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Iskra Pusic, MD

Assistant Professor, Medicine
Division of Oncology
Section of Bone Marrow Transplant

Specialty Areas

Medical Oncology
Bone Marrow Transplant
Hematology

Board Certifications

Internal Medicine
Medical Oncology
Hematology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Medical oncology, hematology, bone marrow transplant, leukemia, post-transplantation complications, graft-versus-host disease

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-454-8304
Fax: 314-454-7551

Education

Education

Masters of Science in Clinical Investigation: Washington University School of Medicine, St. Louis, MO 2015
Residency: Internal Medicine, State University of New York, Brooklyn, New York 2004
Fellowship: Hematology and Oncology, State University of New York, Brooklyn, New York 2007
Fellowship: Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, St. Louis, Missouri 2008
Medical Degree: University of Zagreb School of Medicine, Zagreb, Croatia 1997

Publication & Research

Publication & Research

Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
N Engl J Med. 2018 Sep 13; 379(11)1028-1041. doi: 10.1056/NEJMoa1804714.

PMID:
    30207916
    [PubMed - in process]
Related citations


Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802.
Holtan SG, DeFor TE, Panoskaltsis-Mortari A, Khera N, Levine JE, Flowers MED, Lee SJ, Inamoto Y, Chen GL, Mayer S, Arora M, Palmer J, Cutler CS, Arai S, Lazaryan A, Newell LF, Jagasia MH, Pusic I, Wood WA, Renteria AS, Yanik G, Hogan WJ, Hexner E, Ayuk F, Holler E, Bunworasate U, Efebera YA, Ferrara JLM, Pidala J, Howard A, Wu J, Bolaños-Meade J, Ho V, Alousi A, Blazar BR, Weisdorf DJ, MacMillan ML
Blood Adv. 2018 Aug 14; 2(15)1882-1888. doi: 10.1182/bloodadvances.2018017343.

PMID:
    30087106
    [PubMed - in process]
Related citations


Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
JCI Insight. 2018 Mar 8; 3(5)pii: 98962. doi: 10.1172/jci.insight.98962.

PMID:
    29515031
    [PubMed - as supplied by publisher]
Related citations


Ruxolitinib: a steroid sparing agent in chronic graft-versus-host disease.
Khoury HJ, Langston AA, Kota VK, Wilkinson JA, Pusic I, Jillella A, Bauer S, Kim AS, Roberts D, Al-Kadhimi Z, Bodo I, Winton E, Arellano M, DiPersio JF
Bone Marrow Transplant. 2018 Jul; 53(7)826-831. doi: 10.1038/s41409-017-0081-5.

PMID:
    29367708
    [PubMed - in process]
Related citations


Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10-day decitabine regimen.
Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS
Cancer Med. 2017 Dec; 6(12)2814-2821. doi: 10.1002/cam4.1231.

PMID:
    29058375
    [PubMed - indexed for MEDLINE]
Related citations


Ibrutinib for chronic graft-versus-host disease after failure of prior therapy.
Miklos D, Cutler CS, Arora M, Waller EK, Jagasia M, Pusic I, Flowers ME, Logan AC, Nakamura R, Blazar BR, Li Y, Chang S, Lal I, Dubovsky J, James DF, Styles L, Jaglowski S
Blood. 2017 Nov 23; 130(21)2243-2250. doi: 10.1182/blood-2017-07-793786.

PMID:
    28924018
    [PubMed - indexed for MEDLINE]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036. doi: 10.1056/NEJMoa1605949.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors.
Holtan SG, Khera N, Levine JE, Chai X, Storer B, Liu HD, Inamoto Y, Chen GL, Mayer S, Arora M, Palmer J, Flowers MED, Cutler CS, Lukez A, Arai S, Lazaryan A, Newell LF, Krupski C, Jagasia MH, Pusic I, Wood W, Renteria AS, Yanik G, Hogan WJ, Hexner E, Ayuk F, Holler E, Watanaboonyongcharoen P, Efebera YA, Ferrara JLM, Panoskaltsis-Mortari A, Weisdorf D, Lee SJ, Pidala J
Blood. 2016 Nov 10; 128(19)2350-2358. doi: 10.1182/blood-2015-09-669846.

PMID:
    27625357
    [PubMed - indexed for MEDLINE]
Related citations


Lung Function Trajectory in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplant.
Cheng GS, Storer B, Chien JW, Jagasia M, Hubbard JJ, Burns L, Ho VT, Pidala J, Palmer J, Johnston L, Mayer S, Crothers K, Pusic I, Lee SJ, Williams KM
Ann Am Thorac Soc. 2016 Nov; 13(11)1932-1939.

