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Faculty Physicians

Jeffrey J. Bednarski II, MD

Instructor, Pediatrics
Division of Hematology and Oncology

Specialty Areas

Pediatric Oncology
Pediatric Hematology

Board Certifications

Pediatrics
Pediatric Hematology/Oncology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric cancer, pediatric hematology, pediatric oncology, pediatric brain tumors. 

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6018
Additional Phone: 314-454-2780

Education

Education

B.S.: Chemistry, Duke University, Durham, North Carolina 1995
Medical Degree: University of Michigan Medical School, Ann Arbor, Michigan 2003
Ph.D.: University of Michigan Medical School, Ann Arbor, Michigan 2003
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 2006
Fellowship: Pediatric Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri 2009

Publication & Research

Publication & Research

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells.
Franco M, Panas MW, Marino ND, Lee MC, Buchholz KR, Kelly FD, Bednarski JJ, Sleckman BP, Pourmand N, Boothroyd JC
MBio. 2016 Feb 2; 7(1)e02231-15. doi: 10.1128/mBio.02231-15.

PMID:
    26838724
    [PubMed - in process]
Related citations


RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.
Bednarski JJ, Pandey R, Schulte E, White LS, Chen BR, Sandoval GJ, Kohyama M, Haldar M, Nickless A, Trott A, Cheng G, Murphy KM, Bassing CH, Payton JE, Sleckman BP
J Exp Med. 2016 Feb 8; 213(2)209-23. doi: 10.1084/jem.20151048.

PMID:
    26834154
    [PubMed - in process]
Related citations


Maternal T-Cell Engraftment Interferes With Human Leukocyte Antigen Typing in Severe Combined Immunodeficiency.
Liu C, Duffy B, Bednarski JJ, Calhoun C, Lay L, Rundblad B, Payton JE, Mohanakumar T
Am J Clin Pathol. 2016 Feb; 145(2)251-7. doi: 10.1093/ajcp/aqv079.

PMID:
    26834123
    [PubMed - in process]
Related citations


DNA damage signals inhibit neutrophil function.
Bednarski JJ
Blood. 2015 Dec 24; 126(26)2773-4. doi: 10.1182/blood-2015-11-678672.

PMID:
    26705340
    [PubMed - in process]
Related citations


Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma.
Koues OI, Kowalewski RA, Chang LW, Pyfrom SC, Schmidt JA, Luo H, Sandoval LE, Hughes TB, Bednarski JJ, Cashen AF, Payton JE, Oltz EM
Immunity. 2015 Jan 20; 42(1)186-98. doi: 10.1016/j.immuni.2014.12.021.

PMID:
    25607463
    [PubMed - indexed for MEDLINE]
Related citations


Primary Immune Deficiency Treatment Consortium (PIDTC) report.
Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC, workshop participants
J Allergy Clin Immunol. 2014 Feb; 133(2)335-47. doi: 10.1016/j.jaci.2013.07.052.

PMID:
    24139498
    [PubMed - indexed for MEDLINE]
Related citations


Lymphocyte development: integration of DNA damage response signaling.
Bednarski JJ, Sleckman BP
Adv Immunol. 2012; 116175-204. doi: 10.1016/B978-0-12-394300-2.00006-5.

PMID:
    23063077
    [PubMed - indexed for MEDLINE]
Related citations


Integrated signaling in developing lymphocytes: the role of DNA damage responses.
Bednarski JJ, Sleckman BP
Cell Cycle. 2012 Nov 15; 11(22)4129-34. doi: 10.4161/cc.22021.

PMID:
    23032308
    [PubMed - indexed for MEDLINE]
Related citations


RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.
Bednarski JJ, Nickless A, Bhattacharya D, Amin RH, Schlissel MS, Sleckman BP
J Exp Med. 2012 Jan 16; 209(1)11-7. doi: 10.1084/jem.20112078.

PMID:
    22201128
    [PubMed - indexed for MEDLINE]
Related citations


Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP
Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5)2022-7. doi: 10.1073/pnas.1013295108.

PMID:
    21245316
    [PubMed - indexed for MEDLINE]
Related citations


H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP
Nature. 2011 Jan 13; 469(7329)245-9. doi: 10.1038/nature09585.

PMID:
    21160476
    [PubMed - indexed for MEDLINE]
Related citations


MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP
J Exp Med. 2009 Mar 16; 206(3)669-79. doi: 10.1084/jem.20081326.

PMID:
    19221393
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Cellular responses to DNA damage in lymphocytes and the connection of these responses to immune development.