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Evan D. Kharasch, MD, PhD

Russell D. and Mary B. Shelden Professor of Anesthesiology

Professor, Biochemistry and Molecular Biophysics
Director, The Center for Clinical Pharmacology
Director, Division of Clinical and Translational Research

Specialty Areas

Clinical Pharmacology
Anesthesiology

Board Certifications

Anesthesiology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Education

Education

Residency: Anesthesiology, University of Washington Hospitals, Seattle, Washington 1988
Ph.D.: Pharmacology, Northwestern University, Chicago, Illinois 1983
Medical Degree: Northwestern University Medical School, Evanston, Illinois 1983
Bachelor of Science: Medical Science, Northwestern University, Evanston, Illinois 1979

Publication & Research

Publication & Research

Seeking and reporting apparent research misconduct: errors and integrity.
Kharasch ED, Houle TT
Anaesthesia. 2018 Jan; 73(1)125-126. doi: 10.1111/anae.14147.

PMID:
    29210039
    [PubMed - in process]
Related citations


Errors and Integrity in Seeking and Reporting Apparent Research Misconduct.
Kharasch ED, Houle TT
Anesthesiology. 2017 Nov; 127(5)733-737. doi: 10.1097/ALN.0000000000001875.

PMID:
    28825936
    [PubMed - indexed for MEDLINE]
Related citations


Editor's Note: ANESTHESIOLOGY 2017: Expanding the Richness and Reach.
Kharasch ED
Anesthesiology. 2017 Jul; 127(1)1-2. doi: 10.1097/ALN.0000000000001701.

PMID:
    28520576
    [PubMed - indexed for MEDLINE]
Related citations


Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction.
Wang C, Hu R, Morrissey JJ, Kharasch ED, Singamaneni S
Small. 2017 May; 13(19)doi: 10.1002/smll.201604255.

PMID:
    28322497
    [PubMed - in process]
Related citations


Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.
Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ
Pharmacogenomics J. 2017 Mar 14; doi: 10.1038/tpj.2016.92.

PMID:
    28290528
    [PubMed - as supplied by publisher]
Related citations


Current Concepts in Methadone Metabolism and Transport.
Kharasch ED
Clin Pharmacol Drug Dev. 2017 Mar; 6(2)125-134. doi: 10.1002/cpdd.326.

PMID:
    28263461
    [PubMed - in process]
Related citations


Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther. 2016 Dec 20; doi: 10.1002/cpt.597.

PMID:
    27997040
    [PubMed - as supplied by publisher]
Related citations


Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors.
Hu R, Luan J, Kharasch ED, Singamaneni S, Morrissey JJ
ACS Appl Mater Interfaces. 2017 Jan 11; 9(1)145-151. doi: 10.1021/acsami.6b12505.

PMID:
    27935290
    [PubMed - indexed for MEDLINE]
Related citations


Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips.
Wang C, Tadepalli S, Luan J, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S
Adv Mater. 2017 Feb; 29(7)doi: 10.1002/adma.201604433.

PMID:
    27925296
    [PubMed - in process]
Related citations


Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
Horst J, Kharasch ED
Pediatr Blood Cancer. 2017 May; 64(5)doi: 10.1002/pbc.26343.

PMID:
    27860157
    [PubMed - in process]
Related citations


Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance.
Rao LK, Flaker AM, Friedel CC, Kharasch ED
Anesthesiology. 2016 Dec; 125(6)1103-1112.

PMID:
    27763887
    [PubMed - indexed for MEDLINE]
Related citations


Misidentification of Bupropion Glucuronide Metabolites and Re-evaluation of Metabolite Pharmacokinetics.
Teitelbaum AM, Kharasch ED
Drug Metab Dispos. 2016 Nov; 44(11)1851.

PMID:
    27758826
    [PubMed - in process]
Related citations


Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
Horst J, Frei-Jones M, Deych E, Shannon W, Kharasch ED
Pediatr Blood Cancer. 2016 Dec; 63(12)2123-2130. doi: 10.1002/pbc.26207.

PMID:
    27572136
    [PubMed - indexed for MEDLINE]
Related citations


PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.
Luan J, Liu KK, Tadepalli S, Jiang Q, Morrissey JJ, Kharasch ED, Singamaneni S
ACS Appl Mater Interfaces. 2016 Sep 14; 8(36)23509-16. doi: 10.1021/acsami.6b07252.

PMID:
    27540627
    [PubMed - in process]
Related citations


Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability.
Wang C, Luan J, Tadepalli S, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S
ACS Appl Mater Interfaces. 2016 Oct 12; 8(40)26493-26500.

PMID:
    27438127
    [PubMed - in process]
Related citations


Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.
Teitelbaum AM, Flaker AM, Kharasch ED
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 1; 1027239-53. doi: 10.1016/j.jchromb.2016.05.036.

PMID:
    27318149
    [PubMed - indexed for MEDLINE]
Related citations


Changes: Handing Off and the Future of ANESTHESIOLOGY.
Kharasch ED
Anesthesiology. 2016 Jul; 125(1)4-6. doi: 10.1097/ALN.0000000000001150.

PMID:
    27152576
    [PubMed - indexed for MEDLINE]
Related citations


Changes: Thank You, Dr. Eisenach.
Kharasch ED, Tedeschi V, Kendall G
Anesthesiology. 2016 Jul; 125(1)1-3. doi: 10.1097/ALN.0000000000001149.

PMID:
    27152575
    [PubMed - indexed for MEDLINE]
Related citations


Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma.
Teitelbaum AM, Flaker AM, Kharasch ED
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 1; 1017-1018101-13. doi: 10.1016/j.jchromb.2016.02.032.

PMID:
    26963497
    [PubMed - indexed for MEDLINE]
Related citations


Perioperative Opioids and Public Health.
Kharasch ED, Brunt LM
Anesthesiology. 2016 Apr; 124(4)960-5. doi: 10.1097/ALN.0000000000001012.

PMID:
    26808634
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Clinical pharmacology
Drug metabolism
Drug interactions
Cytochrome P450
Mechanisms of anesthetic toxicity
Interindividual and pharmacogenetic variability in drug disposition and drug effects
Haloalkane and haloalkene toxicology