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George John Despotis, MD

Associate Professor, Pathology & Immunology
Associate Professor, Anesthesiology

Specialty Areas

Pathology
Blood Bank and Transfusion Medicine
Cardiothoracic Anesthesiology

Board Certifications

Anesthesiology
Transfusion Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Anesthesiology, blood bank and transfusion medicine

  • Education
  • Publication & Research

Education

Education

Fellowship: Transfusion Medicine, Washington University, St. Louis, Missouri 1997
Residency: Cardiothoracic Anesthesiology, Barnes-Jewish Hospital, St. Louis, Missouri 1989
Residency: Anesthesiology, Barnes-Jewish Hospital, St. Louis, Missouri 1988
M.D.: St. Louis University School of Medicine, St. Louis, Missouri 1985
B.A.: Biology and Chemistry, Greenville College, Greenville, Illinois 1981

Publication & Research

Publication & Research

Acute graft-versus-host disease following lung transplantation in a patient with a novel <i>TERT</i> mutation.
Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
Thorax. 2018 May; 73(5)489-492. doi: 10.1136/thoraxjnl-2017-211121.

PMID:
    29382801
    [PubMed - in process]
Related citations


Coronary artery bypass grafting in 2 thrombophilic patients with protein s deficiency.
Hsu YM, Despotis GJ
A A Case Rep. 2014 Apr 15; 2(8)92-4. doi: 10.1213/XAA.0000000000000005.

PMID:
    25611767
    [PubMed]
Related citations


2012 update to the Society of Thoracic Surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations.
Ferraris VA, Saha SP, Oestreich JH, Song HK, Rosengart T, Reece TB, Mazer CD, Bridges CR, Despotis GJ, Jointer K, Clough ER, Society of Thoracic Surgeons.
Ann Thorac Surg. 2012 Nov; 94(5)1761-81. doi: 10.1016/j.athoracsur.2012.07.086.

PMID:
    23098967
    [PubMed - indexed for MEDLINE]
Related citations


The occurrence of antibodies to heparin-platelet factor 4 in cardiac and thoracic surgical patients receiving desirudin or heparin for postoperative venous thrombosis prophylaxis.
Avidan MS, Smith JR, Skrupky LP, Hill L, Jacobsohn E, Burnside B, Tymkew H, Eby C, Damiano R, Despotis GJ
Thromb Res. 2011 Dec; 128(6)524-9. doi: 10.1016/j.thromres.2011.05.025.

PMID:
    21794899
    [PubMed - indexed for MEDLINE]
Related citations


2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines.
Society of Thoracic Surgeons Blood Conservation Guideline Task Force., Ferraris VA, Brown JR, Despotis GJ, Hammon JW, Reece TB, Saha SP, Song HK, Clough ER, Society of Cardiovascular Anesthesiologists Special Task Force on Blood Transfusion., Shore-Lesserson LJ, Goodnough LT, Mazer CD, Shander A, Stafford-Smith M, Waters J, International Consortium for Evidence Based Perfusion., Baker RA, Dickinson TA, FitzGerald DJ, Likosky DS, Shann KG
Ann Thorac Surg. 2011 Mar; 91(3)944-82. doi: 10.1016/j.athoracsur.2010.11.078.

PMID:
    21353044
    [PubMed - indexed for MEDLINE]
Related citations


Anticoagulation management during cardiopulmonary bypass: a survey of 54 North American institutions.
Lobato RL, Despotis GJ, Levy JH, Shore-Lesserson LJ, Carlson MO, Bennett-Guerrero E
J Thorac Cardiovasc Surg. 2010 Jun; 139(6)1665-6. doi: 10.1016/j.jtcvs.2010.02.038.

PMID:
    20303507
    [PubMed - indexed for MEDLINE]
Related citations


Plasma exchange for heparin-induced thrombocytopenia: is there enough evidence?
Despotis GJ, Avidan MS
Anesth Analg. 2010 Jan 1; 110(1)7-10. doi: 10.1213/ANE.0b013e3181c427d5.

PMID:
    20023181
    [PubMed - indexed for MEDLINE]
Related citations


The efficacy of photopheresis for bronchiolitis obliterans syndrome after lung transplantation.
Morrell MR, Despotis GJ, Lublin DM, Patterson GA, Trulock EP, Hachem RR
J Heart Lung Transplant. 2010 Apr; 29(4)424-31. doi: 10.1016/j.healun.2009.08.029.

