Patient Portal

Jaquelyn Fleckenstein, MD

Professor, Medicine
Division of Gastroenterology
Director, Hepatology Program

Specialty Areas

Hepatology
Liver Transplantation
Endoscopy

Board Certifications

American Board of Internal Medicine, Subspecialty of Gastroenterology and Hepatology
Transplant Hepatology Board

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Acute and chronic viral hepatitis, liver transplantation and cirrhosis, liver cancer, autoimmune and metabolic liver diseases

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: 314 454-8160
Fax: 314-454-8289

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Office Phone: 314-747-2066

Education

Education

Fellowship, Gastroenterology and Hepatology: The John Hopkins Hospital, Baltimore, MD 1994
Fellowship, Transplant Hepatology: The John Hopkins Hospital, Baltimore, MD 1995
Residency, Internal Medicine: University of Michigan Hospitals, Ann Arbor, MI 1988
BA: Cornell University, Ithaca, NY 1981
Medical Degree: St. Louis University School of Medicine, St. Louis, MO 1985

Publication & Research

Publication & Research

Prevalence of Biopsychosocial Factors of Pain in 865 Sports Students of the Dach (Germany, Austria, Switzerland) Region - A Cross-Sectional Survey.
Bumann A, Banzer W, Fleckenstein J
J Sports Sci Med. 2020 Jun; 19(2)323-336.

PMID:
    32390726
    [PubMed - in process]
Related citations


Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic <i>Escherichia coli</i> infection.
Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M
Gut Microbes. 2020 May 7; 1-12. doi: 10.1080/19490976.2020.1752125.

PMID:
    32378997
    [PubMed - as supplied by publisher]
Related citations


Technological quality requirements for stereotactic radiotherapy : Expert review group consensus from the DGMP Working Group for Physics and Technology in Stereotactic Radiotherapy.
Schmitt D, Blanck O, Gauer T, Fix MK, Brunner TB, Fleckenstein J, Loutfi-Krauss B, Manser P, Werner R, Wilhelm ML, Baus WW, Moustakis C
Strahlenther Onkol. 2020 May; 196(5)421-443. doi: 10.1007/s00066-020-01583-2.

PMID:
    32211939
    [PubMed - in process]
Related citations


Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial.
Nestle U, Schimek-Jasch T, Kremp S, Schaefer-Schuler A, Mix M, Küsters A, Tosch M, Hehr T, Eschmann SM, Bultel YP, Hass P, Fleckenstein J, Thieme A, Stockinger M, Dieckmann K, Miederer M, Holl G, Rischke HC, Gkika E, Adebahr S, König J, Grosu AL, PET-Plan study group.
Lancet Oncol. 2020 Apr; 21(4)581-592. doi: 10.1016/S1470-2045(20)30013-9.

PMID:
    32171429
    [PubMed - in process]
Related citations


Applications, indications, and effects of passive hydrotherapy WATSU (WaterShiatsu)-A systematic review and meta-analysis.
Schitter AM, Fleckenstein J, Frei P, Taeymans J, Kurpiers N, Radlinger L
PLoS One. 2020; 15(3)e0229705. doi: 10.1371/journal.pone.0229705.

PMID:
    32168328
    [PubMed - in process]
Related citations


Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy.
Lorat Y, Fleckenstein J, Görlinger P, Rübe C, Rübe CE
Strahlenther Onkol. 2020 Jan 31; doi: 10.1007/s00066-020-01576-1.

PMID:
    32006067
    [PubMed - as supplied by publisher]
Related citations


Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model.
Sunuwar L, Yin J, Kasendra M, Karalis K, Kaper J, Fleckenstein J, Donowitz M
Infect Immun. 2020 Feb 20; 88(3)pii: e00866-19. doi: 10.1128/IAI.00866-19.

PMID:
    31818966
    [PubMed - indexed for MEDLINE]
Related citations


Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli.
Kuhlmann FM, Martin J, Hazen TH, Vickers TJ, Pashos M, Okhuysen PC, Gómez-Duarte OG, Cebelinski E, Boxrud D, Del Canto F, Vidal R, Qadri F, Mitreva M, Rasko DA, Fleckenstein JM
PLoS Negl Trop Dis. 2019 Nov; 13(11)e0007825. doi: 10.1371/journal.pntd.0007825.

PMID:
    31756188
    [PubMed - indexed for MEDLINE]
Related citations


Comparative genomic analysis and molecular examination of the diversity of enterotoxigenic Escherichia coli isolates from Chile.
Rasko DA, Del Canto F, Luo Q, Fleckenstein JM, Vidal R, Hazen TH
PLoS Negl Trop Dis. 2019 Nov; 13(11)e0007828. doi: 10.1371/journal.pntd.0007828.

PMID:
    31747410
    [PubMed - indexed for MEDLINE]
Related citations


Radiation-induced malignancies after intensity-modulated versus conventional mediastinal radiotherapy in a small animal model.
Gomarteli K, Fleckenstein J, Kirschner S, Bobu V, Brockmann MA, Henzler T, Meyer M, Riffel P, Schönberg SO, Veldwijk MR, Kränzlin B, Hoerner C, Glatting G, Wenz F, Herskind C, Giordano FA
Sci Rep. 2019 Oct 29; 9(1)15489. doi: 10.1038/s41598-019-51735-3.

