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Joel S. Perlmutter, MD

Elliot Stein Family Professor of Neurology
Section Chief, Movement Disorders
Professor, Radiology
Professor , Physical Therapy
Associate Professor, Anatomy and Neurobiology

Specialty Areas

Parkinson's Disease
Movement Disorders
Neurology - Adult
Huntington's Disease
Dystonia
Tremor
Tourette's Syndrome

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Parkinson's disease, Huntington's disease, Tourette syndrome, dystonia, hyperkinetic disorders, essential tremor and other movement disorders, imaging research using PET and MR, clinical drug trials

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6908
Fax: 314-747-3258

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Suite: Lower Level
Office Phone: 314-362-6908
Fax: 314-747-3258

Education

Education

Fellowship: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 1984
Residency: Washington University School Medicine, St. Louis, Missouri 1980
Medical Degree: University Of Missouri, Columbia, Missouri 1979
B.A.: Princeton University, Princeton, New Jersey 1975
Externship: Psychiatry, Menninger Foundation, Topeka, Kansas 1978

Publication & Research

Publication & Research

7T MRI subthalamic nucleus atlas for use with 3T MRI.
Milchenko M, Norris SA, Poston K, Campbell MC, Ushe M, Perlmutter JS, Snyder AZ
J Med Imaging (Bellingham). 2018 Jan; 5(1)015002. doi: 10.1117/1.JMI.5.1.015002.

PMID:
    29340288
    [PubMed]
Related citations


Kinetic modeling of [<sup>18</sup> F]VAT, a novel radioligand for PET imaging vesicular acetylcholine transporter (VAChT) in nonhuman primate brain.
Jin H, Yue X, Liu H, Han J, Flores H, Su Y, Parsons SM, Perlmutter JS, Tu Z
J Neurochem. 2018 Jan 6; doi: 10.1111/jnc.14291.

PMID:
    29315563
    [PubMed - as supplied by publisher]
Related citations


Synthesis and in vitro characterization of a P2X7 radioligand [<sup>123</sup>I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease.
Jin H, Han J, Resing D, Liu H, Yue X, Miller RL, Schoch KM, Miller TM, Perlmutter JS, Egan TM, Tu Z
Eur J Pharmacol. 2018 Feb 5; 8208-17. doi: 10.1016/j.ejphar.2017.12.006.

PMID:
    29225193
    [PubMed - in process]
Related citations


A new measure for end of life planning, preparation, and preferences in Huntington disease: HDQLIFE end of life planning.
Carlozzi NE, Hahn EA, Frank SA, Perlmutter JS, Downing ND, McCormack MK, Barton S, Nance MA, Schilling SG, HDQLIFE Site Investigators and Coordinators.
J Neurol. 2018 Jan; 265(1)98-107. doi: 10.1007/s00415-017-8677-7.

PMID:
    29143208
    [PubMed - in process]
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Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.
Ibanez L, Dube U, Saef B, Budde J, Black K, Medvedeva A, Del-Aguila JL, Davis AA, Perlmutter JS, Harari O, Benitez BA, Cruchaga C
BMC Neurol. 2017 Nov 15; 17(1)198. doi: 10.1186/s12883-017-0978-z.

PMID:
    29141588
    [PubMed - in process]
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Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Robak LA, Jansen IE, van Rooij J, Uitterlinden AG, Kraaij R, Jankovic J, International Parkinson’s Disease Genomics Consortium (IPDGC)., Heutink P, Shulman JM, IPDGC Consortium members., International Parkinson’s Disease Genomics Consortium (IPDGC).
Brain. 2017 Dec 1; 140(12)3191-3203. doi: 10.1093/brain/awx285.

PMID:
    29140481
    [PubMed - indexed for MEDLINE]
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ACR Appropriateness Criteria<sup>®</sup> Cranial Neuropathy.
Expert Panel on Neurologic Imaging:., Policeni B, Corey AS, Burns J, Conley DB, Crowley RW, Harvey HB, Hoang J, Hunt CH, Jagadeesan BD, Juliano AF, Kennedy TA, Moonis G, Pannell JS, Patel ND, Perlmutter JS, Rosenow JM, Schroeder JW, Whitehead MT, Cornelius RS
J Am Coll Radiol. 2017 Nov; 14(11S)S406-S420. doi: 10.1016/j.jacr.2017.08.035.

PMID:
    29101981
    [PubMed - in process]
Related citations


Adult-onset dystonia with marfanoid features.
Norris SA, Pogarcic A, Hicks M, Perlmutter JS, Shinawi M
Neurol Clin Pract. 2017 Aug; 7(4)e31-e34. doi: 10.1212/CPJ.0000000000000297.

