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Faculty Physicians

Gregory J. Zipfel, MD

Professor, Neurosurgery
Professor, Neurology

Specialty Areas

Neurological Surgery
Cerebrovascular Disease
Brain Tumors
Skull Base Tumors
Aneurysms and Vascular Malformations
Stroke
Carotid Disease
Pituitary Tumors
Moyamoya Disease
Neuro Oncology

Board Certifications

Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Cerebrovascular disease including aneurysms, arteriovenous malformations, cavernous malformations, carotid stenosis, Moyamoya disease and arterial bypass surgery, skull base tumors including meningiomas, acoustic neuromas, craniofacial tumors and pituitary brain tumors, Pituitary Center

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-3577
Fax: 314-362-2107

Education

Education

Fellowship: Neurological Surgery, University of Miami, Miami, Florida 2003
Residency: Neurological Surgery, University of Miami, Gainesville, Florida 2003
Medical Degree: Northwestern University Medical School, Chicago, Illinois 1995
B.S.: Biology, University of Illinois College of Liberal Arts and Sciences, Champaign-Urbana, Illinois 1991

Publication & Research

Publication & Research

Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease.
Tarawneh R, D'Angelo G, Crimmins D, Herries E, Griest T, Fagan AM, Zipfel GJ, Ladenson JH, Morris JC, Holtzman DM
JAMA Neurol. 2016 Mar 28; doi: 10.1001/jamaneurol.2016.0086.

PMID:
    27018940
    [PubMed - as supplied by publisher]
Related citations


Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells.
Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ
Mol Neurodegener. 2016 Jan 22; 119. doi: 10.1186/s13024-016-0073-8.

PMID:
    26801396
    [PubMed - in process]
Related citations


Endovascular management of internal carotid artery injuries secondary to endonasal surgery: case series and review of the literature.
Sylvester PT, Moran CJ, Derdeyn CP, Cross DT, Dacey RG, Zipfel GJ, Kim AH, Uppaluri R, Haughey BH, Tempelhoff R, Rich KM, Schneider J, Chole RA, Chicoine MR
J Neurosurg. 2016 Jan 15; 1-21.

PMID:
    26771847
    [PubMed - as supplied by publisher]
Related citations


Effect of Hemodynamics on Stroke Risk in Symptomatic Atherosclerotic Vertebrobasilar Occlusive Disease.
Amin-Hanjani S, Pandey DK, Rose-Finnell L, Du X, Richardson D, Thulborn KR, Elkind MS, Zipfel GJ, Liebeskind DS, Silver FL, Kasner SE, Aletich VA, Caplan LR, Derdeyn CP, Gorelick PB, Charbel FT, Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Study Group
JAMA Neurol. 2016 Feb 1; 73(2)178-85. doi: 10.1001/jamaneurol.2015.3772.

PMID:
    26720181
    [PubMed - in process]
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Radiation Therapy for Residual or Recurrent Atypical Meningioma: The Effects of Modality, Timing, and Tumor Pathology on Long-Term Outcomes.
Sun SQ, Cai C, Murphy RK, DeWees T, Dacey RG, Grubb RL, Rich KM, Zipfel GJ, Dowling JL, Leuthardt EC, Simpson JR, Robinson CG, Chicoine MR, Perrin RJ, Huang J, Kim AH
Neurosurgery. 2015 Nov 26;

PMID:
    26645969
    [PubMed - as supplied by publisher]
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Dural arteriovenous fistula-induced thalamic dementia: report of 4 cases.
Holekamp TF, Mollman ME, Murphy RK, Kolar GR, Kramer NM, Derdeyn CP, Moran CJ, Perrin RJ, Rich KM, Lanzino G, Zipfel GJ
J Neurosurg. 2015 Nov 20; 1-14.

PMID:
    26587655
    [PubMed - as supplied by publisher]
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Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity.
Bales KR, O'Neill SM, Pozdnyakov N, Pan F, Caouette D, Pi Y, Wood KM, Volfson D, Cirrito JR, Han BH, Johnson AW, Zipfel GJ, Samad TA
Brain. 2016 Feb; 139(Pt 2)563-77. doi: 10.1093/brain/awv313.

PMID:
    26493635
    [PubMed - in process]
Related citations


Utility of Screening for Cerebral Vasospasm Using Digital Subtraction Angiography.
Arias EJ, Vajapey S, Reynolds MR, Chicoine MR, Rich KM, Dacey RG Jr, Dorward IG, Derdeyn CP, Moran CJ, Cross DT 3rd, Zipfel GJ, Dhar R
Stroke. 2015 Nov; 46(11)3137-41. doi: 10.1161/STROKEAHA.115.010081.

PMID:
    26405204
    [PubMed - indexed for MEDLINE]
Related citations


Causes of 30-day readmission after aneurysmal subarachnoid hemorrhage.
Greenberg JK, Washington CW, Guniganti R, Dacey RG Jr, Derdeyn CP, Zipfel GJ
J Neurosurg. 2016 Mar; 124(3)743-9. doi: 10.3171/2015.2.JNS142771.

PMID:
    26361278
    [PubMed - in process]
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A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage.
Washington CW, Derdeyn CP, Dhar R, Arias EJ, Chicoine MR, Cross DT, Dacey RG Jr, Han BH, Moran CJ, Rich KM, Vellimana AK, Zipfel GJ
J Neurosurg. 2016 Feb; 124(2)318-27. doi: 10.3171/2015.2.JNS142752.

