Patient Portal

Joel S. Perlmutter, MD

Elliot Stein Family Professor of Neurology
Section Chief, Movement Disorders
Professor, Radiology
Professor , Physical Therapy
Associate Professor, Anatomy and Neurobiology

Specialty Areas

Parkinson's Disease
Movement Disorders
Neurology - Adult
Huntington's Disease
Dystonia
Tremor
Tourette's Syndrome

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Parkinson's disease, Huntington's disease, Tourette syndrome, dystonia, hyperkinetic disorders, essential tremor and other movement disorders, imaging research using PET and MR, clinical drug trials

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6908
Fax: 314-747-3258

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Suite: Lower Level
Office Phone: 314-362-6908
Fax: 314-747-3258

Education

Education

Fellowship: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 1984
Residency: Washington University School Medicine, St. Louis, Missouri 1980
Medical Degree: University Of Missouri, Columbia, Missouri 1979
B.A.: Princeton University, Princeton, New Jersey 1975
Externship: Psychiatry, Menninger Foundation, Topeka, Kansas 1978

Publication & Research

Publication & Research

Emergent Functional Network Effects in Parkinson Disease.
Gratton C, Koller JM, Shannon W, Greene DJ, Snyder AZ, Petersen SE, Perlmutter JS, Campbell MC
Cereb Cortex. 2018 Jun 6; doi: 10.1093/cercor/bhy121.

PMID:
    29878081
    [PubMed - as supplied by publisher]
Related citations


Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease.
Ibanez L, Dube U, Davis AA, Fernandez MV, Budde J, Cooper B, Diez-Fairen M, Ortega-Cubero S, Pastor P, Perlmutter JS, Cruchaga C, Benitez BA
Front Neurosci. 2018; 12230. doi: 10.3389/fnins.2018.00230.

PMID:
    29692703
    [PubMed]
Related citations


Agreement between clinician-rated versus patient-reported outcomes in Huntington disease.
Carlozzi NE, Boileau NR, Perlmutter JS, Chou KL, Stout JC, Paulsen JS, McCormack MK, Cella D, Nance MA, Lai JS, Dayalu P
J Neurol. 2018 Jun; 265(6)1443-1453. doi: 10.1007/s00415-018-8852-5.

PMID:
    29687215
    [PubMed - in process]
Related citations


Relationships Among Apathy, Health-Related Quality of Life, and Function in Huntington's Disease.
Fritz NE, Boileau NR, Stout JC, Ready R, Perlmutter JS, Paulsen JS, Quaid K, Barton S, McCormack MK, Perlman SL, Carlozzi NE, Huntington Disease Quality of Life Site Investigators and Coordinators, University of Michigan, University of Iowa, Indiana University, Johns Hopkins University, University of California, Rutgers University, Piscataway, Washington University, Struthers Parkinson’s Center, Cleveland Clinic Foundation, University of California, Northwestern University.
J Neuropsychiatry Clin Neurosci. 2018 Mar 21; appineuropsych17080173. doi: 10.1176/appi.neuropsych.17080173.

PMID:
    29558861
    [PubMed - as supplied by publisher]
Related citations


Pharmacokinetics and Toxicology of the Neuroprotective e,e,e-Methanofullerene(60)-63-tris Malonic Acid [C<sub>3</sub>] in Mice and Primates.
Hardt JI, Perlmutter JS, Smith CJ, Quick KL, Wei L, Chakraborty SK, Dugan LL
Eur J Drug Metab Pharmacokinet. 2018 Mar 8; doi: 10.1007/s13318-018-0464-z.

PMID:
    29520718
    [PubMed - as supplied by publisher]
Related citations


Physical therapy and deep brain stimulation in Parkinson's Disease: protocol for a pilot randomized controlled trial.
Duncan RP, Van Dillen LR, Garbutt JM, Earhart GM, Perlmutter JS
Pilot Feasibility Stud. 2018; 454. doi: 10.1186/s40814-018-0243-2.

PMID:
    29484198
    [PubMed]
Related citations


Quantitative, clinically relevant acoustic measurements of focal embouchure dystonia.
Morris AE, Norris SA, Perlmutter JS, Mink JW
Mov Disord. 2018 Mar; 33(3)449-458. doi: 10.1002/mds.27298.

PMID:
    29460980
    [PubMed - in process]
Related citations


In Vivo Characterization of Two <sup>18</sup>F-Labeled PDE10A PET Radioligands in Nonhuman Primate Brains.
Liu H, Jin H, Luo Z, Yue X, Zhang X, Flores H, Su Y, Perlmutter JS, Tu Z
ACS Chem Neurosci. 2018 May 16; 9(5)1066-1073. doi: 10.1021/acschemneuro.7b00458.

PMID:
    29400443
    [PubMed - in process]
Related citations


7T MRI subthalamic nucleus atlas for use with 3T MRI.
Milchenko M, Norris SA, Poston K, Campbell MC, Ushe M, Perlmutter JS, Snyder AZ
J Med Imaging (Bellingham). 2018 Jan; 5(1)015002. doi: 10.1117/1.JMI.5.1.015002.

