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Douglas R. Adkins, MD

Associate Professor, Internal Medicine
Division of Oncology
Section of Medical Oncology

Specialty Areas

Medical Oncology
Sarcoma
Head and Neck Oncology
Thyroid Cancer
Bone Sarcoma

Board Certifications

Internal Medicine
Medical Oncology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Medical oncology, bone sarcomas, soft tissue sarcomas, thyroid cancer, head and neck cancer

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-747-7222

Suite: B
Floor: 7
Office Phone: 314-747-1171 (new patients)
Fax: 314-362-7086

Barnes-Jewish West County Hospital
Medical Building Two

10 Barnes West Drive
Creve Coeur, MO 63141

Office Phone: 314-747-1171 (new patients)
Additional Phone: 314-996-8873 (returning patients)
Fax: 314-362-3646

Education

Education

Fellowship: Bone Marrow Transplantation, University of Texas Health Sciences Center, San Antonio, Texas 1992
Fellowship: Medical Oncology/Hematology, University of Texas Health Sciences Center, San Antonio, Texas 1990
Residency: Internal Medicine, University of Texas Health Sciences Center, San Antonio, Texas 1989
Medical Degree: Wright State University School of Medicine, Dayton, Ohio 1986
B.S.: Biological Sciences, Wright State University, Dayton, Ohio 1982

Publication & Research

Publication & Research

NCCN Guidelines Insights: Bone Cancer, Version 2.2017.
Biermann JS, Chow W, Reed DR, Lucas D, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Budd GT, Curry WT, Didwania A, Fabbri N, Hornicek FJ, Kuechle JB, Lindskog D, Mayerson J, McGarry SV, Million L, Morris CD, Movva S, O'Donnell RJ, Randall RL, Rose P, Santana VM, Satcher RL, Schwartz H, Siegel HJ, Thornton K, Villalobos V, Bergman MA, Scavone JL
J Natl Compr Canc Netw. 2017 Feb; 15(2)155-167.

PMID:
    28188186
    [PubMed - in process]
Related citations


Biomarker and Tumor Responses of Oral Cavity Squamous Cell Carcinoma to Trametinib: A Phase II Neoadjuvant Window-of-Opportunity Clinical Trial.
Uppaluri R, Winkler AE, Lin T, Law JH, Haughey BH, Nussenbaum B, Paniello RC, Rich JT, Diaz JA, Michel LP, Wildes T, Dunn GP, Zolkind P, Kallogjeri D, Piccirillo JF, Dehdashti F, Siegel BA, Chernock RD, Lewis JS Jr, Adkins DR
Clin Cancer Res. 2017 May 1; 23(9)2186-2194. doi: 10.1158/1078-0432.CCR-16-1469.

PMID:
    28151720
    [PubMed - in process]
Related citations


Outcomes of surgically treated human papillomavirus-related oropharyngeal squamous cell carcinoma with N3 disease.
Zenga J, Haughey BH, Jackson RS, Adkins DR, Aranake-Chrisinger J, Bhatt N, Gay HA, Kallogjeri D, Martin EJ, Moore EJ, Paniello RC, Rich JT, Thorstad WL, Nussenbaum B
Laryngoscope. 2016 Dec 23; doi: 10.1002/lary.26455.

PMID:
    28008626
    [PubMed - as supplied by publisher]
Related citations


Reevaluation of postoperative radiation dose in the management of human papillomavirus-positive oropharyngeal cancer.
Chin RI, Spencer CR, DeWees T, Hwang MY, Patel P, Sinha P, Gay HA, Haughey BH, Nussenbaum B, Adkins DR, Lewis JS Jr, Thorstad WL
Head Neck. 2016 Nov; 38(11)1643-1649. doi: 10.1002/hed.24486.

PMID:
    27152851
    [PubMed - in process]
Related citations


A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.
Bean GR, Kremer JC, Prudner BC, Schenone AD, Yao JC, Schultze MB, Chen DY, Tanas MR, Adkins DR, Bomalaski J, Rubin BP, Michel LS, Van Tine BA
Cell Death Dis. 2016 Oct 13; 7(10)e2406. doi: 10.1038/cddis.2016.232.

PMID:
    27735949
    [PubMed - in process]
Related citations


High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma.
Khwaja SS, Baker C, Haynes W, Spencer CR, Gay H, Thorstad W, Adkins DR, Nussenbaum B, Chernock RD, Lewis JS Jr, Wang X
Int J Radiat Oncol Biol Phys. 2016 Jul 15; 95(4)1132-41. doi: 10.1016/j.ijrobp.2016.03.001.

PMID:
    27209503
    [PubMed - indexed for MEDLINE]
Related citations


Improved clinical trial enrollments for uterine leiomyosarcoma patients after gynecologic oncology partnership with a sarcoma center.
Lange SE, Liu J, Adkins DR, Powell MA, Van Tine BA, Mutch DG
Gynecol Oncol. 2016 Feb; 140(2)307-12. doi: 10.1016/j.ygyno.2015.12.016.

PMID:
    26718726
    [PubMed - indexed for MEDLINE]
Related citations


Treatment Outcomes for T4 Oropharyngeal Squamous Cell Carcinoma.
Zenga J, Wilson M, Adkins DR, Gay HA, Haughey BH, Kallogjeri D, Michel LS, Paniello RC, Rich JT, Thorstad WL, Nussenbaum B
JAMA Otolaryngol Head Neck Surg. 2015 Dec; 141(12)1118-27. doi: 10.1001/jamaoto.2015.0764.

