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Eric James Duncavage, MD

Assistant Professor,Pathology & Immunology
Division of Anatomic and Molecular Pathology

Specialty Areas

Pathology
Hematopathology

Board Certifications

Anatomical and Clinical Pathology
Molecular Pathology
Hematopathology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Pathology, immunology, hematopathology

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

Medical Degree: University of Tennessee COllege of Medicine, Memphis, TN 2004
BS, Physics and Chemistry: Vanderbilt University, Nashville, TN 1998
Fellowship, Molecular Genetic Pathology: Washington University School of Medicine, St. Louis, MO 2009
Fellowship, Hematopathology: University of Utah, Salt Lake City, Utah 2010
Residency, Anatomical and Clinical Pathology: Barnes-Jewish Hospital, St. Louis, MO 2008

Publication & Research

Publication & Research

Discriminating a common somatic ASXL1 mutation (c.1934dup; p.G646Wfs*12) from artifact in myeloid malignancies using NGS.
Alberti MO, Srivatsan SN, Shao J, McNulty SN, Chang GS, Miller CA, Dunlap JB, Yang F, Press RD, Gao Q, Ding L, Heusel JW, Duncavage EJ, Walter MJ
Leukemia. 2018 Jun 29; doi: 10.1038/s41375-018-0193-y.

PMID:
    29959414
    [PubMed - as supplied by publisher]
Related citations


A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel <i>RARG</i>-<i>CPSF6</i> fusion.
Miller CA, Tricarico C, Skidmore ZL, Uy GL, Lee YS, Hassan A, O'Laughlin MD, Schmidt H, Tian L, Duncavage EJ, Griffith M, Griffith OL, Welch JS, Wartman LD
Blood Adv. 2018 Jun 12; 2(11)1295-1299. doi: 10.1182/bloodadvances.2017014183.

PMID:
    29891591
    [PubMed - in process]
Related citations


Proceedings of the NASHNP Companion Meeting, March 18th, 2018, Vancouver, BC, Canada: Salivary Neuroendocrine Carcinoma-An Overview of a Rare Disease with an Emphasis on Determining Tumor Origin.
Chernock RD, Duncavage EJ
Head Neck Pathol. 2018 Mar; 12(1)13-21. doi: 10.1007/s12105-018-0896-4.

PMID:
    29556963
    [PubMed - in process]
Related citations


Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
JCI Insight. 2018 Mar 8; 3(5)pii: 98962. doi: 10.1172/jci.insight.98962.

PMID:
    29515031
    [PubMed - as supplied by publisher]
Related citations


Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC
Nat Commun. 2018 Jan 31; 9(1)455. doi: 10.1038/s41467-018-02858-0.

PMID:
    29386642
    [PubMed - indexed for MEDLINE]
Related citations


Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the <i>NUP98-HOXD13</i> mouse model of MDS.
Monlish DA, Bhatt ST, Duncavage EJ, Greenberg ZJ, Keller JL, Romine MP, Yang W, Aplan PD, Walter MJ, Schuettpelz LG
Blood. 2018 Mar 1; 131(9)1032-1035. doi: 10.1182/blood-2017-08-801944.

PMID:
    29358180
    [PubMed - in process]
Related citations


Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer.
Rosenbaum JN, Bloom R, Forys JT, Hiken J, Armstrong JR, Branson J, McNulty S, Velu PD, Pepin K, Abel H, Cottrell CE, Pfeifer JD, Kulkarni S, Govindan R, Konnick EQ, Lockwood CM, Duncavage EJ
Mod Pathol. 2018 May; 31(5)791-808. doi: 10.1038/modpathol.2017.181.

PMID:
    29327716
    [PubMed - in process]
Related citations


Authors' Reply.
Li MM, Datto M, Duncavage EJ, Kulkarni S, Lindeman NI, Roy S, Tsimberidou AM, Vnencak-Jones CL, Wolff DJ, Younes A, Nikiforova MN
J Mol Diagn. 2018 Jan; 20(1)125-126. doi: 10.1016/j.jmoldx.2017.11.002.

