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Herbert W. Virgin, MD, PhD

Edward Mallinckrodt Professor and Chair, Pathology and Immunology
Professor, Molecular Microbiology
Professor, Medicine

Specialty Areas

Pathology
Molecular Pathology
Microbiology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Diagnostics using next generation sequencing. Inflammatory bowel disease. Role of the virome in human disease.

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

AB, Biology - magna cum laude: Harvard University, Cambridge, MA 1977
Medical Degree: Harvard Medical School, Boston, MA 1985
PhD, Immunology: Harvard Medical School, Boston, MA 1985
Residency, Internal Medicine: Brigham and Women's Hospital, Harvard Medical School, Boston, MA 1990
Postdoctoral Fellowship (research) - Microbiology and Molecular Genetics: Harvard Medical School, Boston, MA 1990
Fellowship, Infectious Diseases: Washington University School of Medicine, St. Louis, MO 1991

Publication & Research

Publication & Research

MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes.
Kim KW, Williams JW, Wang YT, Ivanov S, Gilfillan S, Colonna M, Virgin HW, Gautier EL, Randolph GJ
J Exp Med. 2016 Sep 19; 213(10)1951-9. doi: 10.1084/jem.20160486.

PMID:
    27551152
    [PubMed - in process]
Related citations


Discovery of a proteinaceous cellular receptor for a norovirus.
Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW
Science. 2016 Aug 26; 353(6302)933-6. doi: 10.1126/science.aaf1220.

PMID:
    27540007
    [PubMed - in process]
Related citations


Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity.
Nice TJ, Osborne LC, Tomov VT, Artis D, Wherry EJ, Virgin HW
PLoS Pathog. 2016 Jun; 12(6)e1005684. doi: 10.1371/journal.ppat.1005684.

PMID:
    27327515
    [PubMed - in process]
Related citations


Accounting for reciprocal host-microbiome interactions in experimental science.
Stappenbeck TS, Virgin HW
Nature. 2016 Jun 8; 534(7606)191-9. doi: 10.1038/nature18285.

PMID:
    27279212
    [PubMed - indexed for MEDLINE]
Related citations


Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK
Science. 2016 May 27; 352(6289)1116-20. doi: 10.1126/science.aad9948.

PMID:
    27230380
    [PubMed - indexed for MEDLINE]
Related citations


Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.
Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW
Cell Host Microbe. 2016 May 11; 19(5)713-9. doi: 10.1016/j.chom.2016.04.003.

PMID:
    27107939
    [PubMed - in process]
Related citations


Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.
Martinez J, Cunha LD, Park S, Yang M, Lu Q, Orchard R, Li QZ, Yan M, Janke L, Guy C, Linkermann A, Virgin HW, Green DR
Nature. 2016 May 5; 533(7601)115-9. doi: 10.1038/nature17950.

PMID:
    27096368
    [PubMed - indexed for MEDLINE]
Related citations


Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.
Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL
J Cell Biol. 2016 Mar 28; 212(7)879. doi: 10.1083/jcb.20150702303082016c.

PMID:
    27002165
    [PubMed]
Related citations


Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.
Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW
Sci Rep. 2016 Mar 18; 623326. doi: 10.1038/srep23326.

PMID:
    26987296
    [PubMed - in process]
Related citations


SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.
Handley SA, Desai C, Zhao G, Droit L, Monaco CL, Schroeder AC, Nkolola JP, Norman ME, Miller AD, Wang D, Barouch DH, Virgin HW
Cell Host Microbe. 2016 Mar 9; 19(3)323-35. doi: 10.1016/j.chom.2016.02.010.

PMID:
    26962943
    [PubMed - in process]
Related citations


Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome.
Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW
Cell Host Microbe. 2016 Mar 9; 19(3)311-22. doi: 10.1016/j.chom.2016.02.011.

PMID:
    26962942
    [PubMed - in process]
Related citations


Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.
Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL
J Cell Biol. 2016 Feb 29; 212(5)545-60. doi: 10.1083/jcb.201507023.

PMID:
    26929451
    [PubMed - indexed for MEDLINE]
Related citations


Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
Dong X, Cheng A, Zou Z, Yang YS, Sumpter RM Jr, Huang CL, Bhagat G, Virgin HW, Lira SA, Levine B
Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11)2994-9. doi: 10.1073/pnas.1601860113.

PMID:
    26929373
    [PubMed - indexed for MEDLINE]
Related citations


Viral immunity. Transkingdom control of viral infection and immunity in the mammalian intestine.
Pfeiffer JK, Virgin HW
Science. 2016 Jan 15; 351(6270)pii: aad5872. doi: 10.1126/science.aad5872.

PMID:
    26816384
    [PubMed - indexed for MEDLINE]
Related citations


Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE
Nat Biotechnol. 2016 Feb; 34(2)184-91. doi: 10.1038/nbt.3437.

PMID:
    26780180
    [PubMed - indexed for MEDLINE]
Related citations


Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.
Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW
Cell Host Microbe. 2016 Jan 13; 19(1)102-13. doi: 10.1016/j.chom.2015.12.011.

PMID:
    26764600
    [PubMed - in process]
Related citations


Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.
Park S, Buck MD, Desai C, Zhang X, Loginicheva E, Martinez J, Freeman ML, Saitoh T, Akira S, Guan JL, He YW, Blackman MA, Handley SA, Levine B, Green DR, Reese TA, Artyomov MN, Virgin HW
Cell Host Microbe. 2016 Jan 13; 19(1)91-101. doi: 10.1016/j.chom.2015.12.010.

PMID:
    26764599
    [PubMed - in process]
Related citations


Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
Kimmey JM, Huynh JP, Weiss LA, Park S, Kambal A, Debnath J, Virgin HW, Stallings CL
Nature. 2015 Dec 24; 528(7583)565-9. doi: 10.1038/nature16451.

PMID:
    26649827
    [PubMed - indexed for MEDLINE]
Related citations


Gut DNA viromes of Malawian twins discordant for severe acute malnutrition.
Reyes A, Blanton LV, Cao S, Zhao G, Manary M, Trehan I, Smith MI, Wang D, Virgin HW, Rohwer F, Gordon JI
Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38)11941-6. doi: 10.1073/pnas.1514285112.

PMID:
    26351661
    [PubMed - indexed for MEDLINE]
Related citations


A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.
Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD
MBio. 2015 Sep 8; 6(5)e01157-15. doi: 10.1128/mBio.01157-15.

PMID:
    26350966
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2015.

Company Name: ATS Labs

Royalties: $10,001 - $25,000

Equity: No

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016


Company Name: Charles River Laboratories

Royalties: $10,001 - $25,000

Equity: No

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016


Company Name: Ecolab

Royalties: $10,001 - $25,000

Equity: No

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016


Company Name: Pieriandx

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016

Areas of Research Interest

Viral infection, immunity, disease pathogenesis, inflammatory bowel disease, AIDS