Patient Portal

Deborah Jane Lenschow, MD, PhD

Associate Professor, Medicine
Division of Rheumatology

Specialty Areas

Rheumatology

Board Certifications

Internal Medicine
Rheumatology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Rheumatology

  • Education
  • Publication & Research

Education

Education

Fellowship: Rheumatology, Washington University School of Medicine, St. Louis, Missouri 2003
Residency: Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 2000
Medical Degree: Univerisity of Chicago Pritzker School of Medicine, Chicago, Illinois 1998
Ph.D.: University of Chicago Pritzker School of Medicine, Chicago, Illinois 1995
B.A.: Wittenberg University, Springfield, Ohio 1990

Publication & Research

Publication & Research

Intracellular C3 Protects Human Airway Epithelial Cells from Stress-Associated Cell Death.
Kulkarni HS, Elvington ML, Perng YC, Liszewski MK, Byers DE, Farkouh C, Yusen RD, Lenschow DJ, Brody SL, Atkinson JP
Am J Respir Cell Mol Biol. 2018 Aug 29; doi: 10.1165/rcmb.2017-0405OC.

PMID:
    30156437
    [PubMed - as supplied by publisher]
Related citations


ISG15 in antiviral immunity and beyond.
Perng YC, Lenschow DJ
Nat Rev Microbiol. 2018 Jul; 16(7)423-439. doi: 10.1038/s41579-018-0020-5.

PMID:
    29769653
    [PubMed - in process]
Related citations


Editorial: Lessons Learned From Chikungunya in the Americas.
Miner JJ, Lenschow DJ
Arthritis Rheumatol. 2018 Apr; 70(4)477-479. doi: 10.1002/art.40421.

PMID:
    29361204
    [PubMed - in process]
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The microbial metabolite desaminotyrosine protects from influenza through type I interferon.
Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS
Science. 2017 Aug 4; 357(6350)498-502. doi: 10.1126/science.aam5336.

PMID:
    28774928
    [PubMed - indexed for MEDLINE]
Related citations


Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.
Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S
Lancet Infect Dis. 2017 Apr; 17(4)e107-e117. doi: 10.1016/S1473-3099(16)30385-1.

PMID:
    28159534
    [PubMed - indexed for MEDLINE]
Related citations


Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis.
Miner JJ, Cook LE, Hong JP, Smith AM, Richner JM, Shimak RM, Young AR, Monte K, Poddar S, Crowe JE Jr, Lenschow DJ, Diamond MS
Sci Transl Med. 2017 Feb 1; 9(375)pii: eaah3438. doi: 10.1126/scitranslmed.aah3438.

PMID:
    28148840
    [PubMed - indexed for MEDLINE]
Related citations


The impact of ISGylation during Mycobacterium tuberculosis infection in mice.
Kimmey JM, Campbell JA, Weiss LA, Monte KJ, Lenschow DJ, Stallings CL
Microbes Infect. 2017 Apr - May; 19(4-5)249-258. doi: 10.1016/j.micinf.2016.12.006.

PMID:
    28087453
    [PubMed - indexed for MEDLINE]
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ISG15 deficiency and increased viral resistance in humans but not mice.
Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D
Nat Commun. 2016 May 19; 711496. doi: 10.1038/ncomms11496.

PMID:
    27193971
    [PubMed - indexed for MEDLINE]
Related citations


Replication-competent fluorescent-expressing influenza B virus.
Nogales A, Rodríguez-Sánchez I, Monte K, Lenschow DJ, Perez DR, Martínez-Sobrido L
Virus Res. 2016 Feb 2; 21369-81. doi: 10.1016/j.virusres.2015.11.014.

PMID:
    26590325
    [PubMed - indexed for MEDLINE]
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Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.
Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP
Proc Natl Acad Sci U S A. 2015 Feb 3; 112(5)1577-82. doi: 10.1073/pnas.1412881112.

PMID:
    25605921
    [PubMed - indexed for MEDLINE]
Related citations


Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.
Miner JJ, Aw-Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AHJ, Diamond MS, Lenschow DJ, Yokoyama WM
Arthritis Rheumatol. 2015 May; 67(5)1214-1220. doi: 10.1002/art.39027.

PMID:
    25605621
    [PubMed - indexed for MEDLINE]
Related citations


Type I interferons link viral infection to enhanced epithelial turnover and repair.
Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS
Cell Host Microbe. 2015 Jan 14; 17(1)85-97. doi: 10.1016/j.chom.2014.11.004.

PMID:
    25482432
    [PubMed - indexed for MEDLINE]
Related citations


Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.
Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ
J Virol. 2015 Jan; 89(1)337-49. doi: 10.1128/JVI.02110-14.

PMID:
    25320315
    [PubMed - indexed for MEDLINE]
Related citations


Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.
Perng YC, Campbell JA, Lenschow DJ, Yu D
PLoS Pathog. 2014 Aug; 10(8)e1004350. doi: 10.1371/journal.ppat.1004350.

PMID:
    25166009
    [PubMed - indexed for MEDLINE]
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A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC
J Virol. 2014 Oct; 88(20)11825-33. doi: 10.1128/JVI.01749-14.

PMID:
    25100850
    [PubMed - indexed for MEDLINE]
Related citations


ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle.
Rodriguez MR, Monte K, Thackray LB, Lenschow DJ
J Virol. 2014 Aug; 88(16)9277-86. doi: 10.1128/JVI.01422-14.

PMID:
    24899198
    [PubMed - indexed for MEDLINE]
Related citations


Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus.
Rohatgi A, Corbo JC, Monte K, Higgs S, Vanlandingham DL, Kardon G, Lenschow DJ
J Virol. 2014 Mar; 88(5)2414-25. doi: 10.1128/JVI.02716-13.

PMID:
    24335291
    [PubMed - indexed for MEDLINE]
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Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor.
Lubman OY, Cella M, Wang X, Monte K, Lenschow DJ, Huang YH, Fremont DH
J Virol. 2014 Jan; 88(1)538-46. doi: 10.1128/JVI.02729-13.

PMID:
    24173234
    [PubMed - indexed for MEDLINE]
Related citations


The antiviral activities of ISG15.
Morales DJ, Lenschow DJ
J Mol Biol. 2013 Dec 13; 425(24)4995-5008. doi: 10.1016/j.jmb.2013.09.041.

PMID:
    24095857
    [PubMed - indexed for MEDLINE]
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Emerging roles for immunomodulatory functions of free ISG15.
Campbell JA, Lenschow DJ
J Interferon Cytokine Res. 2013 Dec; 33(12)728-38. doi: 10.1089/jir.2013.0064.

PMID:
    24010825
    [PubMed - indexed for MEDLINE]
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