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Dennis E. Hallahan, MD, FASTRO

Chairman, Radiation Oncology
Elizabeth H. and James S. McDonnell III Distinguished Professor in Medicine

Specialty Areas

Radiation Oncology
Brain Tumors
Lymphoma
Lung Cancer
Sarcoma

Board Certifications

Therapeutic Radiology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Brain tumors, cancer of the central nervous system, cancer antibody development, immunotherapy, cancer drug development, radiation protecting drugs, nanoparticles, cancer drug delivery gene therapy for cancer

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Floor: LL
Office Phone: 314-747-9600

Education

Education

Postdoctorate Basic Science Research: Radiation and Cellular Oncology, University of Chicago Medical School, Chicago, IL 1990
B.S. (Biology): University of Chicago, Chicago, IL 1980
Medical School: Rush University, Chicago, IL 1984
Residency: Internal Medicine, University of Chicago Medical School, Chicago, IL 1986
Residency: Radiation Oncology, University of Chicago Medical School, Chicago, IL 1989

Publication & Research

Publication & Research

Acoustic field characterization of a clinical magnetic resonance-guided high-intensity focused ultrasound system inside the magnet bore.
Kothapalli SVVN, Altman MB, Partanen A, Wan L, Gach HM, Straube W, Hallahan DE, Chen H
Med Phys. 2017 Sep; 44(9)4890-4899. doi: 10.1002/mp.12412.

PMID:
    28626862
    [PubMed - in process]
Related citations


Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells.
Meyer B, Fabbrizi MR, Raj S, Zobel CL, Hallahan DE, Sharma GG
Stem Cell Reports. 2016 Dec 13; 7(6)1013-1022. doi: 10.1016/j.stemcr.2016.11.004.

PMID:
    27974220
    [PubMed - in process]
Related citations


An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma.
Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, Kim AH
Proc Natl Acad Sci U S A. 2016 Dec 20; 113(51)E8247-E8256. doi: 10.1073/pnas.1610921114.

PMID:
    27930300
    [PubMed - in process]
Related citations


Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.
Dadey DYA, Kapoor V, Hoye K, Khudanyan A, Collins A, Thotala D, Hallahan DE
Clin Cancer Res. 2017 May 15; 23(10)2556-2564. doi: 10.1158/1078-0432.CCR-16-1935.

PMID:
    27815359
    [PubMed - in process]
Related citations


Retargeted adenoviruses for radiation-guided gene delivery.
Kaliberov SA, Kaliberova LN, Yan H, Kapoor V, Hallahan DE
Cancer Gene Ther. 2016 Sep; 23(9)303-14. doi: 10.1038/cgt.2016.32.

PMID:
    27492853
    [PubMed - in process]
Related citations


Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers.
Kapoor V, Dadey DY, Nguyen K, Wildman SA, Hoye K, Khudanyan A, Bandara N, Rogers BE, Thotala D, Hallahan DE
J Nucl Med. 2016 Dec; 57(12)1991-1997.

PMID:
    27445290
    [PubMed - indexed for MEDLINE]
Related citations


Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses.
Jacobs KM, Misri S, Meyer B, Raj S, Zobel CL, Sleckman BP, Hallahan DE, Sharma GG
Mol Biol Cell. 2016 Apr 15; 27(8)1332-45. doi: 10.1091/mbc.E16-01-0017.

PMID:
    26941327
    [PubMed - indexed for MEDLINE]
Related citations


The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.
Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE
Oncotarget. 2016 Jan 12; 7(2)2080-92. doi: 10.18632/oncotarget.6712.

PMID:
    26716508
    [PubMed - indexed for MEDLINE]
Related citations


A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis.
Jiang X, Yuan L, Engelbach JA, Cates J, Perez-Torres CJ, Gao F, Thotala D, Drzymala RE, Schmidt RE, Rich KM, Hallahan DE, Ackerman JJ, Garbow JR
PLoS One. 2015; 10(10)e0139596. doi: 10.1371/journal.pone.0139596.

PMID:
    26440791
    [PubMed - indexed for MEDLINE]
Related citations


Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells.
Thotala D, Karvas RM, Engelbach JA, Garbow JR, Hallahan AN, DeWees TA, Laszlo A, Hallahan DE
Oncotarget. 2015 Oct 27; 6(33)35004-22. doi: 10.18632/oncotarget.5253.

