Patient Portal

Hussam Al-Kateb, MSc, PhD

Assistant Professor, Pathology & Immunology
Medical Director, Genomic and Pathology Services
Associate Director, Cytogenomics and Molecular Pathology Laboratory

Specialty Areas

Pathology
Cytogenetics

Board Certifications

Clinical Cytogenetics
Clinical Molecular Genetics

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

  • Education
  • Publication & Research

Education

Education

Master of Science, Laboratory Diagnosis (Clinical Pathology): School of Pharmacy, Damascus University, Syria 1997
Fellowship (Research), Complex Diseases: Hospital for Sick Children, Toronto, Ontario, Canada 2007
Fellowship, Clinical Cytogenetics: Case Western Reserve University, Cleveland, Ohio 2009
Bachelor's Degree, Pharmacy and Pharmaceutical Chemistry: School of Pharmacy, Damascus University, Syria 1992
PhD, Biology (Human Molecular Genetics): Max Delbrück Center for Molecular Medicine, Berlin, Germany 2004
Fellowship, Clinical Molecular Genetics: Case Western Reserve University, Cleveland, Ohio 2010

Publication & Research

Publication & Research

Unexpected favorable outcome in a patient with high grade B-cell lymphoma with abnormalities of MYC, BCL6 and BCL2 loci.
Adams T, Fuchs D, Shadoan PK, Johnstone L, Lau BM, McGhan L, Anwer F, Al-Kateb H
Cancer Genet. 2018 Apr; 222-22325-31. doi: 10.1016/j.cancergen.2018.01.003.

PMID:
    29666005
    [PubMed - in process]
Related citations


A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, with Anastrozole in Clinical Stage II or III <i>PIK3CA</i>-Mutant ER-Positive and HER2-Negative Breast Cancer.
Ma CX, Suman V, Goetz MP, Northfelt D, Burkard ME, Ademuyiwa F, Naughton M, Margenthaler J, Aft R, Gray R, Tevaarwerk A, Wilke L, Haddad T, Moynihan T, Loprinzi C, Hieken T, Barnell EK, Skidmore ZL, Feng YY, Krysiak K, Hoog J, Guo Z, Nehring L, Wisinski KB, Mardis E, Hagemann IS, Vij K, Sanati S, Al-Kateb H, Griffith OL, Griffith M, Doyle L, Erlichman C, Ellis MJ
Clin Cancer Res. 2017 Nov 15; 23(22)6823-6832. doi: 10.1158/1078-0432.CCR-17-1260.

PMID:
    28874413
    [PubMed - indexed for MEDLINE]
Related citations


Neratinib Efficacy and Circulating Tumor DNA Detection of <i>HER2</i> Mutations in <i>HER2</i> Nonamplified Metastatic Breast Cancer.
Ma CX, Bose R, Gao F, Freedman RA, Telli ML, Kimmick G, Winer E, Naughton M, Goetz MP, Russell C, Tripathy D, Cobleigh M, Forero A, Pluard TJ, Anders C, Niravath PA, Thomas S, Anderson J, Bumb C, Banks KC, Lanman RB, Bryce R, Lalani AS, Pfeifer J, Hayes DF, Pegram M, Blackwell K, Bedard PL, Al-Kateb H, Ellis MJC
Clin Cancer Res. 2017 Oct 1; 23(19)5687-5695. doi: 10.1158/1078-0432.CCR-17-0900.

PMID:
    28679771
    [PubMed - indexed for MEDLINE]
Related citations


NeoPalAna: Neoadjuvant Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, and Anastrozole for Clinical Stage 2 or 3 Estrogen Receptor-Positive Breast Cancer.
Ma CX, Gao F, Luo J, Northfelt DW, Goetz M, Forero A, Hoog J, Naughton M, Ademuyiwa F, Suresh R, Anderson KS, Margenthaler J, Aft R, Hobday T, Moynihan T, Gillanders W, Cyr A, Eberlein TJ, Hieken T, Krontiras H, Guo Z, Lee MV, Spies NC, Skidmore ZL, Griffith OL, Griffith M, Thomas S, Bumb C, Vij K, Bartlett CH, Koehler M, Al-Kateb H, Sanati S, Ellis MJ
Clin Cancer Res. 2017 Aug 1; 23(15)4055-4065. doi: 10.1158/1078-0432.CCR-16-3206.

