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Geoffrey L. Uy, MD

Associate Professor, Medicine
Division of Oncology
Section, Bone Marrow Transplant and Leukemia

Specialty Areas

Bone Marrow Transplant
Oncology
Hematologic Malignancies
Leukemia

Board Certifications

Internal Medicine
Oncology
Hematology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Bone marrow transplant, oncology, cancer, lymphoma, leukemia, aplastic anemia

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-454-8304
Fax: 314-454-7751

Education

Education

Fellowship: Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri 2007
Residency: Internal Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri 2003
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 2001
B.S.: Cornell University, Ithaca, New York 1996

Publication & Research

Publication & Research

Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia.
Guy DG, Uy GL
Curr Hematol Malig Rep. 2018 Oct 2; doi: 10.1007/s11899-018-0472-8.

PMID:
    30280288
    [PubMed - as supplied by publisher]
Related citations


Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
N Engl J Med. 2018 Sep 13; 379(11)1028-1041. doi: 10.1056/NEJMoa1804714.

PMID:
    30207916
    [PubMed - indexed for MEDLINE]
Related citations


CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol. 2018 Sep 10; 36(26)2684-2692. doi: 10.1200/JCO.2017.77.6112.

PMID:
    30024784
    [PubMed - in process]
Related citations


A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel <i>RARG</i>-<i>CPSF6</i> fusion.
Miller CA, Tricarico C, Skidmore ZL, Uy GL, Lee YS, Hassan A, O'Laughlin MD, Schmidt H, Tian L, Duncavage EJ, Griffith M, Griffith OL, Welch JS, Wartman LD
Blood Adv. 2018 Jun 12; 2(11)1295-1299. doi: 10.1182/bloodadvances.2017014183.

PMID:
    29891591
    [PubMed - in process]
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Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM
N Engl J Med. 2018 Jun 21; 378(25)2386-2398. doi: 10.1056/NEJMoa1716984.

PMID:
    29860938
    [PubMed - indexed for MEDLINE]
Related citations


Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.
Cortes J, Tamura K, DeAngelo DJ, de Bono J, Lorente D, Minden M, Uy GL, Kantarjian H, Chen LS, Gandhi V, Godin R, Keating K, McEachern K, Vishwanathan K, Pease JE, Dean E
Br J Cancer. 2018 May; 118(11)1425-1433. doi: 10.1038/s41416-018-0082-1.

PMID:
    29765150
    [PubMed - in process]
Related citations


Discovery and functional implications of a miR-29b-1/miR-29a cluster polymorphism in acute myeloid leukemia.
Ngankeu A, Ranganathan P, Havelange V, Nicolet D, Volinia S, Powell BL, Kolitz JE, Uy GL, Stone RM, Kornblau SM, Andreeff M, Croce CM, Bloomfield CD, Garzon R
Oncotarget. 2018 Jan 12; 9(4)4354-4365. doi: 10.18632/oncotarget.23150.

PMID:
    29435107
    [PubMed]
Related citations


Acute graft-versus-host disease following lung transplantation in a patient with a novel <i>TERT</i> mutation.
Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
Thorax. 2018 May; 73(5)489-492. doi: 10.1136/thoraxjnl-2017-211121.

PMID:
    29382801
    [PubMed - in process]
Related citations


Intergroup LEAP trial (S1612): A randomized phase 2/3 platform trial to test novel therapeutics in medically less fit older adults with acute myeloid leukemia.
Walter RB, Michaelis LC, Othus M, Uy GL, Radich JP, Little RF, Hita S, Saini L, Foran JM, Gerds AT, Klepin HD, Hay AE, Assouline S, Lancet JE, Couban S, Litzow MR, Stone RM, Erba HP
Am J Hematol. 2018 Feb; 93(2)E49-E52. doi: 10.1002/ajh.24980.

PMID:
    29164656
    [PubMed - indexed for MEDLINE]
Related citations


Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10-day decitabine regimen.
Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS
Cancer Med. 2017 Dec; 6(12)2814-2821. doi: 10.1002/cam4.1231.

PMID:
    29058375
    [PubMed - indexed for MEDLINE]
Related citations


US Intergroup Study of Chemotherapy Plus Dasatinib and Allogeneic Stem Cell Transplant in Philadelphia Chromosome Positive ALL.
Ravandi F, Othus M, O'Brien SM, Forman SJ, Ha CS, Wong JYC, Tallman MS, Paietta E, Racevskis J, Uy GL, Horowitz M, Takebe N, Little R, Borate U, Kebriaei P, Kingsbury L, Kantarjian HM, Radich JP, Erba HP, Appelbaum FR
Blood Adv. 2016 Dec 27; 1(3)250-259. doi: 10.1182/bloodadvances.2016001495.

PMID:
    29046900
    [PubMed]
Related citations


A phase 2 study incorporating sorafenib into the chemotherapy for older adults with <i>FLT3</i>-mutated acute myeloid leukemia: CALGB 11001.
Uy GL, Mandrekar SJ, Laumann K, Marcucci G, Zhao W, Levis MJ, Klepin HD, Baer MR, Powell BL, Westervelt P, DeAngelo DJ, Stock W, Sanford B, Blum WG, Bloomfield CD, Stone RM, Larson RA
Blood Adv. 2017 Jan 24; 1(5)331-340. doi: 10.1182/bloodadvances.2016003053.

