer disease: Defining resilience.
Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL, Alzheimer's Disease Neuroimaging Initiative.
Neurology. 2016 Dec 6; 87(23)2443-2450.

PMID:
    27815399
    [Unknown status]
Related citations


Risk of Malignancy in Thyroid Nodules with Non-Diagnostic Fine-Needle Aspiration: A Retrospective Cohort Study.
Espinosa De Ycaza AE, Lowe KM, Dean DS, Castro MR, Fatourechi V, Ryder M, Morris JC, Stan MN
Thyroid. 2016 Nov; 26(11)1598-1604.

PMID:
    27549368
    [Unknown status]
Related citations


Human Central Nervous System (CNS) ApoE Isoforms are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared to Plasma.
Baker-Nigh AT, Mawuenyega KG, Bollinger JG, Ovod V, Kasten T, Franklin EE, Liao F, Jiang H, Holtzman D, Cairns NJ, Morris JC, Bateman RJ
J Biol Chem. 2016 Oct 28; pii: jbc.M116.721779.

PMID:
    27793990
    [PubMed - as supplied by publisher]
Related citations


Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease.
Natelson Love M, Clark DG, Cochran JN, Den Beste KA, Geldmacher DS, Benzinger TL, Gordon BA, Morris JC, Bateman RJ, Roberson ED
Neurobiol Aging. 2016 Oct 3; pii: S0197-4580(16)30234-2. doi: 10.1016/j.neurobiolaging.2016.09.020.

PMID:
    27793474
    [PubMed - as supplied by publisher]
Related citations


Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer's Disease.
Lewczuk P, Matzen A, Blennow K, Parnetti L, Molinuevo JL, Eusebi P, Kornhuber J, Morris JC, Fagan AM
J Alzheimers Dis. 2016 Nov 19; 55(2)813-822.

PMID:
    27792012
    [Unknown status]
Related citations


Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.
Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT, Alzheimer’s Disease Neuroimaging Initiative.
Proc Natl Acad Sci U S A. 2016 Oct 18; 113(42)E6535-E6544.

PMID:
    27702899
    [Unknown status]
Related citations


Physical exam in asymptomatic people drivers the detection of thyroid nodules undergoing ultrasound guided fine needle aspiration biopsy.
Singh Ospina N, Maraka S, Espinosa De Ycaza AE, Ahn HS, Castro MR, Morris JC, Montori VM, Brito JP
Endocrine. 2016 Nov; 54(2)433-439.

PMID:
    27510173
    [Unknown status]
Related citations


Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).
Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ, Dominantly Inherited Alzheimer Network (DIAN).
Lancet Neurol. 2016 Dec; 15(13)1317-1325. doi: 10.1016/S1474-4422(16)30229-0.

PMID:
    27777020
    [Unknown status]
Related citations


Prognosis of patients with benign thyroid nodules: a population-based study.
Singh Ospina N, Maraka S, Espinosa de Ycaza AE, Brito JP, Castro MR, Morris JC, Montori VM
Endocrine. 2016 Oct; 54(1)148-155.

PMID:
    27142412
    [Unknown status]
Related citations


Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels.
Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TL, Fagan AM, Morris JC, Roe CM
Am J Geriatr Psychiatry. 2016 Nov; 24(11)1095-1104. doi: 10.1016/j.jagp.2016.04.004.

PMID:
    27426238
    [Unknown status]
Related citations


Response to Targeted Therapy in BRAF Mutant Anaplastic Thyroid Cancer.
Agarwal R, Wang J, Wilson K, Barrett W, Morris JC
J Natl Compr Canc Netw. 2016 Oct; 14(10)1203-1207.

PMID:
    27697975
    [Unknown status]
Related citations


Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.
Kun-Rodrigues C, Ross OA, Orme T, Shepherd C, Parkkinen L, Darwent L, Hernandez D, Ansorge O, Clark LN, Honig LS, Marder K, Lemstra A, Scheltens P, van der Flier W, Louwersheimer E, Holstege H, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Trojanowski JQ, Serrano GE, Beach TG, Clarimon J, Lleó A, Morenas-Rodríguez E, Lesage S, Galasko D, Masliah E, Santana I, Diez M, Pastor P, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Stone DJ, Pickering-Brown S, Mann D, Dickson DW, Halliday GM, Singleton A, Guerreiro R, Bras J
Neurobiol Aging. 2016 Sep 2; pii: S0197-4580(16)30201-9. doi: 10.1016/j.neurobiolaging.2016.08.023.

PMID:
    27666590
    [PubMed - as supplied by publisher]
Related citations


Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group.
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL, Dominantly Inherited Alzheimer Network.
PLoS One. 2016 Sep 20; 11(9)e0163669. doi: 10.1371/journal.pone.0163669.

PMID:
    27649320
    [PubMed - as supplied by publisher]
Related citations


Drug development in Alzheimer's disease: the path to 2025.
Cummings J, Aisen PS, DuBois B, Frölich L, Jack CR Jr, Jones RW, Morris JC, Raskin J, Dowsett SA, Scheltens P
Alzheimers Res Ther. 2016 Sep 20; 839. doi: 10.1186/s13195-016-0207-9.

PMID:
    27646601
    [Unknown status]
Related citations


Morphometricity as a measure of the neuroanatomical signature of a trait.
Sabuncu MR, Ge T, Holmes AJ, Smoller JW, Buckner RL, Fischl B, Alzheimer's Disease Neuroimaging Initiative.
Proc Natl Acad Sci U S A. 2016 Sep 27; 113(39)E5749-56. doi: 10.1073/pnas.1604378113.

PMID:
    27613854
    [Unknown status]
Related citations


Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology.
Gordon BA, Blazey T, Su Y, Fagan AM, Holtzman DM, Morris JC, Benzinger TL
JAMA Neurol. 2016 Oct 1; 73(10)1192-1200. doi: 10.1001/jamaneurol.2016.2642.

PMID:
    27548756
    [Unknown status]
Related citations