Patient Portal

Joel S. Perlmutter, MD

Elliot Stein Family Professor of Neurology
Section Chief, Movement Disorders
Professor, Radiology
Professor , Physical Therapy
Associate Professor, Anatomy and Neurobiology

Specialty Areas

Parkinson's Disease
Movement Disorders
Neurology - Adult
Huntington's Disease
Dystonia
Tremor
Tourette's Syndrome

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Parkinson's disease, Huntington's disease, Tourette syndrome, dystonia, hyperkinetic disorders, essential tremor and other movement disorders, imaging research using PET and MR, clinical drug trials

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6908
Fax: 314-747-3258

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Suite: Lower Level
Office Phone: 314-362-6908
Fax: 314-747-3258

Education

Education

Fellowship: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 1984
Residency: Washington University School Medicine, St. Louis, Missouri 1980
Medical Degree: University Of Missouri, Columbia, Missouri 1979
B.A.: Princeton University, Princeton, New Jersey 1975
Externship: Psychiatry, Menninger Foundation, Topeka, Kansas 1978

Publication & Research

Publication & Research

Detecting associations between intact connectomes and clinical covariates using recursive partitioning object-oriented data analysis.
Yang D, Deych E, Shands B, Campbell MC, Perlmutter JS, Petersen S, Schlaggar BL, Shannon W
Stat Med. 2019 Dec 20; 38(29)5486-5496. doi: 10.1002/sim.8374.

PMID:
    31650580
    [PubMed - in process]
Related citations


The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases.
Li H, Yang P, Knight W, Guo Y, Perlmutter JS, Benzinger TLS, Morris JC, Xu J
J Neurochem. 2019 Oct 15; doi: 10.1111/jnc.14898.

PMID:
    31613384
    [PubMed - as supplied by publisher]
Related citations


How different aspects of motor dysfunction influence day-to-day function in huntington's disease.
Carlozzi NE, Schilling SG, Boileau NR, Chou KL, Perlmutter JS, Frank S, McCormack MK, Stout JC, Paulsen JS, Lai JS, Dayalu P
Mov Disord. 2019 Oct 14; doi: 10.1002/mds.27866.

PMID:
    31609508
    [PubMed - as supplied by publisher]
Related citations


Neuroinflammation and Myelin Status in Alzheimer's Disease, Parkinson's Disease, and Normal Aging Brains: A Small Sample Study.
Han F, Perrin RJ, Wang Q, Wang Y, Perlmutter JS, Morris JC, Benzinger TLS, Xu J
Parkinsons Dis. 2019; 20197975407. doi: 10.1155/2019/7975407.

PMID:
    31354934
    [PubMed]
Related citations


Low Back Pain--Related Disability in Parkinson Disease: Impact on Functional Mobility, Physical Activity, and Quality of Life.
Duncan RP, Van Dillen LR, Garbutt JM, Earhart GM, Perlmutter JS
Phys Ther. 2019 Oct 28; 99(10)1346-1353. doi: 10.1093/ptj/pzz094.

PMID:
    31343700
    [PubMed - in process]
Related citations


Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [<sup>11</sup>C]CS1P1 for human use.
Luo Z, Gu J, Dennett RC, Gaehle GG, Perlmutter JS, Chen DL, Benzinger TLS, Tu Z
Appl Radiat Isot. 2019 Oct; 15230-36. doi: 10.1016/j.apradiso.2019.06.029.

PMID:
    31280104
    [PubMed - in process]
Related citations


End-of-life measures in Huntington disease: HDQLIFE Meaning and Purpose, Concern with Death and Dying, and End of Life Planning.
Carlozzi NE, Boileau NR, Paulsen JS, Perlmutter JS, Lai JS, Hahn EA, McCormack MK, Nance MA, Cella D, Barton SK, Downing NR
J Neurol. 2019 Oct; 266(10)2406-2422. doi: 10.1007/s00415-019-09417-7.

PMID:
    31190171
    [PubMed - in process]
Related citations


Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain.
Yu Y, Liang Q, Liu H, Luo Z, Hu H, Perlmutter JS, Tu Z
Org Biomol Chem. 2019 Jun 5; 17(22)5586-5594. doi: 10.1039/c9ob00893d.

PMID:
    31115430
    [PubMed - in process]
Related citations


Head tremor at disease onset: an ataxic phenotype of cervical dystonia.
Merola A, Dwivedi AK, Shaikh AG, Tareen TK, Da Prat GA, Kauffman MA, Hampf J, Mahajan A, Marsili L, Jankovic J, Comella CL, Berman BD, Perlmutter JS, Jinnah HA, Espay AJ
J Neurol. 2019 Aug; 266(8)1844-1851. doi: 10.1007/s00415-019-09341-w.