PMID:
    29034366
    [PubMed]
Related citations


Junior investigators: Get engaged in the Alliance for Clinical Trials in Oncology.
Uy GL, Katz MHG, Boughey JC
Bull Am Coll Surg. 2017 Apr; 102(4)62-3.

PMID:
    28920650
    [PubMed - indexed for MEDLINE]
Related citations


NCCN Guidelines Insights: Acute Lymphoblastic Leukemia, Version 1.2017.
Brown PA, Shah B, Fathi A, Wieduwilt M, Advani A, Aoun P, Barta SK, Boyer MW, Bryan T, Burke PW, Cassaday R, Coccia PF, Coutre SE, Damon LE, DeAngelo DJ, Frankfurt O, Greer JP, Kantarjian HM, Klisovic RB, Kupfer G, Litzow M, Liu A, Mattison R, Park J, Rubnitz J, Saad A, Uy GL, Wang ES, Gregory KM, Ogba N
J Natl Compr Canc Netw. 2017 Sep; 15(9)1091-1102. doi: 10.6004/jnccn.2017.0147.

PMID:
    28874594
    [PubMed - indexed for MEDLINE]
Related citations


Results of a Prospective Randomized, Open-Label, Noninferiority Study of Tbo-Filgrastim (Granix) versus Filgrastim (Neupogen) in Combination with Plerixafor for Autologous Stem Cell Mobilization in Patients with Multiple Myeloma and Non-Hodgkin Lymphoma.
Bhamidipati PK, Fiala MA, Grossman BJ, DiPersio JF, Stockerl-Goldstein K, Gao F, Uy GL, Westervelt P, Schroeder MA, Cashen AF, Abboud CN, Vij R
Biol Blood Marrow Transplant. 2017 Dec; 23(12)2065-2069. doi: 10.1016/j.bbmt.2017.07.023.

PMID:
    28797783
    [PubMed - indexed for MEDLINE]
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Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia.
Papaioannou D, Nicolet D, Volinia S, Mrózek K, Yan P, Bundschuh R, Carroll AJ, Kohlschmidt J, Blum W, Powell BL, Uy GL, Kolitz JE, Wang ES, Eisfeld AK, Orwick SJ, Lucas DM, Caligiuri MA, Stone RM, Byrd JC, Garzon R, Bloomfield CD
Haematologica. 2017 Aug; 102(8)1391-1400. doi: 10.3324/haematol.2017.166215.

PMID:
    28473620
    [PubMed - indexed for MEDLINE]
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Fresh or Cryopreserved CD34<sup>+</sup>-Selected Mobilized Peripheral Blood Stem and Progenitor Cells for the Treatment of Poor Graft Function after Allogeneic Hematopoietic Cell Transplantation.
Ghobadi A, Fiala MA, Ramsingh G, Gao F, Abboud CN, Stockerl-Goldstein K, Uy GL, Grossman BJ, Westervelt P, DiPersio JF
Biol Blood Marrow Transplant. 2017 Jul; 23(7)1072-1077. doi: 10.1016/j.bbmt.2017.03.019.

PMID:
    28323004
    [PubMed - indexed for MEDLINE]
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Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft.
Schroeder MA, Rettig MP, Lopez S, Christ S, Fiala M, Eades W, Mir FA, Shao J, McFarland K, Trinkaus K, Shannon W, Deych E, Yu J, Vij R, Stockerl-Goldstein K, Cashen AF, Uy GL, Abboud CN, Westervelt P, DiPersio JF
Blood. 2017 May 11; 129(19)2680-2692. doi: 10.1182/blood-2016-09-739722.

PMID:
    28292947
    [PubMed - indexed for MEDLINE]
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A phase 1/2 study of chemosensitization with plerixafor plus G-CSF in relapsed or refractory acute myeloid leukemia.
Uy GL, Rettig MP, Stone RM, Konopleva MY, Andreeff M, McFarland K, Shannon W, Fletcher TR, Reineck T, Eades W, Stockerl-Goldstein K, Abboud CN, Jacoby MA, Westervelt P, DiPersio JF
Blood Cancer J. 2017 Mar 10; 7(3)e542. doi: 10.1038/bcj.2017.21.

PMID:
    28282031
    [PubMed - indexed for MEDLINE]
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T Cell-Replete Peripheral Blood Haploidentical Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide Results in Outcomes Similar to Transplantation from Traditionally Matched Donors in Active Disease Acute Myeloid Leukemia.
How J, Slade M, Vu K, DiPersio JF, Westervelt P, Uy GL, Abboud CN, Vij R, Schroeder MA, Fehniger TA, Romee R
Biol Blood Marrow Transplant. 2017 Apr; 23(4)648-653. doi: 10.1016/j.bbmt.2017.01.068.

PMID:
    28087457
    [PubMed - indexed for MEDLINE]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: NovoNordisk

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2018