Patient Portal

Dennis E. Hallahan, MD, FASTRO

Chairman, Radiation Oncology
Elizabeth H. and James S. McDonnell III Distinguished Professor in Medicine

Specialty Areas

Radiation Oncology
Brain Tumors
Lymphoma
Lung Cancer
Sarcoma

Board Certifications

Therapeutic Radiology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Brain tumors, cancer of the central nervous system, cancer antibody development, immunotherapy, cancer drug development, radiation protecting drugs, nanoparticles, cancer drug delivery gene therapy for cancer

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Floor: LL
Office Phone: 314-747-9600

Education

Education

Postdoctorate Basic Science Research: Radiation and Cellular Oncology, University of Chicago Medical School, Chicago, IL 1990
B.S. (Biology): University of Chicago, Chicago, IL 1980
Medical School: Rush University, Chicago, IL 1984
Residency: Internal Medicine, University of Chicago Medical School, Chicago, IL 1986
Residency: Radiation Oncology, University of Chicago Medical School, Chicago, IL 1989

Publication & Research

Publication & Research

PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance.
Dadey DYA, Kapoor V, Khudanyan A, Thotala D, Hallahan DE
Mol Cancer Res. 2018 Oct; 16(10)1447-1453. doi: 10.1158/1541-7786.MCR-18-0224.

PMID:
    29991528
    [PubMed - in process]
Related citations


A convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided high-intensity focused ultrasound systems with phased array transducers.
Kothapalli SVVN, Partanen A, Zhu L, Altman MB, Gach HM, Hallahan DE, Chen H
J Ther Ultrasound. 2018; 65. doi: 10.1186/s40349-018-0113-7.

PMID:
    29988649
    [PubMed]
Related citations


Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy.
Fabbrizi MR, Meyer B, Misri S, Raj S, Zobel CL, Hallahan DE, Sharma GG
Cell Death Dis. 2018 May 1; 9(5)492. doi: 10.1038/s41419-018-0559-0.

PMID:
    29706648
    [PubMed - in process]
Related citations


Association of 1p/19q Codeletion and Radiation Necrosis in Adult Cranial Gliomas After Proton or Photon Therapy.
Acharya S, Robinson CG, Michalski JM, Mullen D, DeWees TA, Campian JL, Chundury A, Bottani B, Hallahan DE, Bradley JD, Huang J
Int J Radiat Oncol Biol Phys. 2018 Jun 1; 101(2)334-343. doi: 10.1016/j.ijrobp.2018.01.099.

PMID:
    29534896
    [PubMed - in process]
Related citations


Evaluation and selection of anatomic sites for magnetic resonance imaging-guided mild hyperthermia therapy: a healthy volunteer study.
V V N Kothapalli S, Altman MB, Zhu L, Partanen A, Cheng G, Gach HM, Straube W, Zoberi I, Hallahan DE, Chen H
Int J Hyperthermia. 2018 Dec; 34(8)1381-1389. doi: 10.1080/02656736.2017.1418536.

PMID:
    29301453
    [PubMed - in process]
Related citations


Acoustic field characterization of a clinical magnetic resonance-guided high-intensity focused ultrasound system inside the magnet bore.
Kothapalli SVVN, Altman MB, Partanen A, Wan L, Gach HM, Straube W, Hallahan DE, Chen H
Med Phys. 2017 Sep; 44(9)4890-4899. doi: 10.1002/mp.12412.

PMID:
    28626862
    [PubMed - indexed for MEDLINE]
Related citations


Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells.
Meyer B, Fabbrizi MR, Raj S, Zobel CL, Hallahan DE, Sharma GG
Stem Cell Reports. 2016 Dec 13; 7(6)1013-1022. doi: 10.1016/j.stemcr.2016.11.004.

PMID:
    27974220
    [PubMed - indexed for MEDLINE]
Related citations


An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma.
Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, Kim AH
Proc Natl Acad Sci U S A. 2016 Dec 20; 113(51)E8247-E8256. doi: 10.1073/pnas.1610921114.

PMID:
    27930300
    [PubMed - indexed for MEDLINE]
Related citations


Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.
Dadey DYA, Kapoor V, Hoye K, Khudanyan A, Collins A, Thotala D, Hallahan DE
Clin Cancer Res. 2017 May 15; 23(10)2556-2564. doi: 10.1158/1078-0432.CCR-16-1935.