PMID:
    28840904
    [PubMed]
Related citations


[<sup>18</sup>F]FDOPA positron emission tomography in manganese-exposed workers.
Criswell SR, Nielsen SS, Warden M, Perlmutter JS, Moerlein SM, Flores HP, Huang J, Sheppard L, Seixas N, Checkoway H, Racette BA
Neurotoxicology. 2017 Jul 8; pii: S0161-813X(17)30117-1. doi: 10.1016/j.neuro.2017.07.004.

PMID:
    28694016
    [PubMed - as supplied by publisher]
Related citations


Factors Associated With End-of-Life Planning in Huntington Disease.
Downing NR, Goodnight S, Chae S, Perlmutter JS, McCormack M, Hahn E, Barton SK, Carlozzi N
Am J Hosp Palliat Care. 2017 Jan 1; 1049909117708195. doi: 10.1177/1049909117708195.

PMID:
    28655280
    [PubMed - as supplied by publisher]
Related citations


Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate.
Yue X, Jin H, Liu H, Luo Z, Zhang X, Kaneshige K, Flores HP, Perlmutter JS, Parsons SM, Tu Z
Org Biomol Chem. 2017 Jun 21; 15(24)5197-5209. doi: 10.1039/c7ob00854f.

PMID:
    28590490
    [PubMed - in process]
Related citations


Research Priorities in Limb and Task-Specific Dystonias.
Pirio Richardson S, Altenmüller E, Alter K, Alterman RL, Chen R, Frucht S, Furuya S, Jankovic J, Jinnah HA, Kimberley TJ, Lungu C, Perlmutter JS, Prudente CN, Hallett M
Front Neurol. 2017; 8170. doi: 10.3389/fneur.2017.00170.

PMID:
    28515706
    [PubMed]
Related citations


ACR Appropriateness Criteria<sup>®</sup> Cerebrovascular Disease.
Expert Panel on Neurologic Imaging:., Salmela MB, Mortazavi S, Jagadeesan BD, Broderick DF, Burns J, Deshmukh TK, Harvey HB, Hoang J, Hunt CH, Kennedy TA, Khalessi AA, Mack W, Patel ND, Perlmutter JS, Policeni B, Schroeder JW, Setzen G, Whitehead MT, Cornelius RS, Corey AS
J Am Coll Radiol. 2017 May; 14(5S)S34-S61. doi: 10.1016/j.jacr.2017.01.051.

PMID:
    28473091
    [PubMed - in process]
Related citations


TMEM230 in Parkinson's disease.
Ibanez L, Dube U, Budde J, Black K, Medvedeva A, Davis AA, Perlmutter JS, Benitez BA, Cruchaga C
Neurobiol Aging. 2017 Aug; 56212.e1-212.e3. doi: 10.1016/j.neurobiolaging.2017.03.014.

PMID:
    28457580
    [PubMed - indexed for MEDLINE]
Related citations


Psychiatric associations of adult-onset focal dystonia phenotypes.
Berman BD, Junker J, Shelton E, Sillau SH, Jinnah HA, Perlmutter JS, Espay AJ, Jankovic J, Vidailhet M, Bonnet C, Ondo W, Malaty IA, Rodríguez R, McDonald WM, Marsh L, Zurowski M, Bäumer T, Brüggemann N
J Neurol Neurosurg Psychiatry. 2017 Jul; 88(7)595-602. doi: 10.1136/jnnp-2016-315461.

PMID:
    28438790
    [PubMed - indexed for MEDLINE]
Related citations


Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response.
Han J, Liu H, Liu C, Jin H, Perlmutter JS, Egan TM, Tu Z
Nucl Med Commun. 2017 May; 38(5)372-382. doi: 10.1097/MNM.0000000000000660.

PMID:
    28338530
    [PubMed - indexed for MEDLINE]
Related citations


Striatal molecular imaging of presynaptic markers: Ready, fire, aim.
Takeda A, Perlmutter JS
Neurology. 2017 Apr 11; 88(15)1388-1389. doi: 10.1212/WNL.0000000000003827.

PMID:
    28283591
    [PubMed - in process]
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Pathologic correlates of supranuclear gaze palsy with parkinsonism.
Martin WRW, Hartlein J, Racette BA, Cairns N, Perlmutter JS
Parkinsonism Relat Disord. 2017 May; 3868-71. doi: 10.1016/j.parkreldis.2017.02.027.

PMID:
    28256434
    [PubMed - indexed for MEDLINE]
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No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
Geissler JM, International Parkinson Disease Genomics Consortium members., Romanos M, Gerlach M, Berg D, Schulte C
Atten Defic Hyperact Disord. 2017 Jun; 9(2)121-127. doi: 10.1007/s12402-017-0219-8.

PMID:
    28176268
    [PubMed - in process]
Related citations


Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers.
Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JÁ, Cilia R, Ballanger B, Niethammer M, Stoessl JA, IPMDS-Neuroimaging Study Group.
Mov Disord. 2017 Feb; 32(2)181-192. doi: 10.1002/mds.26907.

PMID:
    28150432
    [PubMed - indexed for MEDLINE]
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