PMID:
    31664066
    [PubMed - in process]
Related citations


Exercise and microstructural changes in the motor cortex of older adults.
Rowley CD, Bock NA, Deichmann R, Engeroff T, Hattingen E, Hellweg R, Pilatus U, Füzéki E, Gerten S, Vogt L, Banzer W, Pantel J, Fleckenstein J, Matura S
Eur J Neurosci. 2020 Apr; 51(7)1711-1722. doi: 10.1111/ejn.14585.

PMID:
    31593327
    [PubMed - in process]
Related citations


Interrogation of a live-attenuated enterotoxigenic <i>Escherichia coli</i> vaccine highlights features unique to wild-type infection.
Chakraborty S, Randall A, Vickers TJ, Molina D, Harro CD, DeNearing B, Brubaker J, Sack DA, Bourgeois AL, Felgner PL, Liang X, Mani S, Wenzel H, Townsend RR, Gilmore PE, Darsley MJ, Rasko DA, Fleckenstein JM
NPJ Vaccines. 2019; 437. doi: 10.1038/s41541-019-0131-7.

PMID:
    31482013
    [PubMed]
Related citations


Ultrasound-based repositioning and real-time monitoring for abdominal SBRT in DIBH.
Boda-Heggemann J, Sihono DSK, Streb L, Mertens L, Vogel L, Stieler F, Wenz F, Giordano FA, Kalisch I, Lohr F, Fleckenstein J
Phys Med. 2019 Sep; 6546-52. doi: 10.1016/j.ejmp.2019.08.003.

PMID:
    31430586
    [PubMed - indexed for MEDLINE]
Related citations


Liver Disease in Pregnancy and Transplant.
Alghamdi S, Fleckenstein J
Curr Gastroenterol Rep. 2019 Jul 25; 21(9)43. doi: 10.1007/s11894-019-0711-8.

PMID:
    31346820
    [PubMed - indexed for MEDLINE]
Related citations


Expanding the Liver Imaging Reporting and Data System (LI-RADS) v2018 diagnostic population: performance and reliability of LI-RADS for distinguishing hepatocellular carcinoma (HCC) from non-HCC primary liver carcinoma in patients who do not meet strict LI-RADS high-risk criteria.
Ludwig DR, Fraum TJ, Cannella R, Tsai R, Naeem M, LeBlanc M, Salter A, Tsung A, Fleckenstein J, Shetty AS, Borhani AA, Furlan A, Fowler KJ
HPB (Oxford). 2019 Dec; 21(12)1697-1706. doi: 10.1016/j.hpb.2019.04.007.

PMID:
    31262487
    [PubMed - in process]
Related citations


Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.
Kumar P, Kuhlmann FM, Chakraborty S, Bourgeois AL, Foulke-Abel J, Tumala B, Vickers TJ, Sack DA, DeNearing B, Harro CD, Wright WS, Gildersleeve JC, Ciorba MA, Santhanam S, Porter CK, Gutierrez RL, Prouty MG, Riddle MS, Polino A, Sheikh A, Donowitz M, Fleckenstein JM
J Clin Invest. 2019 Jul 1; 129(7)2980. doi: 10.1172/JCI130874.

PMID:
    31259744
    [PubMed]
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Concentric and Eccentric Endurance Exercise Reverse Hallmarks of T-Cell Senescence in Pre-diabetic Subjects.
Philippe M, Gatterer H, Burtscher M, Weinberger B, Keller M, Grubeck-Loebenstein B, Fleckenstein J, Alack K, Krüger K
Front Physiol. 2019; 10684. doi: 10.3389/fphys.2019.00684.

PMID:
    31214051
    [PubMed]
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Ultrafast single breath-hold cone-beam CT lung cancer imaging with faster linac gantry rotation.
Arns A, Wertz H, Boda-Heggemann J, Schneider F, Blessing M, Abo-Madyan Y, Steil V, Wenz F, Fleckenstein J
Radiother Oncol. 2019 Jun; 13578-85. doi: 10.1016/j.radonc.2019.02.004.

PMID:
    31015174
    [PubMed - indexed for MEDLINE]
Related citations


Enterotoxigenic Escherichia coli Infections.
Fleckenstein JM, Kuhlmann FM
Curr Infect Dis Rep. 2019 Mar 4; 21(3)9. doi: 10.1007/s11908-019-0665-x.

PMID:
    30830466
    [PubMed]
Related citations


How genomics can be used to understand host susceptibility to enteric infection, aiding in the development of vaccines and immunotherapeutic interventions.
Mottram L, Chakraborty S, Cox E, Fleckenstein J
Vaccine. 2019 Aug 7; 37(34)4805-4810. doi: 10.1016/j.vaccine.2019.01.016.

PMID:
    30709726
    [PubMed - in process]
Related citations

Areas of Research Interest

New therapies for complications of cirrhosis; viral hepatitis treatment