PMID:
    25902372
    [PubMed - indexed for MEDLINE]
Related citations


Alliance A091103 a phase II study of the angiopoietin 1 and 2 peptibody trebananib for the treatment of angiosarcoma.
D' Angelo SP, Mahoney MR, Van Tine BA, Adkins DR, Perdekamp MT, Condy MM, Luke JJ, Hartley EW, Antonescu CR, Tap WD, Schwartz GK
Cancer Chemother Pharmacol. 2015 Mar; 75(3)629-38. doi: 10.1007/s00280-015-2689-8.

PMID:
    25672915
    [PubMed - indexed for MEDLINE]
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Nab-paclitaxel-based compared to docetaxel-based induction chemotherapy regimens for locally advanced squamous cell carcinoma of the head and neck.
Schell A, Ley J, Wu N, Trinkaus K, Wildes TM, Michel L, Thorstad W, Gay H, Lewis J, Rich J, Diaz J, Paniello RC, Nussenbaum B, Adkins DR
Cancer Med. 2015 Apr; 4(4)481-9. doi: 10.1002/cam4.382.

PMID:
    25619559
    [PubMed - indexed for MEDLINE]
Related citations


Pre-radiotherapy feeding tube identifies a poor prognostic subset of postoperative p16 positive oropharyngeal carcinoma patients.
Verma V, Liu J, Eschen L, Danieley J, Spencer C, Lewis JS Jr, Diaz J, Piccirillo JF, Adkins DR, Nussenbaum B, Thorstad WL, Gay HA
Radiat Oncol. 2015 Jan 9; 108. doi: 10.1186/s13014-014-0314-3.

PMID:
    25572866
    [PubMed - indexed for MEDLINE]
Related citations


Epidermal Growth Factor Receptor Expression in Spindle Cell Carcinomas of the Head and Neck.
Watson RF, Chernock RD, Zhang KH, Michel LS, Adkins DR, El-Mofty SK, Lewis JS Jr
Head Neck Pathol. 2015 Sep; 9(3)360-8. doi: 10.1007/s12105-014-0604-y.

PMID:
    25563452
    [PubMed - indexed for MEDLINE]
Related citations


Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma.
Chawla SP, Cranmer LD, Van Tine BA, Reed DR, Okuno SH, Butrynski JE, Adkins DR, Hendifar AE, Kroll S, Ganjoo KN
J Clin Oncol. 2014 Oct 10; 32(29)3299-306. doi: 10.1200/JCO.2013.54.3660.

PMID:
    25185097
    [PubMed - indexed for MEDLINE]
Related citations


Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life.
Spencer CR, Gay HA, Haughey BH, Nussenbaum B, Adkins DR, Wildes TM, DeWees TA, Lewis JS Jr, Thorstad WL
Cancer. 2014 Dec 15; 120(24)3994-4002. doi: 10.1002/cncr.28938.

PMID:
    25143048
    [PubMed - indexed for MEDLINE]
Related citations


Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy.
Schenone AD, Luo J, Montgomery L, Morgensztern D, Adkins DR, Van Tine BA
Cancer Med. 2014 Jun; 3(3)603-12. doi: 10.1002/cam4.209.

PMID:
    24574357
    [PubMed - indexed for MEDLINE]
Related citations


Prognostic value of <sup>18</sup>F-FDG PET metabolic parameters in oropharyngeal squamous cell carcinoma.
Garsa AA, Chang AJ, Dewees T, Spencer CR, Adkins DR, Dehdashti F, Gay HA, Thorstad WL
J Radiat Oncol. 2013 Mar; 2(1)27-34.

PMID:
    24563726
    [PubMed]
Related citations


Antiangiogenic agents for nonmalignant brain tumors.
Hawasli AH, Rubin JB, Tran DD, Adkins DR, Waheed S, Hullar TE, Gutmann DH, Evans J, Leonard JR, Zipfel GJ, Chicoine MR
J Neurol Surg B Skull Base. 2013 Jun; 74(3)136-41. doi: 10.1055/s-0033-1338262.

PMID:
    24436903
    [PubMed]
Related citations


Distant metastasis in p16-positive oropharyngeal squamous cell carcinoma: a critical analysis of patterns and outcomes.
Sinha P, Thorstad WT, Nussenbaum B, Haughey BH, Adkins DR, Kallogjeri D, Lewis JS Jr
Oral Oncol. 2014 Jan; 50(1)45-51. doi: 10.1016/j.oraloncology.2013.10.007.

PMID:
    24211084
    [PubMed - indexed for MEDLINE]
Related citations


Bone cancer.
Biermann JS, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Butrynski JE, Cheong D, Chow W, Curry WT, Frassica DA, Frassica FJ, Hande KR, Hornicek FJ, Jones RL, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, von Mehren M, Bergman MA, Sundar H, National complrehensive cancer network.
J Natl Compr Canc Netw. 2013 Jun 1; 11(6)688-723.

PMID:
    23744868
    [PubMed - indexed for MEDLINE]
Related citations


Radiotherapeutic management of cervical lymph node metastases from an unknown primary site.
Perkins SM, Spencer CR, Chernock RD, Haughey BH, Nussenbaum B, Adkins DR, Kuperman DI, Thorstad WL
Arch Otolaryngol Head Neck Surg. 2012 Jul; 138(7)656-61. doi: 10.1001/archoto.2012.1110.

PMID:
    22801890
    [PubMed - indexed for MEDLINE]
Related citations