PMID:
    27513368
    [PubMed - indexed for MEDLINE]
Related citations


Phase I study of azacitidine following donor lymphocyte infusion for relapsed acute myeloid leukemia post allogeneic stem cell transplantation.
Ghobadi A, Choi J, Fiala MA, Fletcher T, Liu J, Eissenberg LG, Abboud C, Cashen A, Vij R, Schroeder MA, Pusic I, Stockerl-Goldstein K, Jacoby M, Uy G, DiPersio J, Westervelt P
Leuk Res. 2016 Oct; 491-6. doi: 10.1016/j.leukres.2016.07.010.

PMID:
    27505705
    [PubMed - indexed for MEDLINE]
Related citations


Glycoprotein YKL-40: a novel biomarker of chronic graft-vs-host disease activity and severity?
Duraković N, Krečak I, Perić Z, Milošević M, Desnica L, Pulanić D, Pusic I, Kušec V, Vrhovac R, Pavletic SZ, Nemet D
Croat Med J. 2016 Jun 30; 57(3)239-46.

PMID:
    27374825
    [PubMed - indexed for MEDLINE]
Related citations


Transplants for MDS and quality-of-life. But whose quality-of-life?
Gale RP, Pusic I
Bone Marrow Transplant. 2016 Aug; 51(8)1066-8. doi: 10.1038/bmt.2016.147.

PMID:
    27272450
    [PubMed - indexed for MEDLINE]
Related citations


Biomarker Panel for Chronic Graft-Versus-Host Disease.
Yu J, Storer BE, Kushekhar K, Abu Zaid M, Zhang Q, Gafken PR, Ogata Y, Martin PJ, Flowers ME, Hansen JA, Arora M, Cutler C, Jagasia M, Pidala J, Hamilton BK, Chen GL, Pusic I, Lee SJ, Paczesny S
J Clin Oncol. 2016 Aug 1; 34(22)2583-90. doi: 10.1200/JCO.2015.65.9615.

PMID:
    27217465
    [PubMed - indexed for MEDLINE]
Related citations


HLA disparity is not inconsequential in peripheral blood T-replete haploidentical hematopoietic stem cell transplantation.
Rashidi A, DiPersio JF, Westervelt P, Abboud CN, Schroeder MA, Pusic I, Cashen AF, Fehniger TA, Romee R
Bone Marrow Transplant. 2016 Sep; 51(9)1275-8. doi: 10.1038/bmt.2016.117.

PMID:
    27159170
    [PubMed - indexed for MEDLINE]
Related citations


Peritransplant Serum Albumin Decline Predicts Subsequent Severe Acute Graft-versus-Host Disease after Mucotoxic Myeloablative Conditioning.
Rashidi A, DiPersio JF, Westervelt P, Abboud CN, Schroeder MA, Cashen AF, Pusic I, Romee R
Biol Blood Marrow Transplant. 2016 Jun; 22(6)1137-1141. doi: 10.1016/j.bbmt.2016.03.010.

PMID:
    26988741
    [PubMed - indexed for MEDLINE]
Related citations


A phase I study of carfilzomib for relapsed or refractory acute myeloid and acute lymphoblastic leukemia.
Wartman LD, Fiala MA, Fletcher T, Hawkins ER, Cashen A, DiPersio JF, Jacoby MA, Stockerl-Goldstein KE, Pusic I, Uy GL, Westervelt P, Vij R
Leuk Lymphoma. 2016; 57(3)728-30. doi: 10.3109/10428194.2015.1076930.

PMID:
    26674111
    [PubMed - indexed for MEDLINE]
Related citations


Phase-1/-2 study of pomalidomide in chronic GvHD.
Pusic I, Rettig MP, DiPersio JF, Bauer S, McFarland K, Gale RP, Pavletic SZ
Bone Marrow Transplant. 2016 Apr; 51(4)612-4. doi: 10.1038/bmt.2015.298.

PMID:
    26657832
    [PubMed - indexed for MEDLINE]
Related citations


Late Acute and Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation.
Arora M, Cutler CS, Jagasia MH, Pidala J, Chai X, Martin PJ, Flowers ME, Inamoto Y, Chen GL, Wood WA, Khera N, Palmer J, Duong H, Arai S, Mayer S, Pusic I, Lee SJ
Biol Blood Marrow Transplant. 2016 Mar; 22(3)449-55. doi: 10.1016/j.bbmt.2015.10.018.

PMID:
    26541363
    [PubMed - indexed for MEDLINE]
Related citations


Predictors of survival, nonrelapse mortality, and failure-free survival in patients treated for chronic graft-versus-host disease.
Palmer J, Chai X, Pidala J, Inamoto Y, Martin PJ, Storer B, Pusic I, Flowers ME, Arora M, Pavletic SZ, Lee SJ
Blood. 2016 Jan 7; 127(1)160-6. doi: 10.1182/blood-2015-08-662874.

PMID:
    26527676
    [PubMed - indexed for MEDLINE]
Related citations


Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
Blood. 2015 Nov 26; 126(22)2484-90. doi: 10.1182/blood-2015-04-641100.

PMID:
    26492932
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Bone marrow transplantation, leukemia, chronic graft-versus-host disease