Patient Portal

Joel S. Perlmutter, MD

Elliot Stein Family Professor of Neurology
Section Chief, Movement Disorders
Professor, Radiology
Professor , Physical Therapy
Associate Professor, Anatomy and Neurobiology

Specialty Areas

Parkinson's Disease
Movement Disorders
Neurology - Adult
Huntington's Disease
Dystonia
Tremor
Tourette's Syndrome

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Parkinson's disease, Huntington's disease, Tourette syndrome, dystonia, hyperkinetic disorders, essential tremor and other movement disorders, imaging research using PET and MR, clinical drug trials

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6908
Fax: 314-747-3258

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Suite: Lower Level
Office Phone: 314-362-6908
Fax: 314-747-3258

Education

Education

Fellowship: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 1984
Residency: Washington University School Medicine, St. Louis, Missouri 1980
Medical Degree: University Of Missouri, Columbia, Missouri 1979
B.A.: Princeton University, Princeton, New Jersey 1975
Externship: Psychiatry, Menninger Foundation, Topeka, Kansas 1978

Publication & Research

Publication & Research

<i>APOE</i> genotype regulates pathology and disease progression in synucleinopathy.
Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA, Sullivan PM, Cruchaga C, Perlmutter JS, Ulrich JD, Benitez BA, Kotzbauer PT, Holtzman DM
Sci Transl Med. 2020 Feb 5; 12(529)pii: eaay3069. doi: 10.1126/scitranslmed.aay3069.

PMID:
    32024799
    [PubMed - in process]
Related citations


Postural Directionality and Head Tremor in Cervical Dystonia.
Chen Q, Vu JP, Cisneros E, Benadof CN, Zhang Z, Barbano RL, Goetz CG, Jankovic J, Jinnah HA, Perlmutter JS, Appelbaum MI, Stebbins GT, Comella CL, Peterson DA
Tremor Other Hyperkinet Mov (N Y). 2020; 10doi: 10.7916/tohm.v0.745.

PMID:
    32015932
    [PubMed - in process]
Related citations


Little Change in Functional Brain Networks Following Acute Levodopa in Drug-Naïve Parkinson's Disease.
White RL 3rd, Campbell MC, Yang D, Shannon W, Snyder AZ, Perlmutter JS
Mov Disord. 2019 Dec 19; doi: 10.1002/mds.27942.

PMID:
    31854465
    [PubMed - as supplied by publisher]
Related citations


Psychometric properties and responsiveness of Neuro-QoL Cognitive Function in persons with Huntington disease (HD).
Carlozzi NE, Boileau NR, Paulsen JS, Downing NR, Ready R, Perlmutter JS, Cella D, Chou KL, McCormack MK, Barton S, Lai JS
Qual Life Res. 2019 Dec 18; doi: 10.1007/s11136-019-02391-7.

PMID:
    31853881
    [PubMed - as supplied by publisher]
Related citations


Proteinopathy and longitudinal changes in functional connectivity networks in Parkinson disease.
Campbell MC, Jackson JJ, Koller JM, Snyder AZ, Kotzbauer PT, Perlmutter JS
Neurology. 2020 Feb 18; 94(7)e718-e728. doi: 10.1212/WNL.0000000000008677.

PMID:
    31852813
    [PubMed - in process]
Related citations


Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease.
Maiti B, Koller JM, Snyder AZ, Tanenbaum AB, Norris SA, Campbell MC, Perlmutter JS
Neurology. 2020 Jan 28; 94(4)e384-e396. doi: 10.1212/WNL.0000000000008754.

PMID:
    31848257
    [PubMed - in process]
Related citations


Risk of spread in adult-onset isolated focal dystonia: a prospective international cohort study.
Berman BD, Groth CL, Sillau SH, Pirio Richardson S, Norris SA, Junker J, Brüggemann N, Agarwal P, Barbano RL, Espay AJ, Vizcarra JA, Klein C, Bäumer T, Loens S, Reich SG, Vidailhet M, Bonnet C, Roze E, Jinnah HA, Perlmutter JS
J Neurol Neurosurg Psychiatry. 2020 Mar; 91(3)314-320. doi: 10.1136/jnnp-2019-321794.

PMID:
    31848221
    [PubMed - in process]
Related citations


Striatal DAT SPECT: Caveat Emptor!
Perlmutter JS, Stoessl AJ
Mov Disord. 2019 Oct; 34(10)1430-1432. doi: 10.1002/mds.27811.

PMID:
    31769089
    [PubMed - in process]
Related citations


Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?
Yang P, Perlmutter JS, Benzinger TLS, Morris JC, Xu J
Ageing Res Rev. 2020 Jan; 57100994. doi: 10.1016/j.arr.2019.100994.