PMID:
    28270497
    [PubMed - indexed for MEDLINE]
Related citations


Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix.
Tandon B, Hagemann IS, Maluf HM, Pfeifer JD, Al-Kateb H
Int J Gynecol Pathol. 2017 Nov; 36(6)593-599. doi: 10.1097/PGP.0000000000000365.

PMID:
    28177947
    [PubMed - indexed for MEDLINE]
Related citations


Gliosarcomas lack BRAF<sup>V600E</sup> mutation, but a subset exhibit β-catenin nuclear localization.
Schwetye KE, Joseph NM, Al-Kateb H, Rich KM, Schmidt RE, Perry A, Gutmann DH, Dahiya S
Neuropathology. 2016 Oct; 36(5)448-455. doi: 10.1111/neup.12293.

PMID:
    26932501
    [PubMed - indexed for MEDLINE]
Related citations


Urinary Volatile Organic Compounds for the Detection of Prostate Cancer.
Khalid T, Aggio R, White P, De Lacy Costello B, Persad R, Al-Kateb H, Jones P, Probert CS, Ratcliffe N
PLoS One. 2015; 10(11)e0143283. doi: 10.1371/journal.pone.0143283.

PMID:
    26599280
    [PubMed - indexed for MEDLINE]
Related citations


Identification of major factors associated with failed clinical molecular oncology testing performed by next generation sequencing (NGS).
Al-Kateb H, Nguyen TT, Steger-May K, Pfeifer JD
Mol Oncol. 2015 Nov; 9(9)1737-43. doi: 10.1016/j.molonc.2015.05.004.

PMID:
    26071350
    [PubMed - indexed for MEDLINE]
Related citations


Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process.
Chen G, Bai Y, Ren L, Zhu D, Li Y, Fang M, Al-Kateb H, Doran O
PLoS One. 2015; 10(1)e113194. doi: 10.1371/journal.pone.0113194.

PMID:
    25590624
    [PubMed - indexed for MEDLINE]
Related citations


TBX6 null variants and a common hypomorphic allele in congenital scoliosis.
Wu N, Ming X, Xiao J, Wu Z, Chen X, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev ZS, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy KW, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton VR, Wang H, Ming Y, Kulkarni S, Zhong TP, Giampietro PF, Dunwoodie SL, Cheung SW, Zhang X, Jin L, Lupski JR, Qiu G, Zhang F
N Engl J Med. 2015 Jan 22; 372(4)341-50. doi: 10.1056/NEJMoa1406829.

PMID:
    25564734
    [PubMed - indexed for MEDLINE]
Related citations


Clinical next-generation sequencing in patients with non-small cell lung cancer.
Hagemann IS, Devarakonda S, Lockwood CM, Spencer DH, Guebert K, Bredemeyer AJ, Al-Kateb H, Nguyen TT, Duncavage EJ, Cottrell CE, Kulkarni S, Nagarajan R, Seibert K, Baggstrom M, Waqar SN, Pfeifer JD, Morgensztern D, Govindan R
Cancer. 2015 Feb 15; 121(4)631-9. doi: 10.1002/cncr.29089.

PMID:
    25345567
    [PubMed - indexed for MEDLINE]
Related citations


Detection of gene rearrangements in targeted clinical next-generation sequencing.
Abel HJ, Al-Kateb H, Cottrell CE, Bredemeyer AJ, Pritchard CC, Grossmann AH, Wallander ML, Pfeifer JD, Lockwood CM, Duncavage EJ
J Mol Diagn. 2014 Jul; 16(4)405-17. doi: 10.1016/j.jmoldx.2014.03.006.

