FollowMyHealth Patient Portal

George P. Christophi, MD, PhD

Instructor, Medicine
Division of Gastroenterology

Specialty Areas

Gastroenterology
Inflammatory Bowel Disease
Crohn's Disease
Ulcerative Colitis
Endoscopy

Board Certifications

Internal Medicine
Gastroenterology

Hospital Affiliations

Barnes-Jewish Hospital

Languages

Greek

Areas of Clinical Interest

Inflammatory bowel disease, Crohn's disease, ulcerative colitis, microscopic and lymphocytic colitis, colitis-associated dysplasia and colon cancer.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: 314-747-2066
Fax: 314-747-5871

Center for Advanced Medicine - South County

5201 Midamerica Plaza
St. Louis, MO 63129

Suite: 2300
Office Phone: 314-747-2066
Fax: 314-747-5871

Education

Education

Fellowship, Gastroenterology and Hepatology: Washington University School of Medicine, St. Louis, MO 2017
Fellowship (Research), Inflammatory Bowel Disease: Washington University School of Medicine, St. Louis, MO 2017
Residency, Internal Medicine: Barnes-Jewish Hospital, St. Louis, MO 2014
Medical Degree: Upstate Medical University, Syracuse, NY 2011
PhD, Immunology and Microbiology: Upstate Medical University, Syracuse, NY 2011

Publication & Research

Publication & Research

The microbial metabolite desaminotyrosine protects from influenza through type I interferon.
Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS
Science. 2017 Aug 4; 357(6350)498-502. doi: 10.1126/science.aam5336.

PMID:
    28774928
    [PubMed - in process]
Related citations


Erdheim-Chester Disease presenting with histiocytic colitis and cytokine storm.
Christophi GP, Sharma Y, Farhan Q, Jain U, Walker T, Sayuc GS, Rubin DC
J Gastrointestin Liver Dis. 2017 Jun; 26(2)183-187. doi: 10.15403/jgld.2014.1121.262.erd.

PMID:
    28617889
    [PubMed - in process]
Related citations


Rectal budesonide and mesalamine formulations in active ulcerative proctosigmoiditis: efficacy, tolerance, and treatment approach.
Christophi GP, Rengarajan A, Ciorba MA
Clin Exp Gastroenterol. 2016; 9125-30. doi: 10.2147/CEG.S80237.

PMID:
    27274301
    [PubMed]
Related citations


Lower Dose Infliximab for Ulcerative Colitis: How Low Can We Go and How Much Can be Saved?
Christophi GP, Ciorba MA
J Clin Gastroenterol. 2015 Aug; 49(7)539-40. doi: 10.1097/MCG.0000000000000352.

PMID:
    26057322
    [PubMed - indexed for MEDLINE]
Related citations


The control of reactive oxygen species production by SHP-1 in oligodendrocytes.
Gruber RC, LaRocca D, Minchenberg SB, Christophi GP, Hudson CA, Ray AK, Shafit-Zagardo B, Massa PT
Glia. 2015 Oct; 63(10)1753-71. doi: 10.1002/glia.22842.

PMID:
    25919645
    [PubMed - indexed for MEDLINE]
Related citations


Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response.
Panos M, Christophi GP, Rodriguez M, Scarisbrick IA
Biol Chem. 2014 Sep; 395(9)1063-73. doi: 10.1515/hsz-2014-0141.

PMID:
    25153387
    [PubMed - indexed for MEDLINE]
Related citations


Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis.
Christophi GP, Caza T, Curtiss C, Gumber D, Massa PT, Landas SK
Exp Mol Pathol. 2014 Jun; 96(3)393-9. doi: 10.1016/j.yexmp.2014.04.006.

PMID:
    24768588
    [PubMed - indexed for MEDLINE]
Related citations


Immune markers and differential signaling networks in ulcerative colitis and Crohn's disease.
Christophi GP, Rong R, Holtzapple PG, Massa PT, Landas SK
Inflamm Bowel Dis. 2012 Dec; 18(12)2342-56. doi: 10.1002/ibd.22957.