PMID:
    27815359
    [PubMed - indexed for MEDLINE]
Related citations


Retargeted adenoviruses for radiation-guided gene delivery.
Kaliberov SA, Kaliberova LN, Yan H, Kapoor V, Hallahan DE
Cancer Gene Ther. 2016 Sep; 23(9)303-14. doi: 10.1038/cgt.2016.32.

PMID:
    27492853
    [PubMed - indexed for MEDLINE]
Related citations


Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers.
Kapoor V, Dadey DY, Nguyen K, Wildman SA, Hoye K, Khudanyan A, Bandara N, Rogers BE, Thotala D, Hallahan DE
J Nucl Med. 2016 Dec; 57(12)1991-1997.

PMID:
    27445290
    [PubMed - indexed for MEDLINE]
Related citations


Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses.
Jacobs KM, Misri S, Meyer B, Raj S, Zobel CL, Sleckman BP, Hallahan DE, Sharma GG
Mol Biol Cell. 2016 Apr 15; 27(8)1332-45. doi: 10.1091/mbc.E16-01-0017.

PMID:
    26941327
    [PubMed - indexed for MEDLINE]
Related citations


The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.
Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE
Oncotarget. 2016 Jan 12; 7(2)2080-92. doi: 10.18632/oncotarget.6712.

PMID:
    26716508
    [PubMed - indexed for MEDLINE]
Related citations


A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis.
Jiang X, Yuan L, Engelbach JA, Cates J, Perez-Torres CJ, Gao F, Thotala D, Drzymala RE, Schmidt RE, Rich KM, Hallahan DE, Ackerman JJ, Garbow JR
PLoS One. 2015; 10(10)e0139596. doi: 10.1371/journal.pone.0139596.

PMID:
    26440791
    [PubMed - indexed for MEDLINE]
Related citations


Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells.
Thotala D, Karvas RM, Engelbach JA, Garbow JR, Hallahan AN, DeWees TA, Laszlo A, Hallahan DE
Oncotarget. 2015 Oct 27; 6(33)35004-22. doi: 10.18632/oncotarget.5253.

PMID:
    26413814
    [PubMed - indexed for MEDLINE]
Related citations


Specificity of vascular endothelial growth factor treatment for radiation necrosis.
Perez-Torres CJ, Yuan L, Schmidt RE, Rich KM, Drzymala RE, Hallahan DE, Ackerman JJ, Garbow JR
Radiother Oncol. 2015 Nov; 117(2)382-5. doi: 10.1016/j.radonc.2015.09.004.

PMID:
    26376163
    [PubMed - indexed for MEDLINE]
Related citations


Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth.
Zhao DY, Jacobs KM, Hallahan DE, Thotala D
Mol Cancer Ther. 2015 Oct; 14(10)2343-52. doi: 10.1158/1535-7163.MCT-14-1051.

PMID:
    26206332
    [PubMed - indexed for MEDLINE]
Related citations


Stem Cell Transfusion Restores Immune Function in Radiation-Induced Lymphopenic C57BL/6 Mice.
Kapoor V, Khudanyan A, de la Puente P, Campian J, Hallahan DE, Azab AK, Thotala D
Cancer Res. 2015 Sep 1; 75(17)3442-5. doi: 10.1158/0008-5472.CAN-15-1412.

PMID:
    26130648
    [PubMed - indexed for MEDLINE]
Related citations


A GSK-3β inhibitor protects against radiation necrosis in mouse brain.
Jiang X, Perez-Torres CJ, Thotala D, Engelbach JA, Yuan L, Cates J, Gao F, Drzymala RE, Rich KM, Schmidt RE, Ackerman JJ, Hallahan DE, Garbow JR
Int J Radiat Oncol Biol Phys. 2014 Jul 15; 89(4)714-21. doi: 10.1016/j.ijrobp.2014.04.018.

PMID:
    24969790
    [PubMed - indexed for MEDLINE]
Related citations


Anti-VEGF antibodies mitigate the development of radiation necrosis in mouse brain.
Jiang X, Engelbach JA, Yuan L, Cates J, Gao F, Drzymala RE, Hallahan DE, Rich KM, Schmidt RE, Ackerman JJ, Garbow JR
Clin Cancer Res. 2014 May 15; 20(10)2695-702. doi: 10.1158/1078-0432.CCR-13-1941.

PMID:
    24647570
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Medical Guidance Systems

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2018

Areas of Research Interest

Identification of new molecular targets for cancer therapy, drug development to improve cancer response to radiation therapy while minimizing the effect on normal tissues. Also drug development to protect tissues from radiation, antibody development and the use of nanoparticles for drug delivery