Patient Portal

Jing W. Hughes, MD, PhD

Assistant Professor, Medicine
Endocrinology, Metabolism and Lipid Research

Specialty Areas

Internal Medicine

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital



Areas of Clinical Interest

General endocrinology, type 1 diabetes

  • Location(s)
  • Education
  • Publication & Research



Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-362-3500
Fax: 314-747-3963



Fellowship, Endocrinology: Washington University School of Medicine, St. Louis, MO 2015
Residency, Internal Medicine: New Have Hospital, New Haven, CT 2013
PhD, Cell and Molecular Biology: University of Pennsylvania School of Medicine, Philadelphia, PA 2009
Medical Degree: University of Pennsylvania School of Medicine, Philadelphia, PA 2009

Publication & Research

Publication & Research

Nuclear Receptor Rev-erb {alpha} Is a Critical Lithium-Sensitive Component of the Circadian Clock

L Yin, J Wang, PS Klein, MA Lazar

Science's STKE 311 (5763), 1002

The orphan nuclear receptor Rev-erbα regulates circadian expression of plasminogen activator inhibitor type 1

J Wang, L Yin, MA Lazar

Journal of Biological Chemistry 281 (45), 33842-33848



Bifunctional role of Rev-erbα in adipocyte differentiation

J Wang, MA Lazar

Molecular and cellular biology 28 (7), 2213-2220



Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy

J Hughes, N Vudattu, M Sznol, S Gettinger, H Kluger, B Lupsa, KC Herold

Diabetes Care 38 (4), e55-e57



Refractory pituitary granulomatosis with polyangiitis (Wegener's) treated with rituximab

J Hughes, G Barkhoudarian, P Ciarlini, E Laws, E Mody, S Inzucchi, ...

Endocrine Practice 19 (1), e1-e7



Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

UER Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST ...

Proc Natl Acad Sci U S A.



Novel SIRT1 mutation linked to autoimmune diabetes in humans

JW Hughes, KC Herold

Cell metabolism 17 (3), 311-312

Moyamoya syndrome causing stroke in young women with type 1 diabetes

JW Hughes, JA Wyckoff, AS Hollander, CP Derdeyn, JB McGill

Journal of Diabetes and its Complications 30 (8), 1640-1642


Autoimmune diseases in children and adults with type 1 diabetes from the T1D Exchange Clinic Registry

JW Hughes, TD Riddlesworth, LA DiMeglio, KM Miller, MR Rickels, ...

The Journal of Clinical Endocrinology & Metabolism 101 (12), 4931-4937




J Hughes

Reactions 1608, 204-2



Moyamoya Disease Causing Stroke in Young Women with Type 1 Diabetes

JW Hughes, J Wyckoff, A Hollander, C Derdeyn, JB Mcgill

DIABETES 65, A437-A437



Metabolic Syndrome Characteristics in Early Onset T1DM vs. LADA Patients

EC Blustein, OJ Jordan, VE Bouhairie, JW Hughes, JB Mcgill

DIABETES 65, A113-A113



Autoimmune diseases in children and adults with type 1 diabetes from the type 1 diabetes exchange clinic registry

JB McGill, TD Riddlesworth, J Hughes, LA DiMeglio, KM Miller, RW Beck




Response to Pneumococcal Vaccine in Patients with T1DM and Immune Deficiency

J Hughes, JB Mcgill

DIABETES 64, A473-A473


Areas of Research Interest

Type 1 diabetes, islet imaging, novel therapeutics