Patient Portal

Gerald P. Linette, MD, PhD

Associate Professor, Medicine and Neurosurgery
Division of Oncology

Specialty Areas

Oncology
Brain Tumors
Medical Oncology
Melanoma
Skin Cancer
Neuro Oncology

Board Certifications

Internal Medicine
Medical Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Melanoma, Brain tumors, Neuro-oncology, Medical Oncology

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-362-5677
Fax: 314-362-7086

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Fax: 314-362-7086

Education

Education

Fellowship: Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts 1998
Fellowship: Research, Molecular Oncology, Washington University School of Medicine, St. Louis, Missouri, 63110 1995
Residency: Barnes Hospital, St. Louis, Missouri 1992
Medical Degree/PhD: Microbiology, Georgetown University School of Medicine, Washington DC 1990
B.S.: Biology, St. Joseph's University, Philadelphia, Pennsylvania 1980

Publication & Research

Publication & Research

Primary Bone Tumors: Challenges and Opportunities for CAR-T Therapies.
Folkert IW, Devalaraja S, Linette GP, Weber K, Haldar M
J Bone Miner Res. 2019 Aug 23; doi: 10.1002/jbmr.3852.

PMID:
    31441962
    [PubMed - as supplied by publisher]
Related citations


Tumor-Infiltrating Lymphocytes in the Checkpoint Inhibitor Era.
Linette GP, Carreno BM
Curr Hematol Malig Rep. 2019 Aug; 14(4)286-291. doi: 10.1007/s11899-019-00523-x.

PMID:
    31187421
    [PubMed - in process]
Related citations


A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma.
Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, D'Andrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier MW, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao Q, Mogg R, Xu W, Blumenschein WM, Yearley JH, Linette GP, Amaravadi RK, Schuchter LM, Herati RS, Bengsch B, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC
Nat Med. 2019 Mar; 25(3)454-461. doi: 10.1038/s41591-019-0357-y.

PMID:
    30804515
    [PubMed - indexed for MEDLINE]
Related citations


Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma.
D'Angelo SP, Hunger M, Brohl AS, Nghiem P, Bhatia S, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Schlichting M, Hennessy MH, Bharmal M
Cancer Immunol Immunother. 2019 Apr; 68(4)609-618. doi: 10.1007/s00262-018-02295-4.

PMID:
    30721341
    [PubMed - indexed for MEDLINE]
Related citations


RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma.
Bagley SJ, Hwang WT, Brem S, Linette GP, O'Rourke DM, Desai AS
J Neurooncol. 2019 Jan; 141(1)95-102. doi: 10.1007/s11060-018-03010-0.

PMID:
    30353265
    [PubMed - indexed for MEDLINE]
Related citations


Health-related quality of life in patients with malignant melanoma by stage and treatment status.
Rosenberg AR, Weston SJ, Deshields T, Fields RC, Linette GP, Cornelius LA, Semenov YR
J Am Acad Dermatol. 2018 Jun 12; pii: S0190-9622(18)32068-1. doi: 10.1016/j.jaad.2018.06.007.

PMID:
    29906543
    [PubMed - as supplied by publisher]
Related citations


CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges.
Bagley SJ, Desai AS, Linette GP, June CH, O'Rourke DM
Neuro Oncol. 2018 Oct 9; 20(11)1429-1438. doi: 10.1093/neuonc/noy032.

PMID:
    29509936
    [PubMed - in process]
Related citations


Metastatic melanoma after solid organ transplantation: An interdisciplinary, institution-based review of management with systemic and targeted therapies.
Tripathi SV, Morris CR, Alhamad T, Fields RC, Linette GP, Cornelius LA
J Am Acad Dermatol. 2018 Jan; 78(1)184-185. doi: 10.1016/j.jaad.2017.06.031.

PMID:
    29241778
    [PubMed - indexed for MEDLINE]
Related citations


CAR T-Cell Therapies in Glioblastoma: A First Look.
Migliorini D, Dietrich PY, Stupp R, Linette GP, Posey AD Jr, June CH
Clin Cancer Res. 2018 Feb 1; 24(3)535-540. doi: 10.1158/1078-0432.CCR-17-2871.