PMID:
    26314998
    [PubMed - in process]
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The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus.
Etminan N, Brown RD Jr, Beseoglu K, Juvela S, Raymond J, Morita A, Torner JC, Derdeyn CP, Raabe A, Mocco J, Korja M, Abdulazim A, Amin-Hanjani S, Al-Shahi Salman R, Barrow DL, Bederson J, Bonafe A, Dumont AS, Fiorella DJ, Gruber A, Hankey GJ, Hasan DM, Hoh BL, Jabbour P, Kasuya H, Kelly ME, Kirkpatrick PJ, Knuckey N, Koivisto T, Krings T, Lawton MT, Marotta TR, Mayer SA, Mee E, Pereira VM, Molyneux A, Morgan MK, Mori K, Murayama Y, Nagahiro S, Nakayama N, Niemelä M, Ogilvy CS, Pierot L, Rabinstein AA, Roos YB, Rinne J, Rosenwasser RH, Ronkainen A, Schaller K, Seifert V, Solomon RA, Spears J, Steiger HJ, Vergouwen MD, Wanke I, Wermer MJ, Wong GK, Wong JH, Zipfel GJ, Connolly ES Jr, Steinmetz H, Lanzino G, Pasqualin A, Rüfenacht D, Vajkoczy P, McDougall C, Hänggi D, LeRoux P, Rinkel GJ, Macdonald RL
Neurology. 2015 Sep 8; 85(10)881-9. doi: 10.1212/WNL.0000000000001891.

PMID:
    26276380
    [PubMed - indexed for MEDLINE]
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The safety of vasopressor-induced hypertension in subarachnoid hemorrhage patients with coexisting unruptured, unprotected intracranial aneurysms.
Reynolds MR, Buckley RT, Indrakanti SS, Turkmani AH, Oh G, Crobeddu E, Fargen KM, El Ahmadieh TY, Naidech AM, Amin-Hanjani S, Lanzino G, Hoh BL, Bendok BR, Zipfel GJ
J Neurosurg. 2015 Oct; 123(4)862-71. doi: 10.3171/2014.12.JNS141201.

PMID:
    26207606
    [PubMed - indexed for MEDLINE]
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Factors Associated with Acute and Chronic Hydrocephalus in Nonaneurysmal Subarachnoid Hemorrhage.
Kang P, Raya A, Zipfel GJ, Dhar R
Neurocrit Care. 2016 Feb; 24(1)104-9. doi: 10.1007/s12028-015-0152-7.

PMID:
    26136147
    [PubMed - in process]
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Experimental subarachnoid haemorrhage results in multifocal axonal injury.
Kummer TT, Magnoni S, MacDonald CL, Dikranian K, Milner E, Sorrell J, Conte V, Benetatos JJ, Zipfel GJ, Brody DL
Brain. 2015 Sep; 138(Pt 9)2608-18. doi: 10.1093/brain/awv180.

PMID:
    26115676
    [PubMed - indexed for MEDLINE]
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A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.
Mao DD, Gujar AD, Mahlokozera T, Chen I, Pan Y, Luo J, Brost T, Thompson EA, Turski A, Leuthardt EC, Dunn GP, Chicoine MR, Rich KM, Dowling JL, Zipfel GJ, Dacey RG, Achilefu S, Tran DD, Yano H, Kim AH
Cell Rep. 2015 Jun 23; 11(11)1809-21. doi: 10.1016/j.celrep.2015.05.027.

PMID:
    26074073
    [PubMed - indexed for MEDLINE]
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Hemodynamic Features of Symptomatic Vertebrobasilar Disease.
Amin-Hanjani S, Du X, Rose-Finnell L, Pandey DK, Richardson D, Thulborn KR, Elkind MS, Zipfel GJ, Liebeskind DS, Silver FL, Kasner SE, Aletich VA, Caplan LR, Derdeyn CP, Gorelick PB, Charbel FT, VERiTAS Study Group
Stroke. 2015 Jul; 46(7)1850-6. doi: 10.1161/STROKEAHA.115.009215.

PMID:
    25977279
    [PubMed - indexed for MEDLINE]
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Surgical Revascularization in North American Adults with Moyamoya Phenomenon: Long-Term Angiographic Follow-up.
Arias EJ, Dunn GP, Washington CW, Derdeyn CP, Chicoine MR, Grubb RL Jr, Moran CJ, Cross DT 3rd, Dacey RG Jr, Zipfel GJ
J Stroke Cerebrovasc Dis. 2015 Jul; 24(7)1597-608. doi: 10.1016/j.jstrokecerebrovasdis.2015.03.053.

PMID:
    25972283
    [PubMed - indexed for MEDLINE]
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HIF-1α Mediates Isoflurane-Induced Vascular Protection in Subarachnoid Hemorrhage.
Milner E, Johnson AW, Nelson JW, Harries MD, Gidday JM, Han BH, Zipfel GJ
Ann Clin Transl Neurol. 2015 Apr; 2(4)325-37. doi: 10.1002/acn3.170.

PMID:
    25909079
    [PubMed]
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Editorial: Arteriovenous malformations and embolization.
Zipfel GJ
J Neurosurg. 2015 Jun; 122(6)1490-1. doi: 10.3171/2014.9.JNS141419.

PMID:
    25816086
    [PubMed - indexed for MEDLINE]
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No additional protection against ventriculitis with prolonged systemic antibiotic prophylaxis for patients treated with antibiotic-coated external ventricular drains.
Murphy RK, Liu B, Srinath A, Reynolds MR, Liu J, Craighead MC, Camins BC, Dhar R, Kummer TT, Zipfel GJ
J Neurosurg. 2015 May; 122(5)1120-6. doi: 10.3171/2014.9.JNS132882.

PMID:
    25794343
    [PubMed - indexed for MEDLINE]
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