PMID:
    19853479
    [PubMed - indexed for MEDLINE]
Related citations


Safety concerns related to use of unapproved needles for accessing implantable venous access devices.
Powers ML, Lublin D, Eby C, Leitman SF, Dynis M, Despotis GJ
Transfusion. 2009 Sep; 49(9)2008-9. doi: 10.1111/j.1537-2995.2009.02296.x.

PMID:
    19735506
    [PubMed - indexed for MEDLINE]
Related citations


Transfusion and hemostasis in cardiac surgery.
Levy JH, Despotis GJ
Transfusion. 2008 Mar; 48(1 Suppl)1S. doi: 10.1111/j.1537-2995.2007.01572.x.

PMID:
    18302578
    [PubMed - indexed for MEDLINE]
Related citations


Use of activated recombinant factor VII for severe coagulopathy post ventricular assist device or orthotopic heart transplant.
Gandhi MJ, Pierce RA, Zhang L, Moon MR, Despotis GJ, Moazami N
J Cardiothorac Surg. 2007 Jul 6; 232.

PMID:
    17617902
    [PubMed - indexed for MEDLINE]
Related citations


Transfusion algorithms and how they apply to blood conservation: the high-risk cardiac surgical patient.
Steiner ME, Despotis GJ
Hematol Oncol Clin North Am. 2007 Feb; 21(1)177-84.

PMID:
    17258126
    [PubMed - indexed for MEDLINE]
Related citations


Transfusion risks and transfusion-related pro-inflammatory responses.
Despotis GJ, Zhang L, Lublin DM
Hematol Oncol Clin North Am. 2007 Feb; 21(1)147-61.

PMID:
    17258124
    [PubMed - indexed for MEDLINE]
Related citations


B-type natriuretic peptide measured during transfusion-related acute lung injury.
Edelson BT, Despotis GJ, Lublin DM
Transfusion. 2006 Aug; 46(8)1453-4.

PMID:
    16934084
    [PubMed - indexed for MEDLINE]
Related citations


Should aprotinin continue to be used during cardiac surgery?
Levy JH, Despotis GJ, Spitznagel E
Nat Clin Pract Cardiovasc Med. 2006 Jul; 3(7)360-1.

PMID:
    16810168
    [PubMed]
Related citations


Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass.
Avidan MS, Levy JH, van Aken H, Feneck RO, Latimer RD, Ott E, Martin E, Birnbaum DE, Bonfiglio LJ, Kajdasz DK, Despotis GJ
J Thorac Cardiovasc Surg. 2005 Jul; 130(1)107-13.

PMID:
    15999048
    [PubMed - indexed for MEDLINE]
Related citations


Preoperative use of enoxaparin increases the risk of postoperative bleeding and re-exploration in cardiac surgery patients.
McDonald SB, Renna M, Spitznagel EL, Avidan M, Hogue CW Jr, Moon MR, Barzilai B, Saleem R, McDonald JM, Despotis GJ
J Cardiothorac Vasc Anesth. 2005 Feb; 19(1)4-10.

PMID:
    15747262
    [PubMed - indexed for MEDLINE]
Related citations


A phase III, double-blind, placebo-controlled, multicenter study on the efficacy of recombinant human antithrombin in heparin-resistant patients scheduled to undergo cardiac surgery necessitating cardiopulmonary bypass.
Avidan MS, Levy JH, Scholz J, Delphin E, Rosseel PM, Howie MB, Gratz I, Bush CR, Skubas N, Aldea GS, Licina M, Bonfiglio LJ, Kajdasz DK, Ott E, Despotis GJ
Anesthesiology. 2005 Feb; 102(2)276-84.

PMID:
    15681940
    [PubMed - indexed for MEDLINE]
Related citations


Guidelines and alternatives for neuraxial anesthesia and venous thromboembolism prophylaxis in major orthopedic surgery.
Hantler C, Despotis GJ, Sinha R, Chelly JE
J Arthroplasty. 2004 Dec; 19(8)1004-16.

PMID:
    15586337
    [PubMed - indexed for MEDLINE]
Related citations


Transfusion medicine : support of patients undergoing cardiac surgery.
Goodnough LT, Despotis GJ
Am J Cardiovasc Drugs. 2001; 1(5)337-51.

PMID:
    14728016
    [PubMed - indexed for MEDLINE]
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