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Jacqueline Elise Payton, MD, PhD

Assistant Professor, Pathology and Immunology
Division of Laboratory and Genomic Medicine

Specialty Areas

Pathology
Leukemia
Lymphoma
DNA Diagnostics

Board Certifications

Clinical Pathology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Molecular diagnostic testing, cancer genomics, hematologic malignancy, leukemia, lymphoma

  • Education
  • Publication & Research

Education

Education

BS, Biology, Spanish: Bradley University, Peoria, I 1996
PhD, Molecular and Cellular Biology: University of Illinois Champaign-Urbana, Urbana, IL 2002
Residency, Clinical Pathology: Barnes-Jewish Hospital, St. Louis, MO 2008
Medical Degree: University of Illinois at Chicago College of Medicine, Chicago, IL 2004

Publication & Research

Publication & Research

Follicular lymphoma: State-of-the-art ICML workshop in Lugano 2015.
Gascoyne RD, Nadel B, Pasqualucci L, Fitzgibbon J, Payton JE, Melnick A, Weigert O, Tarte K, Gribben JG, Friedberg JW, Seymour JF, Cavalli F, Zucca E
Hematol Oncol. 2017 Dec; 35(4)397-407. doi: 10.1002/hon.2411.

PMID:
    28378425
    [PubMed - indexed for MEDLINE]
Related citations


A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.
Morales AJ, Carrero JA, Hung PJ, Tubbs AT, Andrews JM, Edelson BT, Calderon B, Innes CL, Paules RS, Payton JE, Sleckman BP
Elife. 2017 Mar 31; 6pii: e24655. doi: 10.7554/eLife.24655.

PMID:
    28362262
    [PubMed - indexed for MEDLINE]
Related citations


cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent.
Huang Y, Koues OI, Zhao JY, Liu R, Pyfrom SC, Payton JE, Oltz EM
Cell Rep. 2017 Mar 21; 18(12)2918-2931. doi: 10.1016/j.celrep.2017.02.067.

PMID:
    28329684
    [PubMed - indexed for MEDLINE]
Related citations


CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - indexed for MEDLINE]
Related citations


Targeted epigenetic repression of a lymphoma oncogene by sequence-specific histone modifiers induces apoptosis in DLBCL.
Luo H, Schmidt JA, Lee YS, Oltz EM, Payton JE
Leuk Lymphoma. 2017 Feb; 58(2)445-456.

PMID:
    27268204
    [PubMed - indexed for MEDLINE]
Related citations


NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo.
Raju S, Kretzmer LZ, Koues OI, Payton JE, Oltz EM, Cashen A, Polic B, Schreiber RD, Shaw AS, Markiewicz MA
J Immunol. 2016 Jun 1; 196(11)4805-13. doi: 10.4049/jimmunol.1501982.

PMID:
    27183590
    [PubMed - indexed for MEDLINE]
Related citations


Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Exp Hematol. 2016 Jul; 44(7)603-13. doi: 10.1016/j.exphem.2016.04.011.

PMID:
    27181063
    [PubMed - indexed for MEDLINE]
Related citations


Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells.
Koues OI, Collins PL, Cella M, Robinette ML, Porter SI, Pyfrom SC, Payton JE, Colonna M, Oltz EM
Cell. 2016 May 19; 165(5)1134-1146. doi: 10.1016/j.cell.2016.04.014.

PMID:
    27156452
    [PubMed - indexed for MEDLINE]
Related citations


Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome.
Gu J, Stevens M, Xing X, Li D, Zhang B, Payton JE, Oltz EM, Jarvis JN, Jiang K, Cicero T, Costello JF, Wang T
G3 (Bethesda). 2016 Apr 7; 6(4)973-86. doi: 10.1534/g3.115.025437.

PMID:
    26888867
    [PubMed - indexed for MEDLINE]
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RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.
Bednarski JJ, Pandey R, Schulte E, White LS, Chen BR, Sandoval GJ, Kohyama M, Haldar M, Nickless A, Trott A, Cheng G, Murphy KM, Bassing CH, Payton JE, Sleckman BP
J Exp Med. 2016 Feb 8; 213(2)209-23. doi: 10.1084/jem.20151048.

PMID:
    26834154
    [PubMed - indexed for MEDLINE]
Related citations


Maternal T-Cell Engraftment Interferes With Human Leukocyte Antigen Typing in Severe Combined Immunodeficiency.
Liu C, Duffy B, Bednarski JJ, Calhoun C, Lay L, Rundblad B, Payton JE, Mohanakumar T
Am J Clin Pathol. 2016 Feb; 145(2)251-7. doi: 10.1093/ajcp/aqv079.

