Patient Portal

Joel D. Schilling, MD,PhD

Assistant Professor, Medicine
Division of Cardiovascular Diseases
Section of Heart Failure and Heart Transplantation

Specialty Areas

Congestive Heart Failure
Heart Failure / Transplant

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

outpatient and inpatients management of congestive heart failure, pre- and post-heart transplant care, advanced heart failure, heart failure in diabetic patients

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Center for Advanced Medicine
Heart & Vascular Center

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 8
Office Phone: 314-362-1291

Education

Education

Fellowship: Clinical Cardiology, Washington University School of Medicine, St. Louis, MO 2009
Residency: Internal Medicine, Barnes-Jewish Hospital, St Louis MO 2005
BA: Colorado College, Colorado Springs, Colorado 1996
Medical Degree: Washington University School of Medicine, St. Louis MO 2003
Fellowship (Research): Advanced Heart Failure and Transplant, Washington University School of Medicine 2009
PhD : Immunology, Washington University School of Medicine, St. Louis MO 2003

Publication & Research

Publication & Research

PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN-Dependent Mechanism.
Weber KJ, Sauer M, He L, Tycksen E, Kalugotla G, Razani B, Schilling JD
J Immunol. 2018 Oct 1; 201(7)2054-2069. doi: 10.4049/jimmunol.1800224.

PMID:
    30143592
    [PubMed - in process]
Related citations


A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.
Coverstone ED, Bach RG, Chen L, Bierut LJ, Li AY, Lenzini PA, O'Neill HC, Spertus JA, Sucharov CC, Stitzel JA, Schilling JD, Cresci S
Basic Res Cardiol. 2018 Aug 10; 113(5)38. doi: 10.1007/s00395-018-0697-7.

PMID:
    30097758
    [PubMed - in process]
Related citations


The Hemodynamic Profile of GI Bleeding in Continuous-Flow LVADs: Is it All About the Right Ventricle?
Sparrow CT, Schilling JD
J Card Fail. 2018 Aug; 24(8)494-495. doi: 10.1016/j.cardfail.2018.07.007.

PMID:
    30076881
    [PubMed - in process]
Related citations


Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury.
Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL
JCI Insight. 2018 Jun 7; 3(11)pii: 120137. doi: 10.1172/jci.insight.120137.

PMID:
    29875326
    [PubMed - as supplied by publisher]
Related citations


Intersection of Pulmonary Hypertension and Right Ventricular Dysfunction in Patients on Left Ventricular Assist Device Support: Is There a Role for Pulmonary Vasodilators?
Sparrow CT, LaRue SJ, Schilling JD
Circ Heart Fail. 2018 Jan; 11(1)e004255. doi: 10.1161/CIRCHEARTFAILURE.117.004255.

PMID:
    29321132
    [PubMed - in process]
Related citations


Sildenafil in Left Ventricular Assist Device Is Safe and Well-Tolerated.
Ravichandran AK, LaRue SJ, Novak E, Joseph SA, Schilling JD
ASAIO J. 2018 Mar/Apr; 64(2)280-281. doi: 10.1097/MAT.0000000000000626.

PMID:
    28692527
    [PubMed - in process]
Related citations


Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B
Nat Commun. 2017 Jun 7; 815750. doi: 10.1038/ncomms15750.

PMID:
    28589926
    [PubMed - in process]
Related citations


Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism.
He L, Weber KJ, Diwan A, Schilling JD
J Leukoc Biol. 2016 Nov; 100(5)1113-1124.

PMID:
    27312848
    [PubMed - indexed for MEDLINE]
Related citations


Integrating immunometabolism and macrophage diversity.
Artyomov MN, Sergushichev A, Schilling JD
Semin Immunol. 2016 Oct; 28(5)417-424. doi: 10.1016/j.smim.2016.10.004.

PMID:
    27771140
    [PubMed - indexed for MEDLINE]
Related citations


Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.
Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ
Immunity. 2016 Oct 18; 45(4)817-830. doi: 10.1016/j.immuni.2016.09.016.