PMID:
    29249244
    [PubMed - in process]
Related citations


Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma With Deficient DNA Mismatch Repair.
Lee PJ, McNulty S, Duncavage EJ, Heusel JW, Hagemann IS
Int J Gynecol Pathol. 2017 Oct 27; doi: 10.1097/PGP.0000000000000459.

PMID:
    29084048
    [PubMed - as supplied by publisher]
Related citations


<i>FGFR2</i> amplification in colorectal adenocarcinoma.
Carter JH, Cottrell CE, McNulty SN, Vigh-Conrad KA, Lamp S, Heusel JW, Duncavage EJ
Cold Spring Harb Mol Case Stud. 2017 Nov; 3(6)pii: a001495. doi: 10.1101/mcs.a001495.

PMID:
    28835367
    [PubMed - indexed for MEDLINE]
Related citations


New Insight Into the Biology, Risk Stratification, and Targeted Treatment of Myelodysplastic Syndromes.
Haider M, Duncavage EJ, Afaneh KF, Bejar R, List AF
Am Soc Clin Oncol Educ Book. 2017; 37480-494. doi: 10.14694/EDBK_175397.

PMID:
    28561687
    [PubMed - indexed for MEDLINE]
Related citations


Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing.
Lee PJ, Yoo NS, Hagemann IS, Pfeifer JD, Cottrell CE, Abel HJ, Duncavage EJ
Exp Mol Pathol. 2017 Feb; 102(1)156-161. doi: 10.1016/j.yexmp.2017.01.012.

PMID:
    28093192
    [PubMed - indexed for MEDLINE]
Related citations


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - indexed for MEDLINE]
Related citations


Targeted Next-Generation Sequencing in Molecular Subtyping of Lower-Grade Diffuse Gliomas: Application of the World Health Organization's 2016 Revised Criteria for Central Nervous System Tumors.
Carter JH, McNulty SN, Cimino PJ, Cottrell CE, Heusel JW, Vigh-Conrad KA, Duncavage EJ
J Mol Diagn. 2017 Mar; 19(2)328-337. doi: 10.1016/j.jmoldx.2016.10.010.

PMID:
    28042970
    [PubMed - indexed for MEDLINE]
Related citations


Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.
Li MM, Datto M, Duncavage EJ, Kulkarni S, Lindeman NI, Roy S, Tsimberidou AM, Vnencak-Jones CL, Wolff DJ, Younes A, Nikiforova MN
J Mol Diagn. 2017 Jan; 19(1)4-23. doi: 10.1016/j.jmoldx.2016.10.002.

PMID:
    27993330
    [PubMed - indexed for MEDLINE]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036. doi: 10.1056/NEJMoa1605949.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


In Silico Proficiency Testing for Clinical Next-Generation Sequencing.
Duncavage EJ, Abel HJ, Pfeifer JD
J Mol Diagn. 2017 Jan; 19(1)35-42. doi: 10.1016/j.jmoldx.2016.09.005.

PMID:
    27863262
    [PubMed - indexed for MEDLINE]
Related citations


Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia. 2017 Apr; 31(4)872-881. doi: 10.1038/leu.2016.282.

PMID:
    27740633
    [PubMed - indexed for MEDLINE]
Related citations


Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
Leukemia. 2016 Dec; 30(12)2422-2426. doi: 10.1038/leu.2016.247.

PMID:
    27573557
    [PubMed - indexed for MEDLINE]
Related citations


A Model Study of In Silico Proficiency Testing for Clinical Next-Generation Sequencing.
Duncavage EJ, Abel HJ, Merker JD, Bodner JB, Zhao Q, Voelkerding KV, Pfeifer JD
Arch Pathol Lab Med. 2016 Oct; 140(10)1085-91. doi: 10.5858/arpa.2016-0194-CP.

PMID:
    27388684
    [PubMed - indexed for MEDLINE]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Cofactor Genomics

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2018