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Gavin P. Dunn, MD, PhD

Assistant Professor, Neurological Surgery
Assistant Professor, Pathology and Immunology
Center for Human Immunology and Immunotherapy Programs

Specialty Areas

Brain Tumors
Neuro Oncology
Neurosurgery
Immunotherapy
Gamma Knife

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Brain tumors, including glioma, astrocytoma, oligodendroglioma, glioblastoma; ependymoma, meningioma, metastatic brain tumors; neuro-oncology; Chiari malformation; hydrocephalus, including endoscopic third ventriculostomy; trigeminal neuralgia

  • Maps & Directions
  • Education
  • Publication & Research
  • Videos

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 362-3577
Fax: (314) 362-2107

Education

Education

Residency: Neurological Surgery, Massachusetts General Hospital, Boston 2013
A.B.: Princeton University, Princeton, New Jersey 1998
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 2006
PhD: Washington University School of Medicine, St. Louis, Missouri 2006

Publication & Research

Publication & Research

Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress.
Gelman SJ, Naser F, Mahieu NG, McKenzie LD, Dunn GP, Chheda MG, Patti GJ
Cell Rep. 2018 Jan 9; 22(2)512-522. doi: 10.1016/j.celrep.2017.12.050.

PMID:
    29320744
    [PubMed - in process]
Related citations


Erratum: Genomic landscape of high-grade meningiomas.
Bi WL, Greenwald NF, Abedalthagafi M, Wala J, Gibson WJ, Agarwalla PK, Horowitz P, Schumacher SE, Esaulova E, Mei Y, Chevalier A, A Ducar M, Thorner AR, van Hummelen P, O Stemmer-Rachamimov A, Artyomov M, Al-Mefty O, Dunn GP, Santagata S, Dunn IF, Beroukhim R
NPJ Genom Med. 2017; 226. doi: 10.1038/s41525-017-0023-6.

PMID:
    29263836
    [PubMed - in process]
Related citations


Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastomas.
Mahlokozera T, Vellimana AK, Li T, Mao DD, Zohny ZS, Kim DH, Tran DD, Marcus DS, Fouke SJ, Campian JL, Dunn GP, Miller CA, Kim AH
Neuro Oncol. 2017 Dec 13; doi: 10.1093/neuonc/nox232.

PMID:
    29244145
    [PubMed - as supplied by publisher]
Related citations


Management of intracranial melanomas in the era of precision medicine.
Young GJ, Bi WL, Wu WW, Johanns TM, Dunn GP, Dunn IF
Oncotarget. 2017 Oct 24; 8(51)89326-89347. doi: 10.18632/oncotarget.19223.

PMID:
    29179523
    [PubMed]
Related citations


Direct puncture Onyx embolization of a large calvarial metastasis with intracranial extension: Case report.
Zhou MH, Dunn GP, Osbun JW, Cross DT Rd, Moran CJ, Dacey RG Jr, Kansagra AP
Interv Neuroradiol. 2017 Jan 1; 1591019917740353. doi: 10.1177/1591019917740353.

PMID:
    29119877
    [PubMed - as supplied by publisher]
Related citations


Comprehensive Analysis of Hypermutation in Human Cancer.
Campbell BB, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R, Davidson S, Edwards M, Elvin JA, Hodel KP, Zahurancik WJ, Suo Z, Lipman T, Wimmer K, Kratz CP, Bowers DC, Laetsch TW, Dunn GP, Johanns TM, Grimmer MR, Smirnov IV, Larouche V, Samuel D, Bronsema A, Osborn M, Stearns D, Raman P, Cole KA, Storm PB, Yalon M, Opocher E, Mason G, Thomas GA, Sabel M, George B, Ziegler DS, Lindhorst S, Issai VM, Constantini S, Toledano H, Elhasid R, Farah R, Dvir R, Dirks P, Huang A, Galati MA, Chung J, Ramaswamy V, Irwin MS, Aronson M, Durno C, Taylor MD, Rechavi G, Maris JM, Bouffet E, Hawkins C, Costello JF, Meyn MS, Pursell ZF, Malkin D, Tabori U, Shlien A
Cell. 2017 Nov 16; 171(5)1042-1056.e10. doi: 10.1016/j.cell.2017.09.048.

PMID:
    29056344
    [PubMed - indexed for MEDLINE]
Related citations


Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling.
Mei Y, Du Z, Hu C, Greenwald NF, Abedalthagafi M, Agar NYR, Dunn GP, Bi WL, Santagata S, Dunn IF
Cell Commun Signal. 2017 Sep 18; 15(1)34. doi: 10.1186/s12964-017-0189-7.

PMID:
    28923059
    [PubMed - in process]
Related citations


Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications.
Johanns TM, Bowman-Kirigin JA, Liu C, Dunn GP
Neurosurgery. 2017 Sep 1; 64(CN_suppl_1)165-176. doi: 10.1093/neuros/nyx321.

PMID:
    28899059
    [PubMed - in process]
Related citations


Genomic landscape of high-grade meningiomas.
Bi WL, Greenwald NF, Abedalthagafi M, Wala J, Gibson WJ, Agarwalla PK, Horowitz P, Schumacher SE, Esaulova E, Mei Y, Chevalier A, Ducar M, Thorner AR, van Hummelen P, Stemmer-Rachamimov A, Artyomov M, Al-Mefty O, Dunn GP, Santagata S, Dunn IF, Beroukhim R
NPJ Genom Med. 2017; 2pii: 15. doi: 10.1038/s41525-017-0014-7.

