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Gabriela de Bruin, MD

Associate Professor, Neurology

Specialty Areas

Sleep Medicine
Neurology - Adult

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Sleep medicine, including sleep disorders, narcolepsy, insomnia, sleep apnea, snoring, and restless leg syndrome

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center 40 Building

1600 S. Brentwood Blvd.
Suite 600
St. Louis, MO 63144

Office Phone: (314) 362-4342
Fax: (314) 747-3813

Education

Education

Medical Degree: Universidade Federal DO Ceara Brazil
Residency: Washington University School of Medicine, St. Louis, MO
Fellowship: Washington University School of Medicine, St. Louis, MO

Publication & Research

Publication & Research

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.
Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT
J Clin Invest. 2017 Aug 28; pii: 90895. doi: 10.1172/JCI90895.

PMID:
    28846070
    [PubMed - as supplied by publisher]
Related citations


Monitoring the Diagnostic Process on an Inpatient Neurology Service.
Dhand A, Bucelli R, Varadhachary A, Tsiaklides M, de Bruin G, Dhaliwal G
Neurohospitalist. 2017 Jul; 7(3)132-136. doi: 10.1177/1941874416677681.

PMID:
    28634503
    [PubMed]
Related citations


Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.
Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF
Cell Chem Biol. 2017 Feb 16; 24(2)218-230. doi: 10.1016/j.chembiol.2016.12.016.

PMID:
    28132893
    [PubMed - in process]
Related citations


A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i.
Huber EM, Heinemeyer W, de Bruin G, Overkleeft HS, Groll M
EMBO J. 2016 Dec 1; 35(23)2602-2613.

PMID:
    27789522
    [PubMed - indexed for MEDLINE]
Related citations


The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies.
Bhattarai S, Ghannam K, Krause S, Benveniste O, Marg A, de Bruin G, Xin BT, Overkleeft HS, Spuler S, Stenzel W, Feist E
J Autoimmun. 2016 Dec; 75118-129. doi: 10.1016/j.jaut.2016.08.004.

PMID:
    27522114
    [PubMed - indexed for MEDLINE]
Related citations


Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes.
Xin BT, de Bruin G, Huber EM, Besse A, Florea BI, Filippov DV, van der Marel GA, Kisselev AF, van der Stelt M, Driessen C, Groll M, Overkleeft HS
J Med Chem. 2016 Aug 11; 59(15)7177-87. doi: 10.1021/acs.jmedchem.6b00705.

PMID:
    27438186
    [PubMed - indexed for MEDLINE]
Related citations


Proteasome Subunit Selective Activity-Based Probes Report on Proteasome Core Particle Composition in a Native Polyacrylamide Gel Electrophoresis Fluorescence-Resonance Energy Transfer Assay.
de Bruin G, Xin BT, Florea BI, Overkleeft HS
J Am Chem Soc. 2016 Aug 10; 138(31)9874-80. doi: 10.1021/jacs.6b04207.

PMID:
    27428761
    [PubMed - in process]
Related citations


Sleep Pathology in Creutzfeldt-Jakob Disease.
Kang P, de Bruin GS, Wang LH, Ward BA, Ances BM, Lim MM, Bucelli RC
J Clin Sleep Med. 2016 Jul 15; 12(7)1033-9. doi: 10.5664/jcsm.5944.

PMID:
    27250807
    [PubMed - in process]
Related citations


Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib.
de Bruin G, Mock ED, Hoogendoorn S, van den Nieuwendijk AM, Mazurek J, van der Marel GA, Florea BI, Overkleeft HS
Chem Commun (Camb). 2016 Mar 14; 52(21)4064-7. doi: 10.1039/c6cc01156j.

PMID:
    26894389
    [PubMed - indexed for MEDLINE]
Related citations


A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities.
de Bruin G, Xin BT, Kraus M, van der Stelt M, van der Marel GA, Kisselev AF, Driessen C, Florea BI, Overkleeft HS
Angew Chem Int Ed Engl. 2016 Mar 18; 55(13)4199-203. doi: 10.1002/anie.201509092.

