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Joel S. Perlmutter, MD

Elliot Stein Family Professor of Neurology
Section Chief, Movement Disorders
Professor, Radiology
Professor , Physical Therapy
Associate Professor, Anatomy and Neurobiology

Specialty Areas

Parkinson's Disease
Movement Disorders
Neurology - Adult
Huntington's Disease
Dystonia
Tremor
Tourette's Syndrome

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Parkinson disease, Huntington's disease, Tourette syndrome, dystonia, hyperkinetic disorders, essential tremor and other movement disorders, imaging research using PET and MR, clinical drug trials

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6908
Fax: 314-747-3258

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Suite: Lower Level
Office Phone: 314-362-6908
Fax: 314-747-3258

Education

Education

Fellowship: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 1984
Residency: Washington University School Medicine, St. Louis, Missouri 1980
Medical Degree: University Of Missouri, Columbia, Missouri 1979
B.A.: Princeton University, Princeton, New Jersey 1975
Externship: Psychiatry, Menninger Foundation, Topeka, Kansas 1978

Publication & Research

Publication & Research

Psychiatric associations of adult-onset focal dystonia phenotypes.
Berman BD, Junker J, Shelton E, Sillau SH, Jinnah HA, Perlmutter JS, Espay AJ, Jankovic J, Vidailhet M, Bonnet C, Ondo W, Malaty IA, Rodríguez R, McDonald WM, Marsh L, Zurowski M, Bäumer T, Brüggemann N
J Neurol Neurosurg Psychiatry. 2017 Apr 24; pii: jnnp-2016-315461. doi: 10.1136/jnnp-2016-315461.

PMID:
    28438790
    [PubMed - as supplied by publisher]
Related citations


Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response.
Han J, Liu H, Liu C, Jin H, Perlmutter JS, Egan TM, Tu Z
Nucl Med Commun. 2017 May; 38(5)372-382. doi: 10.1097/MNM.0000000000000660.

PMID:
    28338530
    [PubMed - in process]
Related citations


Striatal molecular imaging of presynaptic markers: Ready, fire, aim.
Takeda A, Perlmutter JS
Neurology. 2017 Apr 11; 88(15)1388-1389. doi: 10.1212/WNL.0000000000003827.

PMID:
    28283591
    [PubMed - in process]
Related citations


Pathologic correlates of supranuclear gaze palsy with parkinsonism.
Martin WRW, Hartlein J, Racette BA, Cairns N, Perlmutter JS
Parkinsonism Relat Disord. 2017 May; 3868-71. doi: 10.1016/j.parkreldis.2017.02.027.

PMID:
    28256434
    [PubMed - in process]
Related citations


No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
Geissler JM, International Parkinson Disease Genomics Consortium members., Romanos M, Gerlach M, Berg D, Schulte C
Atten Defic Hyperact Disord. 2017 Feb 7; doi: 10.1007/s12402-017-0219-8.

PMID:
    28176268
    [PubMed - as supplied by publisher]
Related citations


Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers.
Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JÁ, Cilia R, Ballanger B, Niethammer M, Stoessl JA, IPMDS-Neuroimaging Study Group.
Mov Disord. 2017 Feb; 32(2)181-192. doi: 10.1002/mds.26907.

PMID:
    28150432
    [PubMed - in process]
Related citations


Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
Jansen IE, Ye H, Heetveld S, Lechler MC, Michels H, Seinstra RI, Lubbe SJ, Drouet V, Lesage S, Majounie E, Gibbs JR, Nalls MA, Ryten M, Botia JA, Vandrovcova J, Simon-Sanchez J, Castillo-Lizardo M, Rizzu P, Blauwendraat C, Chouhan AK, Li Y, Yogi P, Amin N, van Duijn CM, International Parkinson’s Disease Genetics Consortium (IPGDC)., Morris HR, Brice A, Singleton AB, David DC, Nollen EA, Jain S, Shulman JM, Heutink P
Genome Biol. 2017 Jan 30; 18(1)22. doi: 10.1186/s13059-017-1147-9.

PMID:
    28137300
    [PubMed - in process]
Related citations


Chiral resolution of serial potent and selective σ<sub>1</sub> ligands and biological evaluation of (-)-[<sup>18</sup>F]TZ3108 in rodent and the nonhuman primate brain.
Yue X, Jin H, Luo Z, Liu H, Zhang X, McSpadden ED, Tian L, Flores HP, Perlmutter JS, Parsons SM, Tu Z
Bioorg Med Chem. 2017 Feb 15; 25(4)1533-1542. doi: 10.1016/j.bmc.2017.01.017.

PMID:
    28129990
    [PubMed - in process]
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Absorbed radiation dosimetry of the D<sub>3</sub>-specific PET radioligand [<sup>18</sup>F]FluorTriopride estimated using rodent and nonhuman primate.
Laforest R, Karimi M, Moerlein SM, Xu J, Flores HP, Bognar C, Li A, Mach RH, Perlmutter JS, Tu Z
Am J Nucl Med Mol Imaging. 2016; 6(6)301-309.

PMID:
    28078183
    [PubMed]
Related citations


A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.
McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, Guttman M, Wojcieszek J, Kumar R, LeDoux MS, Jenkins M, Rosas HD, Nance M, Biglan K, Como P, Dubinsky RM, Shannon KM, O'Suilleabhain P, Chou K, Walker F, Martin W, Wheelock VL, McCusker E, Jankovic J, Singer C, Sanchez-Ramos J, Scott B, Suchowersky O, Factor SA, Higgins DS Jr, Molho E, Revilla F, Caviness JN, Friedman JH, Perlmutter JS, Feigin A, Anderson K, Rodriguez R, McFarland NR, Margolis RL, Farbman ES, Raymond LA, Suski V, Kostyk S, Colcher A, Seeberger L, Epping E, Esmail S, Diaz N, Fung WL, Diamond A, Frank S, Hanna P, Hermanowicz N, Dure LS, Cudkowicz M, Huntington Study Group 2CARE Investigators and Coordinators.
Neurology. 2017 Jan 10; 88(2)152-159. doi: 10.1212/WNL.0000000000003478.

