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John Carl Morris, MD

Harvey A. and Dorismae Hacker Friedman Professor of Neurology
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project
Director, Alzheimer's Disease Research Center

Specialty Areas

Neurology - Adult
Memory Disorders and Diagnosis
Alzheimer's Disease
Dementia

Board Certifications

Internal Medicine
Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Referred by Self or Referring Physician

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985
Email: morrisj@neuro.wustl.edu

Education

Education

Fellowship: Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri 1985
Residency: Neuropathology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1982
Chief Residency: Neurology, Cleveland Metropolitan General Hospital, Cleveland, Ohio 1981
Residency: Internal Medicine, Akron General Medical Center, Akron, Ohio 1979
Medical Degree: University Of Rochester School of Medicine and Dentistry, Rochester, New York 1974
B.A.: Ohio Wesleyan University, Delaware, Ohio 1970

Publication & Research

Publication & Research

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.
Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ, Dominantly Inherited Alzheimer Network (DIAN)., Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O
Genome Med. 2018 Jun 8; 10(1)43. doi: 10.1186/s13073-018-0551-4.

PMID:
    29880032
    [PubMed - in process]
Related citations


A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites.
Voyton CM, Qiu Y, Morris MT, Ackroyd PC, Suryadi J, Crowe L, Morris JC, Christensen KA
PLoS Negl Trop Dis. 2018 May; 12(5)e0006523. doi: 10.1371/journal.pntd.0006523.

PMID:
    29851949
    [PubMed - in process]
Related citations


Using the A/T/N Framework to Examine Driving in Preclinical AD.
Roe CM, Babulal GM, Stout SH, Ott BR, Carr DB, Williams MM, Benzinger TLS, Fagan AM, Holtzman DM, Ances BM, Morris JC
Geriatrics (Basel). 2018 Jun; 3(2)pii: 23. doi: 10.3390/geriatrics3020023.

PMID:
    29805967
    [PubMed]
Related citations


Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology.
Gordon BA, McCullough A, Mishra S, Blazey TM, Su Y, Christensen J, Dincer A, Jackson K, Hornbeck RC, Morris JC, Ances BM, Benzinger TLS
Alzheimers Dement (Amst). 2018; 10245-252. doi: 10.1016/j.dadm.2018.02.003.

PMID:
    29780869
    [PubMed]
Related citations


White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.
Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Fӧrster S, Schofield PR, Sperling RA, Johnson KA, Chhatwal JP, Salloway S, Correia S, Jack CR Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM, Dominantly Inherited Alzheimer Network.
PLoS One. 2018; 13(5)e0195838. doi: 10.1371/journal.pone.0195838.

PMID:
    29742105
    [PubMed - in process]
Related citations


FRET Flow Cytometry-Based High Throughput Screening Assay To Identify Disrupters of Glucose Levels in Trypanosoma brucei.
Voyton CM, Morris MT, Ackroyd PC, Morris JC, Christensen KA
ACS Infect Dis. 2018 May 14; doi: 10.1021/acsinfecdis.8b00058.

PMID:
    29741365
    [PubMed - as supplied by publisher]
Related citations


Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells.
Morrison BJ, Steel JC, Morris JC
BMC Cancer. 2018 Apr 26; 18(1)469. doi: 10.1186/s12885-018-4389-3.

PMID:
    29699516
    [PubMed - in process]
Related citations


Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype.
Mishra S, Blazey TM, Holtzman DM, Cruchaga C, Su Y, Morris JC, Benzinger TLS, Gordon BA
Brain. 2018 Jun 1; 141(6)1828-1839. doi: 10.1093/brain/awy103.

PMID:
    29672664
    [PubMed - in process]
Related citations


Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease.
Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, Norton J, Morris JC, Goate AM, NIA-LOAD family study group., NCRAD., Cruchaga C
Front Neurosci. 2018; 12209. doi: 10.3389/fnins.2018.00209.

PMID:
    29670507
    [PubMed]
Related citations


Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease.
Vlassenko AG, Gordon BA, Goyal MS, Su Y, Blazey TM, Durbin TJ, Couture LE, Christensen JJ, Jafri H, Morris JC, Raichle ME, Benzinger TL
Neurobiol Aging. 2018 Jul; 6795-98. doi: 10.1016/j.neurobiolaging.2018.03.014.

PMID:
    29655050
    [PubMed - in process]
Related citations


Minimizing the Sample Sizes of Clinical Trials on Preclinical and Early Symptomatic Stage of Alzheimer Disease.
Luo J, Weng H, Morris JC, Xiong C
J Prev Alzheimers Dis. 2018; 5(2)110-119. doi: 10.14283/jpad.2018.16.

