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Joel S. Perlmutter, MD

Elliot Stein Family Professor of Neurology
Section Chief, Movement Disorders
Professor, Radiology
Professor , Physical Therapy
Associate Professor, Anatomy and Neurobiology

Specialty Areas

Parkinson's Disease
Movement Disorders
Neurology - Adult
Huntington's Disease
Dystonia
Tremor
Tourette's Syndrome

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Parkinson's disease, Huntington's disease, Tourette syndrome, dystonia, hyperkinetic disorders, essential tremor and other movement disorders, imaging research using PET and MR, clinical drug trials

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6908
Fax: 314-747-3258

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Suite: Lower Level
Office Phone: 314-362-6908
Fax: 314-747-3258

Education

Education

Fellowship: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 1984
Residency: Washington University School Medicine, St. Louis, Missouri 1980
Medical Degree: University Of Missouri, Columbia, Missouri 1979
B.A.: Princeton University, Princeton, New Jersey 1975
Externship: Psychiatry, Menninger Foundation, Topeka, Kansas 1978

Publication & Research

Publication & Research

Adult-onset dystonia with marfanoid features.
Norris SA, Pogarcic A, Hicks M, Perlmutter JS, Shinawi M
Neurol Clin Pract. 2017 Aug; 7(4)e31-e34. doi: 10.1212/CPJ.0000000000000297.

PMID:
    28840904
    [PubMed]
Related citations


[<sup>18</sup>F]FDOPA positron emission tomography in manganese-exposed workers.
Criswell SR, Nielsen SS, Warden M, Perlmutter JS, Moerlein SM, Flores HP, Huang J, Sheppard L, Seixas N, Checkoway H, Racette BA
Neurotoxicology. 2017 Jul 8; pii: S0161-813X(17)30117-1. doi: 10.1016/j.neuro.2017.07.004.

PMID:
    28694016
    [PubMed - as supplied by publisher]
Related citations


Factors Associated With End-of-Life Planning in Huntington Disease.
Downing NR, Goodnight S, Chae S, Perlmutter JS, McCormack M, Hahn E, Barton SK, Carlozzi N
Am J Hosp Palliat Care. 2017 Jan 1; 1049909117708195. doi: 10.1177/1049909117708195.

PMID:
    28655280
    [PubMed - as supplied by publisher]
Related citations


Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate.
Yue X, Jin H, Liu H, Luo Z, Zhang X, Kaneshige K, Flores HP, Perlmutter JS, Parsons SM, Tu Z
Org Biomol Chem. 2017 Jun 21; 15(24)5197-5209. doi: 10.1039/c7ob00854f.

PMID:
    28590490
    [PubMed - in process]
Related citations


Research Priorities in Limb and Task-Specific Dystonias.
Pirio Richardson S, Altenmüller E, Alter K, Alterman RL, Chen R, Frucht S, Furuya S, Jankovic J, Jinnah HA, Kimberley TJ, Lungu C, Perlmutter JS, Prudente CN, Hallett M
Front Neurol. 2017; 8170. doi: 10.3389/fneur.2017.00170.

PMID:
    28515706
    [PubMed]
Related citations


ACR Appropriateness Criteria<sup>®</sup> Cerebrovascular Disease.
Expert Panel on Neurologic Imaging:., Salmela MB, Mortazavi S, Jagadeesan BD, Broderick DF, Burns J, Deshmukh TK, Harvey HB, Hoang J, Hunt CH, Kennedy TA, Khalessi AA, Mack W, Patel ND, Perlmutter JS, Policeni B, Schroeder JW, Setzen G, Whitehead MT, Cornelius RS, Corey AS
J Am Coll Radiol. 2017 May; 14(5S)S34-S61. doi: 10.1016/j.jacr.2017.01.051.

PMID:
    28473091
    [PubMed - in process]
Related citations


TMEM230 in Parkinson's disease.
Ibanez L, Dube U, Budde J, Black K, Medvedeva A, Davis AA, Perlmutter JS, Benitez BA, Cruchaga C
Neurobiol Aging. 2017 Aug; 56212.e1-212.e3. doi: 10.1016/j.neurobiolaging.2017.03.014.

PMID:
    28457580
    [PubMed - in process]
Related citations


Psychiatric associations of adult-onset focal dystonia phenotypes.
Berman BD, Junker J, Shelton E, Sillau SH, Jinnah HA, Perlmutter JS, Espay AJ, Jankovic J, Vidailhet M, Bonnet C, Ondo W, Malaty IA, Rodríguez R, McDonald WM, Marsh L, Zurowski M, Bäumer T, Brüggemann N
J Neurol Neurosurg Psychiatry. 2017 Jul; 88(7)595-602. doi: 10.1136/jnnp-2016-315461.

PMID:
    28438790
    [PubMed - indexed for MEDLINE]
Related citations


Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response.
Han J, Liu H, Liu C, Jin H, Perlmutter JS, Egan TM, Tu Z
Nucl Med Commun. 2017 May; 38(5)372-382. doi: 10.1097/MNM.0000000000000660.

PMID:
    28338530
    [PubMed - indexed for MEDLINE]
Related citations


Striatal molecular imaging of presynaptic markers: Ready, fire, aim.
Takeda A, Perlmutter JS
Neurology. 2017 Apr 11; 88(15)1388-1389. doi: 10.1212/WNL.0000000000003827.