PMID:
    28713588
    [PubMed]
Related citations


Free ammonia offers algal crop protection from predators in dairy wastewater and ammonium-rich media.
Thomas PK, Dunn GP, Passero M, Feris KP
Bioresour Technol. 2017 Nov; 243724-730. doi: 10.1016/j.biortech.2017.07.008.

PMID:
    28711800
    [PubMed - indexed for MEDLINE]
Related citations


Genomic profile of human meningioma cell lines.
Mei Y, Bi WL, Greenwald NF, Agar NY, Beroukhim R, Dunn GP, Dunn IF
PLoS One. 2017; 12(5)e0178322. doi: 10.1371/journal.pone.0178322.

PMID:
    28552950
    [PubMed - indexed for MEDLINE]
Related citations


Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma.
Johanns TM, Dunn GP
Cancer J. 2017 Mar/Apr; 23(2)125-130. doi: 10.1097/PPO.0000000000000247.

PMID:
    28410300
    [PubMed - indexed for MEDLINE]
Related citations


Biomarker and Tumor Responses of Oral Cavity Squamous Cell Carcinoma to Trametinib: A Phase II Neoadjuvant Window-of-Opportunity Clinical Trial.
Uppaluri R, Winkler AE, Lin T, Law JH, Haughey BH, Nussenbaum B, Paniello RC, Rich JT, Diaz JA, Michel LP, Wildes T, Dunn GP, Zolkind P, Kallogjeri D, Piccirillo JF, Dehdashti F, Siegel BA, Chernock RD, Lewis JS Jr, Adkins DR
Clin Cancer Res. 2017 May 1; 23(9)2186-2194. doi: 10.1158/1078-0432.CCR-16-1469.

PMID:
    28151720
    [PubMed - in process]
Related citations


Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy.
Johanns TM, Miller CA, Dorward IG, Tsien C, Chang E, Perry A, Uppaluri R, Ferguson C, Schmidt RE, Dahiya S, Ansstas G, Mardis ER, Dunn GP
Cancer Discov. 2016 Nov; 6(11)1230-1236.

PMID:
    27683556
    [PubMed - indexed for MEDLINE]
Related citations


Endogenous Neoantigen-Specific CD8 T Cells Identified in Two Glioblastoma Models Using a Cancer Immunogenomics Approach.
Johanns TM, Ward JP, Miller CA, Wilson C, Kobayashi DK, Bender D, Fu Y, Alexandrov A, Mardis ER, Artyomov MN, Schreiber RD, Dunn GP
Cancer Immunol Res. 2016 Dec; 4(12)1007-1015.

PMID:
    27799140
    [PubMed - indexed for MEDLINE]
Related citations


Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.
Law JM, Stark SC, Liu K, Liang NE, Hussain MM, Leiendecker M, Ito D, Verho O, Stern AM, Johnston SE, Zhang YL, Dunn GP, Shamji AF, Schreiber SL
ACS Med Chem Lett. 2016 Oct 13; 7(10)944-949.

PMID:
    27774134
    [PubMed]
Related citations


Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma.
Zolkind P, Dunn GP, Lin T, Griffith M, Griffith OL, Uppaluri R
Oral Oncol. 2017 Aug; 71169-176. doi: 10.1016/j.oraloncology.2016.09.010.

PMID:
    27751760
    [PubMed - in process]
Related citations


Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors.
Mei Y, Bi WL, Greenwald NF, Du Z, Agar NY, Kaiser UB, Woodmansee WW, Reardon DA, Freeman GJ, Fecci PE, Laws ER Jr, Santagata S, Dunn GP, Dunn IF
Oncotarget. 2016 Nov 22; 7(47)76565-76576. doi: 10.18632/oncotarget.12088.

PMID:
    27655724
    [PubMed - in process]
Related citations


143 Identification of Neoantigen-specific CD8+ T Cells in Two Murine Orthotopic Glioblastoma Models Using Cancer Immunogenomics.
Johanns TM, Ward J, Wilson C, Kobayashi DK, Bender D, Fu Y, Alexandrov A, Artyomov MN, Miller CA, Mardis ER, Dunn GP
Neurosurgery. 2016 Aug; 63 Suppl 1158. doi: 10.1227/01.neu.0000489713.52326.9a.

PMID:
    27399422
    [PubMed - indexed for MEDLINE]
Related citations


High incidence of TERT mutation in brain tumor cell lines.
Johanns TM, Fu Y, Kobayashi DK, Mei Y, Dunn IF, Mao DD, Kim AH, Dunn GP
Brain Tumor Pathol. 2016 Jul; 33(3)222-7. doi: 10.1007/s10014-016-0257-5.

PMID:
    26960334
    [PubMed - indexed for MEDLINE]
Related citations

Videos

Videos

Areas of Research Interest

Interaction of developing tumors and the immune system;  cancer immunogenomics (intersection of cancer immunology and genomics);  immune system recognition of malignant glioma