PMID:
    26511210
    [PubMed - indexed for MEDLINE]
Related citations


The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.
Kraus J, Kraus M, Liu N, Besse L, Bader J, Geurink PP, de Bruin G, Kisselev AF, Overkleeft H, Driessen C
Cancer Chemother Pharmacol. 2015 Aug; 76(2)383-96. doi: 10.1007/s00280-015-2801-0.

PMID:
    26099967
    [PubMed - indexed for MEDLINE]
Related citations


The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells.
Kraus M, Bader J, Geurink PP, Weyburne ES, Mirabella AC, Silzle T, Shabaneh TB, van der Linden WA, de Bruin G, Haile SR, van Rooden E, Appenzeller C, Li N, Kisselev AF, Overkleeft H, Driessen C
Haematologica. 2015 Oct; 100(10)1350-60. doi: 10.3324/haematol.2014.109421.

PMID:
    26069288
    [PubMed - indexed for MEDLINE]
Related citations


Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
Huber EM, de Bruin G, Heinemeyer W, Paniagua Soriano G, Overkleeft HS, Groll M
J Am Chem Soc. 2015 Jun 24; 137(24)7835-42. doi: 10.1021/jacs.5b03688.

PMID:
    26020686
    [PubMed - indexed for MEDLINE]
Related citations


Bifactor analysis of the mental health continuum-short form (MHC-SF).
de Bruin GP, du Plessis GA
Psychol Rep. 2015 Apr; 116(2)438-46. doi: 10.2466/03.02.PR0.116k20w6.

PMID:
    25730745
    [PubMed - indexed for MEDLINE]
Related citations


Childhood cancer survival rates in two South African units.
Stones DK, De Bruin GP, Esterhuizen TM, Stefan DC
S Afr Med J. 2014 May 19; 104(7)501-4. doi: 10.7196/samj.7882.

PMID:
    25214053
    [PubMed - indexed for MEDLINE]
Related citations


Proteasome inhibitors with photocontrolled activity.
Hansen MJ, Velema WA, de Bruin G, Overkleeft HS, Szymanski W, Feringa BL
Chembiochem. 2014 Sep 22; 15(14)2053-7. doi: 10.1002/cbic.201402237.

PMID:
    25125335
    [PubMed - indexed for MEDLINE]
Related citations


Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.
de Bruin G, Huber EM, Xin BT, van Rooden EJ, Al-Ayed K, Kim KB, Kisselev AF, Driessen C, van der Stelt M, van der Marel GA, Groll M, Overkleeft HS
J Med Chem. 2014 Jul 24; 57(14)6197-209. doi: 10.1021/jm500716s.

PMID:
    25006746
    [PubMed - indexed for MEDLINE]
Related citations


Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides.
Xin BT, de Bruin G, Verdoes M, Filippov DV, van der Marel GA, Overkleeft HS
Org Biomol Chem. 2014 Aug 14; 12(30)5710-8. doi: 10.1039/c4ob00893f.

PMID:
    24968066
    [PubMed - indexed for MEDLINE]
Related citations


Toward understanding induction of oxidative stress and apoptosis by proteasome inhibitors.
Paniagua Soriano G, De Bruin G, Overkleeft HS, Florea BI
Antioxid Redox Signal. 2014 Dec 10; 21(17)2419-43. doi: 10.1089/ars.2013.5794.

PMID:
    24437477
    [PubMed - indexed for MEDLINE]
Related citations


Children with kaposi sarcoma in two southern african hospitals: clinical presentation, management, and outcome.
De Bruin GP, Stefan DC
J Trop Med. 2013; 2013213490. doi: 10.1155/2013/213490.

PMID:
    24396347
    [PubMed]
Related citations