PMID:
    28283591
    [PubMed - in process]
Related citations


Pathologic correlates of supranuclear gaze palsy with parkinsonism.
Martin WRW, Hartlein J, Racette BA, Cairns N, Perlmutter JS
Parkinsonism Relat Disord. 2017 May; 3868-71. doi: 10.1016/j.parkreldis.2017.02.027.

PMID:
    28256434
    [PubMed - indexed for MEDLINE]
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No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
Geissler JM, International Parkinson Disease Genomics Consortium members., Romanos M, Gerlach M, Berg D, Schulte C
Atten Defic Hyperact Disord. 2017 Jun; 9(2)121-127. doi: 10.1007/s12402-017-0219-8.

PMID:
    28176268
    [PubMed - in process]
Related citations


Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers.
Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JÁ, Cilia R, Ballanger B, Niethammer M, Stoessl JA, IPMDS-Neuroimaging Study Group.
Mov Disord. 2017 Feb; 32(2)181-192. doi: 10.1002/mds.26907.

PMID:
    28150432
    [PubMed - in process]
Related citations


Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
Jansen IE, Ye H, Heetveld S, Lechler MC, Michels H, Seinstra RI, Lubbe SJ, Drouet V, Lesage S, Majounie E, Gibbs JR, Nalls MA, Ryten M, Botia JA, Vandrovcova J, Simon-Sanchez J, Castillo-Lizardo M, Rizzu P, Blauwendraat C, Chouhan AK, Li Y, Yogi P, Amin N, van Duijn CM, International Parkinson’s Disease Genetics Consortium (IPGDC)., Morris HR, Brice A, Singleton AB, David DC, Nollen EA, Jain S, Shulman JM, Heutink P
Genome Biol. 2017 Jan 30; 18(1)22. doi: 10.1186/s13059-017-1147-9.

PMID:
    28137300
    [PubMed - in process]
Related citations


Chiral resolution of serial potent and selective σ<sub>1</sub> ligands and biological evaluation of (-)-[<sup>18</sup>F]TZ3108 in rodent and the nonhuman primate brain.
Yue X, Jin H, Luo Z, Liu H, Zhang X, McSpadden ED, Tian L, Flores HP, Perlmutter JS, Parsons SM, Tu Z
Bioorg Med Chem. 2017 Feb 15; 25(4)1533-1542. doi: 10.1016/j.bmc.2017.01.017.

PMID:
    28129990
    [PubMed - indexed for MEDLINE]
Related citations


Absorbed radiation dosimetry of the D<sub>3</sub>-specific PET radioligand [<sup>18</sup>F]FluorTriopride estimated using rodent and nonhuman primate.
Laforest R, Karimi M, Moerlein SM, Xu J, Flores HP, Bognar C, Li A, Mach RH, Perlmutter JS, Tu Z
Am J Nucl Med Mol Imaging. 2016; 6(6)301-309.

PMID:
    28078183
    [PubMed]
Related citations


A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.
McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, Guttman M, Wojcieszek J, Kumar R, LeDoux MS, Jenkins M, Rosas HD, Nance M, Biglan K, Como P, Dubinsky RM, Shannon KM, O'Suilleabhain P, Chou K, Walker F, Martin W, Wheelock VL, McCusker E, Jankovic J, Singer C, Sanchez-Ramos J, Scott B, Suchowersky O, Factor SA, Higgins DS Jr, Molho E, Revilla F, Caviness JN, Friedman JH, Perlmutter JS, Feigin A, Anderson K, Rodriguez R, McFarland NR, Margolis RL, Farbman ES, Raymond LA, Suski V, Kostyk S, Colcher A, Seeberger L, Epping E, Esmail S, Diaz N, Fung WL, Diamond A, Frank S, Hanna P, Hermanowicz N, Dure LS, Cudkowicz M, Huntington Study Group 2CARE Investigators and Coordinators.
Neurology. 2017 Jan 10; 88(2)152-159. doi: 10.1212/WNL.0000000000003478.

PMID:
    27913695
    [PubMed - indexed for MEDLINE]
Related citations


Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia.
Eisenstein SA, Bogdan R, Chen L, Moerlein SM, Black KJ, Perlmutter JS, Hershey T, Barch DM
J Psychiatr Res. 2017 Mar; 869-17. doi: 10.1016/j.jpsychires.2016.11.007.

PMID:
    27886638
    [PubMed - indexed for MEDLINE]
Related citations


Sex-specific effects of the Huntington gene on normal neurodevelopment.
Lee JK, Ding Y, Conrad AL, Cattaneo E, Epping E, Mathews K, Gonzalez-Alegre P, Cahill L, Magnotta V, Schlaggar BL, Perlmutter JS, Kim RE, Dawson JD, Nopoulos P
J Neurosci Res. 2017 Jan 2; 95(1-2)398-408. doi: 10.1002/jnr.23980.

PMID:
    27870408
    [PubMed - in process]
Related citations


Objective, computerized video-based rating of blepharospasm severity.
Peterson DA, Littlewort GC, Bartlett MS, Macerollo A, Perlmutter JS, Jinnah HA, Hallett M, Sejnowski TJ
Neurology. 2016 Nov 15; 87(20)2146-2153.

PMID:
    27770067
    [PubMed - indexed for MEDLINE]
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