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Evan D. Kharasch, MD, PhD

Russell D. and Mary B. Shelden Professor of Anesthesiology

Professor, Biochemistry and Molecular Biophysics
Director, The Center for Clinical Pharmacology
Director, Division of Clinical and Translational Research

Specialty Areas

Clinical Pharmacology
Anesthesiology

Board Certifications

Anesthesiology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Education

Education

Residency: Anesthesiology, University of Washington Hospitals, Seattle, Washington 1988
Ph.D.: Pharmacology, Northwestern University, Chicago, Illinois 1983
Medical Degree: Northwestern University Medical School, Evanston, Illinois 1983
Bachelor of Science: Medical Science, Northwestern University, Evanston, Illinois 1979

Publication & Research

Publication & Research

Editor's Note: ANESTHESIOLOGY 2018: Inspiring Investigation and Education.
Kharasch ED
Anesthesiology. 2018 May 29; doi: 10.1097/ALN.0000000000002264.

PMID:
    29847428
    [PubMed - as supplied by publisher]
Related citations


Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study.
Komen H, Brunt LM, Deych E, Blood J, Kharasch ED
Anesth Analg. 2018 May 25; doi: 10.1213/ANE.0000000000003464.

PMID:
    29847382
    [PubMed - as supplied by publisher]
Related citations


Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody.
Luan J, Xu T, Cashin J, Morrissey JJ, Kharasch ED, Singamaneni S
Anal Chem. 2018 Jun 13; doi: 10.1021/acs.analchem.7b05470.

PMID:
    29790737
    [PubMed - as supplied by publisher]
Related citations


Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.
Kharasch ED, Crafford A
Clin Pharmacol Ther. 2018 May 14; doi: 10.1002/cpt.1116.

PMID:
    29756345
    [PubMed - as supplied by publisher]
Related citations


How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study.
Haroutounian S, Ford AL, Frey K, Nikolajsen L, Finnerup NB, Neiner A, Kharasch ED, Karlsson P, Bottros MM
Pain. 2018 Mar 23; doi: 10.1097/j.pain.0000000000001213.

PMID:
    29570507
    [PubMed - as supplied by publisher]
Related citations


Frontiers in Opioid Pharmacology.
Rathmell JP, Kharasch ED
Anesthesiology. 2018 May; 128(5)865-866. doi: 10.1097/ALN.0000000000002193.

PMID:
    29570112
    [PubMed - in process]
Related citations


The Challenges of Translation.
Kharasch ED
Anesthesiology. 2018 Apr; 128(4)693-696. doi: 10.1097/ALN.0000000000002122.

PMID:
    29533965
    [PubMed - in process]
Related citations


Ultrarobust Biochips with Metal-Organic Framework Coating for Point-of-Care Diagnosis.
Wang C, Wang L, Tadepalli S, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S
ACS Sens. 2018 Feb 23; 3(2)342-351. doi: 10.1021/acssensors.7b00762.

PMID:
    29336151
    [PubMed - in process]
Related citations


Seeking and reporting apparent research misconduct: errors and integrity.
Kharasch ED, Houle TT
Anaesthesia. 2018 Jan; 73(1)125-126. doi: 10.1111/anae.14147.

PMID:
    29210039
    [PubMed - in process]
Related citations


Errors and Integrity in Seeking and Reporting Apparent Research Misconduct.
Kharasch ED, Houle TT
Anesthesiology. 2017 Nov; 127(5)733-737. doi: 10.1097/ALN.0000000000001875.

PMID:
    28825936
    [PubMed - indexed for MEDLINE]
Related citations


Editor's Note: ANESTHESIOLOGY 2017: Expanding the Richness and Reach.
Kharasch ED
Anesthesiology. 2017 Jul; 127(1)1-2. doi: 10.1097/ALN.0000000000001701.

PMID:
    28520576
    [PubMed - indexed for MEDLINE]
Related citations


Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction.
Wang C, Hu R, Morrissey JJ, Kharasch ED, Singamaneni S
Small. 2017 May; 13(19)doi: 10.1002/smll.201604255.

PMID:
    28322497
    [PubMed - in process]
Related citations


Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.
Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ
Pharmacogenomics J. 2018 Jan; 18(1)136-143. doi: 10.1038/tpj.2016.92.

PMID:
    28290528
    [PubMed - in process]
Related citations


Current Concepts in Methadone Metabolism and Transport.
Kharasch ED
Clin Pharmacol Drug Dev. 2017 Mar; 6(2)125-134. doi: 10.1002/cpdd.326.

PMID:
    28263461
    [PubMed - indexed for MEDLINE]
Related citations


Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther. 2016 Dec 20; doi: 10.1002/cpt.597.

PMID:
    27997040
    [PubMed - as supplied by publisher]
Related citations


Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors.
Hu R, Luan J, Kharasch ED, Singamaneni S, Morrissey JJ
ACS Appl Mater Interfaces. 2017 Jan 11; 9(1)145-151. doi: 10.1021/acsami.6b12505.

PMID:
    27935290
    [PubMed - indexed for MEDLINE]
Related citations


Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips.
Wang C, Tadepalli S, Luan J, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S
Adv Mater. 2017 Feb; 29(7)doi: 10.1002/adma.201604433.

PMID:
    27925296
    [PubMed - in process]
Related citations


Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
Horst J, Kharasch ED
Pediatr Blood Cancer. 2017 May; 64(5)doi: 10.1002/pbc.26343.

PMID:
    27860157
    [PubMed - in process]
Related citations


Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance.
Rao LK, Flaker AM, Friedel CC, Kharasch ED
Anesthesiology. 2016 Dec; 125(6)1103-1112.

PMID:
    27763887
    [PubMed - indexed for MEDLINE]
Related citations


Misidentification of Bupropion Glucuronide Metabolites and Re-evaluation of Metabolite Pharmacokinetics.
Teitelbaum AM, Kharasch ED
Drug Metab Dispos. 2016 Nov; 44(11)1851.

PMID:
    27758826
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Ten Healthcare

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2018

Areas of Research Interest

Clinical pharmacology
Drug metabolism
Drug interactions
Cytochrome P450
Mechanisms of anesthetic toxicity
Interindividual and pharmacogenetic variability in drug disposition and drug effects
Haloalkane and haloalkene toxicology