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Faculty Physicians

Dorothy Katherine Grange, MD

Professor, Pediatrics
Division of Medical Genetics

Specialty Areas

Genetics - Pediatric
Medical Genetics - Pediatric

Board Certifications

Pediatrics
Medical Genetics - Clinical Genetics

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

medical genetics, genetic disease, genetic counseling, inherited disorders, inborn errors of metabolism, phenylketonuria (PKU), birth defects, malformation syndromes, chromosomal disorders, metabolic disorders,Marfan syndrome, connective tissue disorders, overgrowth disorders, craniofacial disorders, pediatric pathology

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Medical Genetics
Office Phone: 314-454-6093
Fax: 314-454-2075

Education

Education

Fellowship: Interinstitute Fellowship, Medical Genetics,National Institutes of Health, Bethesda, Maryland 1989
Residency: Pathology, University of Wisconsin 1986
Residency: Pediatrics, University of Wisconsin 1985
Residency: Pathology, University of Florida, Gainesville, Florida, 1982
Medical Degree: University of Florida College of Medicine, Gainesville, Florida 1981
A.B. Biochemistry: Mount Holyoke College, South Hadley, Massachusetts 1976

Publication & Research

Publication & Research

A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex.
You J, Sobreira NL, Gable DL, Jurgens J, Grange DK, Belnap N, Siniard A, Szelinger S, Schrauwen I, Richholt RF, Vallee SE, Dinulos MB, Valle D, Armanios M, Hoover-Fong J
Am J Hum Genet. 2016 Apr 27; pii: S0002-9297(16)30049-0. doi: 10.1016/j.ajhg.2016.03.014.

PMID:
    27132593
    [PubMed - as supplied by publisher]
Related citations


Relationship between age and white matter integrity in children with phenylketonuria.
Wesonga E, Shimony JS, Rutlin J, Grange DK, White DA
Mol Genet Metab Rep. 2016 Jun; 745-9. doi: 10.1016/j.ymgmr.2016.03.003.

PMID:
    27114916
    [PubMed]
Related citations


Multigenerational autosomal dominant inheritance of 5p chromosomal deletions.
Zhang B, Willing M, Grange DK, Shinawi M, Manwaring L, Vineyard M, Kulkarni S, Cottrell CE
Am J Med Genet A. 2016 Mar; 170(3)583-93. doi: 10.1002/ajmg.a.37445.

PMID:
    26601658
    [PubMed - in process]
Related citations


Myhre syndrome: Clinical features and restrictive cardiopulmonary complications.
Starr LJ, Grange DK, Delaney JW, Yetman AT, Hammel JM, Sanmann JN, Perry DA, Schaefer GB, Olney AH
Am J Med Genet A. 2015 Dec; 167(12)2893-901. doi: 10.1002/ajmg.a.37273.

PMID:
    26420300
    [PubMed - in process]
Related citations


Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome.
Levin MD, Zhang H, Uchida K, Grange DK, Singh GK, Nichols CG
Heart Rhythm. 2015 Nov; 12(11)2316-24. doi: 10.1016/j.hrthm.2015.06.042.

PMID:
    26142302
    [PubMed - in process]
Related citations


Brainstem disconnection: two additional patients and expansion of the phenotype.
Poretti A, Denecke J, Miller DC, Schiffmann H, Buhk JH, Grange DK, Doherty D, Boltshauser E
Neuropediatrics. 2015 Apr; 46(2)139-44. doi: 10.1055/s-0034-1544127.

PMID:
    25671339
    [PubMed - indexed for MEDLINE]
Related citations


Prolonged exposure to high and variable phenylalanine levels over the lifetime predicts brain white matter integrity in children with phenylketonuria.
Hood A, Antenor-Dorsey JA, Rutlin J, Hershey T, Shimony JS, McKinstry RC, Grange DK, Christ SE, Steiner R, White DA
Mol Genet Metab. 2015 Jan; 114(1)19-24. doi: 10.1016/j.ymgme.2014.11.007.

PMID:
    25481106
    [PubMed - indexed for MEDLINE]
Related citations


Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia.
Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD
Mol Genet Genomic Med. 2014 Sep; 2(5)422-9. doi: 10.1002/mgg3.84.

PMID:
    25333067
    [PubMed]
Related citations


Overnight pulse oximetry for evaluation of sleep apnea among children with trisomy 21.
Coverstone AM, Bird M, Sicard M, Tao Y, Grange DK, Cleveland C, Molter D, Kemp JS
J Clin Sleep Med. 2014 Dec 15; 10(12)1309-15. doi: 10.5664/jcsm.4286.

PMID:
    25325597
    [PubMed - indexed for MEDLINE]
Related citations


Cantú Syndrome and Related Disorders
Grange DK, Nichols CG, Singh GK, Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K
. 1993;

PMID:
    25275207
    [PubMed]
Related citations


Fabry disease in infancy and early childhood: a systematic literature review.
Laney DA, Peck DS, Atherton AM, Manwaring LP, Christensen KM, Shankar SP, Grange DK, Wilcox WR, Hopkin RJ
Genet Med. 2015 May; 17(5)323-30. doi: 10.1038/gim.2014.120.