PMID:
    24813172
    [PubMed - indexed for MEDLINE]
Related citations


Intragenic CAMTA1 deletions are associated with a spectrum of neurobehavioral phenotypes.
Shinawi M, Coorg R, Shimony JS, Grange DK, Al-Kateb H
Clin Genet. 2015 May; 87(5)478-82. doi: 10.1111/cge.12407.

PMID:
    24738973
    [PubMed - indexed for MEDLINE]
Related citations


Scoliosis and vertebral anomalies: additional abnormal phenotypes associated with chromosome 16p11.2 rearrangement.
Al-Kateb H, Khanna G, Filges I, Hauser N, Grange DK, Shen J, Smyser CD, Kulkarni S, Shinawi M
Am J Med Genet A. 2014 May; 164A(5)1118-26. doi: 10.1002/ajmg.a.36401.

PMID:
    24458548
    [PubMed - indexed for MEDLINE]
Related citations


The relationship between growth stages and aroma composition of lemon basil Ocimum citriodorum Vis.
Al-Kateb H, Mottram DS
Food Chem. 2014; 152440-6. doi: 10.1016/j.foodchem.2013.12.001.

PMID:
    24444959
    [PubMed - indexed for MEDLINE]
Related citations


A review of the volatiles from the healthy human body.
de Lacy Costello B, Amann A, Al-Kateb H, Flynn C, Filipiak W, Khalid T, Osborne D, Ratcliffe NM
J Breath Res. 2014 Mar; 8(1)014001. doi: 10.1088/1752-7155/8/1/014001.

PMID:
    24421258
    [PubMed - indexed for MEDLINE]
Related citations


Clinical genomicist workstation.
Sharma MK, Phillips J, Agarwal S, Wiggins WS, Shrivastava S, Koul SB, Bhattacharjee M, Houchins CD, Kalakota RR, George B, Meyer RR, Spencer DH, Lockwood CM, Nguyen TT, Duncavage EJ, Al-Kateb H, Cottrell CE, Godala S, Lokineni R, Sawant SM, Chatti V, Surampudi S, Sunkishala RR, Darbha R, Macharla S, Milbrandt JD, Virgin HW, Mitra RD, Head RD, Kulkarni S, Bredemeyer A, Pfeifer JD, Seibert K, Nagarajan R
AMIA Jt Summits Transl Sci Proc. 2013; 2013156-7.

PMID:
    24303327
    [PubMed]
Related citations


Validation of a next-generation sequencing assay for clinical molecular oncology.
Cottrell CE, Al-Kateb H, Bredemeyer AJ, Duncavage EJ, Spencer DH, Abel HJ, Lockwood CM, Hagemann IS, O'Guin SM, Burcea LC, Sawyer CS, Oschwald DM, Stratman JL, Sher DA, Johnson MR, Brown JT, Cliften PF, George B, McIntosh LD, Shrivastava S, Nguyen TT, Payton JE, Watson MA, Crosby SD, Head RD, Mitra RD, Nagarajan R, Kulkarni S, Seibert K, Virgin HW 4th, Milbrandt J, Pfeifer JD
J Mol Diagn. 2014 Jan; 16(1)89-105. doi: 10.1016/j.jmoldx.2013.10.002.

PMID:
    24211365
    [PubMed - indexed for MEDLINE]
Related citations


An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS.
Al-Kateb H, de Lacy Costello B, Ratcliffe N
J Breath Res. 2013 Sep; 7(3)036004. doi: 10.1088/1752-7155/7/3/036004.

PMID:
    23867616
    [PubMed - indexed for MEDLINE]
Related citations


NR2F1 haploinsufficiency is associated with optic atrophy, dysmorphism and global developmental delay.
Al-Kateb H, Shimony JS, Vineyard M, Manwaring L, Kulkarni S, Shinawi M
Am J Med Genet A. 2013 Feb; 161A(2)377-81. doi: 10.1002/ajmg.a.35650.

PMID:
    23300014
    [PubMed - indexed for MEDLINE]
Related citations