PMID:
    26413814
    [PubMed - indexed for MEDLINE]
Related citations


Specificity of vascular endothelial growth factor treatment for radiation necrosis.
Perez-Torres CJ, Yuan L, Schmidt RE, Rich KM, Drzymala RE, Hallahan DE, Ackerman JJ, Garbow JR
Radiother Oncol. 2015 Nov; 117(2)382-5. doi: 10.1016/j.radonc.2015.09.004.

PMID:
    26376163
    [PubMed - indexed for MEDLINE]
Related citations


Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth.
Zhao DY, Jacobs KM, Hallahan DE, Thotala D
Mol Cancer Ther. 2015 Oct; 14(10)2343-52. doi: 10.1158/1535-7163.MCT-14-1051.

PMID:
    26206332
    [PubMed - indexed for MEDLINE]
Related citations


Stem Cell Transfusion Restores Immune Function in Radiation-Induced Lymphopenic C57BL/6 Mice.
Kapoor V, Khudanyan A, de la Puente P, Campian J, Hallahan DE, Azab AK, Thotala D
Cancer Res. 2015 Sep 1; 75(17)3442-5. doi: 10.1158/0008-5472.CAN-15-1412.

PMID:
    26130648
    [PubMed - indexed for MEDLINE]
Related citations


A GSK-3β inhibitor protects against radiation necrosis in mouse brain.
Jiang X, Perez-Torres CJ, Thotala D, Engelbach JA, Yuan L, Cates J, Gao F, Drzymala RE, Rich KM, Schmidt RE, Ackerman JJ, Hallahan DE, Garbow JR
Int J Radiat Oncol Biol Phys. 2014 Jul 15; 89(4)714-21. doi: 10.1016/j.ijrobp.2014.04.018.

PMID:
    24969790
    [PubMed - indexed for MEDLINE]
Related citations


Anti-VEGF antibodies mitigate the development of radiation necrosis in mouse brain.
Jiang X, Engelbach JA, Yuan L, Cates J, Gao F, Drzymala RE, Hallahan DE, Rich KM, Schmidt RE, Ackerman JJ, Garbow JR
Clin Cancer Res. 2014 May 15; 20(10)2695-702. doi: 10.1158/1078-0432.CCR-13-1941.

PMID:
    24647570
    [PubMed - indexed for MEDLINE]
Related citations


Thoughts on the future of research, teaching, and testing in the biological sciences of radiation oncology.
Hallahan DE, Freeman ML
Int J Radiat Oncol Biol Phys. 2014 Jan 1; 88(1)1-2. doi: 10.1016/j.ijrobp.2013.09.048.

PMID:
    24331646
    [PubMed - indexed for MEDLINE]
Related citations


Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines.
Bhave SR, Dadey DY, Karvas RM, Ferraro DJ, Kotipatruni RP, Jaboin JJ, Hallahan AN, Dewees TA, Linkous AG, Hallahan DE, Thotala D
Front Oncol. 2013; 3236. doi: 10.3389/fonc.2013.00236.

PMID:
    24062988
    [PubMed]
Related citations


Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models.
Thotala D, Craft JM, Ferraro DJ, Kotipatruni RP, Bhave SR, Jaboin JJ, Hallahan DE
PLoS One. 2013; 8(7)e69688. doi: 10.1371/journal.pone.0069688.

PMID:
    23894523
    [PubMed - indexed for MEDLINE]
Related citations


Membrane phospholipids, EML4-ALK, and Hsp90 as novel targets in lung cancer treatment.
Laszlo A, Thotala D, Hallahan DE
Cancer J. 2013 May-Jun; 19(3)238-46. doi: 10.1097/PPO.0b013e31829a68eb.

PMID:
    23708071
    [PubMed - indexed for MEDLINE]
Related citations


In regard to Shah.
Hallahan DE, Perkins SM
Int J Radiat Oncol Biol Phys. 2013 Jul 15; 86(4)597. doi: 10.1016/j.ijrobp.2013.04.004.

PMID:
    23664328
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Identification of new molecular targets for cancer therapy, drug development to improve cancer response to radiation therapy while minimizing the effect on normal tissues. Also drug development to protect tissues from radiation, antibody development and the use of nanoparticles for drug delivery