PMID:
    25232851
    [PubMed - indexed for MEDLINE]
Related citations


Fatal human herpesvirus 6-associated encephalitis in two boys with underlying POLG mitochondrial disorders.
Al-Zubeidi D, Thangarajh M, Pathak S, Cai C, Schlaggar BL, Storch GA, Grange DK, Watson ME Jr
Pediatr Neurol. 2014 Sep; 51(3)448-52. doi: 10.1016/j.pediatrneurol.2014.04.006.

PMID:
    25160553
    [PubMed - indexed for MEDLINE]
Related citations


Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.
Buchan JG, Alvarado DM, Haller GE, Cruchaga C, Harms MB, Zhang T, Willing MC, Grange DK, Braverman AC, Miller NH, Morcuende JA, Tang NL, Lam TP, Ng BK, Cheng JC, Dobbs MB, Gurnett CA
Hum Mol Genet. 2014 Oct 1; 23(19)5271-82. doi: 10.1093/hmg/ddu224.

PMID:
    24833718
    [PubMed - indexed for MEDLINE]
Related citations


Pathogenic mutations in GLI2 cause a specific phenotype that is distinct from holoprosencephaly.
Bear KA, Solomon BD, Antonini S, Arnhold IJ, França MM, Gerkes EH, Grange DK, Hadley DW, Jääskeläinen J, Paulo SS, Rump P, Stratakis CA, Thompson EM, Willis M, Winder TL, Jorge AA, Roessler E, Muenke M
J Med Genet. 2014 Jun; 51(6)413-8. doi: 10.1136/jmedgenet-2013-102249.

PMID:
    24744436
    [PubMed - indexed for MEDLINE]
Related citations


Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial.
Longo N, Harding CO, Burton BK, Grange DK, Vockley J, Wasserstein M, Rice GM, Dorenbaum A, Neuenburg JK, Musson DG, Gu Z, Sile S
Lancet. 2014 Jul 5; 384(9937)37-44. doi: 10.1016/S0140-6736(13)61841-3.

PMID:
    24743000
    [PubMed - indexed for MEDLINE]
Related citations


Intragenic CAMTA1 deletions are associated with a spectrum of neurobehavioral phenotypes.
Shinawi M, Coorg R, Shimony JS, Grange DK, Al-Kateb H
Clin Genet. 2015 May; 87(5)478-82. doi: 10.1111/cge.12407.

PMID:
    24738973
    [PubMed - indexed for MEDLINE]
Related citations


Cantú syndrome resulting from activating mutation in the KCNJ8 gene.
Cooper PE, Reutter H, Woelfle J, Engels H, Grange DK, van Haaften G, van Bon BW, Hoischen A, Nichols CG
Hum Mutat. 2014 Jul; 35(7)809-13. doi: 10.1002/humu.22555.

PMID:
    24700710
    [PubMed - indexed for MEDLINE]
Related citations


Copy number analysis of NIPBL in a cohort of 510 patients reveals rare copy number variants and a mosaic deletion.
Cheng YW, Tan CA, Minor A, Arndt K, Wysinger L, Grange DK, Kozel BA, Robin NH, Waggoner D, Fitzpatrick C, Das S, Del Gaudio D
Mol Genet Genomic Med. 2014 Mar; 2(2)115-23. doi: 10.1002/mgg3.48.

PMID:
    24689074
    [PubMed]
Related citations


Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry.
Grange DK, Hillman RE, Burton BK, Yano S, Vockley J, Fong CT, Hunt J, Mahoney JJ, Cohen-Pfeffer JL, Phenylketonuria Demographics Outcomes and Safety (PKUDOS) registry, Maternal Phenylketonuria Observational Program (PKU MOMS) sub-registry
Mol Genet Metab. 2014 May; 112(1)9-16. doi: 10.1016/j.ymgme.2014.02.016.

PMID:
    24667082
    [PubMed - indexed for MEDLINE]
Related citations


Phenylketonuria Scientific Review Conference: state of the science and future research needs.
Camp KM, Parisi MA, Acosta PB, Berry GT, Bilder DA, Blau N, Bodamer OA, Brosco JP, Brown CS, Burlina AB, Burton BK, Chang CS, Coates PM, Cunningham AC, Dobrowolski SF, Ferguson JH, Franklin TD, Frazier DM, Grange DK, Greene CL, Groft SC, Harding CO, Howell RR, Huntington KL, Hyatt-Knorr HD, Jevaji IP, Levy HL, Lichter-Konecki U, Lindegren ML, Lloyd-Puryear MA, Matalon K, MacDonald A, McPheeters ML, Mitchell JJ, Mofidi S, Moseley KD, Mueller CM, Mulberg AE, Nerurkar LS, Ogata BN, Pariser AR, Prasad S, Pridjian G, Rasmussen SA, Reddy UM, Rohr FJ, Singh RH, Sirrs SM, Stremer SE, Tagle DA, Thompson SM, Urv TK, Utz JR, van Spronsen F, Vockley J, Waisbren SE, Weglicki LS, White DA, Whitley CB, Wilfond BS, Yannicelli S, Young JM
Mol Genet Metab. 2014 Jun; 112(2)87-122. doi: 10.1016/j.ymgme.2014.02.013.

PMID:
    24667081
    [PubMed - indexed for MEDLINE]
Related citations