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Gerald P. Linette, MD, PhD

Associate Professor, Medicine and Neurosurgery
Division of Oncology

Specialty Areas

Oncology
Brain Tumors
Medical Oncology
Melanoma
Skin Cancer
Neuro Oncology

Board Certifications

Internal Medicine
Medical Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Melanoma, Brain tumors, Neuro-oncology, Medical Oncology

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-747-7222

Suite: B
Floor: 7
Office Phone: 314-362-5677
Fax: 314-362-7086

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Fax: 314-362-7086

Education

Education

Fellowship: Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts 1998
Fellowship: Research, Molecular Oncology, Washington University School of Medicine, St. Louis, Missouri, 63110 1995
Residency: Barnes Hospital, St. Louis, Missouri 1992
Medical Degree/PhD: Microbiology, Georgetown University School of Medicine, Washington DC 1990
B.S.: Biology, St. Joseph's University, Philadelphia, Pennsylvania 1980

Publication & Research

Publication & Research

Extensive tumoral melanosis associated with ipilimumab-treated melanoma.
Staser K, Chen D, Solus J, Rosman IS, Schaffer A, Cornelius L, Linette GP, Fields RC
Br J Dermatol. 2016 Feb 15; doi: 10.1111/bjd.14474.

PMID:
    26877232
    [PubMed - as supplied by publisher]
Related citations


pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens.
Hundal J, Carreno BM, Petti AA, Linette GP, Griffith OL, Mardis ER, Griffith M
Genome Med. 2016 Jan 29; 8(1)11. doi: 10.1186/s13073-016-0264-5.

PMID:
    26825632
    [PubMed - in process]
Related citations


Checkpoint Inhibitors in Kidney Transplant Recipients and the Potential Risk of Rejection.
Alhamad T, Venkatachalam K, Linette GP, Brennan DC
Am J Transplant. 2016 Apr; 16(4)1332-3. doi: 10.1111/ajt.13711.

PMID:
    26752406
    [PubMed - in process]
Related citations


Phase 2 study of sunitinib in patients with metastatic mucosal or acral melanoma.
Buchbinder EI, Sosman JA, Lawrence DP, McDermott DF, Ramaiya NH, Van den Abbeele AD, Linette GP, Giobbie-Hurder A, Hodi FS
Cancer. 2015 Nov 15; 121(22)4007-15. doi: 10.1002/cncr.29622.

PMID:
    26264378
    [PubMed - indexed for MEDLINE]
Related citations


Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
Andtbacka RH, Kaufman HL, Collichio F, Amatruda T, Senzer N, Chesney J, Delman KA, Spitler LE, Puzanov I, Agarwala SS, Milhem M, Cranmer L, Curti B, Lewis K, Ross M, Guthrie T, Linette GP, Daniels GA, Harrington K, Middleton MR, Miller WH Jr, Zager JS, Ye Y, Yao B, Li A, Doleman S, VanderWalde A, Gansert J, Coffin RS
J Clin Oncol. 2015 Sep 1; 33(25)2780-8. doi: 10.1200/JCO.2014.58.3377.

PMID:
    26014293
    [PubMed - indexed for MEDLINE]
Related citations


Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.
Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, Linette GP, Meyer N, Giguere JK, Agarwala SS, Shaheen M, Ernstoff MS, Minor D, Salama AK, Taylor M, Ott PA, Rollin LM, Horak C, Gagnier P, Wolchok JD, Hodi FS
N Engl J Med. 2015 May 21; 372(21)2006-17. doi: 10.1056/NEJMoa1414428.

PMID:
    25891304
    [PubMed - indexed for MEDLINE]
Related citations


Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells.
Carreno BM, Magrini V, Becker-Hapak M, Kaabinejadian S, Hundal J, Petti AA, Ly A, Lie WR, Hildebrand WH, Mardis ER, Linette GP
Science. 2015 May 15; 348(6236)803-8. doi: 10.1126/science.aaa3828.

PMID:
    25837513
    [PubMed - indexed for MEDLINE]
Related citations


Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.
Weber JS, D'Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, Hoeller C, Khushalani NI, Miller WH Jr, Lao CD, Linette GP, Thomas L, Lorigan P, Grossmann KF, Hassel JC, Maio M, Sznol M, Ascierto PA, Mohr P, Chmielowski B, Bryce A, Svane IM, Grob JJ, Krackhardt AM, Horak C, Lambert A, Yang AS, Larkin J
Lancet Oncol. 2015 Apr; 16(4)375-84. doi: 10.1016/S1470-2045(15)70076-8.

PMID:
    25795410
    [PubMed - indexed for MEDLINE]
Related citations


Clonal architectures and driver mutations in metastatic melanomas.
Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, Sondak VK, Fields RC, Ley TJ, Mulé JJ, Wilson RK, Weber JS
PLoS One. 2014; 9(11)e111153. doi: 10.1371/journal.pone.0111153.

PMID:
    25393105
    [PubMed - indexed for MEDLINE]
Related citations


Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.
Carvajal RD, Sosman JA, Quevedo JF, Milhem MM, Joshua AM, Kudchadkar RR, Linette GP, Gajewski TF, Lutzky J, Lawson DH, Lao CD, Flynn PJ, Albertini MR, Sato T, Lewis K, Doyle A, Ancell K, Panageas KS, Bluth M, Hedvat C, Erinjeri J, Ambrosini G, Marr B, Abramson DH, Dickson MA, Wolchok JD, Chapman PB, Schwartz GK
JAMA. 2014 Jun 18; 311(23)2397-405. doi: 10.1001/jama.2014.6096.

