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Faculty Physicians

Eugene Harold Rubin, MD, PhD

Professor, Psychiatry
Vice Chair for Education

Specialty Areas

Adult Psychiatry
Alzheimer's Disease

Board Certifications

Psychiatry

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Research interests include dementias and depression in the context of chronic illness.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital (South)
Renard Hospital Building

4940 Children's Place
Room 1116
St. Louis, MO 63110

Suite: Suite 4409
Office Phone: 314-362-2467
Fax: 314-747-8559

Education

Education

Chief Residency: Psychiatry, Washington University School of Medicine, St. Louis, Missouri 1983
Residency: Psychiatry, Washington University School of Medicine, St. Louis, Missouri 1982
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1978
Ph.D.: Pharmacology, Washington University School of Medicine, St. Louis, Missouri 1977
B.A.: Psychology, University of Rochester, Rochester, New York 1971

Publication & Research

Publication & Research

AACR Cancer Progress Report 2014.
Arteaga CL, Adamson PC, Engelman JA, Foti M, Gaynor RB, Hilsenbeck SG, Limburg PJ, Lowe SW, Mardis ER, Ramsey S, Rebbeck TR, Richardson AL, Rubin EH, Weiner GJ
Clin Cancer Res. 2014 Oct 1; 20(19 Suppl)S1-S112. doi: 10.1158/1078-0432.CCR-14-2123.

PMID:
    25228531
    [PubMed - indexed for MEDLINE]
Related citations


Developing precision medicine in a global world.
Rubin EH, Allen JD, Nowak JA, Bates SE
Clin Cancer Res. 2014 Mar 15; 20(6)1419-27. doi: 10.1158/1078-0432.CCR-14-0091.

PMID:
    24634465
    [PubMed - indexed for MEDLINE]
Related citations


E5501: phase II study of topotecan sequenced with etoposide/cisplatin, and irinotecan/cisplatin sequenced with etoposide for extensive-stage small-cell lung cancer.
Owonikoko TK, Aisner J, Wang XV, Dahlberg SE, Rubin EH, Ramalingam SS, Gounder M, Rausch PG, Axelrod RS, Schiller JH
Cancer Chemother Pharmacol. 2014 Jan; 73(1)171-80. doi: 10.1007/s00280-013-2338-z.

PMID:
    24288121
    [PubMed - indexed for MEDLINE]
Related citations


Clinical pharmacology profile of vorinostat, a histone deacetylase inhibitor.
Iwamoto M, Friedman EJ, Sandhu P, Agrawal NG, Rubin EH, Wagner JA
Cancer Chemother Pharmacol. 2013 Sep; 72(3)493-508. doi: 10.1007/s00280-013-2220-z.

PMID:
    23820962
    [PubMed - indexed for MEDLINE]
Related citations


Phase I/IIa trial of the mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced malignancies and sarcoma.
Mita MM, Poplin E, Britten CD, Tap WD, Rubin EH, Scott BB, Berk L, Rivera VM, Loewy JW, Dodion P, Haluska F, Sarantopoulos J, Mita A, Tolcher A
Ann Oncol. 2013 Apr; 24(4)1104-11. doi: 10.1093/annonc/mds602.

PMID:
    23211938
    [PubMed - indexed for MEDLINE]
Related citations


The BATTLE trial: a bold step toward improving the efficiency of biomarker-based drug development.
Rubin EH, Anderson KM, Gause CK
Cancer Discov. 2011 Jun; 1(1)17-20. doi: 10.1158/2159-8274.CD-11-0036.

PMID:
    22586314
    [PubMed - indexed for MEDLINE]
Related citations


Perspective: Upcoming paradigm shifts for psychiatry in clinical care, research, and education.
Rubin EH, Zorumski CF
Acad Med. 2012 Mar; 87(3)261-5. doi: 10.1097/ACM.0b013e3182441697.

PMID:
    22373615
    [PubMed - indexed for MEDLINE]
Related citations


Drug development and clinical trials--the path to an approved cancer drug.
Rubin EH, Gilliland DG
Nat Rev Clin Oncol. 2012 Feb 28; 9(4)215-22. doi: 10.1038/nrclinonc.2012.22.

PMID:
    22371130
    [PubMed - indexed for MEDLINE]
Related citations


Reports from the 2010 Clinical and Translational Cancer Research Think Tank meeting: design strategies for personalized therapy trials.
Berry DA, Herbst RS, Rubin EH
Clin Cancer Res. 2012 Feb 1; 18(3)638-44. doi: 10.1158/1078-0432.CCR-11-2018.

