Patient Portal

Douglas M. Tollefsen, MD, PhD

Professor, Medicine
Division of Hematology

Specialty Areas

Hematology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hematology, hemostasis, blood coagulation, thrombosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital (South)
Barnard Cancer Center

4960 Children's Place
St. Louis, MO 63110

Suite: Wohl Hospital, 4th Floor
Office Phone: 314-362-7578
Fax: 314-362-8826

Education

Education

Fellowship: Hematology/Oncology, Washington University School of Medicine, St. Louis, Missouri 1980
Residency: Internal Medicine, University of Colorado School of Medicine, Denver, Colorado 1979
Medical Degree/Ph.D.: Washington University School of Medicine, St. Louis, Missouri 1977
B.A.: Grinnell College, Grinnell, Iowa 1971

Publication & Research

Publication & Research

α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.
Marjoram RJ, Li Z, He L, Tollefsen DM, Kunicki TJ, Dickeson SK, Santoro SA, Zutter MM
PLoS One. 2014; 9(11)e114035. doi: 10.1371/journal.pone.0114035.

PMID:
    25415203
    [PubMed - indexed for MEDLINE]
Related citations


Proteolytic activation transforms heparin cofactor II into a host defense molecule.
Kalle M, Papareddy P, Kasetty G, Tollefsen DM, Malmsten M, Mörgelin M, Schmidtchen A
J Immunol. 2013 Jun 15; 190(12)6303-10. doi: 10.4049/jimmunol.1203030.

PMID:
    23656734
    [PubMed - indexed for MEDLINE]
Related citations


The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption.
Charles JF, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, Tsang K, Sigrist K, Tollefsen DM, He L, Storm D, Aliprantis AO
Bone. 2012 Nov; 51(5)902-12. doi: 10.1016/j.bone.2012.08.113.

PMID:
    22985540
    [PubMed - indexed for MEDLINE]
Related citations


Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis.
Vicente CP, Weiler H, Di Cera E, Tollefsen DM
Thromb Res. 2012 Oct; 130(4)646-8. doi: 10.1016/j.thromres.2011.11.026.

PMID:
    22178578
    [PubMed - indexed for MEDLINE]
Related citations


Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II.
Ndonwi M, Burlingame OO, Miller AS, Tollefsen DM, Broze GJ Jr, Goldberg DE
Blood. 2011 Jun 9; 117(23)6347-54. doi: 10.1182/blood-2010-12-326876.

PMID:
    21511958
    [PubMed - indexed for MEDLINE]
Related citations


Dermatan sulfate and bone marrow mononuclear cells used as a new therapeutic strategy after arterial injury in mice.
Godoy JA, Block DB, Tollefsen DM, Werneck CC, Vicente CP
Cytotherapy. 2011 Jul; 13(6)695-704. doi: 10.3109/14653249.2010.548378.

PMID:
    21250866
    [PubMed - indexed for MEDLINE]
Related citations


COX-1(+/-)COX-2(-/-) genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1.
Riehl TE, He L, Zheng L, Greco S, Tollefsen DM, Stenson WF
J Thromb Haemost. 2011 Feb; 9(2)350-60. doi: 10.1111/j.1538-7836.2010.04156.x.

PMID:
    21138526
    [PubMed - indexed for MEDLINE]
Related citations


Vascular dermatan sulfate and heparin cofactor II.
Tollefsen DM
Prog Mol Biol Transl Sci. 2010; 93351-72. doi: 10.1016/S1877-1173(10)93015-9.

PMID:
    20807652
    [PubMed - indexed for MEDLINE]
Related citations


Glycosaminoglycan-binding properties and kinetic characterization of human heparin cofactor II expressed in Escherichia coli.
Sarilla S, Habib SY, Tollefsen DM, Friedman DB, Arnett DR, Verhamme IM
Anal Biochem. 2010 Nov 15; 406(2)166-75. doi: 10.1016/j.ab.2010.07.024.

PMID:
    20670608
    [PubMed - indexed for MEDLINE]
Related citations


A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice.
Metcalf JA, Ma X, Linders B, Wu S, Schambach A, Ohlemiller KK, Kovacs A, Bigg M, He L, Tollefsen DM, Ponder KP
Mol Ther. 2010 Feb; 18(2)334-42. doi: 10.1038/mt.2009.236.

PMID:
    19844196
    [PubMed - indexed for MEDLINE]
Related citations


Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II.
He L, Giri TK, Vicente CP, Tollefsen DM
Blood. 2008 Apr 15; 111(8)4118-25. doi: 10.1182/blood-2007-12-127928.

PMID:
    18281504
    [PubMed - indexed for MEDLINE]
Related citations


Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, Mecham RP
Blood. 2008 Apr 15; 111(8)4137-44. doi: 10.1182/blood-2007-07-101733.

PMID:
    18281502
    [PubMed - indexed for MEDLINE]
Related citations


Accelerated atherogenesis and neointima formation in heparin cofactor II deficient mice.
Vicente CP, He L, Tollefsen DM
Blood. 2007 Dec 15; 110(13)4261-7.

PMID:
    17878401
    [PubMed - indexed for MEDLINE]
Related citations


Heparin cofactor II modulates the response to vascular injury.
Tollefsen DM
Arterioscler Thromb Vasc Biol. 2007 Mar; 27(3)454-60.

PMID:
    17194895
    [PubMed - indexed for MEDLINE]
Related citations


N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate.
Halldórsdóttir AM, Zhang L, Tollefsen DM
Glycobiology. 2006 Aug; 16(8)693-701.

PMID:
    16624894
    [PubMed - indexed for MEDLINE]
Related citations


Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II.
Giri TK, Tollefsen DM
Blood. 2006 Apr 1; 107(7)2753-8.

PMID:
    16339402
    [PubMed - indexed for MEDLINE]
Related citations


Heparin cofactor II levels do not predict the development of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.
Giri TK, Ahn CW, Wu KK, Tollefsen DM
Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12)2689-90.

PMID:
    16306439
    [PubMed - indexed for MEDLINE]
Related citations


Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants.
Chen HH, Vicente CP, He L, Tollefsen DM, Wun TC
Blood. 2005 May 15; 105(10)3902-9.

PMID:
    15677561
    [PubMed - indexed for MEDLINE]
Related citations


Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
Pomin VH, Pereira MS, Valente AP, Tollefsen DM, Pavão MS, Mourão PA
Glycobiology. 2005 Apr; 15(4)369-81.

PMID:
    15590773
    [PubMed - indexed for MEDLINE]
Related citations


Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice.
Vicente CP, He L, Pavão MS, Tollefsen DM
Blood. 2004 Dec 15; 104(13)3965-70.

PMID:
    15315969
    [PubMed - indexed for MEDLINE]
Related citations