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Gary A. Silverman, MD, PhD

The Harriet B. Spoehrer Professor and Chairman, Pediatrics
Pediatrician-in-Chief, St. Louis Children's Hospital
Executive Director, Children's Discovery Institute

Specialty Areas

Neonatal/Perinatal Medicine

Board Certifications

Neonatal/Perinatal Medicine

Hospital Affiliations

St. Louis Children's Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

newborn medicine, neonatology, perinatal medicine

  • Education
  • Publication & Research



Fellowship: St. Louis Children's Hospital, St. Louis, MO 1989
Residency: The Children's Hospital, Boston, MA 1987
Medical Degree: University of Chicago, Pritzer School of Medicine, Chicago, IL 1984
Ph D: Immunology & Pathology : University of Chicago, Chicago, IL 1982

Publication & Research

Publication & Research

  1. Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit. J Biol Chem. 2016;291(27):14012-22. PMCID:PMC4933161  PMID:271899
  2. High-Throughput, Liquid-Based Genome-Wide RNAi Screening in C. elegans.Methods Mol Biol. 2016;1470:151-62. PMID:27581291 
  3. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015;290(50):29742-57. PMCID:PMC4705969  PMID:26494620 
  4. SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry. 2015;54(45):6756-9. PMCID:PMC4900762  PMID:2649760
  5. Niehaus JZ, Good M, Jackson LE, Ozolek JA, Silverman GA, Luke CJ. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem. 2015;63(11):854-65. PMCID:PMC4812677  PMID:26220980 
  6. The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans. Genetics. 2015;200(1):207-19. PMCID:PMC4423363  PMID:25786854 
  7. Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency. PLoS One. 2015;10(10):e0141542. PMCID:PMC4626213  PMID:26512890 
  8. A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency. Hum Mol Genet. 2014;23(19):5123-32. PMCID:PMC4159156  PMID:24838285 
  9. A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover. Hum Mol Genet. 2014;23(19):5109-22. PMCID:PMC4159155  PMID:24838286 


Areas of Research Interest

Silverman Lab