Patient Portal

J. Evan Sadler, MD, PhD

Professor, Medicine
Division of Hematology
Investigator, Howard Hughes Medical Institute of St. Louis

Specialty Areas

Hematology

Board Certifications

Hematology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hematology, von Willebrand disease, thrombomodulin structure and function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital (South)
Barnard Cancer Center

4960 Children's Place
St. Louis, MO 63110

Suite: Wohl Hospital, 4th Floor
Office Phone: 314-362-7578
Fax: 314-362-1608

Education

Education

Fellowship: Hematology, University of Washington, Seattle, Washington 1984
Residency: Medicine, Duke University, Durham, North Carolina 1981
Medical Degree: Duke University, Durham, North Carolina 1979
Ph.D.: Biochemistry, Duke University, Durham, North Carolina 1978
A.B.: Princeton University, Princton, New Jersey 1973

Publication & Research

Publication & Research

Pathophysiology of thrombotic thrombocytopenic purpura.
Sadler JE
Blood. 2017 Sep 7; 130(10)1181-1188. doi: 10.1182/blood-2017-04-636431.

PMID:
    28768626
    [PubMed - indexed for MEDLINE]
Related citations


Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer.
Shen G, Cui W, Zhang H, Zhou F, Huang W, Liu Q, Yang Y, Li S, Bowman GR, Sadler JE, Gross ML, Li W
Nat Struct Mol Biol. 2017 Jan; 24(1)69-76. doi: 10.1038/nsmb.3333.

PMID:
    27918545
    [PubMed - indexed for MEDLINE]
Related citations


Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami.
Obser T, Ledford-Kraemer M, Oyen F, Brehm MA, Denis CV, Marschalek R, Montgomery RR, Sadler JE, Schneppenheim S, Budde U, Schneppenheim R
J Thromb Haemost. 2016 Sep; 14(9)1725-35. doi: 10.1111/jth.13398.

PMID:
    27344059
    [PubMed - indexed for MEDLINE]
Related citations


The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.
Parker DN, Tasneem S, Farndale RW, Bihan D, Sadler JE, Sebastian S, de Groot PG, Hayward CP
Thromb Haemost. 2016 Jul 4; 116(1)87-95. doi: 10.1160/TH15-09-0700.

PMID:
    27052467
    [PubMed - indexed for MEDLINE]
Related citations


What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
Sadler JE
Hematology Am Soc Hematol Educ Program. 2015; 2015631-6. doi: 10.1182/asheducation-2015.1.631.

PMID:
    26637781
    [PubMed - indexed for MEDLINE]
Related citations


Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.
Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K
J Thromb Haemost. 2015 Nov; 13(11)2063-75. doi: 10.1111/jth.13149.

PMID:
    26391536
    [PubMed - indexed for MEDLINE]
Related citations


Atypical HUS may become a diagnosis of inclusion.
Sadler JE
Blood. 2015 Jun 4; 125(23)3525-6. doi: 10.1182/blood-2015-04-640656.

PMID:
    26045594
    [PubMed - indexed for MEDLINE]
Related citations


Allosteric activation of ADAMTS13 by von Willebrand factor.
Muia J, Zhu J, Gupta G, Haberichter SL, Friedman KD, Feys HB, Deforche L, Vanhoorelbeke K, Westfield LA, Roth R, Tolia NH, Heuser JE, Sadler JE
Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52)18584-9. doi: 10.1073/pnas.1413282112.

PMID:
    25512528
    [PubMed - indexed for MEDLINE]
Related citations


Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings.
De Ceunynck K, Rocha S, De Meyer SF, Sadler JE, Uji-i H, Deckmyn H, Hofkens J, Vanhoorelbeke K
J Biol Chem. 2014 Mar 28; 289(13)8903-15. doi: 10.1074/jbc.M113.535963.

PMID:
    24550384
    [PubMed - indexed for MEDLINE]
Related citations


Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis.
Palekar RU, Myerson JW, Schlesinger PH, Sadler JE, Pan H, Wickline SA
Mol Pharm. 2013 Nov 4; 10(11)4168-75. doi: 10.1021/mp400210q.

PMID:
    24063304
    [PubMed - indexed for MEDLINE]
Related citations


An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura.
Muia J, Gao W, Haberichter SL, Dolatshahi L, Zhu J, Westfield LA, Covill SC, Friedman KD, Sadler JE
J Thromb Haemost. 2013 Aug; 11(8)1511-8. doi: 10.1111/jth.12319.

PMID:
    23773695
    [PubMed - indexed for MEDLINE]
Related citations


von Willebrand factor in its native environment.
Sadler JE
Blood. 2013 Apr 4; 121(14)2583-4. doi: 10.1182/blood-2013-02-482000.

PMID:
    23557970
    [PubMed - indexed for MEDLINE]
Related citations


The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner.
Huang J, Haberichter SL, Sadler JE
Blood. 2012 Aug 2; 120(5)1143-9. doi: 10.1182/blood-2012-01-408096.

PMID:
    22718838
    [PubMed - indexed for MEDLINE]
Related citations


Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.
Gao W, Zhu J, Westfield LA, Tuley EA, Anderson PJ, Sadler JE
J Biol Chem. 2012 Aug 3; 287(32)26944-52. doi: 10.1074/jbc.M112.380535.

PMID:
    22707719
    [PubMed - indexed for MEDLINE]
Related citations


Weibel-Palade bodies.
Sadler JE
Clin Adv Hematol Oncol. 2011 Sep; 9(9)673-4.

PMID:
    22402511
    [PubMed - indexed for MEDLINE]
Related citations


Should all adult patients with diarrhoea-associated HUS receive plasma exchange?
Tarr PI, Sadler JE, Chandler WL, George JN, Tsai HM
Lancet. 2012 Feb 11; 379(9815)516; author reply 516-7. doi: 10.1016/S0140-6736(12)60225-6.

PMID:
    22325653
    [PubMed - indexed for MEDLINE]
Related citations


Surface functionalization of electro-deposited nickel.
Sadler JE, Szumski DS, Kierzkowska A, Catarelli SR, Stella K, Nichols RJ, Fonticelli MH, Benitez G, Blum B, Salvarezza RC, Schwarzacher W
Phys Chem Chem Phys. 2011 Oct 28; 13(40)17987-93. doi: 10.1039/c1cp22203a.

PMID:
    21922091
    [PubMed]
Related citations


Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways.
Liu F, Huang J, Sadler JE
Blood. 2011 Sep 22; 118(12)3392-8. doi: 10.1182/blood-2011-06-363648.

PMID:
    21816831
    [PubMed - indexed for MEDLINE]
Related citations


Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor.
Dang LT, Purvis AR, Huang RH, Westfield LA, Sadler JE
J Biol Chem. 2011 Jul 22; 286(29)25763-9. doi: 10.1074/jbc.M111.249151.

PMID:
    21592973
    [PubMed - indexed for MEDLINE]
Related citations


Functional architecture of Weibel-Palade bodies.
Valentijn KM, Sadler JE, Valentijn JA, Voorberg J, Eikenboom J
Blood. 2011 May 12; 117(19)5033-43. doi: 10.1182/blood-2010-09-267492.

PMID:
    21266719
    [PubMed - indexed for MEDLINE]
Related citations