PMID:
    24938562
    [PubMed - indexed for MEDLINE]
Related citations


Histopathologic characteristics of therapy-associated cutaneous neoplasms with vemurafenib, a selective BRAF kinase inhibitor, used in the treatment of melanoma.
Sufficool KE, Hepper DM, Linette GP, Hurst EA, Lu D, Lind AC, Cornelius LA
J Cutan Pathol. 2014 Jul; 41(7)568-75. doi: 10.1111/cup.12346.

PMID:
    24641301
    [PubMed - indexed for MEDLINE]
Related citations


Dendritic cell-based vaccines: Shining the spotlight on signal 3.
Linette GP, Carreno BM
Oncoimmunology. 2013 Nov 1; 2(11)e26512.

PMID:
    24404428
    [PubMed]
Related citations


Codeletions at 1p and 19q predict a lower risk of pseudoprogression in oligodendrogliomas and mixed oligoastrocytomas.
Lin AL, Liu J, Evans J, Leuthardt EC, Rich KM, Dacey RG, Dowling JL, Kim AH, Zipfel GJ, Grubb RL, Huang J, Robinson CG, Simpson JR, Linette GP, Chicoine MR, Tran DD
Neuro Oncol. 2014 Jan; 16(1)123-30. doi: 10.1093/neuonc/not142.

PMID:
    24285548
    [PubMed - indexed for MEDLINE]
Related citations


Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells.
Cameron BJ, Gerry AB, Dukes J, Harper JV, Kannan V, Bianchi FC, Grand F, Brewer JE, Gupta M, Plesa G, Bossi G, Vuidepot A, Powlesland AS, Legg A, Adams KJ, Bennett AD, Pumphrey NJ, Williams DD, Binder-Scholl G, Kulikovskaya I, Levine BL, Riley JL, Varela-Rohena A, Stadtmauer EA, Rapoport AP, Linette GP, June CH, Hassan NJ, Kalos M, Jakobsen BK
Sci Transl Med. 2013 Aug 7; 5(197)197ra103. doi: 10.1126/scitranslmed.3006034.

PMID:
    23926201
    [PubMed - indexed for MEDLINE]
Related citations


IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity.
Carreno BM, Becker-Hapak M, Huang A, Chan M, Alyasiry A, Lie WR, Aft RL, Cornelius LA, Trinkaus KM, Linette GP
J Clin Invest. 2013 Aug; 123(8)3383-94. doi: 10.1172/JCI68395.

PMID:
    23867552
    [PubMed - indexed for MEDLINE]
Related citations


Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
Linette GP, Stadtmauer EA, Maus MV, Rapoport AP, Levine BL, Emery L, Litzky L, Bagg A, Carreno BM, Cimino PJ, Binder-Scholl GK, Smethurst DP, Gerry AB, Pumphrey NJ, Bennett AD, Brewer JE, Dukes J, Harper J, Tayton-Martin HK, Jakobsen BK, Hassan NJ, Kalos M, June CH
Blood. 2013 Aug 8; 122(6)863-71. doi: 10.1182/blood-2013-03-490565.

PMID:
    23770775
    [PubMed - indexed for MEDLINE]
Related citations


Neoadjuvant treatment of a solitary melanoma brain metastasis with vemurafenib.
Kolar GR, Miller-Thomas MM, Schmidt RE, Simpson JR, Rich KM, Linette GP
J Clin Oncol. 2013 Jan 20; 31(3)e40-3. doi: 10.1200/JCO.2012.43.7061.

PMID:
    23233711
    [PubMed - indexed for MEDLINE]
Related citations


Phase II trial of intravenous administration of Reolysin(®) (Reovirus Serotype-3-dearing Strain) in patients with metastatic melanoma.
Galanis E, Markovic SN, Suman VJ, Nuovo GJ, Vile RG, Kottke TJ, Nevala WK, Thompson MA, Lewis JE, Rumilla KM, Roulstone V, Harrington K, Linette GP, Maples WJ, Coffey M, Zwiebel J, Kendra K
Mol Ther. 2012 Oct; 20(10)1998-2003. doi: 10.1038/mt.2012.146.

PMID:
    22871663
    [PubMed - indexed for MEDLINE]
Related citations


Amino-terminal extended peptide single-chain trimers are potent synthetic agonists for memory human CD8+ T cells.
Carreno BM, Becker-Hapak M, Chan M, Lie WR, Wang X, Hansen TH, Linette GP
J Immunol. 2012 Jun 15; 188(12)5839-49. doi: 10.4049/jimmunol.1103647.

PMID:
    22573808
    [PubMed - indexed for MEDLINE]
Related citations


BEAM: a randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma.
Kim KB, Sosman JA, Fruehauf JP, Linette GP, Markovic SN, McDermott DF, Weber JS, Nguyen H, Cheverton P, Chen D, Peterson AC, Carson WE 3rd, O'Day SJ
J Clin Oncol. 2012 Jan 1; 30(1)34-41. doi: 10.1200/JCO.2011.34.6270.

PMID:
    22124101
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Immunological approaches for the treatment of cancer