PMID:
    26834123
    [PubMed - indexed for MEDLINE]
Related citations


Short-Circuiting Gene Regulatory Networks: Origins of B Cell Lymphoma.
Koues OI, Oltz EM, Payton JE
Trends Genet. 2015 Dec; 31(12)720-31. doi: 10.1016/j.tig.2015.09.006.

PMID:
    26604030
    [PubMed - indexed for MEDLINE]
Related citations


Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA. 2015 Aug 25; 314(8)811-22. doi: 10.1001/jama.2015.9643.

PMID:
    26305651
    [PubMed - indexed for MEDLINE]
Related citations


Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma.
Koues OI, Kowalewski RA, Chang LW, Pyfrom SC, Schmidt JA, Luo H, Sandoval LE, Hughes TB, Bednarski JJ, Cashen AF, Payton JE, Oltz EM
Immunity. 2015 Jan 20; 42(1)186-98. doi: 10.1016/j.immuni.2014.12.021.

PMID:
    25607463
    [PubMed - indexed for MEDLINE]
Related citations


HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.
Dorsett Y, Zhou Y, Tubbs AT, Chen BR, Purman C, Lee BS, George R, Bredemeyer AL, Zhao JY, Sodergen E, Weinstock GM, Han ND, Reyes A, Oltz EM, Dorsett D, Misulovin Z, Payton JE, Sleckman BP
Mol Cell. 2014 Dec 18; 56(6)808-18. doi: 10.1016/j.molcel.2014.10.024.

PMID:
    25435138
    [PubMed - indexed for MEDLINE]
Related citations


Acute ischemic stroke and hyperglycemia.
Clark ME, Payton JE, Pittiglio LI
Crit Care Nurs Q. 2014 Apr-Jun; 37(2)182-7. doi: 10.1097/CNQ.0000000000000015.

PMID:
    24595255
    [PubMed - indexed for MEDLINE]
Related citations


Validation of a next-generation sequencing assay for clinical molecular oncology.
Cottrell CE, Al-Kateb H, Bredemeyer AJ, Duncavage EJ, Spencer DH, Abel HJ, Lockwood CM, Hagemann IS, O'Guin SM, Burcea LC, Sawyer CS, Oschwald DM, Stratman JL, Sher DA, Johnson MR, Brown JT, Cliften PF, George B, McIntosh LD, Shrivastava S, Nguyen TT, Payton JE, Watson MA, Crosby SD, Head RD, Mitra RD, Nagarajan R, Kulkarni S, Seibert K, Virgin HW 4th, Milbrandt J, Pfeifer JD
J Mol Diagn. 2014 Jan; 16(1)89-105. doi: 10.1016/j.jmoldx.2013.10.002.

PMID:
    24211365
    [PubMed - indexed for MEDLINE]
Related citations


Quantitative label-free proteomics for discovery of biomarkers in cerebrospinal fluid: assessment of technical and inter-individual variation.
Perrin RJ, Payton JE, Malone JP, Gilmore P, Davis AE, Xiong C, Fagan AM, Townsend RR, Holtzman DM
PLoS One. 2013; 8(5)e64314. doi: 10.1371/journal.pone.0064314.

PMID:
    23700471
    [PubMed - indexed for MEDLINE]
Related citations


An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.
Chang LW, Viader A, Varghese N, Payton JE, Milbrandt J, Nagarajan R
BMC Genomics. 2013 Feb 6; 1484. doi: 10.1186/1471-2164-14-84.

PMID:
    23387820
    [PubMed - indexed for MEDLINE]
Related citations


Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data.
Spencer DH, Abel HJ, Lockwood CM, Payton JE, Szankasi P, Kelley TW, Kulkarni S, Pfeifer JD, Duncavage EJ
J Mol Diagn. 2013 Jan; 15(1)81-93. doi: 10.1016/j.jmoldx.2012.08.001.

PMID:
    23159595
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr. Payton's translational research focuses on the discovery of novel genetic and epigenetic mechanisms of carcinogenesis, particularly those that deregulate gene expression networks, using integrative, multi-platformhigh complexity experimental and bioinformatic approaches. In addition, innovative approaches to selectively target cancer-associated aberrant epigenetic landscapes in order to reverse pathogenic gene expression profiles and regulatory networks is in development.