PMID:
    27913695
    [PubMed - in process]
Related citations


Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia.
Eisenstein SA, Bogdan R, Chen L, Moerlein SM, Black KJ, Perlmutter JS, Hershey T, Barch DM
J Psychiatr Res. 2017 Mar; 869-17. doi: 10.1016/j.jpsychires.2016.11.007.

PMID:
    27886638
    [PubMed - in process]
Related citations


Sex-specific effects of the Huntington gene on normal neurodevelopment.
Lee JK, Ding Y, Conrad AL, Cattaneo E, Epping E, Mathews K, Gonzalez-Alegre P, Cahill L, Magnotta V, Schlaggar BL, Perlmutter JS, Kim RE, Dawson JD, Nopoulos P
J Neurosci Res. 2017 Jan 2; 95(1-2)398-408. doi: 10.1002/jnr.23980.

PMID:
    27870408
    [PubMed - in process]
Related citations


Objective, computerized video-based rating of blepharospasm severity.
Peterson DA, Littlewort GC, Bartlett MS, Macerollo A, Perlmutter JS, Jinnah HA, Hallett M, Sejnowski TJ
Neurology. 2016 Nov 15; 87(20)2146-2153.

PMID:
    27770067
    [PubMed - in process]
Related citations


Clinical and demographic characteristics related to onset site and spread of cervical dystonia.
Norris SA, Jinnah HA, Espay AJ, Klein C, Brüggemann N, Barbano RL, Malaty IA, Rodriguez RL, Vidailhet M, Roze E, Reich SG, Berman BD, LeDoux MS, Richardson SP, Agarwal P, Mari Z, Ondo WG, Shih LC, Fox SH, Berardelli A, Testa CM, Cheng FC, Truong D, Nahab FB, Xie T, Hallett M, Rosen AR, Wright LJ, Perlmutter JS
Mov Disord. 2016 Dec; 31(12)1874-1882. doi: 10.1002/mds.26817.

PMID:
    27753188
    [PubMed - in process]
Related citations


Comparison of [<sup>11</sup>C]TZ1964B and [<sup>18</sup>F]MNI659 for PET imaging brain PDE10A in nonhuman primates.
Liu H, Jin H, Yue X, Han J, Yang H, Flores H, Su Y, Alagille D, Perlmutter JS, Tamagnan G, Tu Z
Pharmacol Res Perspect. 2016 Oct; 4(5)e00253.

PMID:
    27713824
    [PubMed - in process]
Related citations


HDQLIFE: development and assessment of health-related quality of life in Huntington disease (HD).
Carlozzi NE, Schilling SG, Lai JS, Paulsen JS, Hahn EA, Perlmutter JS, Ross CA, Downing NR, Kratz AL, McCormack MK, Nance MA, Quaid KA, Stout JC, Gershon RC, Ready RE, Miner JA, Barton SK, Perlman SL, Rao SM, Frank S, Shoulson I, Marin H, Geschwind MD, Dayalu P, Goodnight SM, Cella D
Qual Life Res. 2016 Oct; 25(10)2441-2455. doi: 10.1007/s11136-016-1386-3.

PMID:
    27522213
    [PubMed - in process]
Related citations


ACR Appropriateness Criteria Low Back Pain.
Patel ND, Broderick DF, Burns J, Deshmukh TK, Fries IB, Harvey HB, Holly L, Hunt CH, Jagadeesan BD, Kennedy TA, O'Toole JE, Perlmutter JS, Policeni B, Rosenow JM, Schroeder JW, Whitehead MT, Cornelius RS, Corey AS
J Am Coll Radiol. 2016 Sep; 13(9)1069-78. doi: 10.1016/j.jacr.2016.06.008.

PMID:
    27496288
    [PubMed - in process]
Related citations


New measures to capture end of life concerns in Huntington disease: Meaning and Purpose and Concern with Death and Dying from HDQLIFE (a patient-reported outcomes measurement system).
Carlozzi NE, Downing NR, McCormack MK, Schilling SG, Perlmutter JS, Hahn EA, Lai J-, Frank S, Quaid KA, Paulsen JS, Cella D, Goodnight SM, Miner JA, Nance MA
Qual Life Res. 2016 Oct; 25(10)2403-2415. doi: 10.1007/s11136-016-1354-y.

PMID:
    27393121
    [PubMed - in process]
Related citations


Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D2 Receptor Binding and Age in Obesity.
Pepino MY, Eisenstein SA, Bischoff AN, Klein S, Moerlein SM, Perlmutter JS, Black KJ, Hershey T
Diabetes. 2016 Sep; 65(9)2618-23. doi: 10.2337/db16-0407.

PMID:
    27307220
    [PubMed - in process]
Related citations


Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status.
Eisenstein SA, Bogdan R, Love-Gregory L, Corral-Frías NS, Koller JM, Black KJ, Moerlein SM, Perlmutter JS, Barch DM, Hershey T
Synapse. 2016 Oct; 70(10)418-31. doi: 10.1002/syn.21916.

PMID:
    27241797
    [PubMed - in process]
Related citations