PMID:
    31028543
    [PubMed - in process]
Related citations


Exercise and Parkinson Disease: Comparing Tango, Treadmill, and Stretching.
Rawson KS, McNeely ME, Duncan RP, Pickett KA, Perlmutter JS, Earhart GM
J Neurol Phys Ther. 2019 Jan; 43(1)26-32. doi: 10.1097/NPT.0000000000000245.

PMID:
    30531383
    [PubMed - in process]
Related citations


Thalamic and ventricular volumes predict motor response to deep brain stimulation for Parkinson's disease.
Younce JR, Campbell MC, Perlmutter JS, Norris SA
Parkinsonism Relat Disord. 2019 Apr; 6164-69. doi: 10.1016/j.parkreldis.2018.11.026.

PMID:
    30527905
    [PubMed - in process]
Related citations


Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates.
Luo Z, Han J, Liu H, Rosenberg AJ, Chen DL, Gropler RJ, Perlmutter JS, Tu Z
Org Biomol Chem. 2018 Dec 5; 16(47)9171-9184. doi: 10.1039/c8ob02609b.

PMID:
    30462126
    [PubMed - indexed for MEDLINE]
Related citations


Emergent Functional Network Effects in Parkinson Disease.
Gratton C, Koller JM, Shannon W, Greene DJ, Maiti B, Snyder AZ, Petersen SE, Perlmutter JS, Campbell MC
Cereb Cortex. 2019 Apr 1; 29(4)1701. doi: 10.1093/cercor/bhy229.

PMID:
    30418543
    [PubMed - in process]
Related citations


Predictors of alcohol responsiveness in dystonia.
Junker J, Brandt V, Berman BD, Vidailhet M, Roze E, Weissbach A, Comella C, Malaty IA, Jankovic J, LeDoux MS, Berardelli A, Barbano R, Reich SG, Perlmutter JS, Jinnah HA, Brüggemann N
Neurology. 2018 Nov 20; 91(21)e2020-e2026. doi: 10.1212/WNL.0000000000006551.

PMID:
    30341158
    [PubMed - indexed for MEDLINE]
Related citations


PET Imaging in Movement Disorders.
Maiti B, Perlmutter JS
Semin Nucl Med. 2018 Nov; 48(6)513-524. doi: 10.1053/j.semnuclmed.2018.07.006.

PMID:
    30322477
    [PubMed - indexed for MEDLINE]
Related citations


Radiosynthesis and evaluation of a fluorine-18 labeled radioligand targeting vesicular acetylcholine transporter.
Yue X, Luo Z, Liu H, Kaneshige K, Parsons SM, Perlmutter JS, Tu Z
Bioorg Med Chem Lett. 2018 Nov 15; 28(21)3425-3430. doi: 10.1016/j.bmcl.2018.09.030.

PMID:
    30274694
    [PubMed - indexed for MEDLINE]
Related citations


ESM-CT: a precise method for localization of DBS electrodes in CT images.
Milchenko M, Snyder AZ, Campbell MC, Dowling JL, Rich KM, Brier LM, Perlmutter JS, Norris SA
J Neurosci Methods. 2018 Oct 1; 308366-376. doi: 10.1016/j.jneumeth.2018.09.009.

PMID:
    30201271
    [PubMed - indexed for MEDLINE]
Related citations


Validation of diffusion tensor imaging measures of nigrostriatal neurons in macaques.
Shimony JS, Rutlin J, Karimi M, Tian L, Snyder AZ, Loftin SK, Norris SA, Perlmutter JS
PLoS One. 2018; 13(9)e0202201. doi: 10.1371/journal.pone.0202201.

PMID:
    30183721
    [PubMed - indexed for MEDLINE]
Related citations


Mapping movement, mood, motivation and mentation in the subthalamic nucleus.
Gourisankar A, Eisenstein SA, Trapp NT, Koller JM, Campbell MC, Ushe M, Perlmutter JS, Hershey T, Black KJ
R Soc Open Sci. 2018 Jul; 5(7)171177. doi: 10.1098/rsos.171177.

PMID:
    30109035
    [PubMed]
Related citations


Selective D2 receptor PET in manganese-exposed workers.
Criswell SR, Warden MN, Searles Nielsen S, Perlmutter JS, Moerlein SM, Sheppard L, Lenox-Krug J, Checkoway H, Racette BA
Neurology. 2018 Sep 11; 91(11)e1022-e1030. doi: 10.1212/WNL.0000000000006163.

PMID:
    30097475
    [PubMed - indexed for MEDLINE]
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