PMID:
    29616704
    [PubMed - in process]
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Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.
Mattsson N, Groot C, Jansen WJ, Landau SM, Villemagne VL, Engelborghs S, Mintun MM, Lleo A, Molinuevo JL, Jagust WJ, Frisoni GB, Ivanoiu A, Chételat G, Resende de Oliveira C, Rodrigue KM, Kornhuber J, Wallin A, Klimkowicz-Mrowiec A, Kandimalla R, Popp J, Aalten PP, Aarsland D, Alcolea D, Almdahl IS, Baldeiras I, van Buchem MA, Cavedo E, Chen K, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gill KD, Gkatzima O, Grimmer T, Hampel H, Herukka SK, Johannsen P, van Laere K, de Leon MJ, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Mroczko B, Nordlund A, Prabhakar S, Peters O, Rami L, Rodríguez-Rodríguez E, Roe CM, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Verhey FRJ, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Vandenberghe R, Brooks DJ, Fladby T, Rowe CC, Drzezga A, Verbeek MM, Sarazin M, Wolk DA, Fleisher AS, Klunk WE, Na DL, Sánchez-Juan P, Lee DY, Nordberg A, Tsolaki M, Camus V, Rinne JO, Fagan AM, Zetterberg H, Blennow K, Rabinovici GD, Hansson O, van Berckel BNM, van der Flier WM, Scheltens P, Visser PJ, Ossenkoppele R
Alzheimers Dement. 2018 Mar 28; pii: S1552-5260(18)30063-3. doi: 10.1016/j.jalz.2018.02.009.

PMID:
    29601787
    [PubMed - as supplied by publisher]
Related citations


Data-driven models of dominantly-inherited Alzheimer's disease progression.
Oxtoby NP, Young AL, Cash DM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Fox NC, Schott JM, Alexander DC
Brain. 2018 May 1; 141(5)1529-1544. doi: 10.1093/brain/awy050.

PMID:
    29579160
    [PubMed - in process]
Related citations


Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults: Role of Spatial Navigation Abilities.
Allison S, Babulal GM, Stout SH, Barco PP, Carr DB, Fagan AM, Morris JC, Roe CM, Head D
Alzheimer Dis Assoc Disord. 2018 Apr-Jun; 32(2)101-106. doi: 10.1097/WAD.0000000000000257.

PMID:
    29578861
    [PubMed - in process]
Related citations


Outcomes of Radiofrequency Ablation Therapy for Large Benign Thyroid Nodules: A Mayo Clinic Case Series.
Hamidi O, Callstrom MR, Lee RA, Dean D, Castro MR, Morris JC, Stan MN
Mayo Clin Proc. 2018 Mar 21; pii: S0025-6196(17)30888-1. doi: 10.1016/j.mayocp.2017.12.011.

PMID:
    29572016
    [PubMed - as supplied by publisher]
Related citations


Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing.
Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA, Dominantly Inherited Alzheimer Network.
Brain. 2018 May 1; 141(5)1486-1500. doi: 10.1093/brain/awy053.

PMID:
    29522171
    [PubMed - in process]
Related citations


Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging.
Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM
Alzheimers Dement. 2018 Mar 2; pii: S1552-5260(18)30039-6. doi: 10.1016/j.jalz.2018.01.013.

PMID:
    29501462
    [PubMed - as supplied by publisher]
Related citations


Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ, Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Als TD, Andreassen OA, Bækvad-Hansen M, Mortensen PB, Pedersen CB, Børglum AD, Bybjerg-Grauholm J, Djurovic S, Durmishi N, Pedersen MG, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Hansen CS, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T, GERAD1 Consortium:., CRESTAR Consortium:., Collier DA, Rujescu D, Kirov G, Owen MJ, O'Donovan MC, Walters JTR, GERAD1 Consortium., CRESTAR Consortium., GERAD1 Consortium., CRESTAR Consortium.
Nat Genet. 2018 Mar; 50(3)381-389. doi: 10.1038/s41588-018-0059-2.

PMID:
    29483656
    [PubMed - in process]
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Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease.
Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J, Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) Research Group.
JAMA Neurol. 2018 May 1; 75(5)608-619. doi: 10.1001/jamaneurol.2017.5135.

PMID:
    29482212
    [PubMed - in process]
Related citations


Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.
Del-Aguila JL, Fernández MV, Schindler S, Ibanez L, Deming Y, Ma S, Saef B, Black K, Budde J, Norton J, Chasse R, Alzheimer’s Disease Neuroimaging Initiative (ADNI)., Harari O, Goate A, Xiong C, Morris JC, Cruchaga C
J Alzheimers Dis. 2018; 62(2)745-756. doi: 10.3233/JAD-170834.

PMID:
    29480181
    [PubMed - in process]
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