PMID:
    29340288
    [PubMed]
Related citations


Kinetic modeling of [<sup>18</sup> F]VAT, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non-human primate brain.
Jin H, Yue X, Liu H, Han J, Flores H, Su Y, Parsons SM, Perlmutter JS, Tu Z
J Neurochem. 2018 Mar; 144(6)791-804. doi: 10.1111/jnc.14291.

PMID:
    29315563
    [PubMed - in process]
Related citations


Synthesis and in vitro characterization of a P2X7 radioligand [<sup>123</sup>I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease.
Jin H, Han J, Resing D, Liu H, Yue X, Miller RL, Schoch KM, Miller TM, Perlmutter JS, Egan TM, Tu Z
Eur J Pharmacol. 2018 Feb 5; 8208-17. doi: 10.1016/j.ejphar.2017.12.006.

PMID:
    29225193
    [PubMed - in process]
Related citations


A new measure for end of life planning, preparation, and preferences in Huntington disease: HDQLIFE end of life planning.
Carlozzi NE, Hahn EA, Frank SA, Perlmutter JS, Downing ND, McCormack MK, Barton S, Nance MA, Schilling SG, HDQLIFE Site Investigators and Coordinators.
J Neurol. 2018 Jan; 265(1)98-107. doi: 10.1007/s00415-017-8677-7.

PMID:
    29143208
    [PubMed - in process]
Related citations


Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.
Ibanez L, Dube U, Saef B, Budde J, Black K, Medvedeva A, Del-Aguila JL, Davis AA, Perlmutter JS, Harari O, Benitez BA, Cruchaga C
BMC Neurol. 2017 Nov 15; 17(1)198. doi: 10.1186/s12883-017-0978-z.

PMID:
    29141588
    [PubMed - indexed for MEDLINE]
Related citations


Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Robak LA, Jansen IE, van Rooij J, Uitterlinden AG, Kraaij R, Jankovic J, International Parkinson’s Disease Genomics Consortium (IPDGC)., Heutink P, Shulman JM
Brain. 2017 Dec 1; 140(12)3191-3203. doi: 10.1093/brain/awx285.

PMID:
    29140481
    [PubMed - indexed for MEDLINE]
Related citations


ACR Appropriateness Criteria<sup>®</sup> Cranial Neuropathy.
Expert Panel on Neurologic Imaging:., Policeni B, Corey AS, Burns J, Conley DB, Crowley RW, Harvey HB, Hoang J, Hunt CH, Jagadeesan BD, Juliano AF, Kennedy TA, Moonis G, Pannell JS, Patel ND, Perlmutter JS, Rosenow JM, Schroeder JW, Whitehead MT, Cornelius RS
J Am Coll Radiol. 2017 Nov; 14(11S)S406-S420. doi: 10.1016/j.jacr.2017.08.035.

PMID:
    29101981
    [PubMed - indexed for MEDLINE]
Related citations


Adult-onset dystonia with marfanoid features.
Norris SA, Pogarcic A, Hicks M, Perlmutter JS, Shinawi M
Neurol Clin Pract. 2017 Aug; 7(4)e31-e34. doi: 10.1212/CPJ.0000000000000297.

PMID:
    28840904
    [PubMed]
Related citations


[<sup>18</sup>F]FDOPA positron emission tomography in manganese-exposed workers.
Criswell SR, Nielsen SS, Warden M, Perlmutter JS, Moerlein SM, Flores HP, Huang J, Sheppard L, Seixas N, Checkoway H, Racette BA
Neurotoxicology. 2018 Jan; 6443-49. doi: 10.1016/j.neuro.2017.07.004.

PMID:
    28694016
    [PubMed - in process]
Related citations


Factors Associated With End-of-Life Planning in Huntington Disease.
Downing NR, Goodnight S, Chae S, Perlmutter JS, McCormack M, Hahn E, Barton SK, Carlozzi N
Am J Hosp Palliat Care. 2018 Mar; 35(3)440-447. doi: 10.1177/1049909117708195.

PMID:
    28655280
    [PubMed - in process]
Related citations


Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate.
Yue X, Jin H, Liu H, Luo Z, Zhang X, Kaneshige K, Flores HP, Perlmutter JS, Parsons SM, Tu Z
Org Biomol Chem. 2017 Jun 21; 15(24)5197-5209. doi: 10.1039/c7ob00854f.

PMID:
    28590490
    [PubMed - indexed for MEDLINE]
Related citations


Research Priorities in Limb and Task-Specific Dystonias.
Pirio Richardson S, Altenmüller E, Alter K, Alterman RL, Chen R, Frucht S, Furuya S, Jankovic J, Jinnah HA, Kimberley TJ, Lungu C, Perlmutter JS, Prudente CN, Hallett M
Front Neurol. 2017; 8170. doi: 10.3389/fneur.2017.00170.

PMID:
    28515706
    [PubMed]
Related citations