PMID:
    27760338
    [PubMed - indexed for MEDLINE]
Related citations


Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome. Focus on "NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx".
Schilling JD
Am J Physiol Cell Physiol. 2016 Jul 1; 311(1)C81-2. doi: 10.1152/ajpcell.00174.2016.

PMID:
    27306368
    [PubMed - indexed for MEDLINE]
Related citations


Slicing Into Human Translational Cardiovascular Biology.
Lavine KJ, Schilling JD
JACC Basic Transl Sci. 2016 Apr; 1(3)168-169. doi: 10.1016/j.jacbts.2016.03.007.

PMID:
    30167509
    [PubMed]
Related citations


Glutamine Modulates Macrophage Lipotoxicity.
He L, Weber KJ, Schilling JD
Nutrients. 2016 Apr 12; 8(4)215. doi: 10.3390/nu8040215.

PMID:
    27077881
    [PubMed - indexed for MEDLINE]
Related citations


Pre-Operative Right Ventricular Dysfunction Is Associated With Gastrointestinal Bleeding in Patients Supported With Continuous-Flow Left Ventricular Assist Devices.
Sparrow CT, Nassif ME, Raymer DS, Novak E, LaRue SJ, Schilling JD
JACC Heart Fail. 2015 Dec; 3(12)956-64. doi: 10.1016/j.jchf.2015.09.009.

PMID:
    26577618
    [PubMed - indexed for MEDLINE]
Related citations


Prognostic utility of novel biomarkers of cardiovascular stress in patients with aortic stenosis undergoing valve replacement.
Lindman BR, Breyley JG, Schilling JD, Vatterott AM, Zajarias A, Maniar HS, Damiano RJ Jr, Moon MR, Lawton JS, Gage BF, Sintek MA, Aquino A, Holley CL, Patel NM, Lawler C, Lasala JM, Novak E
Heart. 2015 Sep; 101(17)1382-8. doi: 10.1136/heartjnl-2015-307742.

PMID:
    26037104
    [PubMed - indexed for MEDLINE]
Related citations


The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise.
Schilling JD
Antioxid Redox Signal. 2015 Jun 10; 22(17)1515-26. doi: 10.1089/ars.2015.6294.

PMID:
    25761843
    [PubMed - indexed for MEDLINE]
Related citations


Treatment of secondary pulmonary hypertension with bosentan after left ventricular assist device implantation.
LaRue SJ, Garcia-Cortes R, Nassif ME, Vader JM, Ray S, Ravichandran A, Rasalingham R, Silvestry SC, Ewald GA, Wang IW, Schilling JD
Cardiovasc Ther. 2015 Apr; 33(2)50-5. doi: 10.1111/1755-5922.12111.

PMID:
    25759010
    [PubMed - indexed for MEDLINE]
Related citations


ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner.
Symington JW, Wang C, Twentyman J, Owusu-Boaitey N, Schwendener R, Núñez G, Schilling JD, Mysorekar IU
Mucosal Immunol. 2015 Nov; 8(6)1388-99. doi: 10.1038/mi.2015.7.

PMID:
    25669147
    [PubMed - indexed for MEDLINE]
Related citations


Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages.
Weber K, Schilling JD
Int J Inflam. 2014; 2014154936. doi: 10.1155/2014/154936.

PMID:
    25587484
    [PubMed]
Related citations


Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart.
Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL
Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45)16029-34. doi: 10.1073/pnas.1406508111.

PMID:
    25349429
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Research is focused on understanding the role of inflammation in diabetic heart disease. Toll-like receptors (TLRs) play a critical role in host defense against pathogens, but they are also activated by noninfectious cellular stress, such as that which occurs in lipid overload, diabetes, and ischemia. My lab is using a combination of cell culture and in vivo models of heart failure and lipotoxic stress to define the mechanisms by which TLR-inflammatory pathways are activated and to address the functional consequences of these pathways in the development and progression of cardiomyopathy. Through this research we hope to create a platform for translational studies involving human subjects with diabetes and heart failure. Ultimately, this work aspires to identify novel targets for treating, and perhaps preventing, heart failure in patients with diabetes.