PMID:
    31765822
    [PubMed - in process]
Related citations


The impact of dopamine D<sub>2</sub>-like agonist/antagonist on [<sup>18</sup>F]VAT PET measurement of VAChT in the brain of nonhuman primates.
Liu H, Luo Z, Gu J, Su Y, Flores H, Parsons SM, Zhou Y, Perlmutter JS, Tu Z
Eur J Pharm Sci. 2020 Feb 15; 143105152. doi: 10.1016/j.ejps.2019.105152.

PMID:
    31740395
    [PubMed - in process]
Related citations


Detecting associations between intact connectomes and clinical covariates using recursive partitioning object-oriented data analysis.
Yang D, Deych E, Shands B, Campbell MC, Perlmutter JS, Petersen S, Schlaggar BL, Shannon W
Stat Med. 2019 Dec 20; 38(29)5486-5496. doi: 10.1002/sim.8374.

PMID:
    31650580
    [PubMed - in process]
Related citations


The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases.
Li H, Yang P, Knight W, Guo Y, Perlmutter JS, Benzinger TLS, Morris JC, Xu J
J Neurochem. 2020 Jan; 152(2)235-251. doi: 10.1111/jnc.14898.

PMID:
    31613384
    [PubMed - in process]
Related citations


How different aspects of motor dysfunction influence day-to-day function in huntington's disease.
Carlozzi NE, Schilling SG, Boileau NR, Chou KL, Perlmutter JS, Frank S, McCormack MK, Stout JC, Paulsen JS, Lai JS, Dayalu P
Mov Disord. 2019 Dec; 34(12)1910-1914. doi: 10.1002/mds.27866.

PMID:
    31609508
    [PubMed - in process]
Related citations


Neuroinflammation and Myelin Status in Alzheimer's Disease, Parkinson's Disease, and Normal Aging Brains: A Small Sample Study.
Han F, Perrin RJ, Wang Q, Wang Y, Perlmutter JS, Morris JC, Benzinger TLS, Xu J
Parkinsons Dis. 2019; 20197975407. doi: 10.1155/2019/7975407.

PMID:
    31354934
    [PubMed]
Related citations


Low Back Pain--Related Disability in Parkinson Disease: Impact on Functional Mobility, Physical Activity, and Quality of Life.
Duncan RP, Van Dillen LR, Garbutt JM, Earhart GM, Perlmutter JS
Phys Ther. 2019 Oct 28; 99(10)1346-1353. doi: 10.1093/ptj/pzz094.

PMID:
    31343700
    [PubMed - indexed for MEDLINE]
Related citations


Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [<sup>11</sup>C]CS1P1 for human use.
Luo Z, Gu J, Dennett RC, Gaehle GG, Perlmutter JS, Chen DL, Benzinger TLS, Tu Z
Appl Radiat Isot. 2019 Oct; 15230-36. doi: 10.1016/j.apradiso.2019.06.029.

PMID:
    31280104
    [PubMed - indexed for MEDLINE]
Related citations


End-of-life measures in Huntington disease: HDQLIFE Meaning and Purpose, Concern with Death and Dying, and End of Life Planning.
Carlozzi NE, Boileau NR, Paulsen JS, Perlmutter JS, Lai JS, Hahn EA, McCormack MK, Nance MA, Cella D, Barton SK, Downing NR
J Neurol. 2019 Oct; 266(10)2406-2422. doi: 10.1007/s00415-019-09417-7.

PMID:
    31190171
    [PubMed - in process]
Related citations


Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain.
Yu Y, Liang Q, Liu H, Luo Z, Hu H, Perlmutter JS, Tu Z
Org Biomol Chem. 2019 Jun 5; 17(22)5586-5594. doi: 10.1039/c9ob00893d.

PMID:
    31115430
    [PubMed - indexed for MEDLINE]
Related citations


Head tremor at disease onset: an ataxic phenotype of cervical dystonia.
Merola A, Dwivedi AK, Shaikh AG, Tareen TK, Da Prat GA, Kauffman MA, Hampf J, Mahajan A, Marsili L, Jankovic J, Comella CL, Berman BD, Perlmutter JS, Jinnah HA, Espay AJ
J Neurol. 2019 Aug; 266(8)1844-1851. doi: 10.1007/s00415-019-09341-w.

PMID:
    31028543
    [PubMed - indexed for MEDLINE]
Related citations


Exercise and Parkinson Disease: Comparing Tango, Treadmill, and Stretching.
Rawson KS, McNeely ME, Duncan RP, Pickett KA, Perlmutter JS, Earhart GM
J Neurol Phys Ther. 2019 Jan; 43(1)26-32. doi: 10.1097/NPT.0000000000000245.

PMID:
    30531383
    [PubMed - in process]
Related citations