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Erik Musiek, MD, PhD

Assistant Professor, Neurology

Specialty Areas

Neurology - Adult
Alzheimer's Disease

Board Certifications

Neurology

Areas of Clinical Interest

Cognitive disorders, Alzheimer's Disease, age-related neurodegenerative diseases

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
Suite 6C
St. Louis, MO 63108

Office Phone: 314-286-1967
Fax: 314-286-1985

Education

Education

Residency: Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 2011
MD: Vanderbilt University, Nashville, Tennessee 2007
Fellowship: Alzheimer's Disease Research, Washington University School of Medicine, St. Louis, Missouri 2012
BS: Biological Psychology, College of William and Mary, Williamsburg, Virginia 1999
PhD: Pharmacology, Vanderbilt University, Nashville, Tennessee 2005

Publication & Research

Publication & Research

Rev-erbs and Glia-Implications for Neurodegenerative Diseases.
Griffin P, Dimitry JM, Musiek ES
J Exp Neurosci. 2019; 131179069519853233. doi: 10.1177/1179069519853233.

PMID:
    31210735
    [PubMed]
Related citations


Correction: Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the ω -3 polyunsaturated fatty acid docosahexaenoic acid.
Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD
J Biol Chem. 2019 Apr 19; 294(16)6657. doi: 10.1074/jbc.AAC119.008639.

PMID:
    31003972
    [PubMed - in process]
Related citations


Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.
Roby DA, Ruiz F, Kermath BA, Voorhees JR, Niehoff M, Zhang J, Morley JE, Musiek ES, Farr SA, Burris TP
PLoS One. 2019; 14(4)e0215004. doi: 10.1371/journal.pone.0215004.

PMID:
    30973894
    [PubMed - in process]
Related citations


Dural lymphatics regulate clearance of extracellular tau from the CNS.
Patel TK, Habimana-Griffin L, Gao X, Xu B, Achilefu S, Alitalo K, McKee CA, Sheehan PW, Musiek ES, Xiong C, Coble D, Holtzman DM
Mol Neurodegener. 2019 Feb 27; 14(1)11. doi: 10.1186/s13024-019-0312-x.

PMID:
    30813965
    [PubMed - in process]
Related citations


Circadian clock protein Rev-erbα regulates neuroinflammation.
Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeño MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES
Proc Natl Acad Sci U S A. 2019 Mar 12; 116(11)5102-5107. doi: 10.1073/pnas.1812405116.

PMID:
    30792350
    [PubMed - indexed for MEDLINE]
Related citations


Association between circadian rhythms and neurodegenerative diseases.
Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K
Lancet Neurol. 2019 Mar; 18(3)307-318. doi: 10.1016/S1474-4422(18)30461-7.

PMID:
    30784558
    [PubMed - in process]
Related citations


Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1.
Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, Musiek ES
Cell Rep. 2018 Oct 2; 25(1)1-9.e5. doi: 10.1016/j.celrep.2018.09.015.

PMID:
    30282019
    [PubMed - in process]
Related citations


Rapidly Progressive Dementia in the Outpatient Clinic: More Than Prions.
Day GS, Musiek ES, Morris JC
Alzheimer Dis Assoc Disord. 2018 Oct-Dec; 32(4)291-297. doi: 10.1097/WAD.0000000000000276.

PMID:
    30222606
    [PubMed - in process]
Related citations


Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models.
Vanderheyden WM, Lim MM, Musiek ES, Gerstner JR
J Neurosci. 2018 Mar 21; 38(12)2901-2910. doi: 10.1523/JNEUROSCI.1135-17.2017.

PMID:
    29563238
    [PubMed - in process]
Related citations


In vivo [<sup>18</sup>F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease.
Day GS, Gordon BA, Perrin RJ, Cairns NJ, Beaumont H, Schwetye K, Ferguson C, Sinha N, Bucelli R, Musiek ES, Ghoshal N, Ponisio MR, Vincent B, Mishra S, Jackson K, Morris JC, Benzinger TLS, Ances BM
Neurology. 2018 Mar 6; 90(10)e896-e906. doi: 10.1212/WNL.0000000000005064.

PMID:
    29438042
    [PubMed - in process]
Related citations


Regulation of amyloid-β dynamics and pathology by the circadian clock.
Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES
J Exp Med. 2018 Apr 2; 215(4)1059-1068. doi: 10.1084/jem.20172347.

PMID:
    29382695
    [PubMed - in process]
Related citations


Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease.
Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju YS
JAMA Neurol. 2018 May 1; 75(5)582-590. doi: 10.1001/jamaneurol.2017.4719.

PMID:
    29379963
    [PubMed - in process]
Related citations


Circadian Rhythms in AD pathogenesis: A Critical Appraisal.
Musiek ES
Curr Sleep Med Rep. 2017 Jun; 3(2)85-92. doi: 10.1007/s40675-017-0072-5.

PMID:
    29308355
    [PubMed]
Related citations


Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms.
Lanctôt KL, Amatniek J, Ancoli-Israel S, Arnold SE, Ballard C, Cohen-Mansfield J, Ismail Z, Lyketsos C, Miller DS, Musiek E, Osorio RS, Rosenberg PB, Satlin A, Steffens D, Tariot P, Bain LJ, Carrillo MC, Hendrix JA, Jurgens H, Boot B
Alzheimers Dement (N Y). 2017 Sep; 3(3)440-449. doi: 10.1016/j.trci.2017.07.001.

PMID:
    29067350
    [PubMed]
Related citations


Mechanisms linking circadian clocks, sleep, and neurodegeneration.
Musiek ES, Holtzman DM
Science. 2016 Nov 25; 354(6315)1004-1008.

PMID:
    27885006
    [PubMed - indexed for MEDLINE]
Related citations


Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning.
Fung CH, Vitiello MV, Alessi CA, Kuchel GA, AGS/NIA Sleep Conference Planning Committee and Faculty.
J Am Geriatr Soc. 2016 Dec; 64(12)e238-e247. doi: 10.1111/jgs.14493.

PMID:
    27858974
    [PubMed - indexed for MEDLINE]
Related citations


Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy.
Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM
Ann Clin Transl Neurol. 2016 Jun; 3(6)434-42. doi: 10.1002/acn3.308.

PMID:
    27547771
    [PubMed]
Related citations


Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study.
Day GS, Musiek ES, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC
JAMA Neurol. 2016 Sep 1; 73(9)1125-32. doi: 10.1001/jamaneurol.2016.1236.

PMID:
    27454811
    [PubMed - indexed for MEDLINE]
Related citations


Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.
Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA
Sci Transl Med. 2016 Feb 3; 8(324)324ra16. doi: 10.1126/scitranslmed.aad3305.

PMID:
    26843191
    [PubMed - indexed for MEDLINE]
Related citations


Three dimensions of the amyloid hypothesis: time, space and 'wingmen'.
Musiek ES, Holtzman DM
Nat Neurosci. 2015 Jun; 18(6)800-6. doi: 10.1038/nn.4018.

PMID:
    26007213
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Molecular mechanisms of neurodegeneration, with a special interest in oxidative stress; role of circadian clock genes in the regulation of brain oxidative stress, bioenergetics, and neurodegeneration; how proteins associated with neurodegenerative disease, such as Apolipoprotein E, modulate oxidative stress responses in the brain;  phenotypic and biochemical similarities between autosomal dominant (familial) and sporadic Alzheimer’s Disease, as well as to employ mass spectrometry and PET-based amyloid imaging techniques to elucidate the relationship between brain amyloid deposition, neuronal oxidative damage, and dementia in living patients