PMID:
    29158268
    [PubMed - indexed for MEDLINE]
Related citations


Vemurafenib treatment for patients with locally advanced, unresectable stage IIIC or metastatic melanoma and activating exon 15 BRAF mutations other than V600E.
Hallmeyer S, Gonzalez R, Lawson DH, Cranmer LD, Linette GP, Puzanov I, Taback B, Cowey CL, Ribas A, Daniels GA, Moore T, Gibney GT, Tawbi H, Whitman E, Lee G, Mun Y, Liu S, Hamid O
Melanoma Res. 2017 Dec; 27(6)585-590. doi: 10.1097/CMR.0000000000000398.

PMID:
    29076950
    [PubMed - indexed for MEDLINE]
Related citations


Neoantigen Vaccines Pass the Immunogenicity Test.
Linette GP, Carreno BM
Trends Mol Med. 2017 Oct; 23(10)869-871. doi: 10.1016/j.molmed.2017.08.007.

PMID:
    28867556
    [PubMed - indexed for MEDLINE]
Related citations


Noninvasive Determination of Melanoma Depth using a Handheld Photoacoustic Probe.
Zhou Y, Tripathi SV, Rosman I, Ma J, Hai P, Linette GP, Council ML, Fields RC, Wang LV, Cornelius LA
J Invest Dermatol. 2017 Jun; 137(6)1370-1372. doi: 10.1016/j.jid.2017.01.016.

PMID:
    28163070
    [PubMed - indexed for MEDLINE]
Related citations


Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma.
Atkinson TM, Hay JL, Shoushtari A, Li Y, Paucar DJ, Smith SC, Kudchadkar RR, Doyle A, Sosman JA, Quevedo JF, Milhem MM, Joshua AM, Linette GP, Gajewski TF, Lutzky J, Lawson DH, Lao CD, Flynn PJ, Albertini MR, Sato T, Lewis K, Marr B, Abramson DH, Dickson MA, Schwartz GK, Carvajal RD
J Cancer Res Clin Oncol. 2017 Mar; 143(3)439-445. doi: 10.1007/s00432-016-2318-x.

PMID:
    27921276
    [PubMed - indexed for MEDLINE]
Related citations


Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial.
Hodi FS, Chesney J, Pavlick AC, Robert C, Grossmann KF, McDermott DF, Linette GP, Meyer N, Giguere JK, Agarwala SS, Shaheen M, Ernstoff MS, Minor DR, Salama AK, Taylor MH, Ott PA, Horak C, Gagnier P, Jiang J, Wolchok JD, Postow MA
Lancet Oncol. 2016 Nov; 17(11)1558-1568. doi: 10.1016/S1470-2045(16)30366-7.

PMID:
    27622997
    [PubMed - indexed for MEDLINE]
Related citations


Management Controversies in Head and Neck Melanoma: A Systematic Review.
Zenga J, Nussenbaum B, Cornelius LA, Linette GP, Desai SC
JAMA Facial Plast Surg. 2017 Jan 1; 19(1)53-62. doi: 10.1001/jamafacial.2016.1038.

PMID:
    27606893
    [PubMed - indexed for MEDLINE]
Related citations


Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial.
Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P
Lancet Oncol. 2016 Oct; 17(10)1374-1385. doi: 10.1016/S1470-2045(16)30364-3.

PMID:
    27592805
    [PubMed - indexed for MEDLINE]
Related citations


A case of recurrent bilateral uveitis independently associated with dabrafenib and pembrolizumab therapy.
Taylor SC, Hrisomalos F, Linette GP, Rao PK
Am J Ophthalmol Case Rep. 2016 Jul; 223-25. doi: 10.1016/j.ajoc.2016.04.004.

PMID:
    29503892
    [PubMed]
Related citations


Extensive tumoral melanosis associated with ipilimumab-treated melanoma.
Staser K, Chen D, Solus J, Rosman IS, Schaffer A, Cornelius L, Linette GP, Fields RC
Br J Dermatol. 2016 Aug; 175(2)391-3. doi: 10.1111/bjd.14474.

PMID:
    26877232
    [PubMed - indexed for MEDLINE]
Related citations


pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens.
Hundal J, Carreno BM, Petti AA, Linette GP, Griffith OL, Mardis ER, Griffith M
Genome Med. 2016 Jan 29; 8(1)11. doi: 10.1186/s13073-016-0264-5.

PMID:
    26825632
    [PubMed - indexed for MEDLINE]
Related citations


Checkpoint Inhibitors in Kidney Transplant Recipients and the Potential Risk of Rejection.
Alhamad T, Venkatachalam K, Linette GP, Brennan DC
Am J Transplant. 2016 Apr; 16(4)1332-3. doi: 10.1111/ajt.13711.

PMID:
    26752406
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Immunological approaches for the treatment of cancer