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Erik Musiek, MD, PhD

Assistant Professor, Neurology

Specialty Areas

Neurology - Adult
Alzheimer's Disease

Board Certifications

Neurology

Areas of Clinical Interest

Cognitive disorders, Alzheimer's Disease, age-related neurodegenerative diseases

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
Suite 6C
St. Louis, MO 63108

Office Phone: 314-286-1967
Fax: 314-286-1985

Education

Education

Residency: Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 2011
MD: Vanderbilt University, Nashville, Tennessee 2007
Fellowship: Alzheimer's Disease Research, Washington University School of Medicine, St. Louis, Missouri 2012
BS: Biological Psychology, College of William and Mary, Williamsburg, Virginia 1999
PhD: Pharmacology, Vanderbilt University, Nashville, Tennessee 2005

Publication & Research

Publication & Research

Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models.
Vanderheyden WM, Lim MM, Musiek ES, Gerstner JR
J Neurosci. 2018 Mar 21; 38(12)2901-2910. doi: 10.1523/JNEUROSCI.1135-17.2017.

PMID:
    29563238
    [PubMed - in process]
Related citations


In vivo [<sup>18</sup>F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease.
Day GS, Gordon BA, Perrin RJ, Cairns NJ, Beaumont H, Schwetye K, Ferguson C, Sinha N, Bucelli R, Musiek ES, Ghoshal N, Ponisio MR, Vincent B, Mishra S, Jackson K, Morris JC, Benzinger TLS, Ances BM
Neurology. 2018 Mar 6; 90(10)e896-e906. doi: 10.1212/WNL.0000000000005064.

PMID:
    29438042
    [PubMed - in process]
Related citations


Regulation of amyloid-β dynamics and pathology by the circadian clock.
Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES
J Exp Med. 2018 Apr 2; 215(4)1059-1068. doi: 10.1084/jem.20172347.

PMID:
    29382695
    [PubMed - in process]
Related citations


Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease.
Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju YS
JAMA Neurol. 2018 Jan 29; doi: 10.1001/jamaneurol.2017.4719.

PMID:
    29379963
    [PubMed - as supplied by publisher]
Related citations


Circadian Rhythms in AD pathogenesis: A Critical Appraisal.
Musiek ES
Curr Sleep Med Rep. 2017 Jun; 3(2)85-92. doi: 10.1007/s40675-017-0072-5.

PMID:
    29308355
    [PubMed]
Related citations


Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms.
Lanctôt KL, Amatniek J, Ancoli-Israel S, Arnold SE, Ballard C, Cohen-Mansfield J, Ismail Z, Lyketsos C, Miller DS, Musiek E, Osorio RS, Rosenberg PB, Satlin A, Steffens D, Tariot P, Bain LJ, Carrillo MC, Hendrix JA, Jurgens H, Boot B
Alzheimers Dement (N Y). 2017 Sep; 3(3)440-449. doi: 10.1016/j.trci.2017.07.001.

PMID:
    29067350
    [PubMed]
Related citations


Mechanisms linking circadian clocks, sleep, and neurodegeneration.
Musiek ES, Holtzman DM
Science. 2016 Nov 25; 354(6315)1004-1008.

PMID:
    27885006
    [PubMed - indexed for MEDLINE]
Related citations


Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning.
Fung CH, Vitiello MV, Alessi CA, Kuchel GA, AGS/NIA Sleep Conference Planning Committee and Faculty.
J Am Geriatr Soc. 2016 Dec; 64(12)e238-e247. doi: 10.1111/jgs.14493.

PMID:
    27858974
    [PubMed - indexed for MEDLINE]
Related citations


Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy.
Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM
Ann Clin Transl Neurol. 2016 Jun; 3(6)434-42. doi: 10.1002/acn3.308.

PMID:
    27547771
    [PubMed]
Related citations


Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study.
Day GS, Musiek ES, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC
JAMA Neurol. 2016 Sep 1; 73(9)1125-32. doi: 10.1001/jamaneurol.2016.1236.

PMID:
    27454811
    [PubMed - indexed for MEDLINE]
Related citations


Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.
Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA
Sci Transl Med. 2016 Feb 3; 8(324)324ra16. doi: 10.1126/scitranslmed.aad3305.

PMID:
    26843191
    [PubMed - indexed for MEDLINE]
Related citations


Three dimensions of the amyloid hypothesis: time, space and 'wingmen'.
Musiek ES, Holtzman DM
Nat Neurosci. 2015 Jun; 18(6)800-6. doi: 10.1038/nn.4018.

PMID:
    26007213
    [PubMed - indexed for MEDLINE]
Related citations


Circadian clock disruption in neurodegenerative diseases: cause and effect?
Musiek ES
Front Pharmacol. 2015; 629. doi: 10.3389/fphar.2015.00029.

PMID:
    25774133
    [PubMed]
Related citations


Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease.
Musiek ES, Xiong DD, Holtzman DM
Exp Mol Med. 2015 Mar 13; 47e148. doi: 10.1038/emm.2014.121.

PMID:
    25766617
    [PubMed - indexed for MEDLINE]
Related citations


Mystery case: a young woman with isolated upbeating nystagmus.
Ong C, Patel K, Musiek E, Van Stavern G
Neurology. 2015 Jan 27; 84(4)e17-9. doi: 10.1212/WNL.0000000000001178.

PMID:
    25628435
    [PubMed - indexed for MEDLINE]
Related citations


Alzheimer disease: current concepts &amp; future directions.
Musiek ES, Schindler SE
Mo Med. 2013 Sep-Oct; 110(5)395-400.

PMID:
    24279190
    [PubMed - indexed for MEDLINE]
Related citations


Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.
Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA
J Clin Invest. 2013 Dec; 123(12)5389-400. doi: 10.1172/JCI70317.

PMID:
    24270424
    [PubMed - indexed for MEDLINE]
Related citations


Knitting up the raveled sleave of care.
Yang G, Paschos G, Curtis AM, Musiek ES, McLoughlin SC, FitzGerald GA
Sci Transl Med. 2013 Nov 20; 5(212)212rv3. doi: 10.1126/scitranslmed.3007225.

PMID:
    24259052
    [PubMed - indexed for MEDLINE]
Related citations


Molecular clocks in pharmacology.
Musiek ES, Fitzgerald GA
Handb Exp Pharmacol. 2013; (217)243-60. doi: 10.1007/978-3-642-25950-0_10.

PMID:
    23604482
    [PubMed - indexed for MEDLINE]
Related citations


Feasibility of estimation of brain volume and 2-deoxy-2-(18)F-fluoro-D-glucose metabolism using a novel automated image analysis method: application in Alzheimer's disease.
Musiek ES, Saboury B, Mishra S, Chen Y, Reddin JS, Newberg AB, Udupa JK, Detre JA, Hofheinz F, Torigian D, Alavi A
Hell J Nucl Med. 2012 Sep-Dec; 15(3)190-6. doi: 10.1967/s002449910052.

PMID:
    23106049
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Molecular mechanisms of neurodegeneration, with a special interest in oxidative stress; role of circadian clock genes in the regulation of brain oxidative stress, bioenergetics, and neurodegeneration; how proteins associated with neurodegenerative disease, such as Apolipoprotein E, modulate oxidative stress responses in the brain;  phenotypic and biochemical similarities between autosomal dominant (familial) and sporadic Alzheimer’s Disease, as well as to employ mass spectrometry and PET-based amyloid imaging techniques to elucidate the relationship between brain amyloid deposition, neuronal oxidative damage, and dementia in living patients