PMID:
    22467146
    [PubMed - indexed for MEDLINE]
Related citations


Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients.
Christophi GP, Gruber RC, Panos M, Christophi RL, Jubelt B, Massa PT
Clin Immunol. 2012 Mar; 142(3)308-19. doi: 10.1016/j.clim.2011.11.007.

PMID:
    22189043
    [PubMed - indexed for MEDLINE]
Related citations


Quantitative differences in the immunomodulatory effects of Rebif and Avonex in IFN-β 1a treated multiple sclerosis patients.
Christophi GP, Christophi JA, Gruber RC, Mihai C, Mejico LJ, Massa PT, Jubelt B
J Neurol Sci. 2011 Aug 15; 307(1-2)41-5. doi: 10.1016/j.jns.2011.05.024.

PMID:
    21658727
    [PubMed - indexed for MEDLINE]
Related citations


Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.
Christophi GP, Massa PT
Viral Immunol. 2009 Dec; 22(6)371-87. doi: 10.1089/vim.2009.0052.

PMID:
    19951174
    [PubMed - indexed for MEDLINE]
Related citations


Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
Clin Immunol. 2009 Oct; 133(1)27-44. doi: 10.1016/j.clim.2009.05.019.

PMID:
    19559654
    [PubMed - indexed for MEDLINE]
Related citations


Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.
Christophi GP, Panos M, Hudson CA, Christophi RL, Gruber RC, Mersich AT, Blystone SD, Jubelt B, Massa PT
Lab Invest. 2009 Jul; 89(7)742-59. doi: 10.1038/labinvest.2009.32.

PMID:
    19398961
    [PubMed - indexed for MEDLINE]
Related citations


Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.
Christophi GP, Hudson CA, Panos M, Gruber RC, Massa PT
J Virol. 2009 Jan; 83(2)522-39. doi: 10.1128/JVI.01210-08.

PMID:
    18987138
    [PubMed - indexed for MEDLINE]
Related citations


Induction of IL-33 expression and activity in central nervous system glia.
Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
J Leukoc Biol. 2008 Sep; 84(3)631-43. doi: 10.1189/jlb.1207830.

PMID:
    18552204
    [PubMed - indexed for MEDLINE]
Related citations


Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia.
Christophi GP, Hudson CA, Gruber R, Christophi CP, Massa PT
J Neurochem. 2008 Jun 1; 105(6)2511-23. doi: 10.1111/j.1471-4159.2008.05337.x.

PMID:
    18331586
    [PubMed - indexed for MEDLINE]
Related citations


Regulation of avoidant behaviors and pain by the anti-inflammatory tyrosine phosphatase SHP-1.
Hudson CA, Christophi GP, Cao L, Gruber RC, Massa PT
Neuron Glia Biol. 2006 Nov; 2(4)235-46. doi: 10.1017/S1740925X07000476.

PMID:
    18250891
    [PubMed]
Related citations


SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.
Christophi GP, Hudson CA, Gruber RC, Christophi CP, Mihai C, Mejico LJ, Jubelt B, Massa PT
Lab Invest. 2008 Mar; 88(3)243-55. doi: 10.1038/labinvest.3700720.

PMID:
    18209728
    [PubMed - indexed for MEDLINE]
Related citations


Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.
Blaber SI, Ciric B, Christophi GP, Bernett MJ, Blaber M, Rodriguez M, Scarisbrick IA
FASEB J. 2004 May; 18(7)920-2.

PMID:
    15033932
    [PubMed - indexed for MEDLINE]
Related citations

Notes

Our goal is to provide compassionate and excellent clinical care based on evidence-based medicine through a highly qualified and specialized multidisciplinary team of support staff, radiologist, colorectal surgeons, and pathologists. We strive to offer applicable novel treatments and preventive care for all patients with inflammatory bowel disease. Our central focus is the patient and improving life quality.   

Areas of Research Interest

Quality improvement of clinical outcomes in inflammatory bowel disease. Clinical trials of novel medications in Crohn’s and ulcerative colitis patients. Role of genetics and environment in the pathogenesis of inflammatory bowel disease. Diet and gut mibrobiota as adjunctive therapy in inflammatory bowel disease.