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George John Broze Jr., MD

Professor, Medicine
Division of Hematology
Professor, Cell Biology and Physiology
Professor, Laboratory Medicine

Specialty Areas

Hematology

Board Certifications

Hematology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hemostasis and thrombosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Office Phone: 314-362-8807

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-362-7578
Fax: 314-362-1608

Education

Education

Fellowship: Research, Washington University School of Medicine, St. Louis, Missouri 1979
Residency: North Carolina Memorial Hospital, Chapel Hill, North Carolina 1976
Fellowship: Washington University School of Medicine, St. Louis, Missouri 1977
Medical Degree: University Of Washington School of Medicine, Seattle, Washington 1972
B.S.: Physics, University of Washington School of Medicine, Seattle, Washington 1968

Publication & Research

Publication & Research

Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia.
van den Boogaard FE, van 't Veer C, Roelofs JJ, Meijers JC, Schultz MJ, Broze GJ Jr, van der Poll T
Thromb Haemost. 2015 Jul; 114(1)115-22. doi: 10.1160/TH14-12-1053.

PMID:
    25832548
    [PubMed - indexed for MEDLINE]
Related citations


Evidence of clinically significant extravascular stores of factor IX.
Feng D, Stafford KA, Broze GJ, Stafford DW
J Thromb Haemost. 2013 Dec; 11(12)2176-8. doi: 10.1111/jth.12421.

PMID:
    24112220
    [PubMed - indexed for MEDLINE]
Related citations


An acquired, calcium-dependent, factor X inhibitor.
Broze GJ Jr
Blood Cells Mol Dis. 2014 Feb-Mar; 52(2-3)116-20. doi: 10.1016/j.bcmd.2013.09.001.

PMID:
    24074948
    [PubMed - indexed for MEDLINE]
Related citations


Factor V, tissue factor pathway inhibitor, and east Texas bleeding disorder.
Broze GJ Jr, Girard TJ
J Clin Invest. 2013 Sep; 123(9)3710-2. doi: 10.1172/JCI71220.

PMID:
    23979154
    [PubMed - indexed for MEDLINE]
Related citations


Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction.
Butschkau A, Nagel P, Grambow E, Zechner D, Broze GJ Jr, Vollmar B
Crit Care Med. 2013 Dec; 41(12)e447-56. doi: 10.1097/CCM.0b013e318298a562.

PMID:
    23963134
    [PubMed - indexed for MEDLINE]
Related citations


Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
Girard TJ, Lasky NM, Tuley EA, Broze GJ Jr
J Thromb Haemost. 2013 Feb; 11(2)375-8. doi: 10.1111/jth.12084.

PMID:
    23205927
    [PubMed - indexed for MEDLINE]
Related citations


Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Huang X, Yan Y, Tu Y, Gatti J, Broze GJ Jr, Zhou A, Olson ST
Blood. 2012 Aug 23; 120(8)1726-33. doi: 10.1182/blood-2012-03-419598.

PMID:
    22786881
    [PubMed - indexed for MEDLINE]
Related citations


The C-terminus of tissue factor pathway inhibitor α is required for its interaction with factors V and Va.
Ndonwi M, Girard TJ, Broze GJ Jr
J Thromb Haemost. 2012 Sep; 10(9)1944-6. doi: 10.1111/j.1538-7836.2012.04834.x.

PMID:
    22738072
    [PubMed - indexed for MEDLINE]
Related citations


Tissue factor pathway inhibitor: structure-function.
Broze GJ Jr, Girard TJ
Front Biosci (Landmark Ed). 2012 Jan 1; 17262-80.

PMID:
    22201743
    [PubMed - indexed for MEDLINE]
Related citations


TFPIβ is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes.
Girard TJ, Tuley E, Broze GJ Jr
Blood. 2012 Feb 2; 119(5)1256-62. doi: 10.1182/blood-2011-10-388512.

PMID:
    22144186
    [PubMed - indexed for MEDLINE]
Related citations


Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II.
Ndonwi M, Burlingame OO, Miller AS, Tollefsen DM, Broze GJ Jr, Goldberg DE
Blood. 2011 Jun 9; 117(23)6347-54. doi: 10.1182/blood-2010-12-326876.

PMID:
    21511958
    [PubMed - indexed for MEDLINE]
Related citations


Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor.
Huang X, Rezaie AR, Broze GJ Jr, Olson ST
J Biol Chem. 2011 Mar 18; 286(11)8740-51. doi: 10.1074/jbc.M110.188375.

PMID:
    21220417
    [PubMed - indexed for MEDLINE]
Related citations


The Kunitz-3 domain of TFPI-alpha is required for protein S-dependent enhancement of factor Xa inhibition.
Ndonwi M, Tuley EA, Broze GJ Jr
Blood. 2010 Aug 26; 116(8)1344-51. doi: 10.1182/blood-2009-10-246686.

PMID:
    20479289
    [PubMed - indexed for MEDLINE]
Related citations


Protein Z and protein Z-dependent protease inhibitor and renal tubules.
Broze GJ Jr, Tu Y
Thromb Haemost. 2010 Feb; 103(2)473-4. doi: 10.1160/TH09-02-0131.

PMID:
    20024489
    [PubMed - indexed for MEDLINE]
Related citations


Protein Z-dependent protease inhibitor and protein Z in peripheral arterial disease patients.
Sofi F, Cesari F, Tu Y, Pratesi G, Pulli R, Pratesi C, Gensini GF, Abbate R, Fedi S, Broze GJ Jr
J Thromb Haemost. 2009 May; 7(5)731-5. doi: 10.1111/j.1538-7836.2009.03325.x.

PMID:
    19228280
    [PubMed - indexed for MEDLINE]
Related citations


Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa.
Huang X, Swanson R, Broze GJ Jr, Olson ST
J Biol Chem. 2008 Oct 31; 283(44)29770-83. doi: 10.1074/jbc.M805214200.

PMID:
    18768472
    [PubMed - indexed for MEDLINE]
Related citations


Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
Zhang J, Tu Y, Lu L, Lasky N, Broze GJ Jr
Blood. 2008 May 15; 111(10)4973-8. doi: 10.1182/blood-2007-12-126391.

PMID:
    18344422
    [PubMed - indexed for MEDLINE]
Related citations


Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX.
Ndonwi M, Broze GJ Jr, Agah S, Schmidt AE, Bajaj SP
J Biol Chem. 2007 May 25; 282(21)15632-44.

PMID:
    17387172
    [PubMed - indexed for MEDLINE]
Related citations


Protein Z and ZPI levels and cardiovascular events.
Refaai MA, Ahn C, Lu L, Wu K, Broze GJ Jr
J Thromb Haemost. 2006 Jul; 4(7)1628-9.

PMID:
    16839367
    [PubMed - indexed for MEDLINE]
Related citations


Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced lung fibrosis.
Fujimoto H, Gabazza EC, Taguchi O, Nishii Y, Nakahara H, Bruno NE, D'Alessandro-Gabazza CN, Kasper M, Yano Y, Nagashima M, Morser J, Broze GJ, Suzuki K, Adachi Y
Am J Pathol. 2006 Apr; 168(4)1086-96.

PMID:
    16565485
    [PubMed - indexed for MEDLINE]
Related citations