Patient Portal

Derek E Byers, PhD, MD

Assistant Professor, Medicine
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Critical Care Medicine
Lung Transplantation
Pulmonary Disease

Board Certifications

Pulmonary Disease
Internal Medicine
Critical Care

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

lung transplantation, advanced lung diseases, immune-related lung disease, airway diseases, immunosuppression

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-362-5378
Fax: 314-362-9272

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Office Phone: 314-362-5378
Fax: 314 362-9272

Education

Education

Doctor of Philosophy (Immunology): University of Texas Southwestern Graduate School at Dallas,TX 1999
B.S.: University of Oklahoma, Norman, OK 1993
Chief Resident: Parkland Memorial Hospital and Dallas Veterans Association Hospital, Dallas, TX 2005
Fellowship: Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 2008
Medical Degree: University of Texas Southwestern Medical School at Dallas, TX 2001
Residency: Internal Medicine, University of Texas Southwestern Medical School at Dallas, TX 2004

Publication & Research

Publication & Research

A single-center experience of 1500 lung transplant patients.
Balsara KR, Krupnick AS, Bell JM, Khiabani A, Scavuzzo M, Hachem R, Trulock E, Witt C, Byers DE, Yusen R, Meyers B, Kozower B, Patterson GA, Puri V, Kreisel D
J Thorac Cardiovasc Surg. 2018 Aug; 156(2)894-905.e3. doi: 10.1016/j.jtcvs.2018.03.112.

PMID:
    29891245
    [PubMed - in process]
Related citations


The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study.
Chen DL, Huang HJ, Byers DE, Shifren A, Belikoff B, Engle JT, Arentson E, Kemp D, Phillips S, Scherrer DE, Fujiwara H, Spayd KJ, Brooks FJ, Pierce RA, Castro M, Isakow W
PLoS One. 2018; 13(2)e0191783. doi: 10.1371/journal.pone.0191783.

PMID:
    29414995
    [PubMed - indexed for MEDLINE]
Related citations


Acute graft-versus-host disease following lung transplantation in a patient with a novel <i>TERT</i> mutation.
Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
Thorax. 2018 May; 73(5)489-492. doi: 10.1136/thoraxjnl-2017-211121.

PMID:
    29382801
    [PubMed - in process]
Related citations


Triggering Receptor Expressed on Myeloid Cells-2 Expression Tracks With M2-Like Macrophage Activity and Disease Severity in COPD.
Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ
Chest. 2018 Jan; 153(1)77-86. doi: 10.1016/j.chest.2017.09.044.

PMID:
    29017955
    [PubMed - in process]
Related citations


The role of C4d deposition in the diagnosis of antibody-mediated rejection after lung transplantation.
Aguilar PR, Carpenter D, Ritter J, Yusen RD, Witt CA, Byers DE, Mohanakumar T, Kreisel D, Trulock EP, Hachem RR
Am J Transplant. 2018 Apr; 18(4)936-944. doi: 10.1111/ajt.14534.

PMID:
    28992372
    [PubMed - in process]
Related citations


Impact of Delayed Chest Closure on Surgical Site Infection After Lung Transplantation.
Aguilar PR, Bemiss BC, Witt C, Byers DE, Kreisel D, Puri V, Meyers B, Patterson GA, Krupnick AS, Yusen RD, Trulock EP, Hachem RR
Ann Thorac Surg. 2017 Oct; 104(4)1208-1214. doi: 10.1016/j.athoracsur.2017.05.023.

PMID:
    28821338
    [PubMed - indexed for MEDLINE]
Related citations


PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.
Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL
Radiology. 2017 Jun; 283(3)758-768. doi: 10.1148/radiol.2016161409.

PMID:
    28045644
    [PubMed - indexed for MEDLINE]
Related citations


Significant Interference in Mass Cytometry from Medicinal Iodine in Human Lung.
Keller BC, Presti RM, Byers DE, Atkinson JJ
Am J Respir Cell Mol Biol. 2016 Jul; 55(1)150-1. doi: 10.1165/rcmb.2015-0403LE.

PMID:
    27362453
    [PubMed - indexed for MEDLINE]
Related citations


Hyperammonemia Syndrome After Lung Transplantation: A Single Center Experience.
Chen C, Bain KB, Iuppa JA, Yusen RD, Byers DE, Patterson GA, Trulock EP, Hachem RR, Witt CA
Transplantation. 2016 Mar; 100(3)678-84. doi: 10.1097/TP.0000000000000868.