PMID:
    22298897
    [PubMed - indexed for MEDLINE]
Related citations


A phase 1 trial of E7974 administered on day 1 of a 21-day cycle in patients with advanced solid tumors.
Rocha-Lima CM, Bayraktar S, Macintyre J, Raez L, Flores AM, Ferrell A, Rubin EH, Poplin EA, Tan AR, Lucarelli A, Zojwalla N
Cancer. 2012 Sep 1; 118(17)4262-70. doi: 10.1002/cncr.27428.

PMID:
    22294459
    [PubMed - indexed for MEDLINE]
Related citations


Adaptive clinical trial designs for simultaneous testing of matched diagnostics and therapeutics.
Scher HI, Nasso SF, Rubin EH, Simon R
Clin Cancer Res. 2011 Nov 1; 17(21)6634-40. doi: 10.1158/1078-0432.CCR-11-1105.

PMID:
    22046024
    [PubMed - indexed for MEDLINE]
Related citations


Obstructive sleep apnea/hypopnea syndrome and poor response to sertraline in patients with coronary heart disease.
Roest AM, Carney RM, Stein PK, Freedland KE, Meyer H, Steinmeyer BC, de Jonge P, Rubin EH
J Clin Psychiatry. 2012 Jan; 73(1)31-6. doi: 10.4088/JCP.10m06455.

PMID:
    21903027
    [PubMed - indexed for MEDLINE]
Related citations


Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach.
Mehnert JM, Tan AR, Moss R, Poplin E, Stein MN, Sovak M, Levinson K, Lin H, Kane M, Gounder M, Lin Y, Shih WJ, White E, Rubin EH, Karantza V
Mol Cancer Ther. 2011 Aug; 10(8)1509-19. doi: 10.1158/1535-7163.MCT-10-0944.

PMID:
    21680752
    [PubMed - indexed for MEDLINE]
Related citations


Inflammation and treatment response to sertraline in patients with coronary heart disease and comorbid major depression.
Bot M, Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Mann DL
J Psychosom Res. 2011 Jul; 71(1)13-7. doi: 10.1016/j.jpsychores.2010.11.006.

PMID:
    21665007
    [PubMed - indexed for MEDLINE]
Related citations


Effect of omega-3 fatty acids on heart rate variability in depressed patients with coronary heart disease.
Carney RM, Freedland KE, Stein PK, Steinmeyer BC, Harris WS, Rubin EH, Krone RJ, Rich MW
Psychosom Med. 2010 Oct; 72(8)748-54. doi: 10.1097/PSY.0b013e3181eff148.

PMID:
    20716712
    [PubMed - indexed for MEDLINE]
Related citations


Finding the right dose for cancer therapeutics--can we do better?
Rubin EH, Anderson KM
Clin Cancer Res. 2010 Feb 15; 16(4)1085-7. doi: 10.1158/1078-0432.CCR-09-3246.

PMID:
    20145182
    [PubMed - indexed for MEDLINE]
Related citations


A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer.
Munster PN, Rubin EH, Van Belle S, Friedman E, Patterson JK, Van Dyck K, Li X, Comisar W, Chodakewitz JA, Wagner JA, Iwamoto M
Clin Cancer Res. 2009 Nov 15; 15(22)7077-84. doi: 10.1158/1078-0432.CCR-09-1214.

PMID:
    19887475
    [PubMed - indexed for MEDLINE]
Related citations


Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial.
Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS
JAMA. 2009 Oct 21; 302(15)1651-7. doi: 10.1001/jama.2009.1487.

PMID:
    19843899
    [PubMed - indexed for MEDLINE]
Related citations


Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors.
Tan AR, Rubin EH, Walton DC, Shuster DE, Wong YN, Fang F, Ashworth S, Rosen LS
Clin Cancer Res. 2009 Jun 15; 15(12)4213-9. doi: 10.1158/1078-0432.CCR-09-0360.

PMID:
    19509146
    [PubMed - indexed for MEDLINE]
Related citations


Treatment of depression after coronary artery bypass surgery: a randomized controlled trial.
Freedland KE, Skala JA, Carney RM, Rubin EH, Lustman PJ, Dávila-Román VG, Steinmeyer BC, Hogue CW Jr
Arch Gen Psychiatry. 2009 Apr; 66(4)387-96. doi: 10.1001/archgenpsychiatry.2009.7.

PMID:
    19349308
    [PubMed - indexed for MEDLINE]
Related citations