PMID:
    26335916
    [PubMed - indexed for MEDLINE]
Related citations


The impact of pre-transplant allosensitization on outcomes after lung transplantation.
Bosanquet JP, Witt CA, Bemiss BC, Byers DE, Yusen RD, Patterson AG, Kreisel D, Mohanakumar T, Trulock EP, Hachem RR
J Heart Lung Transplant. 2015 Nov; 34(11)1415-22. doi: 10.1016/j.healun.2015.06.003.

PMID:
    26169666
    [PubMed - indexed for MEDLINE]
Related citations


TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.
Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ
J Exp Med. 2015 May 4; 212(5)681-97. doi: 10.1084/jem.20141732.

PMID:
    25897174
    [PubMed - indexed for MEDLINE]
Related citations


OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.
Barrow AD, Palarasah Y, Bugatti M, Holehouse AS, Byers DE, Holtzman MJ, Vermi W, Skjødt K, Crouch E, Colonna M
J Immunol. 2015 Apr 1; 194(7)3317-26. doi: 10.4049/jimmunol.1402289.

PMID:
    25716998
    [PubMed - indexed for MEDLINE]
Related citations


Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells.
Holtzman MJ, Byers DE, Brett JA, Patel AC, Agapov E, Jin X, Wu K
Ann Am Thorac Soc. 2014 Dec; 11 Suppl 5S287-91. doi: 10.1513/AnnalsATS.201402-056AW.

PMID:
    25525734
    [PubMed - indexed for MEDLINE]
Related citations


Imaging pulmonary inducible nitric oxide synthase expression with PET.
Huang HJ, Isakow W, Byers DE, Engle JT, Griffin EA, Kemp D, Brody SL, Gropler RJ, Miller JP, Chu W, Zhou D, Pierce RA, Castro M, Mach RH, Chen DL
J Nucl Med. 2015 Jan; 56(1)76-81. doi: 10.2967/jnumed.114.146381.

PMID:
    25525182
    [PubMed - indexed for MEDLINE]
Related citations


Defining the roles of IL-33, thymic stromal lymphopoietin, and IL-25 in human asthma.
Byers DE
Am J Respir Crit Care Med. 2014 Oct 1; 190(7)715-6. doi: 10.1164/rccm.201408-1539ED.

PMID:
    25271740
    [PubMed - indexed for MEDLINE]
Related citations


The role of airway epithelial cells and innate immune cells in chronic respiratory disease.
Holtzman MJ, Byers DE, Alexander-Brett J, Wang X
Nat Rev Immunol. 2014 Oct; 14(10)686-98. doi: 10.1038/nri3739.

PMID:
    25234144
    [PubMed - indexed for MEDLINE]
Related citations


Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.
Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS Jr, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ
J Allergy Clin Immunol. 2014 Dec; 134(6)1402-1412.e7. doi: 10.1016/j.jaci.2014.07.013.

PMID:
    25216987
    [PubMed - indexed for MEDLINE]
Related citations


Myb permits multilineage airway epithelial cell differentiation.
Pan JH, Adair-Kirk TL, Patel AC, Huang T, Yozamp NS, Xu J, Reddy EP, Byers DE, Pierce RA, Holtzman MJ, Brody SL
Stem Cells. 2014 Dec; 32(12)3245-56. doi: 10.1002/stem.1814.

PMID:
    25103188
    [PubMed - indexed for MEDLINE]
Related citations


Acute antibody-mediated rejection after lung transplantation.
Witt CA, Gaut JP, Yusen RD, Byers DE, Iuppa JA, Bennett Bain K, Alexander Patterson G, Mohanakumar T, Trulock EP, Hachem RR
J Heart Lung Transplant. 2013 Oct; 32(10)1034-40. doi: 10.1016/j.healun.2013.07.004.

PMID:
    23953920
    [PubMed - indexed for MEDLINE]
Related citations


Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.
Byers DE, Alexander-Brett J, Patel AC, Agapov E, Dang-Vu G, Jin X, Wu K, You Y, Alevy Y, Girard JP, Stappenbeck TS, Patterson GA, Pierce RA, Brody SL, Holtzman MJ
J Clin Invest. 2013 Sep; 123(9)3967-82. doi: 10.1172/JCI65570.

PMID:
    23945235
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Immunology, chronic lung diseases, airway diseases, COPD, asthma, bronchiolitis obliterans, lung transplant rejection